Incidental Mutation 'R1812:Tas2r120'
ID 202465
Institutional Source Beutler Lab
Gene Symbol Tas2r120
Ensembl Gene ENSMUSG00000059382
Gene Name taste receptor, type 2, member 120
Synonyms Tas2r20, mGR20, mt2r47, T2R20
MMRRC Submission 039840-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R1812 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 132633920-132634807 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 132634564 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tryptophan at position 215 (C215W)
Ref Sequence ENSEMBL: ENSMUSP00000071626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071707]
AlphaFold Q7M721
Predicted Effect probably benign
Transcript: ENSMUST00000071707
AA Change: C215W

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000071626
Gene: ENSMUSG00000059382
AA Change: C215W

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 2.4e-77 PFAM
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.3%
  • 10x: 93.2%
  • 20x: 85.7%
Validation Efficiency 100% (1/1)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik G A 9: 57,164,740 (GRCm39) Q545* probably null Het
Aadacl2 T C 3: 59,932,498 (GRCm39) C338R probably damaging Het
Abcb4 G A 5: 8,978,578 (GRCm39) probably null Het
Adam17 T C 12: 21,411,768 (GRCm39) D41G probably damaging Het
Angptl7 T A 4: 148,582,540 (GRCm39) I119F probably damaging Het
Arid1b T A 17: 5,387,304 (GRCm39) S1586T probably benign Het
Arid4b C T 13: 14,370,014 (GRCm39) A1170V probably damaging Het
Atad5 A G 11: 80,023,873 (GRCm39) T1659A probably damaging Het
Bub1b T G 2: 118,462,902 (GRCm39) D754E probably benign Het
Cdkn1a T C 17: 29,317,539 (GRCm39) V53A probably benign Het
Chsy1 T G 7: 65,821,565 (GRCm39) V600G probably benign Het
Cntrl G A 2: 35,039,481 (GRCm39) V561M probably damaging Het
Col6a5 A G 9: 105,805,253 (GRCm39) C1218R unknown Het
Crhr1 T C 11: 104,059,973 (GRCm39) L140P probably damaging Het
Cyb5b CAGAG CAG 8: 107,897,020 (GRCm39) probably null Het
Cyp3a59 A T 5: 146,039,621 (GRCm39) Q298L probably damaging Het
Dctn1 A G 6: 83,169,500 (GRCm39) E638G possibly damaging Het
Ddx41 A G 13: 55,683,767 (GRCm39) I88T probably benign Het
Dennd11 A G 6: 40,386,365 (GRCm39) I288T probably benign Het
Diaph1 G T 18: 38,024,071 (GRCm39) P589Q unknown Het
Dip2b C A 15: 100,096,819 (GRCm39) probably null Het
Dscaml1 G A 9: 45,662,584 (GRCm39) probably null Het
Dync1h1 C T 12: 110,629,334 (GRCm39) A4246V possibly damaging Het
Epb41l1 T C 2: 156,338,431 (GRCm39) I158T probably damaging Het
Fat1 A G 8: 45,489,840 (GRCm39) Y3584C probably damaging Het
Fxyd5 T A 7: 30,737,355 (GRCm39) probably null Het
Gapvd1 T A 2: 34,615,076 (GRCm39) K336* probably null Het
Gm9637 G A 14: 19,402,395 (GRCm38) noncoding transcript Het
Gpr65 C T 12: 98,242,001 (GRCm39) T218M probably damaging Het
Gsdma3 T C 11: 98,523,219 (GRCm39) V203A probably damaging Het
Helb T A 10: 119,925,471 (GRCm39) K969* probably null Het
Hipk2 G A 6: 38,675,098 (GRCm39) A1188V probably benign Het
Itpk1 T A 12: 102,540,317 (GRCm39) E255D probably benign Het
Kif21a T C 15: 90,855,969 (GRCm39) D596G possibly damaging Het
Kif5a A T 10: 127,077,879 (GRCm39) I405N probably benign Het
Klk1b11 T A 7: 43,427,179 (GRCm39) probably null Het
Luzp1 T A 4: 136,269,642 (GRCm39) L622M probably benign Het
Macf1 T A 4: 123,325,817 (GRCm39) I5227F probably damaging Het
Mapk10 A C 5: 103,061,128 (GRCm39) S470A probably damaging Het
Morc2a C T 11: 3,635,831 (GRCm39) T897I probably damaging Het
Nmbr A G 10: 14,636,283 (GRCm39) probably null Het
Nosip T A 7: 44,725,998 (GRCm39) M214K probably damaging Het
Or13c7d G T 4: 43,770,230 (GRCm39) Y260* probably null Het
Or52m2 A T 7: 102,263,577 (GRCm39) N206K possibly damaging Het
Or52r1 T C 7: 102,537,285 (GRCm39) Y25C probably benign Het
Or5w13 A G 2: 87,523,447 (GRCm39) F260L probably benign Het
Pik3c2a A T 7: 116,016,899 (GRCm39) V286E probably damaging Het
Ppfia4 T A 1: 134,252,311 (GRCm39) I388F probably benign Het
Ppm1f A G 16: 16,735,651 (GRCm39) H289R probably damaging Het
Ptprz1 T A 6: 22,959,711 (GRCm39) D69E probably benign Het
Rad54b A T 4: 11,612,770 (GRCm39) T801S probably damaging Het
Ramp1 A T 1: 91,124,579 (GRCm39) N47Y probably damaging Het
Rnf32 T A 5: 29,411,258 (GRCm39) H181Q possibly damaging Het
Rpa2 T C 4: 132,495,996 (GRCm39) F6L probably benign Het
Ryr2 C A 13: 11,575,472 (GRCm39) R4842L probably damaging Het
Scn11a G T 9: 119,609,931 (GRCm39) C972* probably null Het
Setd2 C T 9: 110,379,170 (GRCm39) T995I probably damaging Het
Slc39a7 A G 17: 34,247,789 (GRCm39) L471P probably damaging Het
Slc6a21 C G 7: 44,932,371 (GRCm39) S350R probably damaging Het
Slx4ip A G 2: 136,910,115 (GRCm39) N300S probably benign Het
Spef2 G A 15: 9,679,435 (GRCm39) P634L probably damaging Het
Stk32b G A 5: 37,624,102 (GRCm39) A215V probably damaging Het
Svil A T 18: 5,097,545 (GRCm39) Y1676F probably damaging Het
Tanc1 G A 2: 59,622,023 (GRCm39) V381M probably damaging Het
Tanc2 T C 11: 105,777,212 (GRCm39) F797L probably benign Het
Tenm4 G A 7: 96,545,147 (GRCm39) D2388N probably damaging Het
Thsd4 C T 9: 59,964,220 (GRCm39) S64N probably damaging Het
Thsd7b C T 1: 129,686,347 (GRCm39) R630C probably damaging Het
Top3a A G 11: 60,650,188 (GRCm39) I145T probably damaging Het
Vmn2r78 A G 7: 86,569,995 (GRCm39) D171G probably benign Het
Vmn2r82 A G 10: 79,215,046 (GRCm39) E343G probably benign Het
Wdr70 T C 15: 8,108,663 (GRCm39) D161G probably benign Het
Other mutations in Tas2r120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00694:Tas2r120 APN 6 132,634,238 (GRCm39) missense probably benign 0.01
IGL01725:Tas2r120 APN 6 132,634,052 (GRCm39) nonsense probably null
IGL01860:Tas2r120 APN 6 132,634,227 (GRCm39) missense probably damaging 0.99
IGL01891:Tas2r120 APN 6 132,634,807 (GRCm39) makesense probably null
PIT4519001:Tas2r120 UTSW 6 132,634,297 (GRCm39) missense probably benign
R0104:Tas2r120 UTSW 6 132,634,809 (GRCm39) splice site probably null
R0108:Tas2r120 UTSW 6 132,634,809 (GRCm39) splice site probably null
R0123:Tas2r120 UTSW 6 132,634,552 (GRCm39) nonsense probably null
R0225:Tas2r120 UTSW 6 132,634,552 (GRCm39) nonsense probably null
R2254:Tas2r120 UTSW 6 132,634,572 (GRCm39) missense probably benign
R3110:Tas2r120 UTSW 6 132,634,731 (GRCm39) missense probably damaging 1.00
R3112:Tas2r120 UTSW 6 132,634,731 (GRCm39) missense probably damaging 1.00
R4829:Tas2r120 UTSW 6 132,634,331 (GRCm39) missense probably benign 0.03
R5248:Tas2r120 UTSW 6 132,634,110 (GRCm39) missense probably damaging 0.97
R5372:Tas2r120 UTSW 6 132,634,446 (GRCm39) missense possibly damaging 0.54
R6379:Tas2r120 UTSW 6 132,634,773 (GRCm39) missense probably benign 0.00
R7015:Tas2r120 UTSW 6 132,634,128 (GRCm39) missense possibly damaging 0.48
R7615:Tas2r120 UTSW 6 132,634,773 (GRCm39) missense probably benign 0.00
R8004:Tas2r120 UTSW 6 132,634,390 (GRCm39) missense possibly damaging 0.82
R8796:Tas2r120 UTSW 6 132,634,081 (GRCm39) missense probably damaging 1.00
R9207:Tas2r120 UTSW 6 132,634,626 (GRCm39) nonsense probably null
R9250:Tas2r120 UTSW 6 132,633,954 (GRCm39) missense probably benign 0.02
R9792:Tas2r120 UTSW 6 132,634,528 (GRCm39) missense possibly damaging 0.93
Z1176:Tas2r120 UTSW 6 132,634,148 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGCATATCTTGGGATGGTGAAC -3'
(R):5'- GATACAAGAATGACCTGCTGGG -3'

Sequencing Primer
(F):5'- GTATTCATGAAGGAAATGTGACCAC -3'
(R):5'- CTGGGTAGAAGGATCCAATTGTCAC -3'
Posted On 2014-06-23