Mutagenetix > Incidental Mutation

Incidental Mutation 'R0091:Kmt2d'

20238

Institutional Source

Beutler Lab

Gene Symbol

Kmt2d

Ensembl Gene

ENSMUSG00000048154

Gene Name

lysine (K)-specific methyltransferase 2D

Synonyms

Mll4, Mll2, C430014K11Rik

MMRRC Submission

038378-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0091 (G1)

Quality Score

150

Status

Validated (trace)

Chromosome

Chromosomal Location

98729550-98769085 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to T at 98742360 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023741] [ENSMUST00000178486]

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000023741
AA Change: Q4267K

SMART Domains

Protein: ENSMUSP00000023741
Gene: ENSMUSG00000048154
AA Change: Q4267K

Domain	Start	End	E-Value	Type
low complexity region	135	145	N/A	INTRINSIC
PHD	171	218	1.65e-5	SMART
RING	172	217	2.01e0	SMART
PHD	228	274	2.13e-8	SMART
RING	229	273	2.11e-3	SMART
PHD	275	321	1.57e-11	SMART
RING	276	320	2.36e0	SMART
low complexity region	430	489	N/A	INTRINSIC
low complexity region	500	562	N/A	INTRINSIC
low complexity region	564	613	N/A	INTRINSIC
low complexity region	619	717	N/A	INTRINSIC
internal_repeat_3	719	768	2.82e-8	PROSPERO
internal_repeat_3	773	822	2.82e-8	PROSPERO
low complexity region	826	842	N/A	INTRINSIC
low complexity region	844	919	N/A	INTRINSIC
low complexity region	958	981	N/A	INTRINSIC
low complexity region	985	1023	N/A	INTRINSIC
low complexity region	1069	1076	N/A	INTRINSIC
low complexity region	1139	1153	N/A	INTRINSIC
low complexity region	1259	1285	N/A	INTRINSIC
low complexity region	1307	1314	N/A	INTRINSIC
PHD	1335	1384	7.01e-9	SMART
RING	1336	1383	1.46e1	SMART
PHD	1385	1431	8.56e-13	SMART
PHD	1462	1513	1.11e-6	SMART
RING	1463	1512	1.46e1	SMART
low complexity region	1514	1538	N/A	INTRINSIC
low complexity region	1567	1576	N/A	INTRINSIC
low complexity region	1589	1612	N/A	INTRINSIC
low complexity region	1634	1646	N/A	INTRINSIC
low complexity region	1707	1719	N/A	INTRINSIC
low complexity region	1883	1896	N/A	INTRINSIC
low complexity region	1931	1950	N/A	INTRINSIC
HMG	1969	2037	6.35e-6	SMART
low complexity region	2064	2079	N/A	INTRINSIC
low complexity region	2147	2167	N/A	INTRINSIC
low complexity region	2170	2181	N/A	INTRINSIC
low complexity region	2306	2323	N/A	INTRINSIC
low complexity region	2334	2359	N/A	INTRINSIC
low complexity region	2366	2388	N/A	INTRINSIC
low complexity region	2402	2419	N/A	INTRINSIC
low complexity region	2546	2559	N/A	INTRINSIC
low complexity region	2610	2622	N/A	INTRINSIC
coiled coil region	2632	2665	N/A	INTRINSIC
coiled coil region	2768	2813	N/A	INTRINSIC
low complexity region	2855	2868	N/A	INTRINSIC
low complexity region	2887	2899	N/A	INTRINSIC
low complexity region	3151	3165	N/A	INTRINSIC
low complexity region	3189	3204	N/A	INTRINSIC
low complexity region	3241	3263	N/A	INTRINSIC
low complexity region	3390	3400	N/A	INTRINSIC
low complexity region	3629	3659	N/A	INTRINSIC
coiled coil region	3712	3749	N/A	INTRINSIC
low complexity region	3781	3801	N/A	INTRINSIC
coiled coil region	3910	4003	N/A	INTRINSIC
low complexity region	4128	4159	N/A	INTRINSIC
low complexity region	4167	4183	N/A	INTRINSIC
low complexity region	4226	4246	N/A	INTRINSIC
low complexity region	4266	4293	N/A	INTRINSIC
low complexity region	4306	4322	N/A	INTRINSIC
low complexity region	4361	4378	N/A	INTRINSIC
coiled coil region	4591	4613	N/A	INTRINSIC
low complexity region	4661	4684	N/A	INTRINSIC
low complexity region	4745	4755	N/A	INTRINSIC
low complexity region	4877	4896	N/A	INTRINSIC
low complexity region	4957	4983	N/A	INTRINSIC
low complexity region	4989	5029	N/A	INTRINSIC
low complexity region	5100	5107	N/A	INTRINSIC
PHD	5142	5188	4.67e-5	SMART
RING	5143	5187	4.87e0	SMART
FYRN	5242	5285	5.07e-21	SMART
FYRC	5291	5378	2.51e-43	SMART
SET	5448	5570	5.69e-36	SMART
PostSET	5572	5588	3.58e-5	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000178486
AA Change: Q4267K

SMART Domains

Protein: ENSMUSP00000135941
Gene: ENSMUSG00000048154
AA Change: Q4267K

Domain	Start	End	E-Value	Type
low complexity region	135	145	N/A	INTRINSIC
PHD	171	218	1.65e-5	SMART
RING	172	217	2.01e0	SMART
PHD	228	274	2.13e-8	SMART
RING	229	273	2.11e-3	SMART
PHD	275	321	1.57e-11	SMART
RING	276	320	2.36e0	SMART
low complexity region	430	489	N/A	INTRINSIC
low complexity region	500	562	N/A	INTRINSIC
low complexity region	564	613	N/A	INTRINSIC
low complexity region	619	717	N/A	INTRINSIC
internal_repeat_3	719	768	2.82e-8	PROSPERO
internal_repeat_3	773	822	2.82e-8	PROSPERO
low complexity region	826	842	N/A	INTRINSIC
low complexity region	844	919	N/A	INTRINSIC
low complexity region	958	981	N/A	INTRINSIC
low complexity region	985	1023	N/A	INTRINSIC
low complexity region	1069	1076	N/A	INTRINSIC
low complexity region	1139	1153	N/A	INTRINSIC
low complexity region	1259	1285	N/A	INTRINSIC
low complexity region	1307	1314	N/A	INTRINSIC
PHD	1335	1384	7.01e-9	SMART
RING	1336	1383	1.46e1	SMART
PHD	1385	1431	8.56e-13	SMART
PHD	1462	1513	1.11e-6	SMART
RING	1463	1512	1.46e1	SMART
low complexity region	1514	1538	N/A	INTRINSIC
low complexity region	1567	1576	N/A	INTRINSIC
low complexity region	1589	1612	N/A	INTRINSIC
low complexity region	1634	1646	N/A	INTRINSIC
low complexity region	1707	1719	N/A	INTRINSIC
low complexity region	1883	1896	N/A	INTRINSIC
low complexity region	1931	1950	N/A	INTRINSIC
HMG	1969	2037	6.35e-6	SMART
low complexity region	2064	2079	N/A	INTRINSIC
low complexity region	2147	2167	N/A	INTRINSIC
low complexity region	2170	2181	N/A	INTRINSIC
low complexity region	2306	2323	N/A	INTRINSIC
low complexity region	2334	2359	N/A	INTRINSIC
low complexity region	2366	2388	N/A	INTRINSIC
low complexity region	2402	2419	N/A	INTRINSIC
low complexity region	2546	2559	N/A	INTRINSIC
low complexity region	2610	2622	N/A	INTRINSIC
coiled coil region	2632	2665	N/A	INTRINSIC
coiled coil region	2768	2813	N/A	INTRINSIC
low complexity region	2855	2868	N/A	INTRINSIC
low complexity region	2887	2899	N/A	INTRINSIC
low complexity region	3151	3165	N/A	INTRINSIC
low complexity region	3189	3204	N/A	INTRINSIC
low complexity region	3241	3263	N/A	INTRINSIC
low complexity region	3390	3400	N/A	INTRINSIC
low complexity region	3629	3659	N/A	INTRINSIC
coiled coil region	3712	3749	N/A	INTRINSIC
low complexity region	3781	3801	N/A	INTRINSIC
coiled coil region	3910	4003	N/A	INTRINSIC
low complexity region	4128	4159	N/A	INTRINSIC
low complexity region	4167	4183	N/A	INTRINSIC
low complexity region	4226	4246	N/A	INTRINSIC
low complexity region	4266	4293	N/A	INTRINSIC
low complexity region	4306	4322	N/A	INTRINSIC
low complexity region	4361	4378	N/A	INTRINSIC
coiled coil region	4591	4613	N/A	INTRINSIC
low complexity region	4661	4684	N/A	INTRINSIC
low complexity region	4745	4755	N/A	INTRINSIC
low complexity region	4877	4896	N/A	INTRINSIC
low complexity region	4957	4983	N/A	INTRINSIC
low complexity region	4989	5029	N/A	INTRINSIC
low complexity region	5100	5107	N/A	INTRINSIC
PHD	5142	5188	4.67e-5	SMART
RING	5143	5187	4.87e0	SMART
FYRN	5242	5285	5.07e-21	SMART
FYRC	5291	5378	2.51e-43	SMART
SET	5448	5570	5.69e-36	SMART
PostSET	5572	5588	3.58e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000229651

Meta Mutation Damage Score

0.0749

Coding Region Coverage

1x: 99.1%
3x: 97.9%
10x: 94.4%
20x: 84.5%

Validation Efficiency

98% (86/88)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit embryonic lethality around E9.5. Mice homozygous for a conditional allele activated in different cell-types exhibit impaired adipogenesis, impaired myogenesis, perturbed germinal B cell development and promoteion of lymphomagenesis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	T	C	3: 121,932,179 (GRCm39)	S278P	possibly damaging	Het
Adam11	A	G	11: 102,663,665 (GRCm39)	Y281C	probably damaging	Het
Adam6a	G	T	12: 113,507,849 (GRCm39)	R74L	possibly damaging	Het
Adcy5	T	C	16: 35,091,368 (GRCm39)		probably null	Het
Adrb2	A	G	18: 62,312,090 (GRCm39)	L245P	probably benign	Het
Aebp2	T	C	6: 140,589,800 (GRCm39)		probably null	Het
Arhgap23	A	G	11: 97,343,070 (GRCm39)	T240A	probably benign	Het
Atp10a	T	C	7: 58,423,794 (GRCm39)		probably benign	Het
Atp13a4	T	A	16: 29,274,213 (GRCm39)	Y416F	probably damaging	Het
Atp5mc2	A	C	15: 102,571,492 (GRCm39)	L133R	probably damaging	Het
Bicral	A	T	17: 47,136,233 (GRCm39)	Y326N	probably damaging	Het
Chst4	T	C	8: 110,757,297 (GRCm39)	S189G	probably damaging	Het
Cnot1	A	T	8: 96,489,772 (GRCm39)	I477N	probably damaging	Het
Col7a1	G	T	9: 108,796,574 (GRCm39)		probably benign	Het
Dchs1	A	G	7: 105,415,301 (GRCm39)		probably benign	Het
Dcn	A	G	10: 97,342,551 (GRCm39)	N169S	probably benign	Het
Dnajc6	T	C	4: 101,473,974 (GRCm39)		probably benign	Het
Egln3	A	G	12: 54,228,432 (GRCm39)	F225L	probably benign	Het
Erap1	G	A	13: 74,816,171 (GRCm39)	R100Q	possibly damaging	Het
Erc2	A	T	14: 27,498,781 (GRCm39)		probably null	Het
Fto	G	A	8: 92,168,435 (GRCm39)		probably null	Het
Gdap1l1	C	T	2: 163,288,011 (GRCm39)	P80S	probably damaging	Het
Gm1123	T	C	9: 98,905,405 (GRCm39)	E35G	possibly damaging	Het
Hhipl1	A	G	12: 108,288,156 (GRCm39)		probably benign	Het
Ift80	A	T	3: 68,822,008 (GRCm39)	L679Q	probably damaging	Het
Il18	A	G	9: 50,488,013 (GRCm39)		probably benign	Het
Inhbb	T	C	1: 119,345,125 (GRCm39)	Y388C	probably damaging	Het
Krt20	A	G	11: 99,328,640 (GRCm39)	V95A	probably damaging	Het
Lck	A	T	4: 129,449,474 (GRCm39)	S274R	possibly damaging	Het
Lrp1	T	A	10: 127,376,848 (GRCm39)	N4243I	probably damaging	Het
Lrrfip2	G	A	9: 111,043,311 (GRCm39)	V506I	probably damaging	Het
Ltbp2	A	G	12: 84,840,507 (GRCm39)	C1000R	probably damaging	Het
Matn3	G	A	12: 9,002,105 (GRCm39)	D106N	probably damaging	Het
Mical2	A	G	7: 111,980,503 (GRCm39)	E49G	probably benign	Het
Mmadhc	A	G	2: 50,182,869 (GRCm39)	S36P	probably damaging	Het
Morn1	T	C	4: 155,229,629 (GRCm39)	Y433H	probably damaging	Het
Mpo	A	G	11: 87,692,436 (GRCm39)	M525V	probably benign	Het
Myo5a	C	T	9: 75,068,774 (GRCm39)	R659C	probably damaging	Het
Obox6	T	C	7: 15,568,364 (GRCm39)	S171G	probably benign	Het
Or1j18	A	G	2: 36,624,917 (GRCm39)	N195D	probably damaging	Het
Or4k36	T	A	2: 111,146,518 (GRCm39)	D231E	probably benign	Het
Or5g29	A	T	2: 85,421,696 (GRCm39)	N271Y	probably benign	Het
P2ry14	A	G	3: 59,023,314 (GRCm39)	Y49H	probably benign	Het
Papss2	C	T	19: 32,611,302 (GRCm39)	T17I	possibly damaging	Het
Pcid2	T	C	8: 13,135,392 (GRCm39)	T206A	probably benign	Het
Pex6	A	G	17: 47,022,844 (GRCm39)	E140G	probably damaging	Het
Ppp1r3b	A	G	8: 35,851,821 (GRCm39)	Y220C	probably damaging	Het
Prdx2	T	G	8: 85,698,330 (GRCm39)		probably benign	Het
Ptbp2	A	T	3: 119,514,310 (GRCm39)	L471Q	probably damaging	Het
Rbm33	T	A	5: 28,557,604 (GRCm39)	D232E	possibly damaging	Het
Rnf214	T	A	9: 45,809,791 (GRCm39)		probably null	Het
Rora	G	A	9: 69,281,330 (GRCm39)	R314H	probably damaging	Het
Rufy4	T	C	1: 74,168,095 (GRCm39)		probably benign	Het
Sag	T	C	1: 87,742,402 (GRCm39)	V58A	probably damaging	Het
Serpina3i	C	T	12: 104,231,423 (GRCm39)	T20M	probably damaging	Het
Slc4a5	A	G	6: 83,254,537 (GRCm39)	N578S	probably benign	Het
Soat2	A	G	15: 102,066,574 (GRCm39)	Y285C	probably damaging	Het
Syk	A	G	13: 52,794,769 (GRCm39)	Y478C	probably damaging	Het
Syne4	G	A	7: 30,018,344 (GRCm39)	G362E	probably damaging	Het
Tas2r126	A	T	6: 42,412,036 (GRCm39)	M190L	probably benign	Het
Tnfrsf21	C	T	17: 43,349,104 (GRCm39)	H239Y	probably benign	Het
Ttc19	A	G	11: 62,199,910 (GRCm39)	D218G	probably damaging	Het
Tut1	T	C	19: 8,942,800 (GRCm39)	V629A	probably damaging	Het
Txndc11	T	C	16: 10,905,968 (GRCm39)	N521D	probably benign	Het
Ushbp1	T	C	8: 71,841,614 (GRCm39)	E405G	possibly damaging	Het
Usp46	C	T	5: 74,163,918 (GRCm39)	R246Q	probably benign	Het
Utrn	T	C	10: 12,610,948 (GRCm39)	D469G	probably damaging	Het
Vmn2r104	T	A	17: 20,262,075 (GRCm39)	I352F	possibly damaging	Het
Wdr4	G	A	17: 31,715,890 (GRCm39)	T398I	probably benign	Het
Ythdc1	T	A	5: 86,968,560 (GRCm39)		probably benign	Het

Other mutations in Kmt2d

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Kmt2d	APN	15	98,760,214 (GRCm39)	missense	unknown
IGL00927:Kmt2d	APN	15	98,742,890 (GRCm39)	unclassified	probably benign
IGL01123:Kmt2d	APN	15	98,735,029 (GRCm39)	missense	unknown
IGL01288:Kmt2d	APN	15	98,762,925 (GRCm39)	missense	probably damaging	1.00
IGL01538:Kmt2d	APN	15	98,758,538 (GRCm39)	unclassified	probably benign
IGL01575:Kmt2d	APN	15	98,744,736 (GRCm39)	utr 3 prime	probably benign
IGL01584:Kmt2d	APN	15	98,754,250 (GRCm39)	unclassified	probably benign
IGL01750:Kmt2d	APN	15	98,751,049 (GRCm39)	unclassified	probably benign
IGL02163:Kmt2d	APN	15	98,733,109 (GRCm39)	unclassified	probably benign
IGL02209:Kmt2d	APN	15	98,752,448 (GRCm39)	unclassified	probably benign
IGL02253:Kmt2d	APN	15	98,756,056 (GRCm39)	unclassified	probably benign
IGL02271:Kmt2d	APN	15	98,764,309 (GRCm39)	missense	possibly damaging	0.89
IGL02291:Kmt2d	APN	15	98,763,373 (GRCm39)	splice site	probably benign
IGL02448:Kmt2d	APN	15	98,741,991 (GRCm39)	unclassified	probably benign
IGL02472:Kmt2d	APN	15	98,747,958 (GRCm39)	missense	probably benign	0.23
IGL02496:Kmt2d	APN	15	98,755,439 (GRCm39)	unclassified	probably benign
IGL02527:Kmt2d	APN	15	98,739,628 (GRCm39)	unclassified	probably benign
IGL02576:Kmt2d	APN	15	98,762,001 (GRCm39)	missense	unknown
IGL02597:Kmt2d	APN	15	98,761,712 (GRCm39)	missense	unknown
IGL02609:Kmt2d	APN	15	98,749,674 (GRCm39)	unclassified	probably benign
IGL03085:Kmt2d	APN	15	98,737,821 (GRCm39)	unclassified	probably benign
IGL03102:Kmt2d	APN	15	98,753,424 (GRCm39)	missense	probably benign
IGL03123:Kmt2d	APN	15	98,759,652 (GRCm39)	missense	unknown
G1citation:Kmt2d	UTSW	15	98,747,340 (GRCm39)	unclassified	probably benign
R0136:Kmt2d	UTSW	15	98,752,159 (GRCm39)	unclassified	probably benign
R0243:Kmt2d	UTSW	15	98,748,018 (GRCm39)	unclassified	probably benign
R0276:Kmt2d	UTSW	15	98,748,192 (GRCm39)	unclassified	probably benign
R0477:Kmt2d	UTSW	15	98,751,462 (GRCm39)	unclassified	probably benign
R0478:Kmt2d	UTSW	15	98,751,462 (GRCm39)	unclassified	probably benign
R0586:Kmt2d	UTSW	15	98,733,088 (GRCm39)	unclassified	probably benign
R0632:Kmt2d	UTSW	15	98,751,462 (GRCm39)	unclassified	probably benign
R0678:Kmt2d	UTSW	15	98,748,294 (GRCm39)	unclassified	probably benign
R0780:Kmt2d	UTSW	15	98,760,738 (GRCm39)	missense	unknown
R0891:Kmt2d	UTSW	15	98,750,572 (GRCm39)	unclassified	probably benign
R1136:Kmt2d	UTSW	15	98,755,646 (GRCm39)	unclassified	probably benign
R1417:Kmt2d	UTSW	15	98,764,311 (GRCm39)	missense	probably damaging	0.99
R1499:Kmt2d	UTSW	15	98,742,819 (GRCm39)	unclassified	probably benign
R1510:Kmt2d	UTSW	15	98,754,258 (GRCm39)	unclassified	probably benign
R1586:Kmt2d	UTSW	15	98,762,934 (GRCm39)	splice site	probably benign
R1640:Kmt2d	UTSW	15	98,742,938 (GRCm39)	unclassified	probably benign
R1714:Kmt2d	UTSW	15	98,760,831 (GRCm39)	missense	unknown
R1725:Kmt2d	UTSW	15	98,743,115 (GRCm39)	unclassified	probably benign
R1728:Kmt2d	UTSW	15	98,763,013 (GRCm39)	missense	probably damaging	1.00
R1729:Kmt2d	UTSW	15	98,763,013 (GRCm39)	missense	probably damaging	1.00
R1741:Kmt2d	UTSW	15	98,743,115 (GRCm39)	unclassified	probably benign
R1744:Kmt2d	UTSW	15	98,762,928 (GRCm39)	missense	probably damaging	0.99
R1746:Kmt2d	UTSW	15	98,762,259 (GRCm39)	missense	probably damaging	0.97
R1753:Kmt2d	UTSW	15	98,741,363 (GRCm39)	unclassified	probably benign
R1782:Kmt2d	UTSW	15	98,755,429 (GRCm39)	unclassified	probably benign
R1789:Kmt2d	UTSW	15	98,749,955 (GRCm39)	unclassified	probably benign
R1802:Kmt2d	UTSW	15	98,760,866 (GRCm39)	missense	unknown
R1808:Kmt2d	UTSW	15	98,764,567 (GRCm39)	missense	probably damaging	1.00
R1822:Kmt2d	UTSW	15	98,759,661 (GRCm39)	missense	unknown
R1831:Kmt2d	UTSW	15	98,753,224 (GRCm39)	missense	probably damaging	0.97
R1920:Kmt2d	UTSW	15	98,753,472 (GRCm39)	missense	probably damaging	1.00
R1920:Kmt2d	UTSW	15	98,753,471 (GRCm39)	missense	probably damaging	0.96
R1956:Kmt2d	UTSW	15	98,757,471 (GRCm39)	unclassified	probably benign
R2100:Kmt2d	UTSW	15	98,744,361 (GRCm39)	unclassified	probably benign
R2120:Kmt2d	UTSW	15	98,737,410 (GRCm39)	unclassified	probably benign
R2188:Kmt2d	UTSW	15	98,737,181 (GRCm39)	unclassified	probably benign
R2191:Kmt2d	UTSW	15	98,758,930 (GRCm39)	critical splice donor site	probably null
R2234:Kmt2d	UTSW	15	98,763,129 (GRCm39)	missense	probably damaging	0.98
R2422:Kmt2d	UTSW	15	98,760,147 (GRCm39)	missense	unknown
R2762:Kmt2d	UTSW	15	98,749,936 (GRCm39)	unclassified	probably benign
R2895:Kmt2d	UTSW	15	98,741,820 (GRCm39)	unclassified	probably benign
R3624:Kmt2d	UTSW	15	98,740,783 (GRCm39)	unclassified	probably benign
R3791:Kmt2d	UTSW	15	98,742,030 (GRCm39)	unclassified	probably benign
R3794:Kmt2d	UTSW	15	98,735,240 (GRCm39)	unclassified	probably benign
R3871:Kmt2d	UTSW	15	98,748,902 (GRCm39)	unclassified	probably benign
R3958:Kmt2d	UTSW	15	98,753,430 (GRCm39)	missense	possibly damaging	0.69
R3983:Kmt2d	UTSW	15	98,743,927 (GRCm39)	unclassified	probably benign
R4211:Kmt2d	UTSW	15	98,738,070 (GRCm39)	unclassified	probably benign
R4212:Kmt2d	UTSW	15	98,742,884 (GRCm39)	unclassified	probably benign
R4240:Kmt2d	UTSW	15	98,742,452 (GRCm39)	unclassified	probably benign
R4246:Kmt2d	UTSW	15	98,737,970 (GRCm39)	unclassified	probably benign
R4361:Kmt2d	UTSW	15	98,761,551 (GRCm39)	missense	unknown
R4388:Kmt2d	UTSW	15	98,751,507 (GRCm39)	unclassified	probably benign
R4602:Kmt2d	UTSW	15	98,748,140 (GRCm39)	unclassified	probably benign
R4606:Kmt2d	UTSW	15	98,737,597 (GRCm39)	unclassified	probably benign
R4658:Kmt2d	UTSW	15	98,750,410 (GRCm39)	unclassified	probably benign
R4840:Kmt2d	UTSW	15	98,759,775 (GRCm39)	missense	unknown
R4895:Kmt2d	UTSW	15	98,742,368 (GRCm39)	unclassified	probably benign
R4906:Kmt2d	UTSW	15	98,747,420 (GRCm39)	unclassified	probably benign
R4976:Kmt2d	UTSW	15	98,745,075 (GRCm39)	utr 3 prime	probably benign
R5093:Kmt2d	UTSW	15	98,754,043 (GRCm39)	missense	probably damaging	1.00
R5119:Kmt2d	UTSW	15	98,745,075 (GRCm39)	utr 3 prime	probably benign
R5160:Kmt2d	UTSW	15	98,738,105 (GRCm39)	unclassified	probably benign
R5260:Kmt2d	UTSW	15	98,740,741 (GRCm39)	unclassified	probably benign
R5274:Kmt2d	UTSW	15	98,752,111 (GRCm39)	unclassified	probably benign
R5450:Kmt2d	UTSW	15	98,752,967 (GRCm39)	missense	probably damaging	1.00
R5461:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5462:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5463:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5465:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5467:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5481:Kmt2d	UTSW	15	98,759,886 (GRCm39)	missense	unknown
R5509:Kmt2d	UTSW	15	98,737,557 (GRCm39)	unclassified	probably benign
R5534:Kmt2d	UTSW	15	98,735,238 (GRCm39)	unclassified	probably benign
R5536:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5537:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5538:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5546:Kmt2d	UTSW	15	98,750,949 (GRCm39)	unclassified	probably benign
R5595:Kmt2d	UTSW	15	98,747,905 (GRCm39)	unclassified	probably benign
R5645:Kmt2d	UTSW	15	98,742,278 (GRCm39)	unclassified	probably benign
R5679:Kmt2d	UTSW	15	98,752,153 (GRCm39)	unclassified	probably benign
R5710:Kmt2d	UTSW	15	98,751,987 (GRCm39)	unclassified	probably benign
R5755:Kmt2d	UTSW	15	98,761,527 (GRCm39)	missense	unknown
R5817:Kmt2d	UTSW	15	98,760,244 (GRCm39)	missense	unknown
R5841:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5842:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5843:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5844:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R5845:Kmt2d	UTSW	15	98,749,990 (GRCm39)	unclassified	probably benign
R6122:Kmt2d	UTSW	15	98,758,573 (GRCm39)	unclassified	probably benign
R6612:Kmt2d	UTSW	15	98,743,739 (GRCm39)	unclassified	probably benign
R6718:Kmt2d	UTSW	15	98,747,467 (GRCm39)	unclassified	probably benign
R6718:Kmt2d	UTSW	15	98,748,420 (GRCm39)	unclassified	probably benign
R6822:Kmt2d	UTSW	15	98,747,340 (GRCm39)	unclassified	probably benign
R6866:Kmt2d	UTSW	15	98,755,274 (GRCm39)	unclassified	probably benign
R6950:Kmt2d	UTSW	15	98,737,901 (GRCm39)	unclassified	probably benign
R7089:Kmt2d	UTSW	15	98,748,153 (GRCm39)	missense	unknown
R7120:Kmt2d	UTSW	15	98,758,946 (GRCm39)	missense	unknown
R7131:Kmt2d	UTSW	15	98,747,497 (GRCm39)	unclassified	probably benign
R7177:Kmt2d	UTSW	15	98,748,267 (GRCm39)	missense	unknown
R7194:Kmt2d	UTSW	15	98,741,714 (GRCm39)	missense	unknown
R7252:Kmt2d	UTSW	15	98,742,147 (GRCm39)	missense	unknown
R7282:Kmt2d	UTSW	15	98,751,985 (GRCm39)	missense	unknown
R7307:Kmt2d	UTSW	15	98,747,299 (GRCm39)	missense	unknown
R7313:Kmt2d	UTSW	15	98,754,504 (GRCm39)	missense	unknown
R7394:Kmt2d	UTSW	15	98,754,265 (GRCm39)	missense	unknown
R7404:Kmt2d	UTSW	15	98,743,376 (GRCm39)	missense	unknown
R7409:Kmt2d	UTSW	15	98,753,235 (GRCm39)	missense	probably damaging	1.00
R7414:Kmt2d	UTSW	15	98,737,737 (GRCm39)	missense	unknown
R7534:Kmt2d	UTSW	15	98,749,899 (GRCm39)	missense	unknown
R7575:Kmt2d	UTSW	15	98,747,492 (GRCm39)	unclassified	probably benign
R7650:Kmt2d	UTSW	15	98,748,751 (GRCm39)	missense	unknown
R7687:Kmt2d	UTSW	15	98,760,001 (GRCm39)	missense	unknown
R7699:Kmt2d	UTSW	15	98,741,600 (GRCm39)	missense	unknown
R7700:Kmt2d	UTSW	15	98,741,600 (GRCm39)	missense	unknown
R7765:Kmt2d	UTSW	15	98,750,215 (GRCm39)	missense	unknown
R7797:Kmt2d	UTSW	15	98,762,287 (GRCm39)	missense	probably benign	0.24
R7803:Kmt2d	UTSW	15	98,760,804 (GRCm39)	missense	unknown
R7952:Kmt2d	UTSW	15	98,748,649 (GRCm39)	missense	unknown
R8054:Kmt2d	UTSW	15	98,741,806 (GRCm39)	missense	unknown
R8084:Kmt2d	UTSW	15	98,739,945 (GRCm39)	missense	unknown
R8089:Kmt2d	UTSW	15	98,740,750 (GRCm39)	missense	unknown
R8133:Kmt2d	UTSW	15	98,762,823 (GRCm39)	missense	probably damaging	1.00
R8138:Kmt2d	UTSW	15	98,741,534 (GRCm39)	missense	unknown
R8343:Kmt2d	UTSW	15	98,750,478 (GRCm39)	missense	unknown
R8681:Kmt2d	UTSW	15	98,743,948 (GRCm39)	missense	unknown
R8694:Kmt2d	UTSW	15	98,742,615 (GRCm39)	missense	unknown
R8837:Kmt2d	UTSW	15	98,762,048 (GRCm39)	missense	unknown
R8855:Kmt2d	UTSW	15	98,754,237 (GRCm39)	missense	unknown
R8934:Kmt2d	UTSW	15	98,759,767 (GRCm39)	missense	unknown
R9100:Kmt2d	UTSW	15	98,747,832 (GRCm39)	missense	unknown
R9158:Kmt2d	UTSW	15	98,741,020 (GRCm39)	missense	unknown
R9190:Kmt2d	UTSW	15	98,749,896 (GRCm39)	missense	unknown
R9222:Kmt2d	UTSW	15	98,747,324 (GRCm39)	missense	unknown
R9263:Kmt2d	UTSW	15	98,747,499 (GRCm39)	frame shift	probably null
R9336:Kmt2d	UTSW	15	98,743,697 (GRCm39)	missense	unknown
R9397:Kmt2d	UTSW	15	98,747,994 (GRCm39)	missense	unknown
R9415:Kmt2d	UTSW	15	98,737,586 (GRCm39)	missense	unknown
R9482:Kmt2d	UTSW	15	98,763,046 (GRCm39)	missense	probably damaging	1.00
R9529:Kmt2d	UTSW	15	98,737,649 (GRCm39)	missense	unknown
R9610:Kmt2d	UTSW	15	98,743,057 (GRCm39)	unclassified	probably benign
R9611:Kmt2d	UTSW	15	98,743,057 (GRCm39)	unclassified	probably benign
R9611:Kmt2d	UTSW	15	98,743,054 (GRCm39)	unclassified	probably benign
R9612:Kmt2d	UTSW	15	98,743,057 (GRCm39)	unclassified	probably benign
R9613:Kmt2d	UTSW	15	98,743,057 (GRCm39)	unclassified	probably benign
R9644:Kmt2d	UTSW	15	98,743,385 (GRCm39)	missense	unknown
R9716:Kmt2d	UTSW	15	98,741,283 (GRCm39)	missense	unknown
R9763:Kmt2d	UTSW	15	98,743,057 (GRCm39)	unclassified	probably benign
R9782:Kmt2d	UTSW	15	98,764,597 (GRCm39)	missense	probably damaging	1.00
X0018:Kmt2d	UTSW	15	98,750,803 (GRCm39)	unclassified	probably benign
X0024:Kmt2d	UTSW	15	98,750,934 (GRCm39)	unclassified	probably benign
X0062:Kmt2d	UTSW	15	98,747,700 (GRCm39)	unclassified	probably benign
Z1187:Kmt2d	UTSW	15	98,749,625 (GRCm39)	missense	unknown
Z1188:Kmt2d	UTSW	15	98,749,625 (GRCm39)	missense	unknown
Z1189:Kmt2d	UTSW	15	98,749,625 (GRCm39)	missense	unknown
Z1190:Kmt2d	UTSW	15	98,749,625 (GRCm39)	missense	unknown
Z1192:Kmt2d	UTSW	15	98,749,625 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- GCCAAGCACTGGTCCTGTAGATAAG -3'
(R):5'- ACCTGAGCCAATGTCTGTTGAGCC -3'

Sequencing Primer
(F):5'- ACTGGTCCTGTAGATAAGGCTCC -3'
(R):5'- GGTGAACTTGCTTCACACAG -3'

Posted On

2013-04-11