Incidental Mutation 'R0020:Or10aa3'
ID 201363
Institutional Source Beutler Lab
Gene Symbol Or10aa3
Ensembl Gene ENSMUSG00000047048
Gene Name olfactory receptor family 10 subfamily AA member 3
Synonyms GA_x6K02T2P20D-21124681-21123743, MOR123-2, Olfr432
MMRRC Submission 038315-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0020 (G1)
Quality Score 30
Status Validated
Chromosome 1
Chromosomal Location 173877941-173878879 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 173878413 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 158 (V158E)
Ref Sequence ENSEMBL: ENSMUSP00000150596 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062665] [ENSMUST00000213211] [ENSMUST00000213381]
AlphaFold E9Q8M2
Predicted Effect probably damaging
Transcript: ENSMUST00000062665
AA Change: V158E

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000060341
Gene: ENSMUSG00000047048
AA Change: V158E

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.7e-47 PFAM
Pfam:7TM_GPCR_Srsx 35 307 1.2e-7 PFAM
Pfam:7tm_1 41 289 6.5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192435
Predicted Effect probably damaging
Transcript: ENSMUST00000213211
AA Change: V158E

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000213381
AA Change: V158E

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.9%
  • 20x: 96.4%
Validation Efficiency 99% (67/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ado T C 10: 67,383,927 (GRCm39) D226G probably benign Het
Agfg2 C T 5: 137,652,064 (GRCm39) V432M probably benign Het
Atf2 T C 2: 73,676,628 (GRCm39) D122G possibly damaging Het
Brd10 A T 19: 29,693,597 (GRCm39) D2032E probably damaging Het
Cd2bp2 G A 7: 126,792,996 (GRCm39) T342M probably damaging Het
Cip2a A T 16: 48,821,975 (GRCm39) H201L probably damaging Het
Col6a3 T A 1: 90,739,272 (GRCm39) I319F probably damaging Het
Cst11 T A 2: 148,613,253 (GRCm39) Y24F probably damaging Het
Cstb T A 10: 78,263,170 (GRCm39) V65E probably benign Het
Cyp2j11 G A 4: 96,195,641 (GRCm39) H352Y probably benign Het
D130043K22Rik T A 13: 25,038,475 (GRCm39) probably benign Het
Dbh A G 2: 27,060,584 (GRCm39) probably benign Het
Dhdh T C 7: 45,137,528 (GRCm39) K53R probably benign Het
Drc3 A G 11: 60,261,371 (GRCm39) Y174C probably damaging Het
Ezr G T 17: 7,010,126 (GRCm39) Q308K probably damaging Het
F3 A T 3: 121,525,265 (GRCm39) N169Y probably damaging Het
Fbn2 G T 18: 58,238,236 (GRCm39) T587K probably damaging Het
Fhl5 A T 4: 25,200,054 (GRCm39) V260E probably benign Het
Glyr1 A G 16: 4,854,913 (GRCm39) I55T probably damaging Het
Gm12695 G C 4: 96,657,972 (GRCm39) P66A probably damaging Het
Gon4l G T 3: 88,766,244 (GRCm39) V428L probably damaging Het
Ighv6-5 T C 12: 114,380,241 (GRCm39) D92G probably null Het
Inhba A C 13: 16,200,949 (GRCm39) K170N possibly damaging Het
Kng2 A G 16: 22,816,046 (GRCm39) V317A probably benign Het
Larp1 T A 11: 57,940,849 (GRCm39) D658E probably damaging Het
Map3k14 T C 11: 103,118,500 (GRCm39) E562G probably damaging Het
Megf10 G T 18: 57,420,965 (GRCm39) V868F possibly damaging Het
Nap1l1 A C 10: 111,326,884 (GRCm39) E148D probably benign Het
Nlrp4a A T 7: 26,149,797 (GRCm39) H468L probably damaging Het
Nphs1 G T 7: 30,162,633 (GRCm39) V357L probably benign Het
Pclo A G 5: 14,719,687 (GRCm39) T1275A unknown Het
Pde4d T A 13: 110,091,104 (GRCm39) C35S possibly damaging Het
Pkd1l1 A G 11: 8,825,765 (GRCm39) probably benign Het
Pkd2 A G 5: 104,651,382 (GRCm39) E910G probably damaging Het
Pot1b T A 17: 55,960,429 (GRCm39) M634L probably benign Het
Ppp2r5c C T 12: 110,541,257 (GRCm39) Q469* probably null Het
Ppp6r2 T A 15: 89,143,342 (GRCm39) M163K probably damaging Het
Prss43 C A 9: 110,657,580 (GRCm39) probably benign Het
Rb1cc1 C A 1: 6,334,772 (GRCm39) N1444K possibly damaging Het
Rimoc1 T C 15: 4,021,350 (GRCm39) probably benign Het
Scube2 A G 7: 109,430,095 (GRCm39) probably benign Het
Slamf9 T C 1: 172,303,082 (GRCm39) S7P possibly damaging Het
Slc35b2 T A 17: 45,877,782 (GRCm39) M303K probably damaging Het
Slc4a7 T A 14: 14,796,108 (GRCm38) F1116I probably benign Het
Slco1a8 A T 6: 141,918,076 (GRCm39) V600E possibly damaging Het
Smarcad1 T A 6: 65,060,991 (GRCm39) probably benign Het
Tamalin T C 15: 101,128,433 (GRCm39) V157A probably damaging Het
Tns3 A C 11: 8,495,227 (GRCm39) probably null Het
Zfp282 T G 6: 47,856,943 (GRCm39) W59G probably damaging Het
Zfp746 C A 6: 48,041,641 (GRCm39) A362S probably benign Het
Other mutations in Or10aa3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01025:Or10aa3 APN 1 173,878,251 (GRCm39) missense probably damaging 1.00
IGL03002:Or10aa3 APN 1 173,878,191 (GRCm39) missense probably benign 0.03
R0386:Or10aa3 UTSW 1 173,877,965 (GRCm39) missense probably benign 0.00
R1735:Or10aa3 UTSW 1 173,878,365 (GRCm39) missense probably benign
R1932:Or10aa3 UTSW 1 173,878,244 (GRCm39) missense probably damaging 1.00
R2363:Or10aa3 UTSW 1 173,878,814 (GRCm39) missense probably damaging 1.00
R3930:Or10aa3 UTSW 1 173,878,076 (GRCm39) missense probably damaging 1.00
R4024:Or10aa3 UTSW 1 173,878,683 (GRCm39) missense probably benign 0.00
R4777:Or10aa3 UTSW 1 173,878,244 (GRCm39) missense probably damaging 1.00
R4946:Or10aa3 UTSW 1 173,878,400 (GRCm39) missense possibly damaging 0.95
R5250:Or10aa3 UTSW 1 173,878,838 (GRCm39) missense probably benign
R5646:Or10aa3 UTSW 1 173,878,853 (GRCm39) nonsense probably null
R6178:Or10aa3 UTSW 1 173,878,533 (GRCm39) missense probably benign 0.00
R6634:Or10aa3 UTSW 1 173,878,535 (GRCm39) missense probably benign 0.11
R7578:Or10aa3 UTSW 1 173,878,266 (GRCm39) missense possibly damaging 0.71
R7653:Or10aa3 UTSW 1 173,878,488 (GRCm39) missense probably benign 0.36
R8110:Or10aa3 UTSW 1 173,878,091 (GRCm39) missense probably benign 0.01
R8426:Or10aa3 UTSW 1 173,878,146 (GRCm39) missense probably damaging 1.00
R9008:Or10aa3 UTSW 1 173,878,413 (GRCm39) missense probably damaging 0.99
R9408:Or10aa3 UTSW 1 173,878,329 (GRCm39) missense
RF014:Or10aa3 UTSW 1 173,878,553 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- TATCTCCTCACACTGGCAGGGAAC -3'
(R):5'- AGGCTTTTGCACGACTAGCAGC -3'

Sequencing Primer
(F):5'- TCTTGATCCAGGCAGATTCAG -3'
(R):5'- TGAAGGCAGCTTCAGCAC -3'
Posted On 2014-06-02