Mutagenetix > Incidental Mutation

Incidental Mutation 'R1796:Herc1'

202272

Institutional Source

Beutler Lab

Gene Symbol

Herc1

Ensembl Gene

ENSMUSG00000038664

Gene Name

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

Synonyms

tbl, D130015N03Rik, 2810449H11Rik

MMRRC Submission

039826-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1796 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

66257732-66416057 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 66296138 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 578 (K578*)

Ref Sequence

ENSEMBL: ENSMUSP00000044801 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042824]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000042824
AA Change: K578*

SMART Domains

Protein: ENSMUSP00000044801
Gene: ENSMUSG00000038664
AA Change: K578*

Domain	Start	End	E-Value	Type
low complexity region	79	90	N/A	INTRINSIC
low complexity region	136	147	N/A	INTRINSIC
Pfam:RCC1	476	526	5.4e-15	PFAM
Pfam:RCC1_2	513	542	1.3e-9	PFAM
Pfam:RCC1	529	576	5.5e-16	PFAM
Pfam:RCC1	579	629	1.5e-10	PFAM
Pfam:RCC1	632	680	3.6e-9	PFAM
Pfam:RCC1_2	667	696	2.2e-11	PFAM
Pfam:RCC1	683	733	1.2e-14	PFAM
low complexity region	787	807	N/A	INTRINSIC
low complexity region	852	864	N/A	INTRINSIC
low complexity region	1014	1025	N/A	INTRINSIC
low complexity region	1080	1100	N/A	INTRINSIC
low complexity region	1348	1378	N/A	INTRINSIC
low complexity region	1659	1676	N/A	INTRINSIC
low complexity region	1865	1874	N/A	INTRINSIC
low complexity region	2002	2030	N/A	INTRINSIC
SPRY	2067	2188	1.8e-30	SMART
coiled coil region	2251	2280	N/A	INTRINSIC
low complexity region	2410	2423	N/A	INTRINSIC
low complexity region	2613	2629	N/A	INTRINSIC
low complexity region	2633	2648	N/A	INTRINSIC
low complexity region	2650	2667	N/A	INTRINSIC
low complexity region	2736	2749	N/A	INTRINSIC
low complexity region	2882	2896	N/A	INTRINSIC
low complexity region	2924	2935	N/A	INTRINSIC
low complexity region	2971	2987	N/A	INTRINSIC
low complexity region	3045	3051	N/A	INTRINSIC
low complexity region	3168	3186	N/A	INTRINSIC
low complexity region	3191	3213	N/A	INTRINSIC
low complexity region	3364	3379	N/A	INTRINSIC
WD40	3415	3454	1.68e-6	SMART
WD40	3570	3608	3.68e1	SMART
WD40	3613	3652	4.3e-1	SMART
WD40	3657	3702	3.17e-2	SMART
WD40	3734	3773	8.29e-6	SMART
low complexity region	3950	3964	N/A	INTRINSIC
Pfam:RCC1_2	4079	4111	7.3e-9	PFAM
Pfam:RCC1	4098	4147	3.4e-16	PFAM
Pfam:RCC1_2	4134	4163	1.8e-7	PFAM
Pfam:RCC1	4150	4199	7.2e-16	PFAM
Pfam:RCC1	4204	4252	6.1e-12	PFAM
Pfam:RCC1	4255	4304	2.4e-7	PFAM
Pfam:RCC1_2	4291	4320	5.8e-12	PFAM
Pfam:RCC1	4307	4356	8.9e-16	PFAM
Blast:HECTc	4389	4423	2e-11	BLAST
HECTc	4497	4846	8.2e-148	SMART

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.1%
20x: 92.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
PHENOTYPE: Homozygotes for this spontaneous mutation exhibit an abnormal cerebellar Purkinje cell layer and Purkinje cell degeneration. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 109 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd4	G	A	12: 84,662,156 (GRCm39)	S30F	probably benign	Het
Abtb1	T	C	6: 88,813,601 (GRCm39)	D379G	possibly damaging	Het
Adgre1	A	G	17: 57,748,350 (GRCm39)	I517V	probably benign	Het
Ajm1	C	T	2: 25,468,000 (GRCm39)	G637D	probably damaging	Het
Akap8l	C	T	17: 32,551,457 (GRCm39)	R511H	probably damaging	Het
Angpt4	G	A	2: 151,780,909 (GRCm39)	V386M	probably damaging	Het
Asic1	A	G	15: 99,594,535 (GRCm39)	H360R	probably null	Het
Asxl1	G	A	2: 153,243,526 (GRCm39)	A1359T	probably benign	Het
Atp8a2	C	T	14: 60,258,207 (GRCm39)		probably null	Het
Bltp3a	T	C	17: 28,109,045 (GRCm39)	F1088S	possibly damaging	Het
C1qtnf2	T	A	11: 43,382,114 (GRCm39)	F279I	probably damaging	Het
Car8	A	T	4: 8,221,671 (GRCm39)	L100*	probably null	Het
Cd52	T	C	4: 133,822,295 (GRCm39)	M1V	probably null	Het
Celf5	T	C	10: 81,303,053 (GRCm39)	I163V	possibly damaging	Het
Cep250	A	T	2: 155,834,107 (GRCm39)	T2010S	possibly damaging	Het
Cfap65	C	T	1: 74,958,107 (GRCm39)	V934M	probably damaging	Het
Colec11	A	T	12: 28,644,858 (GRCm39)	I212N	probably damaging	Het
Cpa3	C	T	3: 20,277,391 (GRCm39)		probably null	Het
Ctnnd1	G	T	2: 84,445,553 (GRCm39)	H495N	probably damaging	Het
Cyb5a	T	C	18: 84,869,686 (GRCm39)	V28A	probably benign	Het
Ddo	A	T	10: 40,523,625 (GRCm39)	Q205L	probably benign	Het
Dnah1	T	A	14: 30,983,050 (GRCm39)	N4195I	probably benign	Het
E2f1	A	T	2: 154,402,849 (GRCm39)	V306E	probably benign	Het
Ece1	C	T	4: 137,685,312 (GRCm39)	R601W	probably damaging	Het
Eef1d	A	C	15: 75,773,024 (GRCm39)	F25C	probably damaging	Het
Ehd3	A	T	17: 74,137,354 (GRCm39)	I508F	probably damaging	Het
Eml6	T	A	11: 29,831,975 (GRCm39)	I232F	probably benign	Het
Enc1	T	A	13: 97,382,991 (GRCm39)	D500E	probably benign	Het
Enc1	C	A	13: 97,382,993 (GRCm39)	T501K	possibly damaging	Het
Fam83f	C	T	15: 80,574,283 (GRCm39)	R213W	possibly damaging	Het
Fbxo31	A	T	8: 122,287,177 (GRCm39)	L158*	probably null	Het
Fcgbpl1	C	T	7: 27,854,797 (GRCm39)	P1808S	probably damaging	Het
Foxi3	C	A	6: 70,937,794 (GRCm39)	T342N	possibly damaging	Het
Gpr179	T	A	11: 97,227,382 (GRCm39)	D1591V	possibly damaging	Het
Gpsm2	A	G	3: 108,609,166 (GRCm39)	V151A	probably damaging	Het
Grk2	T	G	19: 4,337,968 (GRCm39)	I513L	probably benign	Het
H2-Ab1	A	G	17: 34,486,346 (GRCm39)	E135G	probably damaging	Het
Hycc1	T	G	5: 24,191,149 (GRCm39)	T173P	probably damaging	Het
Itpr2	T	C	6: 146,198,171 (GRCm39)	N1533S	probably benign	Het
Kif3c	A	G	12: 3,417,299 (GRCm39)	N440S	probably benign	Het
Klhdc2	T	C	12: 69,347,071 (GRCm39)		probably null	Het
Kmo	G	T	1: 175,465,461 (GRCm39)	V72L	probably benign	Het
Krt71	A	G	15: 101,651,315 (GRCm39)	I56T	possibly damaging	Het
Krt72	T	C	15: 101,689,987 (GRCm39)		probably null	Het
Krt78	T	A	15: 101,859,300 (GRCm39)	Q299L	probably damaging	Het
Loxhd1	C	T	18: 77,493,603 (GRCm39)	R1521C	probably damaging	Het
Loxhd1	G	A	18: 77,513,335 (GRCm39)	E1774K	possibly damaging	Het
Ly6g6f	T	C	17: 35,302,478 (GRCm39)	S20G	probably benign	Het
Mecr	T	A	4: 131,592,382 (GRCm39)	M282K	probably damaging	Het
Mfsd14a	G	T	3: 116,428,596 (GRCm39)	A353D	probably damaging	Het
Mroh9	A	T	1: 162,873,279 (GRCm39)	N564K	probably damaging	Het
Mrs2	T	A	13: 25,181,111 (GRCm39)	T237S	possibly damaging	Het
Mycbpap	A	G	11: 94,398,377 (GRCm39)	L534S	probably damaging	Het
Myh1	T	C	11: 67,115,183 (GRCm39)	I1906T	probably benign	Het
Myh4	T	A	11: 67,151,150 (GRCm39)	V1935D	probably benign	Het
Myo18a	T	C	11: 77,720,170 (GRCm39)	I684T	possibly damaging	Het
Myo7b	C	T	18: 32,119,728 (GRCm39)	R788H	possibly damaging	Het
Nbea	A	T	3: 55,551,129 (GRCm39)	D2678E	possibly damaging	Het
Ndufs3	A	C	2: 90,729,050 (GRCm39)	Y145*	probably null	Het
Nrros	A	G	16: 31,962,329 (GRCm39)	F563L	probably damaging	Het
Ntn4	T	C	10: 93,581,633 (GRCm39)	V602A	probably damaging	Het
Obscn	C	A	11: 58,920,163 (GRCm39)	R6736L	possibly damaging	Het
Odr4	T	C	1: 150,251,305 (GRCm39)	N283S	probably benign	Het
Or13c7d	T	A	4: 43,770,495 (GRCm39)	D172V	possibly damaging	Het
Or2ag16	T	C	7: 106,351,756 (GRCm39)	I280V	probably benign	Het
Or7g22	C	A	9: 19,049,213 (GRCm39)	T308K	probably benign	Het
Or8d1	T	A	9: 38,766,820 (GRCm39)	V154D	probably benign	Het
Or8g54	C	T	9: 39,707,301 (GRCm39)	P210L	possibly damaging	Het
Or8g55	A	G	9: 39,785,267 (GRCm39)	E232G	probably benign	Het
Pik3cd	A	G	4: 149,738,576 (GRCm39)	F751L	possibly damaging	Het
Plekhh2	A	G	17: 84,906,561 (GRCm39)		probably null	Het
Postn	A	G	3: 54,281,177 (GRCm39)	H434R	probably damaging	Het
Prss39	A	G	1: 34,539,114 (GRCm39)	D118G	possibly damaging	Het
Ralyl	G	T	3: 14,208,493 (GRCm39)	G211V	possibly damaging	Het
Rbak	T	A	5: 143,159,202 (GRCm39)	E617V	probably damaging	Het
Rbms3	A	T	9: 116,548,401 (GRCm39)	W80R	probably damaging	Het
Retnlg	A	T	16: 48,694,610 (GRCm39)	Y86F	probably benign	Het
Rtel1	T	A	2: 180,993,896 (GRCm39)	S643T	probably benign	Het
Semp2l2a	A	T	8: 13,886,816 (GRCm39)	L425*	probably null	Het
Serpina11	A	T	12: 103,950,954 (GRCm39)	F256I	probably damaging	Het
Setd2	A	T	9: 110,446,884 (GRCm39)		probably null	Het
Setd2	A	T	9: 110,379,413 (GRCm39)	Y1076F	probably benign	Het
Sgsm1	T	C	5: 113,421,483 (GRCm39)	T248A	possibly damaging	Het
Slc6a21	T	C	7: 44,930,179 (GRCm39)	Y193H	probably damaging	Het
Slfn9	T	C	11: 82,872,781 (GRCm39)	K652E	probably benign	Het
Stt3b	A	T	9: 115,077,675 (GRCm39)	Y692*	probably null	Het
Sval3	A	G	6: 41,945,096 (GRCm39)	Q8R	probably benign	Het
Synm	T	A	7: 67,383,748 (GRCm39)	I1305F	possibly damaging	Het
Tdrd1	T	C	19: 56,826,215 (GRCm39)	F169L	probably damaging	Het
Tecta	T	A	9: 42,295,493 (GRCm39)	D334V	probably damaging	Het
Tle2	G	A	10: 81,425,331 (GRCm39)		probably null	Het
Tmem243	A	G	5: 9,166,489 (GRCm39)	I30V	probably benign	Het
Treml2	T	C	17: 48,616,530 (GRCm39)	*330R	probably null	Het
Trpm6	A	G	19: 18,804,931 (GRCm39)	D961G	possibly damaging	Het
Ubr4	T	C	4: 139,155,907 (GRCm39)	V2244A	probably benign	Het
Unc79	G	T	12: 103,109,005 (GRCm39)	V2148F	probably damaging	Het
Ush2a	A	C	1: 188,643,024 (GRCm39)	T4129P	probably benign	Het
Vgll2	G	A	10: 51,901,324 (GRCm39)	V85I	probably damaging	Het
Vmn1r16	T	C	6: 57,300,256 (GRCm39)	Y122C	probably benign	Het
Vmn1r22	A	T	6: 57,877,134 (GRCm39)	I91N	probably damaging	Het
Vmn2r70	A	T	7: 85,213,011 (GRCm39)	Y465*	probably null	Het
Wdr64	A	T	1: 175,544,897 (GRCm39)	E110V	probably damaging	Het
Wfdc6a	A	T	2: 164,422,231 (GRCm39)	C123S	probably damaging	Het
Xrcc1	A	G	7: 24,247,252 (GRCm39)	Y30C	probably damaging	Het
Zdhhc7	T	C	8: 120,812,157 (GRCm39)	K155R	probably benign	Het
Zfp560	A	G	9: 20,263,226 (GRCm39)	F50S	possibly damaging	Het
Zfp616	C	T	11: 73,976,671 (GRCm39)	T980I	probably damaging	Het
Zfp808	C	T	13: 62,319,670 (GRCm39)	P300S	probably damaging	Het
Zfp979	G	A	4: 147,697,740 (GRCm39)	T323I	probably damaging	Het

Other mutations in Herc1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00092:Herc1	APN	9	66,391,248 (GRCm39)	missense	probably benign	0.02
IGL00159:Herc1	APN	9	66,344,964 (GRCm39)	missense	possibly damaging	0.94
IGL00486:Herc1	APN	9	66,383,402 (GRCm39)	missense	probably benign
IGL00717:Herc1	APN	9	66,392,284 (GRCm39)	missense	probably damaging	1.00
IGL00766:Herc1	APN	9	66,358,023 (GRCm39)	missense	probably damaging	1.00
IGL00776:Herc1	APN	9	66,328,320 (GRCm39)	missense	probably benign
IGL00987:Herc1	APN	9	66,315,334 (GRCm39)	missense	probably benign	0.07
IGL01090:Herc1	APN	9	66,376,457 (GRCm39)	nonsense	probably null
IGL01098:Herc1	APN	9	66,369,204 (GRCm39)	critical splice donor site	probably null
IGL01106:Herc1	APN	9	66,383,720 (GRCm39)	splice site	probably benign
IGL01120:Herc1	APN	9	66,336,162 (GRCm39)	missense	probably benign
IGL01359:Herc1	APN	9	66,346,550 (GRCm39)	missense	probably benign	0.01
IGL01360:Herc1	APN	9	66,390,981 (GRCm39)	missense	probably benign
IGL01364:Herc1	APN	9	66,306,643 (GRCm39)	missense	probably benign	0.00
IGL01470:Herc1	APN	9	66,404,918 (GRCm39)	missense	possibly damaging	0.94
IGL01670:Herc1	APN	9	66,394,342 (GRCm39)	missense	probably damaging	1.00
IGL01825:Herc1	APN	9	66,307,089 (GRCm39)	missense	probably benign	0.00
IGL01903:Herc1	APN	9	66,294,154 (GRCm39)	nonsense	probably null
IGL01988:Herc1	APN	9	66,395,357 (GRCm39)	splice site	probably benign
IGL02074:Herc1	APN	9	66,358,265 (GRCm39)	missense	probably benign
IGL02089:Herc1	APN	9	66,388,151 (GRCm39)	missense	probably damaging	1.00
IGL02177:Herc1	APN	9	66,341,793 (GRCm39)	missense	probably benign
IGL02300:Herc1	APN	9	66,383,645 (GRCm39)	missense	probably benign	0.01
IGL02304:Herc1	APN	9	66,383,696 (GRCm39)	missense	probably benign	0.06
IGL02369:Herc1	APN	9	66,399,293 (GRCm39)	nonsense	probably null
IGL02445:Herc1	APN	9	66,340,764 (GRCm39)	missense	possibly damaging	0.95
IGL02447:Herc1	APN	9	66,404,610 (GRCm39)	missense	possibly damaging	0.59
IGL02549:Herc1	APN	9	66,307,183 (GRCm39)	missense	probably damaging	0.98
IGL02571:Herc1	APN	9	66,341,887 (GRCm39)	splice site	probably benign
IGL02709:Herc1	APN	9	66,404,962 (GRCm39)	missense	probably damaging	0.97
IGL02717:Herc1	APN	9	66,279,203 (GRCm39)	nonsense	probably null
IGL02726:Herc1	APN	9	66,349,270 (GRCm39)	missense	probably benign	0.37
IGL02733:Herc1	APN	9	66,358,274 (GRCm39)	missense	probably benign
IGL02963:Herc1	APN	9	66,296,105 (GRCm39)	missense	probably damaging	0.99
IGL03101:Herc1	APN	9	66,395,279 (GRCm39)	missense	probably benign
IGL03193:Herc1	APN	9	66,309,962 (GRCm39)	missense	probably benign
IGL03203:Herc1	APN	9	66,296,182 (GRCm39)	critical splice donor site	probably null
IGL03216:Herc1	APN	9	66,386,228 (GRCm39)	missense	probably benign	0.06
IGL03282:Herc1	APN	9	66,358,741 (GRCm39)	missense	probably benign	0.05
IGL03295:Herc1	APN	9	66,303,985 (GRCm39)	missense	possibly damaging	0.56
cradle	UTSW	9	66,391,148 (GRCm39)	splice site	probably null
miracles	UTSW	9	66,370,119 (GRCm39)	nonsense	probably null
newton	UTSW	9	66,375,085 (GRCm39)	missense	probably damaging	1.00
R0907_Herc1_362	UTSW	9	66,340,710 (GRCm39)	missense	possibly damaging	0.94
R4427_Herc1_231	UTSW	9	66,403,287 (GRCm39)	missense	probably damaging	1.00
R5026_Herc1_363	UTSW	9	66,393,408 (GRCm39)	missense	probably benign	0.03
stables	UTSW	9	66,386,735 (GRCm39)	missense	probably benign	0.13
strangle	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
IGL03134:Herc1	UTSW	9	66,341,345 (GRCm39)	critical splice acceptor site	probably benign
PIT4243001:Herc1	UTSW	9	66,279,489 (GRCm39)	missense	probably benign	0.00
PIT4486001:Herc1	UTSW	9	66,279,671 (GRCm39)	missense	probably damaging	1.00
PIT4696001:Herc1	UTSW	9	66,386,291 (GRCm39)	missense	probably damaging	1.00
R0044:Herc1	UTSW	9	66,355,457 (GRCm39)	missense	probably benign	0.04
R0044:Herc1	UTSW	9	66,355,457 (GRCm39)	missense	probably benign	0.04
R0052:Herc1	UTSW	9	66,307,438 (GRCm39)	missense	probably damaging	0.99
R0114:Herc1	UTSW	9	66,369,128 (GRCm39)	missense	probably damaging	0.99
R0129:Herc1	UTSW	9	66,355,357 (GRCm39)	missense	probably damaging	1.00
R0131:Herc1	UTSW	9	66,388,192 (GRCm39)	missense	probably benign	0.00
R0131:Herc1	UTSW	9	66,388,192 (GRCm39)	missense	probably benign	0.00
R0132:Herc1	UTSW	9	66,388,192 (GRCm39)	missense	probably benign	0.00
R0158:Herc1	UTSW	9	66,403,203 (GRCm39)	nonsense	probably null
R0333:Herc1	UTSW	9	66,371,981 (GRCm39)	splice site	probably null
R0384:Herc1	UTSW	9	66,388,332 (GRCm39)	splice site	probably benign
R0419:Herc1	UTSW	9	66,353,356 (GRCm39)	splice site	probably benign
R0453:Herc1	UTSW	9	66,307,054 (GRCm39)	missense	probably benign	0.20
R0458:Herc1	UTSW	9	66,383,663 (GRCm39)	missense	probably benign	0.12
R0490:Herc1	UTSW	9	66,392,281 (GRCm39)	missense	probably damaging	1.00
R0506:Herc1	UTSW	9	66,355,441 (GRCm39)	missense	probably damaging	0.99
R0513:Herc1	UTSW	9	66,352,927 (GRCm39)	missense	possibly damaging	0.96
R0628:Herc1	UTSW	9	66,358,163 (GRCm39)	missense	probably benign	0.35
R0666:Herc1	UTSW	9	66,392,170 (GRCm39)	splice site	probably benign
R0674:Herc1	UTSW	9	66,408,474 (GRCm39)	missense	probably damaging	0.99
R0682:Herc1	UTSW	9	66,389,263 (GRCm39)	missense	possibly damaging	0.95
R0690:Herc1	UTSW	9	66,294,120 (GRCm39)	nonsense	probably null
R0701:Herc1	UTSW	9	66,395,232 (GRCm39)	missense	probably damaging	1.00
R0766:Herc1	UTSW	9	66,412,122 (GRCm39)	missense	probably damaging	1.00
R0850:Herc1	UTSW	9	66,373,952 (GRCm39)	missense	probably damaging	1.00
R0907:Herc1	UTSW	9	66,340,710 (GRCm39)	missense	possibly damaging	0.94
R0972:Herc1	UTSW	9	66,279,427 (GRCm39)	missense	probably damaging	1.00
R0976:Herc1	UTSW	9	66,347,160 (GRCm39)	missense	possibly damaging	0.74
R1027:Herc1	UTSW	9	66,363,250 (GRCm39)	missense	probably benign
R1200:Herc1	UTSW	9	66,393,406 (GRCm39)	missense	probably damaging	1.00
R1226:Herc1	UTSW	9	66,323,545 (GRCm39)	missense	probably benign	0.00
R1364:Herc1	UTSW	9	66,307,375 (GRCm39)	missense	probably damaging	1.00
R1395:Herc1	UTSW	9	66,346,463 (GRCm39)	missense	probably benign	0.13
R1432:Herc1	UTSW	9	66,372,751 (GRCm39)	missense	probably benign	0.13
R1440:Herc1	UTSW	9	66,375,085 (GRCm39)	missense	probably damaging	1.00
R1476:Herc1	UTSW	9	66,415,548 (GRCm39)	missense	probably damaging	1.00
R1590:Herc1	UTSW	9	66,399,235 (GRCm39)	splice site	probably benign
R1634:Herc1	UTSW	9	66,380,820 (GRCm39)	missense	possibly damaging	0.51
R1700:Herc1	UTSW	9	66,357,960 (GRCm39)	splice site	probably null
R1753:Herc1	UTSW	9	66,409,366 (GRCm39)	critical splice donor site	probably null
R1753:Herc1	UTSW	9	66,376,292 (GRCm39)	missense	probably damaging	1.00
R1830:Herc1	UTSW	9	66,404,881 (GRCm39)	missense	possibly damaging	0.95
R1855:Herc1	UTSW	9	66,298,708 (GRCm39)	missense	possibly damaging	0.95
R1866:Herc1	UTSW	9	66,358,073 (GRCm39)	missense	probably damaging	1.00
R1894:Herc1	UTSW	9	66,386,743 (GRCm39)	missense	probably damaging	1.00
R1918:Herc1	UTSW	9	66,383,408 (GRCm39)	splice site	probably null
R1999:Herc1	UTSW	9	66,393,360 (GRCm39)	missense	probably benign	0.07
R2034:Herc1	UTSW	9	66,349,254 (GRCm39)	missense	probably benign	0.01
R2138:Herc1	UTSW	9	66,377,589 (GRCm39)	missense	possibly damaging	0.94
R2186:Herc1	UTSW	9	66,347,183 (GRCm39)	missense	probably benign	0.45
R2192:Herc1	UTSW	9	66,372,688 (GRCm39)	missense	probably damaging	0.99
R2312:Herc1	UTSW	9	66,415,563 (GRCm39)	nonsense	probably null
R2338:Herc1	UTSW	9	66,336,251 (GRCm39)	missense	possibly damaging	0.69
R3035:Herc1	UTSW	9	66,391,217 (GRCm39)	missense	possibly damaging	0.89
R3732:Herc1	UTSW	9	66,352,922 (GRCm39)	missense	probably damaging	1.00
R3732:Herc1	UTSW	9	66,352,922 (GRCm39)	missense	probably damaging	1.00
R3733:Herc1	UTSW	9	66,352,922 (GRCm39)	missense	probably damaging	1.00
R3917:Herc1	UTSW	9	66,341,748 (GRCm39)	missense	possibly damaging	0.94
R3953:Herc1	UTSW	9	66,341,075 (GRCm39)	nonsense	probably null
R4073:Herc1	UTSW	9	66,325,774 (GRCm39)	missense	probably benign	0.12
R4075:Herc1	UTSW	9	66,325,774 (GRCm39)	missense	probably benign	0.12
R4241:Herc1	UTSW	9	66,355,630 (GRCm39)	frame shift	probably null
R4260:Herc1	UTSW	9	66,355,630 (GRCm39)	frame shift	probably null
R4261:Herc1	UTSW	9	66,355,630 (GRCm39)	frame shift	probably null
R4300:Herc1	UTSW	9	66,396,688 (GRCm39)	missense	probably damaging	1.00
R4398:Herc1	UTSW	9	66,386,735 (GRCm39)	missense	probably benign	0.13
R4426:Herc1	UTSW	9	66,403,287 (GRCm39)	missense	probably damaging	1.00
R4427:Herc1	UTSW	9	66,403,287 (GRCm39)	missense	probably damaging	1.00
R4590:Herc1	UTSW	9	66,344,946 (GRCm39)	missense	probably damaging	0.97
R4630:Herc1	UTSW	9	66,340,996 (GRCm39)	splice site	probably null
R4656:Herc1	UTSW	9	66,301,993 (GRCm39)	missense	probably damaging	0.97
R4658:Herc1	UTSW	9	66,386,773 (GRCm39)	missense	possibly damaging	0.50
R4663:Herc1	UTSW	9	66,340,660 (GRCm39)	missense	probably damaging	0.98
R4675:Herc1	UTSW	9	66,298,740 (GRCm39)	missense	probably damaging	1.00
R4678:Herc1	UTSW	9	66,323,551 (GRCm39)	missense	probably benign	0.00
R4754:Herc1	UTSW	9	66,408,488 (GRCm39)	missense	probably benign	0.00
R4766:Herc1	UTSW	9	66,349,211 (GRCm39)	missense	probably benign	0.00
R4792:Herc1	UTSW	9	66,403,266 (GRCm39)	missense	possibly damaging	0.67
R4828:Herc1	UTSW	9	66,404,625 (GRCm39)	splice site	probably null
R4832:Herc1	UTSW	9	66,403,253 (GRCm39)	missense	probably benign	0.11
R4879:Herc1	UTSW	9	66,370,119 (GRCm39)	nonsense	probably null
R4948:Herc1	UTSW	9	66,392,184 (GRCm39)	missense	probably benign
R5021:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5022:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5023:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5024:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5025:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5026:Herc1	UTSW	9	66,393,408 (GRCm39)	missense	probably benign	0.03
R5027:Herc1	UTSW	9	66,380,811 (GRCm39)	missense	probably benign	0.01
R5027:Herc1	UTSW	9	66,411,900 (GRCm39)	missense	probably damaging	0.98
R5038:Herc1	UTSW	9	66,383,742 (GRCm39)	intron	probably benign
R5041:Herc1	UTSW	9	66,336,327 (GRCm39)	missense	possibly damaging	0.86
R5053:Herc1	UTSW	9	66,377,608 (GRCm39)	missense	possibly damaging	0.48
R5137:Herc1	UTSW	9	66,355,505 (GRCm39)	missense	probably benign
R5197:Herc1	UTSW	9	66,355,786 (GRCm39)	missense	probably damaging	0.99
R5207:Herc1	UTSW	9	66,307,151 (GRCm39)	nonsense	probably null
R5247:Herc1	UTSW	9	66,341,833 (GRCm39)	missense	probably benign	0.01
R5267:Herc1	UTSW	9	66,369,091 (GRCm39)	missense	probably damaging	1.00
R5274:Herc1	UTSW	9	66,306,691 (GRCm39)	missense	probably benign
R5375:Herc1	UTSW	9	66,375,169 (GRCm39)	missense	probably damaging	0.99
R5401:Herc1	UTSW	9	66,409,338 (GRCm39)	missense	probably damaging	1.00
R5560:Herc1	UTSW	9	66,358,401 (GRCm39)	missense	probably benign	0.02
R5566:Herc1	UTSW	9	66,372,819 (GRCm39)	missense	possibly damaging	0.95
R5577:Herc1	UTSW	9	66,389,263 (GRCm39)	missense	probably damaging	0.99
R5596:Herc1	UTSW	9	66,341,345 (GRCm39)	critical splice acceptor site	probably benign
R5665:Herc1	UTSW	9	66,372,717 (GRCm39)	missense	probably damaging	1.00
R5744:Herc1	UTSW	9	66,415,475 (GRCm39)	missense	probably damaging	1.00
R5802:Herc1	UTSW	9	66,370,160 (GRCm39)	missense	probably damaging	1.00
R5822:Herc1	UTSW	9	66,352,894 (GRCm39)	missense	probably benign	0.00
R5954:Herc1	UTSW	9	66,358,774 (GRCm39)	splice site	probably benign
R5977:Herc1	UTSW	9	66,340,604 (GRCm39)	missense	possibly damaging	0.77
R6022:Herc1	UTSW	9	66,390,967 (GRCm39)	missense	probably damaging	1.00
R6043:Herc1	UTSW	9	66,315,436 (GRCm39)	missense	probably benign
R6046:Herc1	UTSW	9	66,352,831 (GRCm39)	missense	probably damaging	0.99
R6089:Herc1	UTSW	9	66,352,814 (GRCm39)	missense	probably damaging	1.00
R6123:Herc1	UTSW	9	66,404,532 (GRCm39)	missense	probably damaging	0.97
R6155:Herc1	UTSW	9	66,340,705 (GRCm39)	missense	possibly damaging	0.95
R6190:Herc1	UTSW	9	66,283,663 (GRCm39)	missense	possibly damaging	0.56
R6220:Herc1	UTSW	9	66,341,070 (GRCm39)	missense	probably damaging	1.00
R6265:Herc1	UTSW	9	66,279,298 (GRCm39)	missense	probably benign	0.05
R6348:Herc1	UTSW	9	66,395,258 (GRCm39)	missense	possibly damaging	0.77
R6362:Herc1	UTSW	9	66,379,190 (GRCm39)	missense	probably damaging	1.00
R6394:Herc1	UTSW	9	66,302,341 (GRCm39)	missense	probably damaging	0.99
R6434:Herc1	UTSW	9	66,393,464 (GRCm39)	missense	probably damaging	0.99
R6483:Herc1	UTSW	9	66,355,811 (GRCm39)	missense	possibly damaging	0.64
R6607:Herc1	UTSW	9	66,325,849 (GRCm39)	missense	probably benign	0.02
R6633:Herc1	UTSW	9	66,346,534 (GRCm39)	nonsense	probably null
R6634:Herc1	UTSW	9	66,345,026 (GRCm39)	missense	probably benign
R6693:Herc1	UTSW	9	66,386,258 (GRCm39)	missense	probably damaging	0.99
R6695:Herc1	UTSW	9	66,391,148 (GRCm39)	splice site	probably null
R6748:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6750:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6751:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6774:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6785:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6786:Herc1	UTSW	9	66,408,470 (GRCm39)	frame shift	probably null
R6856:Herc1	UTSW	9	66,305,180 (GRCm39)	missense	probably benign	0.05
R6966:Herc1	UTSW	9	66,318,347 (GRCm39)	missense	probably benign	0.07
R7020:Herc1	UTSW	9	66,393,360 (GRCm39)	missense	probably benign	0.07
R7109:Herc1	UTSW	9	66,389,171 (GRCm39)	missense	probably benign	0.03
R7122:Herc1	UTSW	9	66,307,056 (GRCm39)	missense	possibly damaging	0.69
R7209:Herc1	UTSW	9	66,292,314 (GRCm39)	missense	possibly damaging	0.95
R7222:Herc1	UTSW	9	66,374,781 (GRCm39)	missense	probably damaging	0.98
R7303:Herc1	UTSW	9	66,358,098 (GRCm39)	missense	possibly damaging	0.93
R7305:Herc1	UTSW	9	66,369,150 (GRCm39)	missense
R7438:Herc1	UTSW	9	66,302,038 (GRCm39)	missense	probably benign	0.00
R7535:Herc1	UTSW	9	66,382,135 (GRCm39)	missense	probably damaging	1.00
R7585:Herc1	UTSW	9	66,352,829 (GRCm39)	missense	probably damaging	1.00
R7603:Herc1	UTSW	9	66,358,665 (GRCm39)	nonsense	probably null
R7670:Herc1	UTSW	9	66,323,629 (GRCm39)	missense	probably damaging	0.99
R7705:Herc1	UTSW	9	66,347,116 (GRCm39)	missense	possibly damaging	0.86
R7723:Herc1	UTSW	9	66,279,158 (GRCm39)	missense	probably benign	0.24
R7730:Herc1	UTSW	9	66,400,472 (GRCm39)	small deletion	probably benign
R7880:Herc1	UTSW	9	66,415,506 (GRCm39)	missense	probably damaging	0.99
R7958:Herc1	UTSW	9	66,393,475 (GRCm39)	missense	probably damaging	1.00
R7976:Herc1	UTSW	9	66,341,552 (GRCm39)	missense	possibly damaging	0.94
R8006:Herc1	UTSW	9	66,352,842 (GRCm39)	nonsense	probably null
R8084:Herc1	UTSW	9	66,383,217 (GRCm39)	missense	probably benign	0.45
R8094:Herc1	UTSW	9	66,400,462 (GRCm39)	missense	probably damaging	0.98
R8099:Herc1	UTSW	9	66,279,422 (GRCm39)	missense	probably damaging	1.00
R8151:Herc1	UTSW	9	66,341,073 (GRCm39)	missense	probably damaging	0.98
R8159:Herc1	UTSW	9	66,369,003 (GRCm39)	missense	probably null
R8190:Herc1	UTSW	9	66,325,733 (GRCm39)	missense	probably benign	0.00
R8213:Herc1	UTSW	9	66,358,170 (GRCm39)	missense	probably damaging	0.99
R8230:Herc1	UTSW	9	66,377,598 (GRCm39)	missense	probably damaging	0.99
R8265:Herc1	UTSW	9	66,293,986 (GRCm39)	nonsense	probably null
R8270:Herc1	UTSW	9	66,395,232 (GRCm39)	missense	probably damaging	1.00
R8353:Herc1	UTSW	9	66,415,571 (GRCm39)	missense	possibly damaging	0.88
R8423:Herc1	UTSW	9	66,415,442 (GRCm39)	missense	probably damaging	0.99
R8506:Herc1	UTSW	9	66,380,863 (GRCm39)	missense	possibly damaging	0.52
R8523:Herc1	UTSW	9	66,358,224 (GRCm39)	missense	probably benign
R8530:Herc1	UTSW	9	66,325,910 (GRCm39)	missense	probably benign
R8545:Herc1	UTSW	9	66,279,257 (GRCm39)	nonsense	probably null
R8682:Herc1	UTSW	9	66,370,130 (GRCm39)	missense
R8720:Herc1	UTSW	9	66,389,105 (GRCm39)	missense	probably benign	0.38
R8792:Herc1	UTSW	9	66,372,768 (GRCm39)	missense	probably damaging	1.00
R8915:Herc1	UTSW	9	66,318,456 (GRCm39)	missense	probably damaging	1.00
R8964:Herc1	UTSW	9	66,352,872 (GRCm39)	missense	probably damaging	1.00
R9056:Herc1	UTSW	9	66,380,782 (GRCm39)	missense	probably benign	0.10
R9158:Herc1	UTSW	9	66,376,400 (GRCm39)	missense	probably benign	0.00
R9167:Herc1	UTSW	9	66,411,900 (GRCm39)	missense	possibly damaging	0.75
R9192:Herc1	UTSW	9	66,321,413 (GRCm39)	missense	probably benign	0.35
R9252:Herc1	UTSW	9	66,309,834 (GRCm39)	missense	probably damaging	1.00
R9260:Herc1	UTSW	9	66,325,691 (GRCm39)	nonsense	probably null
R9261:Herc1	UTSW	9	66,412,129 (GRCm39)	missense	probably damaging	0.98
R9430:Herc1	UTSW	9	66,325,785 (GRCm39)	nonsense	probably null
R9519:Herc1	UTSW	9	66,307,356 (GRCm39)	missense	probably damaging	0.97
R9563:Herc1	UTSW	9	66,294,193 (GRCm39)	critical splice donor site	probably null
R9589:Herc1	UTSW	9	66,372,840 (GRCm39)	missense	possibly damaging	0.95
R9600:Herc1	UTSW	9	66,304,594 (GRCm39)	missense	possibly damaging	0.95
R9659:Herc1	UTSW	9	66,307,185 (GRCm39)	missense	probably benign	0.03
R9740:Herc1	UTSW	9	66,355,796 (GRCm39)	missense	probably damaging	1.00
R9774:Herc1	UTSW	9	66,372,032 (GRCm39)	missense	probably null
R9781:Herc1	UTSW	9	66,280,004 (GRCm39)	missense	probably benign
R9788:Herc1	UTSW	9	66,307,185 (GRCm39)	missense	probably benign	0.03
RF023:Herc1	UTSW	9	66,365,616 (GRCm39)	missense
X0011:Herc1	UTSW	9	66,307,441 (GRCm39)	missense	probably benign	0.28
X0067:Herc1	UTSW	9	66,355,806 (GRCm39)	missense	probably benign	0.03
Z1176:Herc1	UTSW	9	66,341,858 (GRCm39)	missense	probably benign
Z1177:Herc1	UTSW	9	66,379,193 (GRCm39)	missense	probably damaging	0.99
Z1177:Herc1	UTSW	9	66,365,707 (GRCm39)	missense	probably null

Predicted Primers

PCR Primer
(F):5'- AGCAGGTAGAGAGGATTCACTTT -3'
(R):5'- TGTCTGTTCATCTACATTTGAGATTT -3'

Sequencing Primer
(F):5'- CATGGTGACAGTAACAGC -3'
(R):5'- CCAAAGCTACCAATAGGTTTT -3'

Posted On

2014-06-23