Mutagenetix > Incidental Mutation

Incidental Mutation 'R0627:Myo18b'

201514

Institutional Source

Beutler Lab

Gene Symbol

Myo18b

Ensembl Gene

ENSMUSG00000072720

Gene Name

myosin XVIIIb

Synonyms

4932408L24Rik, 4933411E19Rik

MMRRC Submission

038816-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0627 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

112836742-113044228 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 112946700 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 1591 (T1591A)

Ref Sequence

ENSEMBL: ENSMUSP00000083810 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086617]

AlphaFold

E9PV66

Predicted Effect

probably benign
Transcript: ENSMUST00000086617
AA Change: T1591A

PolyPhen 2 Score 0.380 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000083810
Gene: ENSMUSG00000072720
AA Change: T1591A

Domain	Start	End	E-Value	Type
low complexity region	20	28	N/A	INTRINSIC
low complexity region	43	59	N/A	INTRINSIC
low complexity region	86	100	N/A	INTRINSIC
low complexity region	185	200	N/A	INTRINSIC
low complexity region	273	290	N/A	INTRINSIC
low complexity region	291	304	N/A	INTRINSIC
low complexity region	355	372	N/A	INTRINSIC
low complexity region	377	419	N/A	INTRINSIC
MYSc	605	1374	8.78e-30	SMART
IQ	1375	1397	5.92e-4	SMART
Pfam:Myosin_tail_1	1423	1875	5e-12	PFAM
low complexity region	1965	1985	N/A	INTRINSIC
coiled coil region	2052	2126	N/A	INTRINSIC
low complexity region	2184	2199	N/A	INTRINSIC
low complexity region	2325	2336	N/A	INTRINSIC
low complexity region	2408	2424	N/A	INTRINSIC
low complexity region	2544	2558	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182349

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182801

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183029

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189538

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189887

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.2%
20x: 94.2%

Validation Efficiency

99% (111/112)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis with internal hemorrhage, pericaridal effusion, enlargement of the right atrium, and cardiac myofibril abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 105 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adm2	T	A	15: 89,208,508 (GRCm39)	Y149*	probably null	Het
Ahi1	G	A	10: 20,841,421 (GRCm39)	R236H	probably benign	Het
Armcx4	A	G	X: 133,596,572 (GRCm39)	N2160S	possibly damaging	Het
Asns	A	T	6: 7,675,516 (GRCm39)	D495E	probably benign	Het
Atosb	G	T	4: 43,036,242 (GRCm39)	P163Q	probably damaging	Het
Bcl9	A	G	3: 97,112,789 (GRCm39)	V1222A	probably damaging	Het
Cd46	A	T	1: 194,774,494 (GRCm39)	C14S	probably benign	Het
Cdk11b	T	A	4: 155,725,229 (GRCm39)		probably benign	Het
Cdkl3	T	C	11: 51,902,135 (GRCm39)	Y115H	probably damaging	Het
Cep41	C	A	6: 30,656,630 (GRCm39)	C274F	probably damaging	Het
Ces1a	C	A	8: 93,768,671 (GRCm39)	V108F	probably benign	Het
Clca4b	A	G	3: 144,634,020 (GRCm39)	Y132H	probably benign	Het
Col5a3	T	C	9: 20,686,781 (GRCm39)	E1323G	unknown	Het
Cttnbp2	A	G	6: 18,367,372 (GRCm39)	*1139Q	probably null	Het
Cyp2d9	T	A	15: 82,339,991 (GRCm39)	I127N	probably damaging	Het
Dennd1b	A	G	1: 139,008,957 (GRCm39)	Y220C	probably damaging	Het
Desi2	T	C	1: 178,076,918 (GRCm39)	S141P	possibly damaging	Het
Dgcr2	A	G	16: 17,661,872 (GRCm39)	S453P	probably damaging	Het
Dnah3	A	G	7: 119,620,138 (GRCm39)	L1586P	probably damaging	Het
Dpep3	T	C	8: 106,705,363 (GRCm39)	D129G	possibly damaging	Het
Eci3	C	T	13: 35,132,126 (GRCm39)	V241I	possibly damaging	Het
Ecm2	A	T	13: 49,674,559 (GRCm39)		probably benign	Het
Emilin3	A	G	2: 160,750,096 (GRCm39)	L551P	probably damaging	Het
Erap1	A	C	13: 74,823,933 (GRCm39)		probably benign	Het
Ern1	T	C	11: 106,289,519 (GRCm39)	D928G	probably benign	Het
Fancc	C	A	13: 63,465,292 (GRCm39)	A472S	probably damaging	Het
Fkbp7	A	T	2: 76,503,188 (GRCm39)	D57E	probably damaging	Het
Gabbr2	T	A	4: 46,681,223 (GRCm39)	I703F	possibly damaging	Het
Gabrg3	A	T	7: 56,374,343 (GRCm39)	C408S	probably damaging	Het
Gm8674	T	C	13: 50,053,751 (GRCm39)		noncoding transcript	Het
Gnas	G	A	2: 174,139,928 (GRCm39)		probably benign	Het
Grhl3	A	G	4: 135,279,992 (GRCm39)	V354A	probably benign	Het
Gsdme	G	T	6: 50,206,259 (GRCm39)		probably benign	Het
H2-D1	A	G	17: 35,484,898 (GRCm39)	E253G	probably damaging	Het
Habp2	A	G	19: 56,302,478 (GRCm39)	T31A	probably damaging	Het
Ifrd1	A	G	12: 40,256,986 (GRCm39)		probably null	Het
Il20	A	G	1: 130,837,476 (GRCm39)		probably benign	Het
Isx	A	T	8: 75,619,328 (GRCm39)	I160F	possibly damaging	Het
Itgb2l	T	G	16: 96,224,111 (GRCm39)		probably benign	Het
Kcnv1	T	G	15: 44,976,277 (GRCm39)		probably benign	Het
Kif17	T	C	4: 138,015,798 (GRCm39)		probably null	Het
Kirrel3	A	C	9: 34,946,470 (GRCm39)	D743A	probably damaging	Het
Lmod3	T	C	6: 97,225,032 (GRCm39)	D263G	probably damaging	Het
Manf	A	G	9: 106,766,385 (GRCm39)	L132P	probably damaging	Het
Mark2	C	T	19: 7,259,325 (GRCm39)		probably null	Het
Med10	G	A	13: 69,963,720 (GRCm39)	S107N	possibly damaging	Het
Med31	A	G	11: 72,104,601 (GRCm39)		probably null	Het
Mki67	C	A	7: 135,309,987 (GRCm39)	A155S	probably benign	Het
Mprip	T	A	11: 59,660,798 (GRCm39)	L2193Q	probably damaging	Het
Mylk	A	G	16: 34,820,799 (GRCm39)	N126S	probably damaging	Het
Myo16	A	G	8: 10,489,689 (GRCm39)	I715V	probably benign	Het
Myt1	T	A	2: 181,437,482 (GRCm39)	D64E	probably benign	Het
Ndufa10	A	T	1: 92,397,618 (GRCm39)	Y61N	probably damaging	Het
Nob1	A	G	8: 108,142,856 (GRCm39)	F275S	probably damaging	Het
Nop2	T	C	6: 125,116,667 (GRCm39)	V333A	possibly damaging	Het
Ogdh	T	A	11: 6,297,216 (GRCm39)	V545D	possibly damaging	Het
Or1l4b	T	G	2: 37,036,342 (GRCm39)	N39K	probably damaging	Het
Or4p21	A	G	2: 88,276,563 (GRCm39)	S240P	probably damaging	Het
Or5b107	A	G	19: 13,142,614 (GRCm39)	T79A	probably benign	Het
Or5t16	T	C	2: 86,819,358 (GRCm39)	N54S	probably benign	Het
Or6d13	T	A	6: 116,517,949 (GRCm39)	N178K	possibly damaging	Het
Or6n2	G	T	1: 173,897,643 (GRCm39)	V260F	probably damaging	Het
Or9k2b	A	G	10: 130,016,557 (GRCm39)	F64S	probably damaging	Het
Pcdhb1	T	C	18: 37,398,774 (GRCm39)	F242L	probably damaging	Het
Pkd2l2	A	G	18: 34,558,155 (GRCm39)	Y278C	probably damaging	Het
Plxdc1	T	A	11: 97,823,030 (GRCm39)		probably null	Het
Ppp2r5b	A	G	19: 6,282,664 (GRCm39)		probably benign	Het
Pramel31	C	A	4: 144,089,416 (GRCm39)	L245I	probably benign	Het
Prelid2	T	A	18: 42,070,717 (GRCm39)	T39S	possibly damaging	Het
Prkd1	A	T	12: 50,536,824 (GRCm39)	F87I	probably benign	Het
Prl3d3	C	T	13: 27,340,830 (GRCm39)	T4I	probably damaging	Het
Proser3	T	A	7: 30,240,208 (GRCm39)	T299S	probably benign	Het
Ptprc	G	T	1: 137,996,058 (GRCm39)	H1095N	probably damaging	Het
Rab11fip5	G	T	6: 85,325,033 (GRCm39)	P425T	probably benign	Het
Rac2	T	C	15: 78,449,168 (GRCm39)	T115A	probably damaging	Het
Rtl9	C	A	X: 141,884,271 (GRCm39)	T561K	possibly damaging	Het
Runx2	T	C	17: 44,969,392 (GRCm39)		probably benign	Het
Rxfp1	C	T	3: 79,555,518 (GRCm39)	V613I	probably benign	Het
Scn9a	T	C	2: 66,367,721 (GRCm39)	K656R	probably benign	Het
Sec31b	A	G	19: 44,514,046 (GRCm39)	S406P	probably benign	Het
Septin5	T	C	16: 18,444,115 (GRCm39)	D44G	possibly damaging	Het
Slc17a3	C	T	13: 24,039,841 (GRCm39)	S293F	probably damaging	Het
Slc35c2	T	C	2: 165,124,056 (GRCm39)	T94A	possibly damaging	Het
Slc8a3	T	A	12: 81,361,616 (GRCm39)	D401V	probably damaging	Het
Slitrk1	A	T	14: 109,149,671 (GRCm39)	C347S	probably damaging	Het
Smg1	G	T	7: 117,767,084 (GRCm39)		probably benign	Het
Snx14	T	C	9: 88,276,483 (GRCm39)	K610E	probably benign	Het
Spata31e2	A	G	1: 26,724,970 (GRCm39)	M70T	probably benign	Het
Sppl2a	A	G	2: 126,762,337 (GRCm39)		probably benign	Het
Stk-ps2	T	A	1: 46,068,851 (GRCm39)		noncoding transcript	Het
Sult3a1	T	C	10: 33,740,010 (GRCm39)	M23T	probably benign	Het
Syt5	A	G	7: 4,548,682 (GRCm39)	L50P	possibly damaging	Het
Tacr1	A	G	6: 82,532,012 (GRCm39)	I303V	possibly damaging	Het
Trip12	C	A	1: 84,746,318 (GRCm39)	V487F	probably damaging	Het
Vcp	A	G	4: 42,983,011 (GRCm39)	S612P	possibly damaging	Het
Vmn1r47	A	G	6: 89,999,788 (GRCm39)	I307V	probably null	Het
Vmn1r83	T	G	7: 12,055,919 (GRCm39)	D46A	probably damaging	Het
Vmn2r118	G	T	17: 55,917,772 (GRCm39)	Q247K	probably benign	Het
Vmn2r94	C	T	17: 18,477,427 (GRCm39)	C328Y	probably damaging	Het
Vps13b	T	A	15: 35,372,145 (GRCm39)	Y13*	probably null	Het
Vps13d	C	T	4: 144,813,754 (GRCm39)	R3241H	probably damaging	Het
Wdr5b	A	G	16: 35,862,840 (GRCm39)	T320A	probably benign	Het
Zfhx2	A	T	14: 55,302,784 (GRCm39)	D1733E	probably benign	Het
Zfp541	A	G	7: 15,829,607 (GRCm39)		probably benign	Het
Zfp708	A	T	13: 67,218,781 (GRCm39)	Y314*	probably null	Het

Other mutations in Myo18b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Myo18b	APN	5	113,021,997 (GRCm39)	missense	probably benign	0.05
IGL00847:Myo18b	APN	5	112,978,255 (GRCm39)	splice site	probably benign
IGL00848:Myo18b	APN	5	113,019,351 (GRCm39)	missense	probably damaging	1.00
IGL00969:Myo18b	APN	5	113,022,873 (GRCm39)	unclassified	probably benign
IGL01018:Myo18b	APN	5	112,957,613 (GRCm39)	missense	probably damaging	1.00
IGL01448:Myo18b	APN	5	112,959,570 (GRCm39)	missense	probably damaging	1.00
IGL01490:Myo18b	APN	5	112,957,566 (GRCm39)	missense	possibly damaging	0.84
IGL01556:Myo18b	APN	5	112,905,315 (GRCm39)	splice site	probably benign
IGL01637:Myo18b	APN	5	112,988,495 (GRCm39)	missense	possibly damaging	0.82
IGL01819:Myo18b	APN	5	113,025,916 (GRCm39)	missense	unknown
IGL02007:Myo18b	APN	5	113,022,838 (GRCm39)	unclassified	probably benign
IGL02146:Myo18b	APN	5	112,991,151 (GRCm39)	missense	probably damaging	1.00
IGL02229:Myo18b	APN	5	113,025,976 (GRCm39)	missense	unknown
IGL02319:Myo18b	APN	5	112,939,005 (GRCm39)	missense	probably damaging	0.99
IGL02398:Myo18b	APN	5	112,978,178 (GRCm39)	missense	possibly damaging	0.92
IGL02420:Myo18b	APN	5	112,975,852 (GRCm39)	missense	possibly damaging	0.64
IGL02626:Myo18b	APN	5	113,025,951 (GRCm39)	missense	unknown
IGL02815:Myo18b	APN	5	112,957,601 (GRCm39)	missense	probably damaging	1.00
IGL02822:Myo18b	APN	5	112,923,211 (GRCm39)	missense	probably damaging	1.00
IGL02852:Myo18b	APN	5	112,863,377 (GRCm39)	missense	probably benign	0.03
IGL02995:Myo18b	APN	5	112,923,279 (GRCm39)	splice site	probably benign
IGL03019:Myo18b	APN	5	112,840,263 (GRCm39)	missense	probably benign	0.21
IGL03039:Myo18b	APN	5	112,988,637 (GRCm39)	missense	probably damaging	1.00
IGL03112:Myo18b	APN	5	113,021,856 (GRCm39)	missense	probably benign	0.02
IGL03123:Myo18b	APN	5	113,022,804 (GRCm39)	unclassified	probably benign
IGL03288:Myo18b	APN	5	112,937,863 (GRCm39)	missense	probably damaging	1.00
IGL03391:Myo18b	APN	5	113,022,345 (GRCm39)	unclassified	probably benign
klippel	UTSW	5	112,905,319 (GRCm39)	critical splice donor site	probably null
PIT4651001:Myo18b	UTSW	5	112,982,301 (GRCm39)	missense	probably benign	0.01
R0271:Myo18b	UTSW	5	112,957,551 (GRCm39)	missense	possibly damaging	0.91
R0277:Myo18b	UTSW	5	112,841,213 (GRCm39)	splice site	probably benign
R0352:Myo18b	UTSW	5	113,022,389 (GRCm39)	unclassified	probably benign
R0504:Myo18b	UTSW	5	113,021,442 (GRCm39)	unclassified	probably benign
R0539:Myo18b	UTSW	5	112,871,734 (GRCm39)	missense	probably damaging	0.99
R0599:Myo18b	UTSW	5	113,013,616 (GRCm39)	missense	probably damaging	1.00
R0659:Myo18b	UTSW	5	112,908,193 (GRCm39)	missense	possibly damaging	0.66
R0671:Myo18b	UTSW	5	112,840,632 (GRCm39)	missense	probably benign	0.00
R0847:Myo18b	UTSW	5	113,022,354 (GRCm39)	unclassified	probably benign
R1082:Myo18b	UTSW	5	112,908,280 (GRCm39)	missense	probably damaging	1.00
R1116:Myo18b	UTSW	5	112,951,145 (GRCm39)	missense	probably damaging	1.00
R1264:Myo18b	UTSW	5	112,978,185 (GRCm39)	missense	probably benign	0.12
R1280:Myo18b	UTSW	5	112,871,671 (GRCm39)	critical splice donor site	probably null
R1444:Myo18b	UTSW	5	112,923,117 (GRCm39)	critical splice donor site	probably null
R1446:Myo18b	UTSW	5	112,905,425 (GRCm39)	missense	probably damaging	1.00
R1470:Myo18b	UTSW	5	112,840,899 (GRCm39)	missense	probably damaging	1.00
R1470:Myo18b	UTSW	5	112,840,899 (GRCm39)	missense	probably damaging	1.00
R1590:Myo18b	UTSW	5	113,023,132 (GRCm39)	nonsense	probably null
R1601:Myo18b	UTSW	5	113,019,364 (GRCm39)	missense	possibly damaging	0.73
R1903:Myo18b	UTSW	5	112,840,624 (GRCm39)	missense	probably damaging	1.00
R1935:Myo18b	UTSW	5	112,908,222 (GRCm39)	missense	probably benign	0.04
R1936:Myo18b	UTSW	5	112,908,222 (GRCm39)	missense	probably benign	0.04
R2008:Myo18b	UTSW	5	113,021,423 (GRCm39)	missense	probably benign
R2127:Myo18b	UTSW	5	112,978,944 (GRCm39)	missense	probably damaging	1.00
R2129:Myo18b	UTSW	5	112,978,944 (GRCm39)	missense	probably damaging	1.00
R2141:Myo18b	UTSW	5	113,021,892 (GRCm39)	missense	probably benign	0.01
R2170:Myo18b	UTSW	5	112,871,724 (GRCm39)	missense	probably benign	0.23
R2258:Myo18b	UTSW	5	113,022,529 (GRCm39)	unclassified	probably benign
R2265:Myo18b	UTSW	5	112,930,539 (GRCm39)	missense	probably damaging	1.00
R2483:Myo18b	UTSW	5	113,006,274 (GRCm39)	missense	probably damaging	1.00
R2931:Myo18b	UTSW	5	112,840,993 (GRCm39)	missense	probably benign	0.01
R3160:Myo18b	UTSW	5	112,840,594 (GRCm39)	missense	probably damaging	0.99
R3162:Myo18b	UTSW	5	112,840,594 (GRCm39)	missense	probably damaging	0.99
R3777:Myo18b	UTSW	5	112,905,462 (GRCm39)	missense	probably damaging	0.99
R4240:Myo18b	UTSW	5	112,951,053 (GRCm39)	critical splice donor site	probably null
R4243:Myo18b	UTSW	5	112,840,261 (GRCm39)	missense	possibly damaging	0.95
R4245:Myo18b	UTSW	5	112,840,261 (GRCm39)	missense	possibly damaging	0.95
R4533:Myo18b	UTSW	5	112,840,891 (GRCm39)	missense	probably damaging	1.00
R4631:Myo18b	UTSW	5	112,994,266 (GRCm39)	missense	probably damaging	1.00
R4661:Myo18b	UTSW	5	113,023,041 (GRCm39)	unclassified	probably benign
R4755:Myo18b	UTSW	5	113,022,340 (GRCm39)	nonsense	probably null
R4771:Myo18b	UTSW	5	112,840,093 (GRCm39)	nonsense	probably null
R4812:Myo18b	UTSW	5	112,957,584 (GRCm39)	missense	possibly damaging	0.95
R4840:Myo18b	UTSW	5	113,021,895 (GRCm39)	missense	probably benign	0.02
R4888:Myo18b	UTSW	5	113,022,346 (GRCm39)	unclassified	probably benign
R4995:Myo18b	UTSW	5	112,908,258 (GRCm39)	missense	probably damaging	0.99
R5001:Myo18b	UTSW	5	112,909,206 (GRCm39)	missense	probably damaging	0.99
R5015:Myo18b	UTSW	5	112,937,923 (GRCm39)	missense	probably damaging	1.00
R5055:Myo18b	UTSW	5	113,023,083 (GRCm39)	unclassified	probably benign
R5070:Myo18b	UTSW	5	112,909,212 (GRCm39)	missense	probably damaging	1.00
R5105:Myo18b	UTSW	5	112,988,644 (GRCm39)	missense	probably damaging	1.00
R5121:Myo18b	UTSW	5	113,022,346 (GRCm39)	unclassified	probably benign
R5130:Myo18b	UTSW	5	113,021,769 (GRCm39)	missense	probably benign	0.06
R5186:Myo18b	UTSW	5	113,019,336 (GRCm39)	missense	probably damaging	1.00
R5437:Myo18b	UTSW	5	112,905,439 (GRCm39)	missense	possibly damaging	0.73
R5535:Myo18b	UTSW	5	112,937,908 (GRCm39)	missense	probably damaging	1.00
R5560:Myo18b	UTSW	5	113,016,161 (GRCm39)	missense	probably damaging	0.96
R5810:Myo18b	UTSW	5	112,982,316 (GRCm39)	missense	probably damaging	1.00
R5898:Myo18b	UTSW	5	112,950,196 (GRCm39)	splice site	probably null
R6065:Myo18b	UTSW	5	112,840,647 (GRCm39)	missense	probably benign	0.00
R6104:Myo18b	UTSW	5	113,022,157 (GRCm39)	unclassified	probably benign
R6113:Myo18b	UTSW	5	113,014,251 (GRCm39)	missense	probably damaging	1.00
R6158:Myo18b	UTSW	5	113,022,038 (GRCm39)	missense	probably benign	0.01
R6167:Myo18b	UTSW	5	113,020,373 (GRCm39)	splice site	probably null
R6220:Myo18b	UTSW	5	112,905,373 (GRCm39)	missense	possibly damaging	0.93
R6276:Myo18b	UTSW	5	112,959,508 (GRCm39)	missense	probably benign	0.31
R6290:Myo18b	UTSW	5	113,013,601 (GRCm39)	missense	possibly damaging	0.69
R6291:Myo18b	UTSW	5	113,013,601 (GRCm39)	missense	possibly damaging	0.69
R6795:Myo18b	UTSW	5	112,994,230 (GRCm39)	missense	probably damaging	0.99
R6798:Myo18b	UTSW	5	112,909,252 (GRCm39)	missense	probably damaging	0.98
R6817:Myo18b	UTSW	5	112,978,104 (GRCm39)	missense	probably benign	0.00
R6937:Myo18b	UTSW	5	112,950,258 (GRCm39)	missense	probably benign	0.12
R7034:Myo18b	UTSW	5	112,871,770 (GRCm39)	nonsense	probably null
R7097:Myo18b	UTSW	5	113,022,271 (GRCm39)	missense	unknown
R7145:Myo18b	UTSW	5	112,965,545 (GRCm39)	nonsense	probably null
R7201:Myo18b	UTSW	5	112,863,325 (GRCm39)	missense	probably damaging	1.00
R7260:Myo18b	UTSW	5	112,923,154 (GRCm39)	missense	probably benign	0.01
R7265:Myo18b	UTSW	5	112,959,938 (GRCm39)	missense	probably damaging	1.00
R7409:Myo18b	UTSW	5	113,021,971 (GRCm39)	missense	probably benign	0.25
R7466:Myo18b	UTSW	5	112,871,758 (GRCm39)	missense	probably benign	0.02
R7487:Myo18b	UTSW	5	112,982,299 (GRCm39)	missense	possibly damaging	0.93
R7571:Myo18b	UTSW	5	112,978,194 (GRCm39)	missense	probably damaging	1.00
R7600:Myo18b	UTSW	5	113,025,969 (GRCm39)	missense	unknown
R7612:Myo18b	UTSW	5	113,013,168 (GRCm39)	missense	possibly damaging	0.82
R7617:Myo18b	UTSW	5	112,905,319 (GRCm39)	critical splice donor site	probably null
R7696:Myo18b	UTSW	5	112,840,158 (GRCm39)	missense	probably damaging	1.00
R7710:Myo18b	UTSW	5	113,022,891 (GRCm39)	missense	unknown
R8047:Myo18b	UTSW	5	112,871,681 (GRCm39)	missense	possibly damaging	0.91
R8070:Myo18b	UTSW	5	112,938,986 (GRCm39)	missense	probably benign	0.01
R8088:Myo18b	UTSW	5	113,027,376 (GRCm39)	start gained	probably benign
R8247:Myo18b	UTSW	5	112,840,062 (GRCm39)	missense	probably damaging	1.00
R8276:Myo18b	UTSW	5	112,943,273 (GRCm39)	missense	possibly damaging	0.50
R8313:Myo18b	UTSW	5	113,023,045 (GRCm39)	missense	unknown
R8375:Myo18b	UTSW	5	112,908,259 (GRCm39)	missense	possibly damaging	0.85
R8432:Myo18b	UTSW	5	112,912,378 (GRCm39)	missense	probably benign	0.00
R8475:Myo18b	UTSW	5	113,021,422 (GRCm39)	nonsense	probably null
R8482:Myo18b	UTSW	5	113,019,489 (GRCm39)	nonsense	probably null
R8671:Myo18b	UTSW	5	113,022,609 (GRCm39)	missense	unknown
R8681:Myo18b	UTSW	5	113,021,429 (GRCm39)	critical splice acceptor site	probably null
R8918:Myo18b	UTSW	5	113,022,873 (GRCm39)	unclassified	probably benign
R8941:Myo18b	UTSW	5	113,022,795 (GRCm39)	unclassified	probably benign
R8962:Myo18b	UTSW	5	113,006,346 (GRCm39)	missense	probably benign	0.24
R8972:Myo18b	UTSW	5	112,841,164 (GRCm39)	missense	probably benign	0.00
R9116:Myo18b	UTSW	5	112,975,862 (GRCm39)	missense	probably damaging	1.00
R9209:Myo18b	UTSW	5	113,022,927 (GRCm39)	missense	unknown
R9358:Myo18b	UTSW	5	112,943,269 (GRCm39)	missense	possibly damaging	0.93
R9469:Myo18b	UTSW	5	112,994,247 (GRCm39)	missense	probably benign	0.15
R9607:Myo18b	UTSW	5	113,022,544 (GRCm39)	missense	unknown
R9659:Myo18b	UTSW	5	113,022,382 (GRCm39)	missense	unknown
Z1088:Myo18b	UTSW	5	112,905,350 (GRCm39)	missense	probably benign	0.25
Z1088:Myo18b	UTSW	5	112,840,809 (GRCm39)	missense	possibly damaging	0.89
Z1176:Myo18b	UTSW	5	112,979,056 (GRCm39)	missense	probably damaging	1.00
Z1176:Myo18b	UTSW	5	112,957,604 (GRCm39)	missense	possibly damaging	0.87
Z1176:Myo18b	UTSW	5	112,910,587 (GRCm39)	missense	not run
Z1177:Myo18b	UTSW	5	113,021,407 (GRCm39)	nonsense	probably null
Z1177:Myo18b	UTSW	5	112,910,587 (GRCm39)	missense	not run
Z1177:Myo18b	UTSW	5	112,840,765 (GRCm39)	missense	probably damaging	1.00
Z1177:Myo18b	UTSW	5	113,023,018 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGTGGTGACTTTACAGGCCAGAAC -3'
(R):5'- ACTTCCAAGTGACAAGCACAGGG -3'

Sequencing Primer
(F):5'- TTGATTCCTGCGAGACCAAG -3'
(R):5'- CACAGGGCCGAGAAGTG -3'

Posted On

2014-06-16