Mutagenetix > Incidental Mutation

Incidental Mutation 'Y4340:Dennd11'

200614

Institutional Source

Beutler Lab

Gene Symbol

Dennd11

Ensembl Gene

ENSMUSG00000037172

Gene Name

DENN domain containing 11

Synonyms

E330009J07Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

Y4340 ()

Quality Score

105

Status

Not validated

Chromosome

Chromosomal Location

40378309-40413069 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 40412992 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 23 (Q23L)

Ref Sequence

ENSEMBL: ENSMUSP00000099031 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039008] [ENSMUST00000101492] [ENSMUST00000201712] [ENSMUST00000202464]

AlphaFold

Q3UHG7

Predicted Effect

probably benign
Transcript: ENSMUST00000039008
AA Change: Q23L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000045103
Gene: ENSMUSG00000037172
AA Change: Q23L

Domain	Start	End	E-Value	Type
low complexity region	30	60	N/A	INTRINSIC
Pfam:DUF2347	80	347	3.4e-79	PFAM
Pfam:SPA	234	345	5.2e-15	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000101492
AA Change: Q23L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000099031
Gene: ENSMUSG00000037172
AA Change: Q23L

Domain	Start	End	E-Value	Type
low complexity region	30	60	N/A	INTRINSIC
Pfam:DUF2347	80	347	3.2e-78	PFAM
Pfam:SPA	234	345	6.3e-16	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200994

Predicted Effect

probably benign
Transcript: ENSMUST00000201712

SMART Domains

Protein: ENSMUSP00000143916
Gene: ENSMUSG00000037172

Domain	Start	End	E-Value	Type
Pfam:DUF2347	15	133	1.4e-29	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000202464

SMART Domains

Protein: ENSMUSP00000144628
Gene: ENSMUSG00000037159

Domain	Start	End	E-Value	Type
low complexity region	117	128	N/A	INTRINSIC

Coding Region Coverage

1x: 97.4%
3x: 96.9%
10x: 95.5%
20x: 93.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 2 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ush2a	C	T	1: 188,475,826 (GRCm39)	T2921M	possibly damaging	Het
Zfp28	C	A	7: 6,397,656 (GRCm39)	T697N	probably damaging	Het

Other mutations in Dennd11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02813:Dennd11	APN	6	40,395,473 (GRCm39)	missense	probably benign	0.00
IGL03143:Dennd11	APN	6	40,399,828 (GRCm39)	splice site	probably benign
R1812:Dennd11	UTSW	6	40,386,365 (GRCm39)	missense	probably benign	0.02
R1928:Dennd11	UTSW	6	40,388,648 (GRCm39)	missense	probably benign	0.14
R2443:Dennd11	UTSW	6	40,383,710 (GRCm39)	missense	probably damaging	0.99
R3012:Dennd11	UTSW	6	40,412,926 (GRCm39)	missense	probably benign
R6913:Dennd11	UTSW	6	40,383,851 (GRCm39)	missense	possibly damaging	0.91
R7318:Dennd11	UTSW	6	40,386,098 (GRCm39)	missense	possibly damaging	0.72
R7456:Dennd11	UTSW	6	40,383,774 (GRCm39)	missense	probably benign	0.33
R8087:Dennd11	UTSW	6	40,395,526 (GRCm39)	missense	possibly damaging	0.94
R8231:Dennd11	UTSW	6	40,395,546 (GRCm39)	missense	probably benign	0.35
R8776:Dennd11	UTSW	6	40,395,775 (GRCm39)	intron	probably benign
R8858:Dennd11	UTSW	6	40,399,669 (GRCm39)	missense	probably benign	0.02

Predicted Primers

Posted On

2014-05-23