Incidental Mutation 'R1795:Dlg1'
| ID |
202184 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dlg1
|
| Ensembl Gene |
ENSMUSG00000022770 |
| Gene Name |
discs large MAGUK scaffold protein 1 |
| Synonyms |
B130052P05Rik, SAP97, Dlgh1 |
| MMRRC Submission |
039825-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1795 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
31482261-31692174 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 31561965 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 120
(H120Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000110859
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023454]
[ENSMUST00000064477]
[ENSMUST00000100001]
[ENSMUST00000115201]
[ENSMUST00000115205]
[ENSMUST00000132176]
|
| AlphaFold |
Q811D0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023454
AA Change: H120Q
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000023454
Gene: ENSMUSG00000022770
AA Change: H120Q
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
190 |
4.33e-44 |
SMART |
|
PDZ
|
199 |
278 |
5.98e-22 |
SMART |
|
PDZ
|
294 |
373 |
1.94e-21 |
SMART |
|
PDZ
|
441 |
514 |
1.84e-22 |
SMART |
|
low complexity region
|
534 |
542 |
N/A |
INTRINSIC |
|
SH3
|
551 |
617 |
1.27e-9 |
SMART |
|
GuKc
|
681 |
860 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064477
AA Change: H120Q
PolyPhen 2
Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000064280
Gene: ENSMUSG00000022770
AA Change: H120Q
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
736 |
915 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100001
AA Change: H120Q
PolyPhen 2
Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000097581
Gene: ENSMUSG00000022770
AA Change: H120Q
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
714 |
893 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115201
AA Change: H120Q
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000110855
Gene: ENSMUSG00000022770
AA Change: H120Q
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
721 |
900 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115205
AA Change: H120Q
PolyPhen 2
Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000110859
Gene: ENSMUSG00000022770
AA Change: H120Q
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
714 |
893 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132176
AA Change: H120Q
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000138782
Gene: ENSMUSG00000022770
AA Change: H120Q
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
190 |
4.33e-44 |
SMART |
|
PDZ
|
199 |
278 |
5.98e-22 |
SMART |
|
PDZ
|
294 |
373 |
1.94e-21 |
SMART |
|
PDZ
|
426 |
499 |
1.84e-22 |
SMART |
|
low complexity region
|
519 |
527 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155958
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000158386
|
| Meta Mutation Damage Score |
0.0902 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.4%
- 20x: 92.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit neonatal lethality, craniofacial defects, and abnormal eye morphology. Mice homozygous for knock-out alleles exhibit neonatal lethality, kidney defects, reproductive organ morphology, and cleft palate. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
A |
G |
11: 109,941,792 (GRCm39) |
I1159T |
probably benign |
Het |
| Abcc1 |
T |
C |
16: 14,283,001 (GRCm39) |
V1159A |
possibly damaging |
Het |
| Abcg5 |
A |
G |
17: 84,981,007 (GRCm39) |
I194T |
probably damaging |
Het |
| Abtb2 |
A |
G |
2: 103,397,369 (GRCm39) |
T100A |
probably benign |
Het |
| Adam4 |
C |
T |
12: 81,468,068 (GRCm39) |
M184I |
probably benign |
Het |
| Afap1l2 |
T |
C |
19: 56,916,841 (GRCm39) |
D155G |
probably damaging |
Het |
| Ahnak |
T |
C |
19: 8,979,802 (GRCm39) |
V362A |
possibly damaging |
Het |
| Ak7 |
C |
T |
12: 105,692,482 (GRCm39) |
R179* |
probably null |
Het |
| Akap8 |
C |
A |
17: 32,534,451 (GRCm39) |
G332C |
probably damaging |
Het |
| Akr1e1 |
T |
A |
13: 4,645,071 (GRCm39) |
Q204L |
probably damaging |
Het |
| Ankrd12 |
T |
C |
17: 66,293,222 (GRCm39) |
E737G |
possibly damaging |
Het |
| Atrn |
A |
G |
2: 130,814,208 (GRCm39) |
D718G |
probably benign |
Het |
| Bco2 |
A |
G |
9: 50,452,469 (GRCm39) |
S200P |
possibly damaging |
Het |
| C030005K15Rik |
A |
T |
10: 97,561,648 (GRCm39) |
S28T |
unknown |
Het |
| Cdc14a |
T |
A |
3: 116,092,122 (GRCm39) |
Q356L |
possibly damaging |
Het |
| Cdk5rap3 |
A |
G |
11: 96,799,654 (GRCm39) |
L387P |
probably damaging |
Het |
| Celsr1 |
A |
T |
15: 85,914,524 (GRCm39) |
S1150T |
probably damaging |
Het |
| Cntfr |
A |
G |
4: 41,670,841 (GRCm39) |
|
probably null |
Het |
| Cramp1 |
T |
C |
17: 25,183,884 (GRCm39) |
N1244D |
probably damaging |
Het |
| Csmd3 |
G |
T |
15: 47,721,316 (GRCm39) |
D1542E |
possibly damaging |
Het |
| Cyp4f17 |
A |
T |
17: 32,736,943 (GRCm39) |
I92F |
probably benign |
Het |
| Dhx30 |
A |
T |
9: 109,937,051 (GRCm39) |
|
probably null |
Het |
| Dmgdh |
A |
T |
13: 93,843,207 (GRCm39) |
M348L |
probably benign |
Het |
| Dnmt3b |
G |
A |
2: 153,525,559 (GRCm39) |
E741K |
possibly damaging |
Het |
| Dock3 |
T |
G |
9: 106,902,534 (GRCm39) |
H292P |
probably damaging |
Het |
| Ercc6 |
T |
A |
14: 32,238,985 (GRCm39) |
N24K |
probably benign |
Het |
| Esco2 |
T |
C |
14: 66,064,726 (GRCm39) |
Q338R |
probably benign |
Het |
| Etl4 |
T |
C |
2: 20,812,837 (GRCm39) |
|
probably null |
Het |
| Exoc7 |
A |
T |
11: 116,183,347 (GRCm39) |
I498N |
probably damaging |
Het |
| Fap |
G |
A |
2: 62,378,933 (GRCm39) |
S123L |
probably damaging |
Het |
| Foxn1 |
T |
C |
11: 78,262,051 (GRCm39) |
E106G |
probably benign |
Het |
| Fscb |
T |
A |
12: 64,521,175 (GRCm39) |
D97V |
probably damaging |
Het |
| Gabrg1 |
T |
C |
5: 70,939,596 (GRCm39) |
T174A |
possibly damaging |
Het |
| Gan |
C |
T |
8: 117,923,199 (GRCm39) |
A461V |
possibly damaging |
Het |
| Gbp2 |
T |
A |
3: 142,336,284 (GRCm39) |
D211E |
possibly damaging |
Het |
| Gm10271 |
A |
T |
10: 116,792,746 (GRCm39) |
Y47N |
unknown |
Het |
| Gm17333 |
G |
T |
16: 77,649,711 (GRCm39) |
|
noncoding transcript |
Het |
| Gm1758 |
T |
A |
16: 14,320,142 (GRCm39) |
|
noncoding transcript |
Het |
| Golga3 |
A |
G |
5: 110,355,493 (GRCm39) |
K989R |
possibly damaging |
Het |
| Gucy2g |
C |
A |
19: 55,187,973 (GRCm39) |
V1041F |
probably damaging |
Het |
| Guk1 |
A |
T |
11: 59,077,639 (GRCm39) |
F25I |
probably benign |
Het |
| H2al1o |
C |
T |
X: 9,438,329 (GRCm39) |
E87K |
possibly damaging |
Het |
| Hemgn |
C |
A |
4: 46,395,958 (GRCm39) |
C426F |
probably damaging |
Het |
| Hps3 |
A |
G |
3: 20,066,859 (GRCm39) |
|
probably null |
Het |
| Il2rb |
A |
T |
15: 78,368,187 (GRCm39) |
D287E |
probably damaging |
Het |
| Ino80 |
A |
T |
2: 119,237,340 (GRCm39) |
V1123D |
probably damaging |
Het |
| Kdm2b |
A |
G |
5: 123,122,523 (GRCm39) |
|
probably null |
Het |
| Kif21a |
A |
T |
15: 90,856,930 (GRCm39) |
|
probably null |
Het |
| Klhl33 |
A |
T |
14: 51,129,583 (GRCm39) |
N347K |
probably damaging |
Het |
| Krt1c |
A |
G |
15: 101,724,861 (GRCm39) |
F250L |
possibly damaging |
Het |
| Krt82 |
T |
A |
15: 101,451,819 (GRCm39) |
N332I |
possibly damaging |
Het |
| Lgi1 |
A |
G |
19: 38,294,631 (GRCm39) |
I444V |
probably benign |
Het |
| Lmod1 |
G |
A |
1: 135,252,862 (GRCm39) |
V39M |
probably damaging |
Het |
| Lonrf2 |
G |
A |
1: 38,852,357 (GRCm39) |
P165S |
probably benign |
Het |
| Mex3d |
T |
C |
10: 80,217,376 (GRCm39) |
T149A |
probably benign |
Het |
| Mideas |
A |
G |
12: 84,205,748 (GRCm39) |
|
probably null |
Het |
| Mlxipl |
A |
C |
5: 135,136,024 (GRCm39) |
D83A |
probably damaging |
Het |
| Mroh8 |
T |
A |
2: 157,111,471 (GRCm39) |
E161V |
probably benign |
Het |
| Mroh9 |
G |
A |
1: 162,884,347 (GRCm39) |
T397I |
probably damaging |
Het |
| Mtss1 |
T |
C |
15: 58,930,249 (GRCm39) |
D32G |
possibly damaging |
Het |
| Mus81 |
T |
C |
19: 5,533,504 (GRCm39) |
D495G |
probably benign |
Het |
| Neurod1 |
A |
C |
2: 79,284,673 (GRCm39) |
S237A |
probably benign |
Het |
| Npas1 |
G |
A |
7: 16,208,725 (GRCm39) |
R51C |
probably damaging |
Het |
| Or11g27 |
T |
C |
14: 50,771,159 (GRCm39) |
S97P |
possibly damaging |
Het |
| P2ry14 |
T |
C |
3: 59,023,274 (GRCm39) |
N62S |
probably damaging |
Het |
| Pcdh15 |
A |
G |
10: 74,460,087 (GRCm39) |
Y1308C |
probably damaging |
Het |
| Pcdhb14 |
A |
T |
18: 37,582,588 (GRCm39) |
M565L |
probably benign |
Het |
| Pde6a |
A |
G |
18: 61,390,283 (GRCm39) |
E502G |
probably damaging |
Het |
| Pde8b |
A |
G |
13: 95,178,527 (GRCm39) |
V566A |
probably benign |
Het |
| Phf11b |
G |
T |
14: 59,565,554 (GRCm39) |
Q108K |
probably benign |
Het |
| Pikfyve |
T |
C |
1: 65,291,716 (GRCm39) |
Y1312H |
probably damaging |
Het |
| Plcb3 |
T |
C |
19: 6,933,381 (GRCm39) |
|
probably benign |
Het |
| Plxna2 |
G |
A |
1: 194,488,611 (GRCm39) |
G1629D |
probably damaging |
Het |
| Plxnb1 |
T |
C |
9: 108,929,813 (GRCm39) |
V223A |
probably benign |
Het |
| Prkca |
A |
T |
11: 107,903,518 (GRCm39) |
Y285N |
possibly damaging |
Het |
| Prl2a1 |
A |
T |
13: 27,992,554 (GRCm39) |
N226I |
probably damaging |
Het |
| Pus7 |
A |
C |
5: 23,946,914 (GRCm39) |
M636R |
probably damaging |
Het |
| Samd9l |
G |
A |
6: 3,375,264 (GRCm39) |
Q666* |
probably null |
Het |
| Sema3d |
A |
G |
5: 12,634,854 (GRCm39) |
D640G |
probably benign |
Het |
| Slc6a15 |
A |
G |
10: 103,236,121 (GRCm39) |
I279V |
probably benign |
Het |
| Slk |
T |
C |
19: 47,608,973 (GRCm39) |
V642A |
possibly damaging |
Het |
| Spata31e2 |
C |
A |
1: 26,722,070 (GRCm39) |
G1037* |
probably null |
Het |
| Spta1 |
T |
A |
1: 174,073,296 (GRCm39) |
M2305K |
probably damaging |
Het |
| Srrt |
T |
C |
5: 137,301,274 (GRCm39) |
|
probably benign |
Het |
| Stfa2l1 |
A |
T |
16: 35,977,228 (GRCm39) |
I8L |
probably benign |
Het |
| Tap1 |
T |
C |
17: 34,413,899 (GRCm39) |
L638P |
probably benign |
Het |
| Tbccd1 |
A |
T |
16: 22,640,995 (GRCm39) |
L461M |
probably benign |
Het |
| Tecta |
T |
C |
9: 42,289,345 (GRCm39) |
T407A |
probably benign |
Het |
| Tmbim7 |
T |
C |
5: 3,707,493 (GRCm39) |
|
probably null |
Het |
| Tnrc18 |
C |
A |
5: 142,800,869 (GRCm39) |
V30L |
probably benign |
Het |
| Tomm7 |
A |
G |
5: 24,049,025 (GRCm39) |
F16S |
probably damaging |
Het |
| Ugt2a2 |
A |
G |
5: 87,622,315 (GRCm39) |
S428P |
probably benign |
Het |
| Vmn1r189 |
T |
C |
13: 22,286,324 (GRCm39) |
E171G |
probably benign |
Het |
| Vmn1r61 |
T |
C |
7: 5,614,324 (GRCm39) |
|
probably benign |
Het |
| Vmn2r120 |
A |
T |
17: 57,832,038 (GRCm39) |
S250R |
probably benign |
Het |
| Vmn2r8 |
T |
C |
5: 108,950,972 (GRCm39) |
R158G |
probably benign |
Het |
| Vmn2r98 |
A |
T |
17: 19,286,702 (GRCm39) |
Y400F |
probably damaging |
Het |
| Vps13c |
C |
A |
9: 67,801,267 (GRCm39) |
Y582* |
probably null |
Het |
| Zfp518a |
T |
A |
19: 40,904,000 (GRCm39) |
F1310I |
probably benign |
Het |
| Zswim1 |
A |
G |
2: 164,667,320 (GRCm39) |
I191V |
probably benign |
Het |
|
| Other mutations in Dlg1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01604:Dlg1
|
APN |
16 |
31,675,256 (GRCm39) |
splice site |
probably benign |
|
|
IGL02277:Dlg1
|
APN |
16 |
31,609,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02897:Dlg1
|
APN |
16 |
31,590,674 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03025:Dlg1
|
APN |
16 |
31,624,545 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03271:Dlg1
|
APN |
16 |
31,676,710 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4812001:Dlg1
|
UTSW |
16 |
31,665,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0068:Dlg1
|
UTSW |
16 |
31,655,018 (GRCm39) |
unclassified |
probably benign |
|
|
R0115:Dlg1
|
UTSW |
16 |
31,624,508 (GRCm39) |
nonsense |
probably null |
|
|
R0128:Dlg1
|
UTSW |
16 |
31,676,883 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0257:Dlg1
|
UTSW |
16 |
31,661,671 (GRCm39) |
splice site |
probably benign |
|
|
R0268:Dlg1
|
UTSW |
16 |
31,503,011 (GRCm39) |
missense |
probably benign |
|
|
R0312:Dlg1
|
UTSW |
16 |
31,609,085 (GRCm39) |
missense |
probably benign |
|
|
R0321:Dlg1
|
UTSW |
16 |
31,676,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0355:Dlg1
|
UTSW |
16 |
31,502,992 (GRCm39) |
nonsense |
probably null |
|
|
R0538:Dlg1
|
UTSW |
16 |
31,615,682 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0540:Dlg1
|
UTSW |
16 |
31,656,992 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0607:Dlg1
|
UTSW |
16 |
31,656,992 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0607:Dlg1
|
UTSW |
16 |
31,484,398 (GRCm39) |
missense |
probably benign |
0.37 |
|
R0894:Dlg1
|
UTSW |
16 |
31,561,965 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1107:Dlg1
|
UTSW |
16 |
31,665,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1349:Dlg1
|
UTSW |
16 |
31,631,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1372:Dlg1
|
UTSW |
16 |
31,631,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Dlg1
|
UTSW |
16 |
31,661,640 (GRCm39) |
splice site |
probably null |
|
|
R1468:Dlg1
|
UTSW |
16 |
31,661,640 (GRCm39) |
splice site |
probably null |
|
|
R1696:Dlg1
|
UTSW |
16 |
31,600,616 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1772:Dlg1
|
UTSW |
16 |
31,484,485 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2106:Dlg1
|
UTSW |
16 |
31,631,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2206:Dlg1
|
UTSW |
16 |
31,672,664 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2207:Dlg1
|
UTSW |
16 |
31,672,664 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2846:Dlg1
|
UTSW |
16 |
31,682,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3954:Dlg1
|
UTSW |
16 |
31,676,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Dlg1
|
UTSW |
16 |
31,609,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4758:Dlg1
|
UTSW |
16 |
31,610,570 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4898:Dlg1
|
UTSW |
16 |
31,676,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Dlg1
|
UTSW |
16 |
31,573,626 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4966:Dlg1
|
UTSW |
16 |
31,573,626 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4985:Dlg1
|
UTSW |
16 |
31,606,953 (GRCm39) |
splice site |
probably null |
|
|
R5068:Dlg1
|
UTSW |
16 |
31,503,113 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5069:Dlg1
|
UTSW |
16 |
31,503,113 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5078:Dlg1
|
UTSW |
16 |
31,675,287 (GRCm39) |
nonsense |
probably null |
|
|
R5090:Dlg1
|
UTSW |
16 |
31,656,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5225:Dlg1
|
UTSW |
16 |
31,655,085 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5888:Dlg1
|
UTSW |
16 |
31,610,704 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5950:Dlg1
|
UTSW |
16 |
31,484,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6029:Dlg1
|
UTSW |
16 |
31,612,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6132:Dlg1
|
UTSW |
16 |
31,655,059 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6246:Dlg1
|
UTSW |
16 |
31,484,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6294:Dlg1
|
UTSW |
16 |
31,656,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6322:Dlg1
|
UTSW |
16 |
31,675,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7147:Dlg1
|
UTSW |
16 |
31,610,672 (GRCm39) |
missense |
probably benign |
|
|
R7216:Dlg1
|
UTSW |
16 |
31,615,736 (GRCm39) |
frame shift |
probably null |
|
|
R7963:Dlg1
|
UTSW |
16 |
31,609,119 (GRCm39) |
missense |
probably null |
0.92 |
|
R7985:Dlg1
|
UTSW |
16 |
31,606,923 (GRCm39) |
nonsense |
probably null |
|
|
R8041:Dlg1
|
UTSW |
16 |
31,656,885 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8111:Dlg1
|
UTSW |
16 |
31,661,620 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8751:Dlg1
|
UTSW |
16 |
31,600,648 (GRCm39) |
missense |
probably benign |
|
|
R9052:Dlg1
|
UTSW |
16 |
31,656,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9674:Dlg1
|
UTSW |
16 |
31,610,580 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9725:Dlg1
|
UTSW |
16 |
31,665,683 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9741:Dlg1
|
UTSW |
16 |
31,676,735 (GRCm39) |
nonsense |
probably null |
|
|
X0021:Dlg1
|
UTSW |
16 |
31,484,526 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGACTTCATTCAAACAGTTGC -3'
(R):5'- CTGTTTATGAAGAGACACAACCAAG -3'
Sequencing Primer
(F):5'- GCCTTTTAGATATACATGTAGCGTTG -3'
(R):5'- TCACATGTGAGATTTCAAAGATGC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation