Incidental Mutation 'R1743:Or2b2'
ID 200535
Institutional Source Beutler Lab
Gene Symbol Or2b2
Ensembl Gene ENSMUSG00000108674
Gene Name olfactory receptor family 2 subfamily B member 2
Synonyms MOR256-60, MOR256-35, Olfr1359, GA_x6K02T2QHY8-11534186-11533245
MMRRC Submission 039775-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R1743 (G1)
Quality Score 117
Status Not validated
Chromosome 13
Chromosomal Location 21887144-21888135 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21887620 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 150 (I150V)
Ref Sequence ENSEMBL: ENSMUSP00000074361 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077843] [ENSMUST00000079135] [ENSMUST00000205788] [ENSMUST00000214435]
AlphaFold Q7TQU5
Predicted Effect probably benign
Transcript: ENSMUST00000077843
AA Change: I150V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000077010
Gene: ENSMUSG00000108674
AA Change: I150V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2e-55 PFAM
Pfam:7tm_1 41 290 1.7e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000079135
AA Change: I150V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000074361
Gene: ENSMUSG00000108534
AA Change: I150V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3e-55 PFAM
Pfam:7tm_1 41 290 1.1e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205788
AA Change: I150V
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214006
Predicted Effect probably benign
Transcript: ENSMUST00000214435
AA Change: I150V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.1%
  • 20x: 91.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff4 T A 11: 53,259,522 (GRCm39) M11K possibly damaging Het
Ank2 T C 3: 126,722,324 (GRCm39) D88G probably damaging Het
Arhgap32 A G 9: 32,170,727 (GRCm39) E1169G probably benign Het
Atp7b A T 8: 22,496,403 (GRCm39) V865E probably damaging Het
Bcl2l13 T A 6: 120,825,504 (GRCm39) Y13* probably null Het
Birc6 A G 17: 74,886,751 (GRCm39) Q693R possibly damaging Het
Bub1 T C 2: 127,655,770 (GRCm39) D520G probably damaging Het
Ccdc15 A T 9: 37,188,773 (GRCm39) Y770* probably null Het
Cenpf T C 1: 189,386,460 (GRCm39) E1940G probably benign Het
Cep295 C T 9: 15,252,179 (GRCm39) E397K probably damaging Het
Cmya5 A G 13: 93,233,825 (GRCm39) V421A probably benign Het
Cnnm1 A T 19: 43,460,352 (GRCm39) Y698F possibly damaging Het
Cnst C T 1: 179,437,957 (GRCm39) T507I probably benign Het
Coq8a T C 1: 180,009,794 (GRCm39) M4V probably benign Het
Csmd3 A G 15: 48,485,485 (GRCm39) L140P probably damaging Het
Cul2 A T 18: 3,426,851 (GRCm39) I431F probably damaging Het
Dnah8 G T 17: 30,988,625 (GRCm39) E3198D probably benign Het
Dnai3 C A 3: 145,803,017 (GRCm39) R58L possibly damaging Het
Epn2 T A 11: 61,437,237 (GRCm39) I112F possibly damaging Het
Ext2 T C 2: 93,560,570 (GRCm39) E532G probably damaging Het
Fndc3a A T 14: 72,889,521 (GRCm39) V37E probably damaging Het
Gabbr2 A G 4: 46,677,603 (GRCm39) F759S possibly damaging Het
Ghr G A 15: 3,349,723 (GRCm39) P485L probably benign Het
Glipr1l2 G T 10: 111,928,470 (GRCm39) V122L probably benign Het
Gm10608 CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA 9: 118,989,784 (GRCm39) probably benign Het
Gm6871 G T 7: 41,195,876 (GRCm39) T287K probably damaging Het
Gm7275 A G 16: 47,894,120 (GRCm39) noncoding transcript Het
Hephl1 C T 9: 15,001,364 (GRCm39) V254I probably damaging Het
Hnf4a C A 2: 163,408,259 (GRCm39) Q362K possibly damaging Het
Kcne3 C T 7: 99,833,631 (GRCm39) R83C probably damaging Het
Klb C A 5: 65,533,204 (GRCm39) N504K probably damaging Het
Loxl2 T A 14: 69,929,851 (GRCm39) I743N possibly damaging Het
Lrrc9 A T 12: 72,502,891 (GRCm39) L287F probably damaging Het
Mcm3ap C T 10: 76,320,508 (GRCm39) P822L possibly damaging Het
Nacc2 T C 2: 25,950,155 (GRCm39) N527S probably benign Het
Ncam1 G T 9: 49,468,445 (GRCm39) P338H probably damaging Het
Nfkbiz G T 16: 55,636,757 (GRCm39) Q515K possibly damaging Het
Nipsnap2 T C 5: 129,834,149 (GRCm39) L263P probably damaging Het
Nlrp1a A T 11: 71,015,032 (GRCm39) S73T probably benign Het
Nomo1 G A 7: 45,719,461 (GRCm39) probably null Het
Nos3 G A 5: 24,582,310 (GRCm39) G594D probably benign Het
Oprm1 A G 10: 6,780,105 (GRCm39) I256V probably damaging Het
Or10ak16 A G 4: 118,750,723 (GRCm39) T148A probably benign Het
Or10n1 A T 9: 39,524,916 (GRCm39) T18S possibly damaging Het
Oxct2a A T 4: 123,217,309 (GRCm39) L24Q possibly damaging Het
Pcdhb14 T G 18: 37,581,231 (GRCm39) S112R probably benign Het
Polr2a A G 11: 69,630,329 (GRCm39) I1246T probably damaging Het
Ppil4 A T 10: 7,683,145 (GRCm39) K327N probably damaging Het
Pramel30 T C 4: 144,059,575 (GRCm39) S429P probably benign Het
Pstpip1 T C 9: 56,033,214 (GRCm39) Y249H probably damaging Het
Qrsl1 A T 10: 43,757,511 (GRCm39) V369E probably damaging Het
Ranbp10 G T 8: 106,506,610 (GRCm39) P237T probably damaging Het
Rapgef6 A G 11: 54,567,110 (GRCm39) N1097S probably damaging Het
Repin1 T A 6: 48,574,684 (GRCm39) S538T probably damaging Het
Rims2 A T 15: 39,543,046 (GRCm39) M1151L probably benign Het
Rin3 T A 12: 102,356,355 (GRCm39) D965E possibly damaging Het
Sdc2 A G 15: 33,028,224 (GRCm39) D114G probably benign Het
Slc25a30 C A 14: 76,012,523 (GRCm39) A42S probably benign Het
Sphkap G A 1: 83,255,236 (GRCm39) R838* probably null Het
Ssh2 T A 11: 77,328,582 (GRCm39) F383I probably damaging Het
St8sia1 A T 6: 142,774,742 (GRCm39) V279E probably damaging Het
Tacc2 C A 7: 130,228,328 (GRCm39) S1690* probably null Het
Taf1b A G 12: 24,597,177 (GRCm39) D372G possibly damaging Het
Timm21 G C 18: 84,967,387 (GRCm39) L130V probably damaging Het
Tmem165 G T 5: 76,355,673 (GRCm39) G272C probably damaging Het
Tsc22d2 TCAGTTAACACCTATGAACAGT TCAGT 3: 58,324,960 (GRCm39) probably null Het
Tssk4 C A 14: 55,888,488 (GRCm39) A119D probably damaging Het
Usp9y A G Y: 1,316,727 (GRCm39) Y1941H probably damaging Het
Vmn2r42 A T 7: 8,187,264 (GRCm39) M786K probably benign Het
Wdfy3 G T 5: 101,991,931 (GRCm39) T3470K probably benign Het
Zc3h14 T C 12: 98,745,448 (GRCm39) V479A probably benign Het
Zfp821 G A 8: 110,450,796 (GRCm39) R263Q probably damaging Het
Other mutations in Or2b2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01563:Or2b2 APN 13 21,887,243 (GRCm39) missense probably benign 0.21
R1601:Or2b2 UTSW 13 21,887,396 (GRCm39) missense probably damaging 1.00
R1944:Or2b2 UTSW 13 21,887,287 (GRCm39) missense possibly damaging 0.95
R4084:Or2b2 UTSW 13 21,887,239 (GRCm39) missense probably damaging 1.00
R4084:Or2b2 UTSW 13 21,887,238 (GRCm39) nonsense probably null
R5677:Or2b2 UTSW 13 21,887,393 (GRCm39) missense probably benign 0.03
R6485:Or2b2 UTSW 13 21,887,600 (GRCm39) missense probably benign 0.00
R6981:Or2b2 UTSW 13 21,887,243 (GRCm39) missense probably benign 0.21
R7028:Or2b2 UTSW 13 21,887,440 (GRCm39) missense possibly damaging 0.95
R7221:Or2b2 UTSW 13 21,887,272 (GRCm39) missense probably damaging 1.00
R7799:Or2b2 UTSW 13 21,887,369 (GRCm39) missense probably damaging 1.00
R8400:Or2b2 UTSW 13 21,888,085 (GRCm39) missense probably benign 0.00
R9050:Or2b2 UTSW 13 21,887,150 (GRCm39) utr 5 prime probably benign
Predicted Primers PCR Primer
(F):5'- TAACCTGTCCTTGCTGGACCTGTG -3'
(R):5'- ATGTCCCAAATGCCTTTCGCCG -3'

Sequencing Primer
(F):5'- CCCGGAAGGTGATCAGCTATG -3'
(R):5'- ATTCTCAACACTGCCTGGAC -3'
Posted On 2014-05-23