Incidental Mutation 'R1797:Cux1'
| ID |
202365 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cux1
|
| Ensembl Gene |
ENSMUSG00000029705 |
| Gene Name |
cut-like homeobox 1 |
| Synonyms |
CDP, Cutl1, Cux, Cux-1 |
| MMRRC Submission |
039827-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.892)
|
| Stock # |
R1797 (G1)
|
| Quality Score |
94 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
136276989-136596344 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 136304169 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 1253
(E1253K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000004097
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004097]
[ENSMUST00000175918]
[ENSMUST00000175975]
[ENSMUST00000175998]
[ENSMUST00000176172]
[ENSMUST00000176778]
[ENSMUST00000176216]
[ENSMUST00000176745]
[ENSMUST00000177297]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000004097
AA Change: E1253K
PolyPhen 2
Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000004097
Gene: ENSMUSG00000029705
AA Change: E1253K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
436 |
N/A |
INTRINSIC |
|
CUT
|
452 |
538 |
5.06e-39 |
SMART |
|
low complexity region
|
602 |
608 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
642 |
N/A |
INTRINSIC |
|
CUT
|
841 |
929 |
3.31e-43 |
SMART |
|
low complexity region
|
956 |
972 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1011 |
N/A |
INTRINSIC |
|
CUT
|
1024 |
1110 |
3.78e-38 |
SMART |
|
HOX
|
1150 |
1212 |
6.32e-15 |
SMART |
|
low complexity region
|
1224 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1317 |
1379 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148082
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000163906
|
| SMART Domains |
Protein: ENSMUSP00000131685
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
45 |
N/A |
INTRINSIC |
|
CUT
|
58 |
144 |
2.9e-42 |
SMART |
|
HOX
|
184 |
246 |
3.3e-17 |
SMART |
|
low complexity region
|
258 |
273 |
N/A |
INTRINSIC |
|
low complexity region
|
351 |
413 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175918
|
| SMART Domains |
Protein: ENSMUSP00000135606
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
73 |
328 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175975
AA Change: E1331K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000135223
Gene: ENSMUSG00000029705
AA Change: E1331K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
235 |
251 |
N/A |
INTRINSIC |
|
low complexity region
|
277 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
331 |
342 |
N/A |
INTRINSIC |
|
CUT
|
358 |
444 |
5.06e-39 |
SMART |
|
low complexity region
|
508 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
548 |
N/A |
INTRINSIC |
|
CUT
|
747 |
835 |
3.31e-43 |
SMART |
|
low complexity region
|
862 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
917 |
N/A |
INTRINSIC |
|
CUT
|
930 |
1016 |
3.78e-38 |
SMART |
|
HOX
|
1056 |
1118 |
6.32e-15 |
SMART |
|
low complexity region
|
1130 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1285 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175998
|
| SMART Domains |
Protein: ENSMUSP00000135816
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
coiled coil region
|
76 |
148 |
N/A |
INTRINSIC |
|
Pfam:CASP_C
|
204 |
430 |
8.6e-72 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176172
AA Change: E1344K
PolyPhen 2
Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000135086
Gene: ENSMUSG00000029705
AA Change: E1344K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
99 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
420 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
474 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
527 |
N/A |
INTRINSIC |
|
CUT
|
543 |
629 |
5.06e-39 |
SMART |
|
low complexity region
|
693 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
733 |
N/A |
INTRINSIC |
|
CUT
|
932 |
1020 |
3.31e-43 |
SMART |
|
low complexity region
|
1047 |
1063 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1102 |
N/A |
INTRINSIC |
|
CUT
|
1115 |
1201 |
3.78e-38 |
SMART |
|
HOX
|
1241 |
1303 |
6.32e-15 |
SMART |
|
low complexity region
|
1315 |
1330 |
N/A |
INTRINSIC |
|
low complexity region
|
1408 |
1470 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176778
AA Change: E1336K
PolyPhen 2
Score 0.185 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000135892
Gene: ENSMUSG00000029705
AA Change: E1336K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
86 |
N/A |
INTRINSIC |
|
coiled coil region
|
195 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
519 |
N/A |
INTRINSIC |
|
CUT
|
535 |
621 |
5.06e-39 |
SMART |
|
low complexity region
|
685 |
691 |
N/A |
INTRINSIC |
|
low complexity region
|
703 |
725 |
N/A |
INTRINSIC |
|
CUT
|
924 |
1012 |
3.31e-43 |
SMART |
|
low complexity region
|
1039 |
1055 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1094 |
N/A |
INTRINSIC |
|
CUT
|
1107 |
1193 |
3.78e-38 |
SMART |
|
HOX
|
1233 |
1295 |
6.32e-15 |
SMART |
|
low complexity region
|
1307 |
1322 |
N/A |
INTRINSIC |
|
low complexity region
|
1400 |
1462 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000176486
AA Change: E1215K
|
| SMART Domains |
Protein: ENSMUSP00000135370
Gene: ENSMUSG00000029705
AA Change: E1215K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
429 |
445 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
483 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
536 |
N/A |
INTRINSIC |
|
CUT
|
552 |
638 |
5.06e-39 |
SMART |
|
Blast:CUT
|
641 |
840 |
3e-50 |
BLAST |
|
CUT
|
919 |
1007 |
3.31e-43 |
SMART |
|
low complexity region
|
1034 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1068 |
1089 |
N/A |
INTRINSIC |
|
CUT
|
1102 |
1188 |
3.78e-38 |
SMART |
|
HOX
|
1228 |
1290 |
6.32e-15 |
SMART |
|
low complexity region
|
1302 |
1317 |
N/A |
INTRINSIC |
|
low complexity region
|
1395 |
1457 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176216
|
| SMART Domains |
Protein: ENSMUSP00000135054
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
9.35e-5 |
PROSPERO |
|
Pfam:CASP_C
|
421 |
647 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176745
|
| SMART Domains |
Protein: ENSMUSP00000135512
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
367 |
388 |
8.95e-5 |
PROSPERO |
|
Pfam:CASP_C
|
419 |
645 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177297
|
| SMART Domains |
Protein: ENSMUSP00000134819
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
8.99e-6 |
PROSPERO |
|
Pfam:CASP_C
|
422 |
527 |
1.8e-17 |
PFAM |
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933427D14Rik |
T |
C |
11: 72,089,285 (GRCm39) |
K200E |
possibly damaging |
Het |
| Abcc2 |
A |
G |
19: 43,803,225 (GRCm39) |
E687G |
possibly damaging |
Het |
| Abcc2 |
A |
T |
19: 43,822,426 (GRCm39) |
Q1421H |
probably damaging |
Het |
| Abcg3 |
C |
T |
5: 105,087,030 (GRCm39) |
S534N |
possibly damaging |
Het |
| Acp1 |
A |
G |
12: 30,946,113 (GRCm39) |
|
probably null |
Het |
| Adam12 |
C |
A |
7: 133,569,590 (GRCm39) |
R295L |
probably benign |
Het |
| Albfm1 |
A |
T |
5: 90,727,460 (GRCm39) |
E359D |
probably damaging |
Het |
| Alg1 |
C |
A |
16: 5,057,007 (GRCm39) |
H213Q |
probably benign |
Het |
| Ap4b1 |
T |
A |
3: 103,726,149 (GRCm39) |
W410R |
possibly damaging |
Het |
| As3mt |
A |
G |
19: 46,713,373 (GRCm39) |
T307A |
possibly damaging |
Het |
| Cdc14a |
T |
C |
3: 116,115,843 (GRCm39) |
I289V |
probably damaging |
Het |
| Cdk17 |
A |
G |
10: 93,044,114 (GRCm39) |
I18V |
possibly damaging |
Het |
| Cep131 |
C |
T |
11: 119,964,562 (GRCm39) |
|
probably null |
Het |
| Clca3a2 |
A |
G |
3: 144,503,398 (GRCm39) |
Y851H |
probably benign |
Het |
| Cnih2 |
T |
C |
19: 5,144,314 (GRCm39) |
K66E |
probably benign |
Het |
| Cpsf3 |
T |
A |
12: 21,356,851 (GRCm39) |
N491K |
probably benign |
Het |
| Dcc |
A |
C |
18: 71,500,232 (GRCm39) |
L1005R |
probably damaging |
Het |
| Ddx19b |
A |
T |
8: 111,739,439 (GRCm39) |
M200K |
probably damaging |
Het |
| Ech1 |
A |
G |
7: 28,531,288 (GRCm39) |
Y292C |
probably damaging |
Het |
| Edc4 |
G |
T |
8: 106,617,717 (GRCm39) |
A1121S |
probably benign |
Het |
| Eml6 |
T |
A |
11: 29,832,041 (GRCm39) |
I210F |
probably benign |
Het |
| Fam135b |
T |
C |
15: 71,324,290 (GRCm39) |
T1226A |
probably benign |
Het |
| Flg2 |
C |
T |
3: 93,108,283 (GRCm39) |
R104C |
probably damaging |
Het |
| Frzb |
T |
C |
2: 80,276,872 (GRCm39) |
I105V |
possibly damaging |
Het |
| Gli3 |
A |
G |
13: 15,888,097 (GRCm39) |
D504G |
probably damaging |
Het |
| Gm42669 |
A |
T |
5: 107,655,683 (GRCm39) |
K1161* |
probably null |
Het |
| Gm6665 |
T |
C |
18: 31,953,186 (GRCm39) |
E63G |
possibly damaging |
Het |
| Gm9923 |
T |
C |
10: 72,145,593 (GRCm39) |
V148A |
probably benign |
Het |
| Hoxc5 |
T |
C |
15: 102,922,866 (GRCm39) |
I118T |
probably benign |
Het |
| Hsp90b1 |
A |
G |
10: 86,537,609 (GRCm39) |
V232A |
possibly damaging |
Het |
| Impdh1 |
T |
A |
6: 29,207,168 (GRCm39) |
I59F |
probably damaging |
Het |
| Iqch |
G |
A |
9: 63,495,659 (GRCm39) |
P111S |
possibly damaging |
Het |
| Itih1 |
G |
T |
14: 30,651,856 (GRCm39) |
Q829K |
probably damaging |
Het |
| Kcnh2 |
C |
T |
5: 24,527,670 (GRCm39) |
R894H |
probably damaging |
Het |
| Kmt5b |
G |
T |
19: 3,864,833 (GRCm39) |
E632D |
probably benign |
Het |
| L2hgdh |
C |
T |
12: 69,746,340 (GRCm39) |
M373I |
probably benign |
Het |
| Map3k4 |
C |
T |
17: 12,482,906 (GRCm39) |
E604K |
probably benign |
Het |
| Mok |
T |
A |
12: 110,774,479 (GRCm39) |
Y420F |
probably benign |
Het |
| Nedd1 |
G |
A |
10: 92,534,601 (GRCm39) |
T303I |
possibly damaging |
Het |
| Nipal4 |
T |
A |
11: 46,042,160 (GRCm39) |
M174L |
probably benign |
Het |
| Or6c213 |
A |
C |
10: 129,574,578 (GRCm39) |
I69M |
probably benign |
Het |
| Pag1 |
T |
A |
3: 9,758,946 (GRCm39) |
T391S |
probably benign |
Het |
| Palm3 |
A |
G |
8: 84,755,432 (GRCm39) |
R315G |
probably benign |
Het |
| Patj |
C |
T |
4: 98,575,675 (GRCm39) |
R1177W |
probably damaging |
Het |
| Pbld2 |
G |
A |
10: 62,910,903 (GRCm39) |
|
probably null |
Het |
| Phldb1 |
A |
T |
9: 44,627,842 (GRCm39) |
M81K |
probably damaging |
Het |
| Pkn2 |
A |
G |
3: 142,515,289 (GRCm39) |
F682L |
probably damaging |
Het |
| Plce1 |
T |
C |
19: 38,747,392 (GRCm39) |
|
probably null |
Het |
| Plekha8 |
T |
A |
6: 54,617,959 (GRCm39) |
V518E |
probably damaging |
Het |
| Ppp1r3a |
T |
A |
6: 14,717,981 (GRCm39) |
M978L |
probably benign |
Het |
| Ppp4r4 |
T |
A |
12: 103,564,410 (GRCm39) |
C592S |
possibly damaging |
Het |
| Prdx6b |
T |
A |
2: 80,123,546 (GRCm39) |
D118E |
possibly damaging |
Het |
| Ptprg |
T |
C |
14: 12,199,743 (GRCm38) |
V52A |
probably damaging |
Het |
| Rab27b |
A |
G |
18: 70,122,617 (GRCm39) |
M114T |
probably damaging |
Het |
| Ralgps1 |
A |
G |
2: 33,230,723 (GRCm39) |
|
probably null |
Het |
| Rasa3 |
G |
A |
8: 13,632,372 (GRCm39) |
P506L |
probably benign |
Het |
| Rps6kb1 |
G |
A |
11: 86,393,634 (GRCm39) |
R499* |
probably null |
Het |
| S1pr4 |
A |
G |
10: 81,335,024 (GRCm39) |
M150T |
probably damaging |
Het |
| Scube2 |
T |
C |
7: 109,430,882 (GRCm39) |
D439G |
probably damaging |
Het |
| Serpina1e |
T |
C |
12: 103,917,150 (GRCm39) |
K173R |
probably benign |
Het |
| Serpina3m |
T |
A |
12: 104,355,774 (GRCm39) |
I147N |
probably damaging |
Het |
| Sh3rf3 |
G |
T |
10: 58,922,489 (GRCm39) |
G522* |
probably null |
Het |
| Smad1 |
A |
T |
8: 80,070,473 (GRCm39) |
V355E |
probably damaging |
Het |
| Srsf11 |
A |
G |
3: 157,725,065 (GRCm39) |
V211A |
possibly damaging |
Het |
| Stard9 |
C |
A |
2: 120,504,117 (GRCm39) |
S221R |
probably damaging |
Het |
| Stt3a |
C |
T |
9: 36,654,711 (GRCm39) |
|
probably null |
Het |
| Syne2 |
T |
C |
12: 76,010,557 (GRCm39) |
V2488A |
probably benign |
Het |
| Tbc1d23 |
T |
C |
16: 56,993,463 (GRCm39) |
T568A |
possibly damaging |
Het |
| Tnn |
A |
C |
1: 159,968,258 (GRCm39) |
V378G |
probably damaging |
Het |
| Trim50 |
T |
C |
5: 135,382,355 (GRCm39) |
V69A |
possibly damaging |
Het |
| Ttll10 |
A |
T |
4: 156,132,024 (GRCm39) |
D19E |
probably damaging |
Het |
| Ushbp1 |
G |
A |
8: 71,841,567 (GRCm39) |
R421C |
probably damaging |
Het |
| Vmn2r2 |
T |
C |
3: 64,042,128 (GRCm39) |
T196A |
probably benign |
Het |
| Wdr64 |
G |
A |
1: 175,639,585 (GRCm39) |
S1028N |
probably damaging |
Het |
| Wwtr1 |
T |
C |
3: 57,369,996 (GRCm39) |
Y373C |
probably damaging |
Het |
| Zeb1 |
A |
T |
18: 5,766,298 (GRCm39) |
K216* |
probably null |
Het |
| Zfp39 |
T |
C |
11: 58,791,486 (GRCm39) |
D67G |
probably damaging |
Het |
| Zfp40 |
A |
G |
17: 23,394,514 (GRCm39) |
I691T |
possibly damaging |
Het |
| Zfp532 |
T |
C |
18: 65,758,215 (GRCm39) |
V716A |
probably benign |
Het |
| Zfp616 |
T |
A |
11: 73,976,105 (GRCm39) |
C791* |
probably null |
Het |
| Zfp932 |
G |
A |
5: 110,144,489 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Cux1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00846:Cux1
|
APN |
5 |
136,355,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00966:Cux1
|
APN |
5 |
136,340,345 (GRCm39) |
intron |
probably benign |
|
|
IGL01129:Cux1
|
APN |
5 |
136,333,572 (GRCm39) |
intron |
probably benign |
|
|
IGL01885:Cux1
|
APN |
5 |
136,337,301 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01947:Cux1
|
APN |
5 |
136,303,979 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02259:Cux1
|
APN |
5 |
136,355,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Cux1
|
APN |
5 |
136,304,169 (GRCm39) |
nonsense |
probably null |
|
|
IGL02826:Cux1
|
APN |
5 |
136,336,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Cux1
|
UTSW |
5 |
136,594,379 (GRCm39) |
intron |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0057:Cux1
|
UTSW |
5 |
136,285,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0295:Cux1
|
UTSW |
5 |
136,342,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0361:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0533:Cux1
|
UTSW |
5 |
136,336,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Cux1
|
UTSW |
5 |
136,315,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0801:Cux1
|
UTSW |
5 |
136,355,783 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0884:Cux1
|
UTSW |
5 |
136,336,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0976:Cux1
|
UTSW |
5 |
136,342,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1073:Cux1
|
UTSW |
5 |
136,281,395 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1222:Cux1
|
UTSW |
5 |
136,304,003 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1518:Cux1
|
UTSW |
5 |
136,337,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1686:Cux1
|
UTSW |
5 |
136,304,235 (GRCm39) |
nonsense |
probably null |
|
|
R1687:Cux1
|
UTSW |
5 |
136,341,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Cux1
|
UTSW |
5 |
136,421,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1919:Cux1
|
UTSW |
5 |
136,392,173 (GRCm39) |
nonsense |
probably null |
|
|
R2051:Cux1
|
UTSW |
5 |
136,361,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2339:Cux1
|
UTSW |
5 |
136,315,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3438:Cux1
|
UTSW |
5 |
136,340,414 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3713:Cux1
|
UTSW |
5 |
136,594,397 (GRCm39) |
intron |
probably benign |
|
|
R3800:Cux1
|
UTSW |
5 |
136,344,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3964:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4135:Cux1
|
UTSW |
5 |
136,336,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4198:Cux1
|
UTSW |
5 |
136,315,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4467:Cux1
|
UTSW |
5 |
136,341,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4498:Cux1
|
UTSW |
5 |
136,341,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4623:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4652:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4658:Cux1
|
UTSW |
5 |
136,279,448 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4665:Cux1
|
UTSW |
5 |
136,315,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Cux1
|
UTSW |
5 |
136,278,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4867:Cux1
|
UTSW |
5 |
136,303,815 (GRCm39) |
intron |
probably benign |
|
|
R4965:Cux1
|
UTSW |
5 |
136,340,410 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5090:Cux1
|
UTSW |
5 |
136,342,054 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5155:Cux1
|
UTSW |
5 |
136,594,295 (GRCm39) |
intron |
probably benign |
|
|
R5226:Cux1
|
UTSW |
5 |
136,399,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5252:Cux1
|
UTSW |
5 |
136,337,151 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5266:Cux1
|
UTSW |
5 |
136,341,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5399:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5509:Cux1
|
UTSW |
5 |
136,304,171 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5609:Cux1
|
UTSW |
5 |
136,421,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5681:Cux1
|
UTSW |
5 |
136,337,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5993:Cux1
|
UTSW |
5 |
136,392,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6049:Cux1
|
UTSW |
5 |
136,361,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Cux1
|
UTSW |
5 |
136,340,412 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6310:Cux1
|
UTSW |
5 |
136,304,018 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6351:Cux1
|
UTSW |
5 |
136,338,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6531:Cux1
|
UTSW |
5 |
136,303,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6590:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6663:Cux1
|
UTSW |
5 |
136,514,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6690:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6777:Cux1
|
UTSW |
5 |
136,594,422 (GRCm39) |
intron |
probably benign |
|
|
R6786:Cux1
|
UTSW |
5 |
136,596,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6817:Cux1
|
UTSW |
5 |
136,402,027 (GRCm39) |
splice site |
probably null |
|
|
R6989:Cux1
|
UTSW |
5 |
136,308,502 (GRCm39) |
nonsense |
probably null |
|
|
R7011:Cux1
|
UTSW |
5 |
136,388,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Cux1
|
UTSW |
5 |
136,338,895 (GRCm39) |
splice site |
probably null |
|
|
R7699:Cux1
|
UTSW |
5 |
136,514,593 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7861:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7876:Cux1
|
UTSW |
5 |
136,392,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Cux1
|
UTSW |
5 |
136,311,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Cux1
|
UTSW |
5 |
136,402,251 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8154:Cux1
|
UTSW |
5 |
136,281,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Cux1
|
UTSW |
5 |
136,311,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8305:Cux1
|
UTSW |
5 |
136,388,863 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8319:Cux1
|
UTSW |
5 |
136,594,251 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8405:Cux1
|
UTSW |
5 |
136,304,241 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8483:Cux1
|
UTSW |
5 |
136,303,944 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8506:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8671:Cux1
|
UTSW |
5 |
136,279,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8680:Cux1
|
UTSW |
5 |
136,336,710 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8737:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8738:Cux1
|
UTSW |
5 |
136,402,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8793:Cux1
|
UTSW |
5 |
136,594,539 (GRCm39) |
missense |
unknown |
|
|
R8897:Cux1
|
UTSW |
5 |
136,315,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8926:Cux1
|
UTSW |
5 |
136,338,404 (GRCm39) |
intron |
probably benign |
|
|
R8954:Cux1
|
UTSW |
5 |
136,402,203 (GRCm39) |
nonsense |
probably null |
|
|
R9092:Cux1
|
UTSW |
5 |
136,514,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9205:Cux1
|
UTSW |
5 |
136,398,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Cux1
|
UTSW |
5 |
136,340,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9578:Cux1
|
UTSW |
5 |
136,282,919 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9682:Cux1
|
UTSW |
5 |
136,337,116 (GRCm39) |
missense |
probably benign |
|
|
R9701:Cux1
|
UTSW |
5 |
136,343,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9712:Cux1
|
UTSW |
5 |
136,338,673 (GRCm39) |
missense |
probably benign |
0.35 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTTGGCAACGCAGAACTC -3'
(R):5'- CTCCACTTGTGTCTCACAGG -3'
Sequencing Primer
(F):5'- ACGCAGAACTCCTCTCGG -3'
(R):5'- GTGTCTCACAGGTCTCGGATC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation