Incidental Mutation 'R1786:Or1j13'
ID 202782
Institutional Source Beutler Lab
Gene Symbol Or1j13
Ensembl Gene ENSMUSG00000075387
Gene Name olfactory receptor family 1 subfamily J member 13
Synonyms MOR136-2, GA_x6K02T2NLDC-33174915-33173974, Olfr341
MMRRC Submission 039817-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R1786 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 36369199-36370140 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36370059 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 28 (S28P)
Ref Sequence ENSEMBL: ENSMUSP00000150801 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100154] [ENSMUST00000213300]
AlphaFold Q8VGK9
Predicted Effect possibly damaging
Transcript: ENSMUST00000100154
AA Change: S28P

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000097731
Gene: ENSMUSG00000075387
AA Change: S28P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 35 305 4e-6 PFAM
Pfam:7tm_1 41 290 9.1e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213300
AA Change: S28P

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.3%
  • 20x: 92.4%
Validation Efficiency 97% (98/101)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T A 6: 128,553,223 (GRCm39) N178I probably damaging Het
Abcc4 G A 14: 118,790,761 (GRCm39) R749C probably damaging Het
Acot11 T C 4: 106,619,232 (GRCm39) E201G probably damaging Het
Akap13 G T 7: 75,261,182 (GRCm39) A1269S probably benign Het
Aldh4a1 T C 4: 139,371,439 (GRCm39) V451A probably benign Het
Aopep T A 13: 63,357,963 (GRCm39) C656S probably benign Het
Aox3 A G 1: 58,209,002 (GRCm39) H845R probably damaging Het
Asb6 G A 2: 30,717,088 (GRCm39) R46W probably damaging Het
Bpifb6 T C 2: 153,748,781 (GRCm39) F259S probably damaging Het
Cad T A 5: 31,215,416 (GRCm39) F76I probably damaging Het
Camk2b T C 11: 5,927,880 (GRCm39) E390G probably benign Het
Cars1 C A 7: 143,146,211 (GRCm39) R71M probably damaging Het
Ccdc170 T G 10: 4,469,043 (GRCm39) I197S probably benign Het
Ccn4 G A 15: 66,778,338 (GRCm39) C53Y probably damaging Het
Cdc20b A T 13: 113,217,668 (GRCm39) K362N probably damaging Het
Cntrl CAGAG CAG 2: 35,012,818 (GRCm39) probably null Het
Cpd T C 11: 76,683,624 (GRCm39) D1045G probably benign Het
Crocc T C 4: 140,749,113 (GRCm39) D1564G probably damaging Het
Csf1r A T 18: 61,262,149 (GRCm39) M802L probably damaging Het
Dctn4 T C 18: 60,679,407 (GRCm39) probably null Het
Dnah5 A G 15: 28,313,932 (GRCm39) Q1916R probably damaging Het
Dpysl2 A G 14: 67,100,114 (GRCm39) probably benign Het
Dync2h1 A G 9: 7,081,084 (GRCm39) Y2871H probably damaging Het
Fam221b T A 4: 43,665,537 (GRCm39) H307L probably damaging Het
Foxn4 C T 5: 114,401,193 (GRCm39) D37N probably damaging Het
Gemin4 G C 11: 76,101,876 (GRCm39) P962A probably damaging Het
Gm9797 T C 10: 11,485,069 (GRCm39) noncoding transcript Het
Golim4 A T 3: 75,815,456 (GRCm39) V116D probably damaging Het
Gper1 C T 5: 139,412,477 (GRCm39) P274L probably damaging Het
Gpr132 A G 12: 112,816,023 (GRCm39) S268P probably damaging Het
Gtpbp2 T C 17: 46,472,128 (GRCm39) M21T probably benign Het
Hivep1 C T 13: 42,337,262 (GRCm39) A2447V possibly damaging Het
Ift20 G A 11: 78,430,860 (GRCm39) E68K probably damaging Het
Insrr G A 3: 87,717,879 (GRCm39) probably null Het
Kcnh8 T C 17: 53,200,961 (GRCm39) V465A probably damaging Het
Kif5c T A 2: 49,648,817 (GRCm39) probably benign Het
Kmt2a G A 9: 44,730,972 (GRCm39) probably benign Het
Lhx6 G T 2: 35,977,470 (GRCm39) C327* probably null Het
Lifr A G 15: 7,211,337 (GRCm39) D625G possibly damaging Het
Llgl1 T C 11: 60,598,066 (GRCm39) V370A probably benign Het
Lman1 A T 18: 66,124,653 (GRCm39) M362K probably damaging Het
Lmtk2 C T 5: 144,111,806 (GRCm39) T842I possibly damaging Het
Lpin3 T A 2: 160,738,729 (GRCm39) L227* probably null Het
Ltv1 C G 10: 13,058,280 (GRCm39) probably benign Het
Magel2 A T 7: 62,027,486 (GRCm39) H130L unknown Het
Mettl17 A T 14: 52,126,192 (GRCm39) probably benign Het
Mnx1 T A 5: 29,679,187 (GRCm39) S299C unknown Het
Mov10 A T 3: 104,725,432 (GRCm39) I59N possibly damaging Het
Myo7b T C 18: 32,127,950 (GRCm39) I581V probably benign Het
Ncdn T A 4: 126,639,066 (GRCm39) probably null Het
Ndufa4 A T 6: 11,900,574 (GRCm39) V37E probably benign Het
Nhsl1 T G 10: 18,400,412 (GRCm39) L546R probably benign Het
Nop9 T C 14: 55,988,599 (GRCm39) L347P probably damaging Het
Nrp1 A T 8: 129,224,997 (GRCm39) E782D probably damaging Het
Ntrk3 G A 7: 78,127,683 (GRCm39) probably benign Het
Or2z8 A G 8: 72,812,280 (GRCm39) Y252C probably damaging Het
Or8g53 A T 9: 39,683,791 (GRCm39) C102S probably benign Het
Osbpl6 T A 2: 76,416,558 (GRCm39) I546K probably damaging Het
Pard6g T C 18: 80,160,523 (GRCm39) V212A probably damaging Het
Pknox2 A G 9: 36,820,980 (GRCm39) V294A probably damaging Het
Plekha1 T C 7: 130,493,983 (GRCm39) V106A probably benign Het
Plekha6 C A 1: 133,207,103 (GRCm39) probably null Het
Ptgdr A T 14: 45,096,036 (GRCm39) Y225* probably null Het
Ptpn22 A G 3: 103,781,368 (GRCm39) I90V probably damaging Het
Pygb C T 2: 150,658,692 (GRCm39) T372I probably damaging Het
Pzp T C 6: 128,468,124 (GRCm39) probably null Het
Qrich2 C T 11: 116,332,275 (GRCm39) G2307D probably damaging Het
Rfwd3 A T 8: 112,024,034 (GRCm39) V96E probably benign Het
Senp1 T A 15: 97,973,848 (GRCm39) T132S probably benign Het
Slc9a4 T G 1: 40,646,901 (GRCm39) probably null Het
Slfn9 T A 11: 82,872,133 (GRCm39) I868F probably damaging Het
St3gal6 T C 16: 58,296,234 (GRCm39) D137G probably damaging Het
Synj1 G T 16: 90,761,405 (GRCm39) A687D probably damaging Het
Syt4 A G 18: 31,576,496 (GRCm39) probably benign Het
Tacc1 A T 8: 25,654,509 (GRCm39) N271K probably damaging Het
Tdrd6 T C 17: 43,935,724 (GRCm39) T1775A probably benign Het
Tecpr1 T A 5: 144,145,463 (GRCm39) T595S probably benign Het
Tjp3 T A 10: 81,113,888 (GRCm39) M457L possibly damaging Het
Tmem200a T A 10: 25,869,825 (GRCm39) H148L probably damaging Het
Trappc8 A G 18: 20,967,997 (GRCm39) probably null Het
Txk T A 5: 72,853,922 (GRCm39) T472S probably damaging Het
Ubr4 T A 4: 139,151,256 (GRCm39) M1897K probably damaging Het
Uggt2 A G 14: 119,298,788 (GRCm39) L391P probably damaging Het
Uncx T C 5: 139,533,302 (GRCm39) S456P probably benign Het
Vps13b A G 15: 35,879,937 (GRCm39) Y3004C probably damaging Het
Vps35l T C 7: 118,393,798 (GRCm39) Y516H probably damaging Het
Zbtb46 C T 2: 181,033,224 (GRCm39) C479Y probably damaging Het
Zc3h7a A T 16: 10,968,469 (GRCm39) Y503* probably null Het
Zdhhc13 T A 7: 48,474,392 (GRCm39) L548Q possibly damaging Het
Zfp236 T C 18: 82,639,429 (GRCm39) M1225V probably benign Het
Zfp280d T C 9: 72,215,287 (GRCm39) F133L probably damaging Het
Zfp503 A T 14: 22,035,588 (GRCm39) C443S possibly damaging Het
Zfyve26 T A 12: 79,315,208 (GRCm39) I1423F possibly damaging Het
Other mutations in Or1j13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01455:Or1j13 APN 2 36,369,368 (GRCm39) missense probably damaging 1.00
IGL01469:Or1j13 APN 2 36,369,836 (GRCm39) missense probably benign 0.44
IGL02269:Or1j13 APN 2 36,369,579 (GRCm39) missense possibly damaging 0.86
IGL02870:Or1j13 APN 2 36,370,043 (GRCm39) missense probably benign
IGL03190:Or1j13 APN 2 36,369,734 (GRCm39) missense probably damaging 1.00
R0988:Or1j13 UTSW 2 36,369,779 (GRCm39) missense probably damaging 1.00
R1214:Or1j13 UTSW 2 36,369,981 (GRCm39) missense possibly damaging 0.67
R1785:Or1j13 UTSW 2 36,370,059 (GRCm39) missense possibly damaging 0.87
R2130:Or1j13 UTSW 2 36,370,059 (GRCm39) missense possibly damaging 0.87
R2131:Or1j13 UTSW 2 36,370,059 (GRCm39) missense possibly damaging 0.87
R2132:Or1j13 UTSW 2 36,370,059 (GRCm39) missense possibly damaging 0.87
R2133:Or1j13 UTSW 2 36,370,059 (GRCm39) missense possibly damaging 0.87
R2568:Or1j13 UTSW 2 36,369,986 (GRCm39) missense probably damaging 1.00
R4115:Or1j13 UTSW 2 36,369,797 (GRCm39) missense probably damaging 1.00
R4384:Or1j13 UTSW 2 36,370,010 (GRCm39) missense probably damaging 1.00
R4721:Or1j13 UTSW 2 36,369,836 (GRCm39) missense probably benign 0.44
R5375:Or1j13 UTSW 2 36,369,309 (GRCm39) missense probably damaging 0.98
R6035:Or1j13 UTSW 2 36,369,996 (GRCm39) missense probably damaging 1.00
R6035:Or1j13 UTSW 2 36,369,996 (GRCm39) missense probably damaging 1.00
R6084:Or1j13 UTSW 2 36,369,524 (GRCm39) missense probably benign 0.01
R6340:Or1j13 UTSW 2 36,370,032 (GRCm39) missense probably benign 0.31
R7238:Or1j13 UTSW 2 36,369,726 (GRCm39) missense possibly damaging 0.54
R7532:Or1j13 UTSW 2 36,370,138 (GRCm39) start codon destroyed probably null 0.27
R7830:Or1j13 UTSW 2 36,369,392 (GRCm39) missense probably damaging 1.00
R7910:Or1j13 UTSW 2 36,369,345 (GRCm39) missense probably damaging 0.98
R8737:Or1j13 UTSW 2 36,369,629 (GRCm39) missense probably benign 0.00
R8821:Or1j13 UTSW 2 36,369,794 (GRCm39) missense possibly damaging 0.94
R8831:Or1j13 UTSW 2 36,369,794 (GRCm39) missense possibly damaging 0.94
R8847:Or1j13 UTSW 2 36,369,483 (GRCm39) nonsense probably null
R9070:Or1j13 UTSW 2 36,369,268 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCATGAGCATCTTTGGAGCTG -3'
(R):5'- GGCACCTTGATCTGGAAATGG -3'

Sequencing Primer
(F):5'- CTTTGGAGCTGTGACTGATGAGAAAG -3'
(R):5'- ATCACAGCTCATTTTTGTCACAG -3'
Posted On 2014-06-23