Incidental Mutation 'R0089:Or9m1b'
ID 20038
Institutional Source Beutler Lab
Gene Symbol Or9m1b
Ensembl Gene ENSMUSG00000075141
Gene Name olfactory receptor family 9 subfamily M member 1B
Synonyms Olfr1160, MOR173-1, GA_x6K02T2Q125-49498697-49497765
MMRRC Submission 038376-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # R0089 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 2
Chromosomal Location 87836161-87837120 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87836331 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 264 (I264V)
Ref Sequence ENSEMBL: ENSMUSP00000097427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099839] [ENSMUST00000215457]
AlphaFold A2AVT0
Predicted Effect probably damaging
Transcript: ENSMUST00000099839
AA Change: I264V

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000097427
Gene: ENSMUSG00000075141
AA Change: I264V

DomainStartEndE-ValueType
Pfam:7tm_4 40 316 1.2e-46 PFAM
Pfam:7tm_1 50 298 2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215457
AA Change: I255V

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.6%
  • 20x: 90.5%
Validation Efficiency 98% (82/84)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm2 T A 4: 144,282,303 (GRCm39) H163L probably benign Het
Abca13 T A 11: 9,242,886 (GRCm39) V1583E possibly damaging Het
Ablim1 G T 19: 57,031,463 (GRCm39) S654Y probably damaging Het
Acbd4 T C 11: 102,994,819 (GRCm39) F59S probably damaging Het
Acot1 T C 12: 84,063,708 (GRCm39) I272T probably damaging Het
Ankhd1 A G 18: 36,773,409 (GRCm39) D1402G probably damaging Het
Birc6 T A 17: 74,945,371 (GRCm39) F2800I possibly damaging Het
Brd1 T C 15: 88,585,401 (GRCm39) E811G probably benign Het
Catspere2 C T 1: 177,874,555 (GRCm39) P141S unknown Het
Ccdc106 A G 7: 5,059,220 (GRCm39) probably null Het
Ccdc81 G T 7: 89,542,324 (GRCm39) A184E possibly damaging Het
Cenpt T C 8: 106,573,000 (GRCm39) T364A probably benign Het
Crybg2 T C 4: 133,808,505 (GRCm39) S1060P probably damaging Het
Dnttip2 A G 3: 122,069,111 (GRCm39) T109A possibly damaging Het
Dpy19l2 A G 9: 24,607,089 (GRCm39) L124P probably benign Het
Eif1ad19 A T 12: 87,740,283 (GRCm39) I92N probably damaging Het
Fat3 T C 9: 15,849,501 (GRCm39) D3967G probably benign Het
Fbxo21 T A 5: 118,146,208 (GRCm39) F610L probably benign Het
Fmo9 T C 1: 166,494,878 (GRCm39) D341G probably benign Het
Frem3 A T 8: 81,342,507 (GRCm39) H1600L possibly damaging Het
Fry A T 5: 150,263,892 (GRCm39) K133N possibly damaging Het
Gm10647 A G 9: 66,705,612 (GRCm39) probably benign Het
Gmps T C 3: 63,906,119 (GRCm39) F472S probably benign Het
Grb10 T C 11: 11,884,192 (GRCm39) probably benign Het
Grm6 G A 11: 50,750,792 (GRCm39) G652S probably damaging Het
Heca G T 10: 17,783,848 (GRCm39) D468E probably damaging Het
Heg1 C T 16: 33,583,985 (GRCm39) S1033L probably damaging Het
Hepacam2 A G 6: 3,487,094 (GRCm39) S12P probably damaging Het
Impdh1 G T 6: 29,206,325 (GRCm39) H195N probably benign Het
Ipo7 T C 7: 109,649,972 (GRCm39) probably benign Het
Itpr2 C T 6: 146,251,520 (GRCm39) probably null Het
Kcnh6 G A 11: 105,899,848 (GRCm39) C39Y probably benign Het
Kif26a T C 12: 112,143,837 (GRCm39) S1364P probably damaging Het
Lins1 T A 7: 66,361,796 (GRCm39) probably benign Het
Lrpap1 C T 5: 35,252,232 (GRCm39) V328M possibly damaging Het
Lyn T G 4: 3,748,768 (GRCm39) L249V probably benign Het
Mpp7 A G 18: 7,439,555 (GRCm39) probably benign Het
Mtmr9 A G 14: 63,765,696 (GRCm39) F400L possibly damaging Het
Mto1 G A 9: 78,381,154 (GRCm39) S666N probably benign Het
Nanos3 C T 8: 84,902,763 (GRCm39) R133Q probably damaging Het
Nsg1 T C 5: 38,312,974 (GRCm39) E75G probably benign Het
Nsun4 A G 4: 115,892,970 (GRCm39) M283T probably benign Het
Obscn A G 11: 58,890,888 (GRCm39) S7215P unknown Het
Or11j4 T C 14: 50,630,321 (GRCm39) I36T probably benign Het
Or13a20 T C 7: 140,232,224 (GRCm39) S111P probably damaging Het
Or1j12 G A 2: 36,343,107 (GRCm39) R170K probably benign Het
Or2y13 G A 11: 49,415,033 (GRCm39) S161N possibly damaging Het
Or52e4 T A 7: 104,706,297 (GRCm39) Y281* probably null Het
Or5al1 A C 2: 85,989,918 (GRCm39) S265R possibly damaging Het
Per1 T C 11: 68,994,869 (GRCm39) F563S probably benign Het
Pik3c3 T A 18: 30,436,131 (GRCm39) probably benign Het
Pitrm1 A T 13: 6,605,675 (GRCm39) K207N probably damaging Het
Prdm10 C T 9: 31,227,526 (GRCm39) R44C probably damaging Het
Rab40c A T 17: 26,104,122 (GRCm39) I90N probably damaging Het
Rbl1 A G 2: 157,041,334 (GRCm39) probably null Het
Rnf17 G A 14: 56,751,563 (GRCm39) G1467E probably damaging Het
Rpgrip1 A G 14: 52,386,841 (GRCm39) probably benign Het
Sall1 A T 8: 89,756,896 (GRCm39) N1069K probably benign Het
Scap T C 9: 110,201,290 (GRCm39) I93T possibly damaging Het
Sez6 T C 11: 77,865,170 (GRCm39) probably benign Het
Slc22a30 A T 19: 8,347,561 (GRCm39) S280T probably benign Het
Slc26a5 A C 5: 22,016,342 (GRCm39) probably null Het
St18 T C 1: 6,919,172 (GRCm39) V901A probably benign Het
Syne2 T C 12: 76,010,650 (GRCm39) L2519P probably damaging Het
Syne4 G A 7: 30,018,344 (GRCm39) G362E probably damaging Het
Tmem51 T C 4: 141,759,236 (GRCm39) T171A probably benign Het
Tns4 A T 11: 98,966,024 (GRCm39) I453N probably damaging Het
Trank1 A T 9: 111,221,978 (GRCm39) H2905L probably benign Het
Trim13 C T 14: 61,842,166 (GRCm39) T61I possibly damaging Het
Trim75 T C 8: 65,435,580 (GRCm39) Q290R possibly damaging Het
Ttn C A 2: 76,559,544 (GRCm39) R29619L probably damaging Het
Ugt2b38 T A 5: 87,568,417 (GRCm39) M293L probably benign Het
Vmn1r22 T A 6: 57,877,513 (GRCm39) N155Y probably benign Het
Vmn2r18 T C 5: 151,508,269 (GRCm39) Y285C probably benign Het
Vmn2r84 C T 10: 130,222,588 (GRCm39) probably benign Het
Vwde A C 6: 13,220,004 (GRCm39) L49R probably damaging Het
Yipf2 T A 9: 21,503,262 (GRCm39) E68D possibly damaging Het
Zfand5 C A 19: 21,257,122 (GRCm39) probably benign Het
Other mutations in Or9m1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00272:Or9m1b APN 2 87,836,988 (GRCm39) missense probably damaging 1.00
IGL01321:Or9m1b APN 2 87,836,589 (GRCm39) missense probably damaging 0.97
IGL02009:Or9m1b APN 2 87,837,117 (GRCm39) missense probably benign
IGL03409:Or9m1b APN 2 87,836,239 (GRCm39) missense probably damaging 1.00
R0685:Or9m1b UTSW 2 87,836,762 (GRCm39) missense probably damaging 1.00
R1416:Or9m1b UTSW 2 87,836,915 (GRCm39) missense probably damaging 1.00
R1852:Or9m1b UTSW 2 87,836,865 (GRCm39) missense probably damaging 1.00
R1965:Or9m1b UTSW 2 87,836,648 (GRCm39) missense probably damaging 1.00
R2206:Or9m1b UTSW 2 87,836,579 (GRCm39) missense probably benign 0.00
R4853:Or9m1b UTSW 2 87,836,448 (GRCm39) missense probably damaging 1.00
R5599:Or9m1b UTSW 2 87,836,349 (GRCm39) missense probably benign 0.44
R6851:Or9m1b UTSW 2 87,836,300 (GRCm39) missense probably damaging 0.98
R6995:Or9m1b UTSW 2 87,836,529 (GRCm39) missense probably benign 0.00
R7817:Or9m1b UTSW 2 87,836,355 (GRCm39) missense probably benign
R7970:Or9m1b UTSW 2 87,836,169 (GRCm39) missense probably benign 0.02
R7984:Or9m1b UTSW 2 87,836,969 (GRCm39) missense probably damaging 1.00
R8325:Or9m1b UTSW 2 87,836,537 (GRCm39) missense probably damaging 1.00
R8912:Or9m1b UTSW 2 87,836,661 (GRCm39) missense possibly damaging 0.93
Z1176:Or9m1b UTSW 2 87,836,781 (GRCm39) missense probably damaging 0.98
Z31818:Or9m1b UTSW 2 87,836,234 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TTGCTAATGCTGTAAAGCCCATCGT -3'
(R):5'- GGCTGCAATGGCTTATGACAGGTA -3'

Sequencing Primer
(F):5'- GCTGTAAAGCCCATCGTTAAATAG -3'
(R):5'- CAATGGCTTATGACAGGTACATTGC -3'
Posted On 2013-04-11