Incidental Mutation 'R1793:Dock1'
| ID |
201940 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock1
|
| Ensembl Gene |
ENSMUSG00000058325 |
| Gene Name |
dedicator of cytokinesis 1 |
| Synonyms |
D630004B07Rik, 9130006G06Rik, b2b3190Clo, Dock180 |
| MMRRC Submission |
039823-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1793 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
134272416-134775376 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 134700456 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000081531
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084488]
[ENSMUST00000084488]
|
| AlphaFold |
Q8BUR4 |
| PDB Structure |
Solution structure of the SH3 domain of DOCK180 [SOLUTION NMR]
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000084488
|
| SMART Domains |
Protein: ENSMUSP00000081531
Gene: ENSMUSG00000058325
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
12 |
69 |
7.57e-17 |
SMART |
|
Pfam:DOCK_N
|
72 |
416 |
1.7e-113 |
PFAM |
|
Pfam:DOCK-C2
|
421 |
618 |
1.2e-61 |
PFAM |
|
low complexity region
|
628 |
639 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1111 |
1610 |
3.3e-102 |
PFAM |
|
low complexity region
|
1639 |
1664 |
N/A |
INTRINSIC |
|
low complexity region
|
1683 |
1701 |
N/A |
INTRINSIC |
|
low complexity region
|
1756 |
1773 |
N/A |
INTRINSIC |
|
low complexity region
|
1823 |
1857 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000084488
|
| SMART Domains |
Protein: ENSMUSP00000081531
Gene: ENSMUSG00000058325
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
12 |
69 |
7.57e-17 |
SMART |
|
Pfam:DOCK_N
|
72 |
416 |
1.7e-113 |
PFAM |
|
Pfam:DOCK-C2
|
421 |
618 |
1.2e-61 |
PFAM |
|
low complexity region
|
628 |
639 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1111 |
1610 |
3.3e-102 |
PFAM |
|
low complexity region
|
1639 |
1664 |
N/A |
INTRINSIC |
|
low complexity region
|
1683 |
1701 |
N/A |
INTRINSIC |
|
low complexity region
|
1756 |
1773 |
N/A |
INTRINSIC |
|
low complexity region
|
1823 |
1857 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.4%
- 20x: 92.9%
|
| Validation Efficiency |
100% (122/122) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a null allele exhibit postnatal lethality associated with abnormal muscle development and failure of lungs to inflate. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
T |
5: 109,884,144 (GRCm39) |
H571Q |
probably damaging |
Het |
| Abcf2 |
T |
A |
5: 24,773,774 (GRCm39) |
M372L |
probably benign |
Het |
| Acaca |
A |
C |
11: 84,206,795 (GRCm39) |
T1552P |
probably damaging |
Het |
| Acaca |
A |
G |
11: 84,229,219 (GRCm39) |
D1682G |
probably damaging |
Het |
| Acvr1b |
T |
C |
15: 101,091,906 (GRCm39) |
V62A |
probably benign |
Het |
| Aimp1 |
C |
T |
3: 132,379,825 (GRCm39) |
V97M |
probably benign |
Het |
| Aldh1l1 |
C |
T |
6: 90,554,813 (GRCm39) |
T557I |
possibly damaging |
Het |
| Alpk1 |
T |
C |
3: 127,471,447 (GRCm39) |
T1012A |
probably damaging |
Het |
| Amot |
G |
A |
X: 144,233,585 (GRCm39) |
|
probably benign |
Het |
| Arap1 |
T |
A |
7: 101,037,829 (GRCm39) |
H477Q |
probably benign |
Het |
| Arhgap18 |
T |
A |
10: 26,736,732 (GRCm39) |
|
probably benign |
Het |
| Arhgef10l |
C |
T |
4: 140,242,684 (GRCm39) |
V862M |
probably damaging |
Het |
| Arl4d |
A |
G |
11: 101,557,554 (GRCm39) |
I27V |
probably benign |
Het |
| Asb18 |
G |
A |
1: 89,942,277 (GRCm39) |
P8L |
probably damaging |
Het |
| Ash1l |
A |
G |
3: 88,977,616 (GRCm39) |
H2682R |
probably damaging |
Het |
| Aspm |
T |
A |
1: 139,385,079 (GRCm39) |
V241E |
probably benign |
Het |
| Atf7ip |
G |
T |
6: 136,586,217 (GRCm39) |
|
probably benign |
Het |
| AY358078 |
T |
G |
14: 52,042,051 (GRCm39) |
M142R |
unknown |
Het |
| C3 |
T |
A |
17: 57,526,592 (GRCm39) |
K796N |
possibly damaging |
Het |
| Ceacam16 |
T |
C |
7: 19,590,041 (GRCm39) |
T301A |
probably damaging |
Het |
| Ceacam5 |
T |
G |
7: 17,481,320 (GRCm39) |
Y356D |
probably benign |
Het |
| Cep192 |
C |
T |
18: 67,984,838 (GRCm39) |
A1616V |
possibly damaging |
Het |
| Cfap91 |
T |
A |
16: 38,141,781 (GRCm39) |
N384Y |
possibly damaging |
Het |
| Cherp |
A |
T |
8: 73,216,994 (GRCm39) |
H645Q |
probably benign |
Het |
| CK137956 |
T |
C |
4: 127,845,242 (GRCm39) |
D167G |
probably benign |
Het |
| Clcn1 |
T |
A |
6: 42,275,860 (GRCm39) |
|
probably null |
Het |
| Cntn1 |
C |
T |
15: 92,189,552 (GRCm39) |
T625I |
possibly damaging |
Het |
| Cpn2 |
T |
A |
16: 30,078,142 (GRCm39) |
N520Y |
probably damaging |
Het |
| Crocc |
G |
A |
4: 140,746,620 (GRCm39) |
R1762W |
probably damaging |
Het |
| Cts3 |
C |
A |
13: 61,715,967 (GRCm39) |
V100F |
probably benign |
Het |
| Ddx56 |
A |
T |
11: 6,216,934 (GRCm39) |
V87D |
probably damaging |
Het |
| Dnah9 |
C |
T |
11: 66,010,420 (GRCm39) |
|
probably null |
Het |
| Dst |
T |
A |
1: 34,191,552 (GRCm39) |
Y291* |
probably null |
Het |
| Eif4g3 |
T |
C |
4: 137,898,442 (GRCm39) |
I1071T |
probably damaging |
Het |
| Fblim1 |
T |
C |
4: 141,322,549 (GRCm39) |
Q78R |
probably damaging |
Het |
| Fcamr |
C |
T |
1: 130,739,284 (GRCm39) |
P195S |
probably benign |
Het |
| Fcho1 |
G |
A |
8: 72,161,666 (GRCm39) |
Q835* |
probably null |
Het |
| Frem3 |
A |
G |
8: 81,339,741 (GRCm39) |
N678S |
probably benign |
Het |
| Frk |
G |
A |
10: 34,483,878 (GRCm39) |
R413H |
probably benign |
Het |
| Gm10619 |
C |
A |
7: 73,459,758 (GRCm39) |
|
noncoding transcript |
Het |
| Gm12185 |
G |
A |
11: 48,806,583 (GRCm39) |
R203* |
probably null |
Het |
| Gm12886 |
A |
G |
4: 121,280,174 (GRCm39) |
V34A |
probably benign |
Het |
| Gna12 |
A |
T |
5: 140,746,707 (GRCm39) |
I246N |
probably damaging |
Het |
| Gpm6a |
T |
C |
8: 55,507,867 (GRCm39) |
M201T |
probably benign |
Het |
| Gpsm2 |
T |
G |
3: 108,608,225 (GRCm39) |
D220A |
probably benign |
Het |
| Grip2 |
C |
G |
6: 91,760,623 (GRCm39) |
V325L |
probably benign |
Het |
| Grk5 |
C |
A |
19: 61,065,200 (GRCm39) |
A288D |
probably damaging |
Het |
| Herpud2 |
G |
A |
9: 25,021,953 (GRCm39) |
A231V |
possibly damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,624,834 (GRCm39) |
S1024G |
probably benign |
Het |
| Hp1bp3 |
A |
G |
4: 137,957,820 (GRCm39) |
D295G |
probably damaging |
Het |
| Igsf21 |
T |
C |
4: 139,761,703 (GRCm39) |
H325R |
probably damaging |
Het |
| Ing2 |
T |
A |
8: 48,122,364 (GRCm39) |
L61F |
probably damaging |
Het |
| Jak3 |
T |
C |
8: 72,138,590 (GRCm39) |
|
probably benign |
Het |
| Kcnn3 |
T |
A |
3: 89,516,712 (GRCm39) |
C374S |
probably benign |
Het |
| Klk1b22 |
A |
G |
7: 43,765,775 (GRCm39) |
|
probably benign |
Het |
| Larp1 |
T |
C |
11: 57,940,764 (GRCm39) |
M630T |
possibly damaging |
Het |
| Lhx5 |
T |
A |
5: 120,572,725 (GRCm39) |
C115S |
probably damaging |
Het |
| Lmcd1 |
C |
A |
6: 112,305,712 (GRCm39) |
T271K |
probably benign |
Het |
| Lpar1 |
G |
A |
4: 58,486,798 (GRCm39) |
R158* |
probably null |
Het |
| Lyst |
T |
A |
13: 13,821,668 (GRCm39) |
C1347* |
probably null |
Het |
| Map3k8 |
G |
A |
18: 4,332,389 (GRCm39) |
Q441* |
probably null |
Het |
| Mboat1 |
T |
C |
13: 30,403,633 (GRCm39) |
V144A |
probably damaging |
Het |
| Mcur1 |
C |
T |
13: 43,713,491 (GRCm39) |
G38S |
unknown |
Het |
| Med13 |
T |
A |
11: 86,220,177 (GRCm39) |
M276L |
probably benign |
Het |
| Mefv |
A |
G |
16: 3,526,528 (GRCm39) |
S699P |
possibly damaging |
Het |
| Mfsd4a |
C |
A |
1: 131,987,077 (GRCm39) |
A62S |
probably damaging |
Het |
| Mmp27 |
A |
G |
9: 7,571,459 (GRCm39) |
M1V |
probably null |
Het |
| Myo1c |
C |
T |
11: 75,548,415 (GRCm39) |
T58I |
probably damaging |
Het |
| Myom3 |
A |
T |
4: 135,538,066 (GRCm39) |
D1316V |
probably benign |
Het |
| Naa25 |
T |
A |
5: 121,555,478 (GRCm39) |
C235S |
possibly damaging |
Het |
| Naa25 |
C |
A |
5: 121,558,656 (GRCm39) |
R333S |
probably damaging |
Het |
| Nav3 |
G |
A |
10: 109,539,233 (GRCm39) |
T2056I |
probably benign |
Het |
| Nol4 |
A |
G |
18: 22,902,878 (GRCm39) |
Y378H |
probably damaging |
Het |
| Npat |
G |
A |
9: 53,463,589 (GRCm39) |
R124Q |
probably damaging |
Het |
| Npr3 |
T |
A |
15: 11,848,665 (GRCm39) |
E434V |
probably benign |
Het |
| Nptx2 |
A |
G |
5: 144,485,130 (GRCm39) |
T208A |
probably benign |
Het |
| Obscn |
C |
T |
11: 58,968,606 (GRCm39) |
V2798M |
probably damaging |
Het |
| Odad4 |
C |
A |
11: 100,460,679 (GRCm39) |
|
probably null |
Het |
| Or10j7 |
A |
T |
1: 173,011,976 (GRCm39) |
H8Q |
probably benign |
Het |
| Or52r1 |
A |
G |
7: 102,537,250 (GRCm39) |
Y37H |
probably benign |
Het |
| Or5b122 |
C |
T |
19: 13,562,779 (GRCm39) |
T37I |
probably benign |
Het |
| Padi1 |
G |
A |
4: 140,541,967 (GRCm39) |
P652S |
probably damaging |
Het |
| Pcdh1 |
G |
T |
18: 38,331,938 (GRCm39) |
P355Q |
probably damaging |
Het |
| Pck2 |
G |
A |
14: 55,781,422 (GRCm39) |
R189H |
possibly damaging |
Het |
| Pcsk5 |
T |
A |
19: 17,432,114 (GRCm39) |
K1500N |
possibly damaging |
Het |
| Phc3 |
A |
T |
3: 31,002,865 (GRCm39) |
S218T |
probably damaging |
Het |
| Piezo2 |
T |
A |
18: 63,239,355 (GRCm39) |
M510L |
possibly damaging |
Het |
| Polr1g |
T |
C |
7: 19,091,904 (GRCm39) |
T68A |
possibly damaging |
Het |
| Ppp1r3a |
A |
T |
6: 14,754,717 (GRCm39) |
Y177N |
probably damaging |
Het |
| Psme2b |
A |
T |
11: 48,836,361 (GRCm39) |
D195E |
probably damaging |
Het |
| Ptprr |
T |
C |
10: 116,088,827 (GRCm39) |
V463A |
probably damaging |
Het |
| Pwwp2b |
G |
A |
7: 138,836,281 (GRCm39) |
R574Q |
probably damaging |
Het |
| Rap1gds1 |
T |
A |
3: 138,756,314 (GRCm39) |
T14S |
possibly damaging |
Het |
| Rbm11 |
A |
T |
16: 75,397,685 (GRCm39) |
K205M |
probably damaging |
Het |
| Rfx1 |
T |
A |
8: 84,793,050 (GRCm39) |
|
probably benign |
Het |
| Rnasel |
C |
A |
1: 153,630,169 (GRCm39) |
H228Q |
probably damaging |
Het |
| Sap130 |
T |
A |
18: 31,831,640 (GRCm39) |
I710K |
probably benign |
Het |
| Slc27a4 |
C |
A |
2: 29,695,733 (GRCm39) |
D89E |
probably benign |
Het |
| Spata31d1b |
T |
C |
13: 59,863,779 (GRCm39) |
V309A |
probably benign |
Het |
| Syt7 |
T |
G |
19: 10,421,354 (GRCm39) |
Y420D |
probably damaging |
Het |
| Tanc2 |
A |
G |
11: 105,515,859 (GRCm39) |
|
probably null |
Het |
| Tbc1d10b |
A |
G |
7: 126,802,930 (GRCm39) |
S333P |
possibly damaging |
Het |
| Tenm2 |
G |
A |
11: 35,914,209 (GRCm39) |
P2442S |
probably damaging |
Het |
| Tenm3 |
C |
T |
8: 49,127,579 (GRCm39) |
C33Y |
probably damaging |
Het |
| Timmdc1 |
A |
G |
16: 38,319,419 (GRCm39) |
L245P |
possibly damaging |
Het |
| Tlr5 |
T |
C |
1: 182,800,012 (GRCm39) |
F5L |
probably benign |
Het |
| Ttll4 |
T |
A |
1: 74,726,999 (GRCm39) |
F784L |
possibly damaging |
Het |
| Tulp4 |
A |
G |
17: 6,189,387 (GRCm39) |
T70A |
possibly damaging |
Het |
| Txndc17 |
T |
A |
11: 72,099,571 (GRCm39) |
N81K |
probably benign |
Het |
| Ubr3 |
C |
T |
2: 69,830,895 (GRCm39) |
|
probably benign |
Het |
| Uri1 |
A |
C |
7: 37,681,116 (GRCm39) |
V96G |
probably damaging |
Het |
| Uspl1 |
T |
A |
5: 149,150,246 (GRCm39) |
I482N |
probably damaging |
Het |
| Vmn1r229 |
A |
G |
17: 21,034,974 (GRCm39) |
N73S |
possibly damaging |
Het |
| Vwa7 |
G |
T |
17: 35,243,388 (GRCm39) |
G689* |
probably null |
Het |
| Zfp114 |
T |
A |
7: 23,877,164 (GRCm39) |
|
probably null |
Het |
| Zfp618 |
A |
G |
4: 63,051,474 (GRCm39) |
S659G |
probably damaging |
Het |
| Zfp872 |
A |
G |
9: 22,111,349 (GRCm39) |
K275R |
probably damaging |
Het |
| Zzef1 |
C |
T |
11: 72,777,535 (GRCm39) |
P1789S |
probably damaging |
Het |
|
| Other mutations in Dock1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00484:Dock1
|
APN |
7 |
134,748,260 (GRCm39) |
splice site |
probably benign |
|
|
IGL01319:Dock1
|
APN |
7 |
134,391,007 (GRCm39) |
missense |
probably benign |
|
|
IGL01390:Dock1
|
APN |
7 |
134,346,776 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01394:Dock1
|
APN |
7 |
134,367,945 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01489:Dock1
|
APN |
7 |
134,601,050 (GRCm39) |
splice site |
probably benign |
|
|
IGL01505:Dock1
|
APN |
7 |
134,760,239 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01586:Dock1
|
APN |
7 |
134,355,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01637:Dock1
|
APN |
7 |
134,739,542 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL01649:Dock1
|
APN |
7 |
134,379,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01652:Dock1
|
APN |
7 |
134,379,226 (GRCm39) |
splice site |
probably benign |
|
|
IGL01859:Dock1
|
APN |
7 |
134,678,890 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02068:Dock1
|
APN |
7 |
134,373,277 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02168:Dock1
|
APN |
7 |
134,678,860 (GRCm39) |
splice site |
probably benign |
|
|
IGL02200:Dock1
|
APN |
7 |
134,346,000 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02244:Dock1
|
APN |
7 |
134,379,174 (GRCm39) |
nonsense |
probably null |
|
|
IGL02285:Dock1
|
APN |
7 |
134,683,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02319:Dock1
|
APN |
7 |
134,374,178 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02334:Dock1
|
APN |
7 |
134,747,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02338:Dock1
|
APN |
7 |
134,734,804 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02351:Dock1
|
APN |
7 |
134,710,548 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02358:Dock1
|
APN |
7 |
134,710,548 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02607:Dock1
|
APN |
7 |
134,453,242 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02638:Dock1
|
APN |
7 |
134,748,209 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02724:Dock1
|
APN |
7 |
134,765,082 (GRCm39) |
missense |
probably benign |
|
|
IGL02820:Dock1
|
APN |
7 |
134,768,944 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02950:Dock1
|
APN |
7 |
134,331,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02993:Dock1
|
APN |
7 |
134,346,027 (GRCm39) |
missense |
probably benign |
|
|
IGL03000:Dock1
|
APN |
7 |
134,390,969 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03092:Dock1
|
APN |
7 |
134,366,945 (GRCm39) |
splice site |
probably benign |
|
|
IGL03131:Dock1
|
APN |
7 |
134,475,912 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03136:Dock1
|
APN |
7 |
134,770,118 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03210:Dock1
|
APN |
7 |
134,358,668 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL03220:Dock1
|
APN |
7 |
134,710,251 (GRCm39) |
critical splice donor site |
probably null |
|
|
P0028:Dock1
|
UTSW |
7 |
134,601,053 (GRCm39) |
splice site |
probably benign |
|
|
PIT4453001:Dock1
|
UTSW |
7 |
134,754,029 (GRCm39) |
missense |
probably benign |
|
|
R0003:Dock1
|
UTSW |
7 |
134,331,793 (GRCm39) |
splice site |
probably benign |
|
|
R0058:Dock1
|
UTSW |
7 |
134,710,490 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0058:Dock1
|
UTSW |
7 |
134,710,490 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0062:Dock1
|
UTSW |
7 |
134,379,224 (GRCm39) |
splice site |
probably null |
|
|
R0062:Dock1
|
UTSW |
7 |
134,379,224 (GRCm39) |
splice site |
probably null |
|
|
R0179:Dock1
|
UTSW |
7 |
134,700,566 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0180:Dock1
|
UTSW |
7 |
134,700,566 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0347:Dock1
|
UTSW |
7 |
134,365,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0399:Dock1
|
UTSW |
7 |
134,765,171 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0457:Dock1
|
UTSW |
7 |
134,739,874 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0480:Dock1
|
UTSW |
7 |
134,339,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Dock1
|
UTSW |
7 |
134,745,507 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0792:Dock1
|
UTSW |
7 |
134,475,879 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1136:Dock1
|
UTSW |
7 |
134,449,902 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1224:Dock1
|
UTSW |
7 |
134,710,548 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1267:Dock1
|
UTSW |
7 |
134,348,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1373:Dock1
|
UTSW |
7 |
134,768,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1401:Dock1
|
UTSW |
7 |
134,735,665 (GRCm39) |
nonsense |
probably null |
|
|
R1454:Dock1
|
UTSW |
7 |
134,453,338 (GRCm39) |
splice site |
probably benign |
|
|
R1465:Dock1
|
UTSW |
7 |
134,384,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1465:Dock1
|
UTSW |
7 |
134,384,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Dock1
|
UTSW |
7 |
134,345,976 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1643:Dock1
|
UTSW |
7 |
134,700,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1659:Dock1
|
UTSW |
7 |
134,390,972 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1864:Dock1
|
UTSW |
7 |
134,748,236 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1911:Dock1
|
UTSW |
7 |
134,601,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2567:Dock1
|
UTSW |
7 |
134,747,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3816:Dock1
|
UTSW |
7 |
134,346,015 (GRCm39) |
nonsense |
probably null |
|
|
R3971:Dock1
|
UTSW |
7 |
134,348,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4063:Dock1
|
UTSW |
7 |
134,717,021 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4163:Dock1
|
UTSW |
7 |
134,346,051 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4271:Dock1
|
UTSW |
7 |
134,335,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4684:Dock1
|
UTSW |
7 |
134,326,138 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Dock1
|
UTSW |
7 |
134,449,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4725:Dock1
|
UTSW |
7 |
134,346,743 (GRCm39) |
nonsense |
probably null |
|
|
R4788:Dock1
|
UTSW |
7 |
134,747,213 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4869:Dock1
|
UTSW |
7 |
134,335,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4889:Dock1
|
UTSW |
7 |
134,346,705 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4953:Dock1
|
UTSW |
7 |
134,754,017 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5031:Dock1
|
UTSW |
7 |
134,753,975 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5161:Dock1
|
UTSW |
7 |
134,335,791 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5168:Dock1
|
UTSW |
7 |
134,720,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5212:Dock1
|
UTSW |
7 |
134,390,923 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5648:Dock1
|
UTSW |
7 |
134,348,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5685:Dock1
|
UTSW |
7 |
134,374,091 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5834:Dock1
|
UTSW |
7 |
134,365,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6181:Dock1
|
UTSW |
7 |
134,760,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6334:Dock1
|
UTSW |
7 |
134,453,305 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6406:Dock1
|
UTSW |
7 |
134,747,215 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6425:Dock1
|
UTSW |
7 |
134,765,110 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6489:Dock1
|
UTSW |
7 |
134,592,270 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6616:Dock1
|
UTSW |
7 |
134,710,221 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6706:Dock1
|
UTSW |
7 |
134,735,615 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6766:Dock1
|
UTSW |
7 |
134,358,522 (GRCm39) |
splice site |
probably null |
|
|
R6861:Dock1
|
UTSW |
7 |
134,373,207 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6985:Dock1
|
UTSW |
7 |
134,765,132 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7259:Dock1
|
UTSW |
7 |
134,384,477 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7285:Dock1
|
UTSW |
7 |
134,346,737 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7471:Dock1
|
UTSW |
7 |
134,765,072 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7497:Dock1
|
UTSW |
7 |
134,367,003 (GRCm39) |
missense |
probably benign |
|
|
R7691:Dock1
|
UTSW |
7 |
134,739,886 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7732:Dock1
|
UTSW |
7 |
134,346,699 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7818:Dock1
|
UTSW |
7 |
134,365,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Dock1
|
UTSW |
7 |
134,747,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7960:Dock1
|
UTSW |
7 |
134,678,917 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7961:Dock1
|
UTSW |
7 |
134,346,786 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7985:Dock1
|
UTSW |
7 |
134,348,683 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8009:Dock1
|
UTSW |
7 |
134,346,786 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8060:Dock1
|
UTSW |
7 |
134,592,358 (GRCm39) |
splice site |
probably benign |
|
|
R8060:Dock1
|
UTSW |
7 |
134,770,132 (GRCm39) |
missense |
probably benign |
|
|
R8061:Dock1
|
UTSW |
7 |
134,374,052 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8101:Dock1
|
UTSW |
7 |
134,601,017 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8405:Dock1
|
UTSW |
7 |
134,379,192 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8508:Dock1
|
UTSW |
7 |
134,384,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8803:Dock1
|
UTSW |
7 |
134,475,816 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9007:Dock1
|
UTSW |
7 |
134,500,825 (GRCm39) |
intron |
probably benign |
|
|
R9026:Dock1
|
UTSW |
7 |
134,720,746 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9111:Dock1
|
UTSW |
7 |
134,601,017 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9359:Dock1
|
UTSW |
7 |
134,770,125 (GRCm39) |
missense |
probably benign |
|
|
R9398:Dock1
|
UTSW |
7 |
134,774,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9403:Dock1
|
UTSW |
7 |
134,770,125 (GRCm39) |
missense |
probably benign |
|
|
R9408:Dock1
|
UTSW |
7 |
134,717,065 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9476:Dock1
|
UTSW |
7 |
134,592,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9478:Dock1
|
UTSW |
7 |
134,367,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9510:Dock1
|
UTSW |
7 |
134,592,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9544:Dock1
|
UTSW |
7 |
134,348,186 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9605:Dock1
|
UTSW |
7 |
134,384,141 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R9657:Dock1
|
UTSW |
7 |
134,339,429 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9767:Dock1
|
UTSW |
7 |
134,342,796 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
X0062:Dock1
|
UTSW |
7 |
134,710,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Dock1
|
UTSW |
7 |
134,406,276 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Dock1
|
UTSW |
7 |
134,384,129 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTAGATCATGATTGAACTCGAG -3'
(R):5'- TAGCTCTGGAATCGCCTGTG -3'
Sequencing Primer
(F):5'- GAGACCAGAGGTTCACTTTAAGTGTC -3'
(R):5'- TGGAATCGCCTGTGTCTTC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation