|Institutional Source||Beutler Lab|
|Gene Name||sphingosine-1-phosphate receptor 2|
|Synonyms||LPb2, 1100001A16Rik, H218, Edg5, Gpcr13, S1P2|
|Is this an essential gene?||Probably non essential (E-score: 0.173)|
|Stock #||R1815 (G1)|
|Chromosomal Location||20962361-20976781 bp(-) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||G to A at 20968092 bp|
|Amino Acid Change||Arginine to Stop codon at position 147 (R147*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000053394 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000054197] [ENSMUST00000214218]|
|Predicted Effect||probably null
AA Change: R147*
AA Change: R147*
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
PHENOTYPE: Homozygous null mutations in this gene may lead to impaired auditory and vestibular function, multiple inner ear pathologies, deafness, altered neuronal excitability, lethal seizures, altered physiology of germinal center B cells, small litter size, and enhanced tumor angiogenesis and tumor growth. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in S1pr2||
(F):5'- CCACGATAGCCAGTAAGATGAC -3'
(R):5'- ACCTGTTCCTTGGCAACCTG -3'
(F):5'- TGACGGAGAAGATGGTGACCAC -3'
(R):5'- AACCTGGCAGCCTCTGAC -3'