Mutagenetix > Incidental Mutation

Incidental Mutation 'R1800:Fat2'

203058

Institutional Source

Beutler Lab

Gene Symbol

Fat2

Ensembl Gene

ENSMUSG00000055333

Gene Name

FAT atypical cadherin 2

Synonyms

LOC245827, mKIAA0811, EMI2, Fath2

MMRRC Submission

039830-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1800 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

55141435-55227390 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 55174718 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 1998 (N1998K)

Ref Sequence

ENSEMBL: ENSMUSP00000104492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068853] [ENSMUST00000108864]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000068853
AA Change: N1998K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000067556
Gene: ENSMUSG00000055333
AA Change: N1998K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108864
AA Change: N1998K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104492
Gene: ENSMUSG00000055333
AA Change: N1998K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CA	55	146	3.65e-4	SMART
CA	170	254	3.99e-10	SMART
low complexity region	337	348	N/A	INTRINSIC
CA	384	456	5.11e-8	SMART
CA	480	562	2.71e-21	SMART
CA	586	664	1.12e-2	SMART
CA	737	818	1.69e-22	SMART
CA	842	923	9.59e-22	SMART
CA	947	1028	7.39e-14	SMART
CA	1054	1135	3.74e-24	SMART
CA	1159	1240	1.84e-23	SMART
CA	1266	1342	8.9e-8	SMART
CA	1368	1446	7.4e-5	SMART
CA	1470	1553	1.98e-14	SMART
CA	1577	1658	6.84e-18	SMART
CA	1682	1756	2.76e-13	SMART
CA	1787	1870	1.49e-18	SMART
CA	1894	1966	1.11e-1	SMART
CA	1990	2068	2.4e-13	SMART
CA	2092	2171	3.42e-18	SMART
CA	2190	2270	1.9e-16	SMART
CA	2294	2377	1.49e-27	SMART
CA	2401	2479	8.31e-8	SMART
CA	2503	2583	6.48e-19	SMART
CA	2607	2690	1.53e-6	SMART
CA	2714	2797	3e-14	SMART
CA	2821	2906	5.85e-26	SMART
CA	2930	3011	4.58e-19	SMART
CA	3035	3113	2.1e-27	SMART
CA	3137	3218	9.67e-18	SMART
CA	3243	3321	1.92e-12	SMART
CA	3345	3426	4.04e-29	SMART
CA	3450	3531	1.79e-12	SMART
CA	3555	3629	9.3e-2	SMART
LamG	3794	3923	1.77e-28	SMART
EGF	3952	3986	6.5e-5	SMART
EGF	3991	4024	1.6e-4	SMART
transmembrane domain	4051	4073	N/A	INTRINSIC

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.0%
20x: 91.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are healthy, fertile and overtly normal, with no apparent defects in the development of red blood cells or platelets. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 92 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110002E22Rik	A	G	3: 137,772,479 (GRCm39)	K556R	probably damaging	Het
4933406P04Rik	A	T	10: 20,186,893 (GRCm39)		probably benign	Het
Acmsd	C	A	1: 127,687,493 (GRCm39)	Y258*	probably null	Het
Adgrf5	A	T	17: 43,761,973 (GRCm39)	I1223F	probably damaging	Het
Afp	C	T	5: 90,638,655 (GRCm39)	P6S	probably benign	Het
Agap2	C	A	10: 126,927,540 (GRCm39)	H1120Q	probably damaging	Het
Angpt1	A	G	15: 42,375,800 (GRCm39)	V152A	probably damaging	Het
Ankrd1	A	T	19: 36,096,759 (GRCm39)	F23I	probably damaging	Het
Armc12	T	C	17: 28,757,869 (GRCm39)	S334P	possibly damaging	Het
Arnt2	C	A	7: 83,924,583 (GRCm39)	D415Y	probably damaging	Het
Cacna1s	G	T	1: 136,004,592 (GRCm39)	V131L	probably benign	Het
Cacna2d2	T	C	9: 107,404,632 (GRCm39)	V1141A	possibly damaging	Het
Cfap61	T	C	2: 145,884,542 (GRCm39)	L580P	probably damaging	Het
Chga	A	T	12: 102,522,164 (GRCm39)	S23C	probably damaging	Het
Chrna5	A	G	9: 54,912,159 (GRCm39)	T320A	probably damaging	Het
Col17a1	G	T	19: 47,639,301 (GRCm39)	N1081K	possibly damaging	Het
Cox7b2	A	T	5: 71,600,406 (GRCm39)	C51S	possibly damaging	Het
Cstdc3	T	A	16: 36,132,895 (GRCm39)	D57E	probably damaging	Het
Cwc22	A	T	2: 77,759,797 (GRCm39)	D83E	possibly damaging	Het
D130043K22Rik	A	C	13: 25,067,877 (GRCm39)	D871A	probably damaging	Het
Dab2	A	T	15: 6,464,948 (GRCm39)	M361L	probably benign	Het
Dnah11	A	C	12: 117,880,523 (GRCm39)	Y3866D	probably damaging	Het
Dnmbp	A	G	19: 43,890,159 (GRCm39)	I536T	probably benign	Het
Ehmt1	A	T	2: 24,774,302 (GRCm39)	S43R	probably damaging	Het
Ercc5	T	C	1: 44,212,540 (GRCm39)	L666P	probably benign	Het
F5	A	G	1: 164,010,403 (GRCm39)	H378R	probably damaging	Het
Fbxo28	T	C	1: 182,169,099 (GRCm39)	D13G	unknown	Het
Fras1	T	C	5: 96,857,741 (GRCm39)	S2012P	probably benign	Het
Gm5624	T	A	14: 44,799,302 (GRCm39)	N41I	probably damaging	Het
Gm8104	A	G	14: 42,959,028 (GRCm39)	I73V	possibly damaging	Het
Gpr141b	T	C	13: 19,913,849 (GRCm39)		noncoding transcript	Het
Gpr68	G	A	12: 100,845,167 (GRCm39)	P126S	probably damaging	Het
Gucy1a2	A	T	9: 3,582,685 (GRCm39)	T156S	possibly damaging	Het
Hacl1	T	A	14: 31,336,221 (GRCm39)	Y429F	probably damaging	Het
Haus3	A	C	5: 34,320,916 (GRCm39)	L510R	probably damaging	Het
Helq	C	T	5: 100,921,990 (GRCm39)	G738D	probably benign	Het
Hsd3b2	G	C	3: 98,619,553 (GRCm39)	P131A	probably damaging	Het
Il22ra1	G	T	4: 135,475,471 (GRCm39)	C247F	probably benign	Het
Ivl	T	C	3: 92,479,891 (GRCm39)	E58G	unknown	Het
Kcnk9	G	T	15: 72,417,948 (GRCm39)	Q61K	probably benign	Het
Kremen1	CGGG	CGGGGGG	11: 5,151,791 (GRCm39)		probably benign	Het
Loxhd1	G	T	18: 77,490,198 (GRCm39)	A1314S	probably damaging	Het
Lratd1	T	C	12: 14,200,226 (GRCm39)	Y167C	probably damaging	Het
Lrba	A	G	3: 86,259,175 (GRCm39)	I1397V	probably benign	Het
Lrig3	T	A	10: 125,832,920 (GRCm39)		probably null	Het
Lrrc36	A	G	8: 106,176,397 (GRCm39)	D378G	probably damaging	Het
Lrrc49	G	A	9: 60,505,474 (GRCm39)	T527I	probably damaging	Het
Map4k4	C	A	1: 40,062,620 (GRCm39)	T1195K	probably damaging	Het
Mrps33	G	A	6: 39,779,429 (GRCm39)	R89C	probably damaging	Het
Mtor	T	C	4: 148,547,349 (GRCm39)	V444A	probably benign	Het
Myh2	A	G	11: 67,079,764 (GRCm39)	E1046G	probably damaging	Het
Myo15b	G	T	11: 115,771,335 (GRCm39)		probably null	Het
Myo5c	T	C	9: 75,153,446 (GRCm39)	Y111H	probably damaging	Het
Ncoa4-ps	A	T	12: 119,225,506 (GRCm39)		noncoding transcript	Het
Ndufv2	G	C	17: 66,390,481 (GRCm39)	T163R	probably damaging	Het
Nf1	A	G	11: 79,444,794 (GRCm39)	N373S	possibly damaging	Het
Nwd2	A	G	5: 63,962,917 (GRCm39)	M834V	probably benign	Het
Ogfod2	T	C	5: 124,253,019 (GRCm39)	V343A	probably damaging	Het
Or11g2	C	T	14: 50,856,143 (GRCm39)	L155F	probably benign	Het
Or11j4	C	A	14: 50,630,786 (GRCm39)	S191*	probably null	Het
Or3a1b	A	T	11: 74,012,234 (GRCm39)	T40S	probably benign	Het
Or4c115	T	A	2: 88,928,050 (GRCm39)	T74S	probably benign	Het
Or51ag1	T	C	7: 103,155,248 (GRCm39)	I302V	possibly damaging	Het
Or52ab2	T	A	7: 102,969,621 (GRCm39)	M1K	probably null	Het
Or8g34	A	T	9: 39,373,410 (GRCm39)	I228F	probably damaging	Het
Parp1	T	A	1: 180,428,091 (GRCm39)		probably null	Het
Ppp3ca	A	T	3: 136,640,792 (GRCm39)	I448F	probably damaging	Het
Prss44	T	C	9: 110,646,272 (GRCm39)	V333A	probably damaging	Het
Pxk	C	T	14: 8,151,507 (GRCm38)	R441*	probably null	Het
Rars1	A	C	11: 35,716,822 (GRCm39)	D231E	probably benign	Het
Rfc1	T	C	5: 65,421,722 (GRCm39)	Y1059C	probably damaging	Het
Rilpl1	T	A	5: 124,652,719 (GRCm39)	I2F	probably damaging	Het
Sarm1	G	T	11: 78,381,820 (GRCm39)	A221E	possibly damaging	Het
Serpina3f	A	G	12: 104,183,665 (GRCm39)	T176A	probably damaging	Het
Slc22a20	T	C	19: 6,035,695 (GRCm39)	E131G	probably benign	Het
Slc26a11	T	C	11: 119,263,979 (GRCm39)	V343A	probably damaging	Het
Slc2a4	A	G	11: 69,837,133 (GRCm39)	I9T	probably benign	Het
Slc39a6	G	T	18: 24,718,259 (GRCm39)	D599E	probably damaging	Het
Slc5a6	G	T	5: 31,198,020 (GRCm39)	S285*	probably null	Het
Spata9	A	G	13: 76,125,760 (GRCm39)	H81R	probably benign	Het
St7l	A	G	3: 104,826,812 (GRCm39)	E436G	probably damaging	Het
Tecrl	A	G	5: 83,427,077 (GRCm39)	I357T	probably damaging	Het
Thop1	C	T	10: 80,909,043 (GRCm39)	R25C	probably damaging	Het
Tmprss12	A	G	15: 100,190,428 (GRCm39)	E266G	probably benign	Het
Tpgs1	T	A	10: 79,511,344 (GRCm39)	V162D	possibly damaging	Het
Trpa1	C	T	1: 14,944,648 (GRCm39)	R1032Q	probably benign	Het
Tspan12	A	G	6: 21,795,699 (GRCm39)	Y164H	probably damaging	Het
Ubr4	T	C	4: 139,135,274 (GRCm39)	Y869H	probably damaging	Het
Vmn1r21	A	G	6: 57,820,799 (GRCm39)	I215T	probably benign	Het
Zan	A	T	5: 137,384,713 (GRCm39)	S5104T	unknown	Het
Zfp318	T	C	17: 46,722,980 (GRCm39)	V1661A	probably benign	Het
Zfp365	C	T	10: 67,724,772 (GRCm39)	R372K	probably damaging	Het

Other mutations in Fat2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00720:Fat2	APN	11	55,202,070 (GRCm39)	missense	probably benign
IGL00897:Fat2	APN	11	55,180,078 (GRCm39)	missense	probably damaging	0.99
IGL01161:Fat2	APN	11	55,175,017 (GRCm39)	missense	probably benign
IGL01306:Fat2	APN	11	55,201,698 (GRCm39)	missense	probably benign	0.28
IGL01393:Fat2	APN	11	55,160,135 (GRCm39)	missense	probably benign	0.00
IGL01529:Fat2	APN	11	55,172,982 (GRCm39)	missense	probably damaging	1.00
IGL01530:Fat2	APN	11	55,174,213 (GRCm39)	missense	probably benign	0.42
IGL01555:Fat2	APN	11	55,169,756 (GRCm39)	missense	probably damaging	0.99
IGL01758:Fat2	APN	11	55,187,035 (GRCm39)	missense	probably damaging	1.00
IGL01768:Fat2	APN	11	55,153,394 (GRCm39)	missense	probably damaging	1.00
IGL01939:Fat2	APN	11	55,174,806 (GRCm39)	missense	probably benign	0.01
IGL01941:Fat2	APN	11	55,202,831 (GRCm39)	missense	probably benign	0.01
IGL01967:Fat2	APN	11	55,202,649 (GRCm39)	missense	probably damaging	1.00
IGL01978:Fat2	APN	11	55,160,972 (GRCm39)	missense	probably benign	0.34
IGL01998:Fat2	APN	11	55,187,021 (GRCm39)	missense	probably benign	0.00
IGL02001:Fat2	APN	11	55,203,071 (GRCm39)	start codon destroyed	probably null	0.89
IGL02004:Fat2	APN	11	55,173,666 (GRCm39)	missense	probably damaging	1.00
IGL02103:Fat2	APN	11	55,180,122 (GRCm39)	missense	probably damaging	0.96
IGL02131:Fat2	APN	11	55,199,868 (GRCm39)	missense	probably damaging	1.00
IGL02155:Fat2	APN	11	55,153,245 (GRCm39)	missense	probably benign	0.00
IGL02223:Fat2	APN	11	55,163,955 (GRCm39)	missense	probably benign	0.01
IGL02231:Fat2	APN	11	55,171,918 (GRCm39)	missense	probably damaging	0.98
IGL02312:Fat2	APN	11	55,161,085 (GRCm39)	missense	probably damaging	1.00
IGL02476:Fat2	APN	11	55,201,950 (GRCm39)	missense	probably damaging	1.00
IGL02539:Fat2	APN	11	55,172,619 (GRCm39)	missense	probably damaging	1.00
IGL02553:Fat2	APN	11	55,202,109 (GRCm39)	missense	probably damaging	1.00
IGL02645:Fat2	APN	11	55,173,654 (GRCm39)	missense	probably damaging	1.00
IGL02664:Fat2	APN	11	55,201,922 (GRCm39)	missense	probably damaging	1.00
IGL02708:Fat2	APN	11	55,173,211 (GRCm39)	missense	probably damaging	0.99
IGL02883:Fat2	APN	11	55,147,444 (GRCm39)	missense	probably benign	0.16
IGL02894:Fat2	APN	11	55,147,479 (GRCm39)	missense	probably damaging	1.00
IGL02975:Fat2	APN	11	55,161,020 (GRCm39)	missense	probably benign	0.00
IGL03085:Fat2	APN	11	55,174,072 (GRCm39)	missense	probably benign	0.09
IGL03106:Fat2	APN	11	55,202,727 (GRCm39)	missense	probably benign	0.45
IGL03132:Fat2	APN	11	55,144,746 (GRCm39)	missense	probably benign	0.25
IGL03133:Fat2	APN	11	55,176,869 (GRCm39)	missense	probably benign	0.01
IGL03194:Fat2	APN	11	55,201,821 (GRCm39)	missense	probably benign	0.02
IGL03266:Fat2	APN	11	55,174,855 (GRCm39)	missense	possibly damaging	0.62
IGL03290:Fat2	APN	11	55,147,045 (GRCm39)	missense	probably benign	0.33
IGL03291:Fat2	APN	11	55,153,421 (GRCm39)	missense	probably benign
IGL03325:Fat2	APN	11	55,173,168 (GRCm39)	missense	probably damaging	1.00
IGL03345:Fat2	APN	11	55,173,187 (GRCm39)	missense	probably damaging	1.00
IGL03371:Fat2	APN	11	55,201,990 (GRCm39)	missense	probably benign	0.10
ANU23:Fat2	UTSW	11	55,201,698 (GRCm39)	missense	probably benign	0.28
BB001:Fat2	UTSW	11	55,153,613 (GRCm39)	missense	probably benign	0.03
BB011:Fat2	UTSW	11	55,153,613 (GRCm39)	missense	probably benign	0.03
P0040:Fat2	UTSW	11	55,173,039 (GRCm39)	missense	possibly damaging	0.89
PIT4504001:Fat2	UTSW	11	55,146,936 (GRCm39)	missense	possibly damaging	0.68
R0008:Fat2	UTSW	11	55,202,075 (GRCm39)	missense	probably damaging	1.00
R0008:Fat2	UTSW	11	55,202,075 (GRCm39)	missense	probably damaging	1.00
R0012:Fat2	UTSW	11	55,153,697 (GRCm39)	missense	probably benign	0.16
R0012:Fat2	UTSW	11	55,153,697 (GRCm39)	missense	probably benign	0.16
R0048:Fat2	UTSW	11	55,200,865 (GRCm39)	missense	probably benign	0.00
R0048:Fat2	UTSW	11	55,200,865 (GRCm39)	missense	probably benign	0.00
R0098:Fat2	UTSW	11	55,189,431 (GRCm39)	missense	probably damaging	0.98
R0124:Fat2	UTSW	11	55,174,504 (GRCm39)	missense	probably damaging	0.98
R0127:Fat2	UTSW	11	55,180,112 (GRCm39)	missense	probably benign	0.01
R0130:Fat2	UTSW	11	55,142,944 (GRCm39)	missense	probably benign	0.26
R0131:Fat2	UTSW	11	55,164,037 (GRCm39)	missense	probably benign
R0158:Fat2	UTSW	11	55,187,011 (GRCm39)	missense	probably benign	0.00
R0184:Fat2	UTSW	11	55,187,114 (GRCm39)	missense	probably damaging	1.00
R0367:Fat2	UTSW	11	55,182,919 (GRCm39)	splice site	probably benign
R0384:Fat2	UTSW	11	55,160,291 (GRCm39)	missense	possibly damaging	0.81
R0390:Fat2	UTSW	11	55,201,603 (GRCm39)	missense	probably damaging	0.99
R0403:Fat2	UTSW	11	55,161,175 (GRCm39)	missense	probably benign	0.42
R0416:Fat2	UTSW	11	55,174,960 (GRCm39)	missense	possibly damaging	0.94
R0437:Fat2	UTSW	11	55,173,625 (GRCm39)	missense	probably benign	0.02
R0463:Fat2	UTSW	11	55,153,655 (GRCm39)	missense	probably damaging	1.00
R0497:Fat2	UTSW	11	55,174,228 (GRCm39)	missense	probably benign	0.03
R0617:Fat2	UTSW	11	55,202,669 (GRCm39)	missense	possibly damaging	0.60
R0622:Fat2	UTSW	11	55,173,954 (GRCm39)	missense	probably damaging	1.00
R0675:Fat2	UTSW	11	55,200,035 (GRCm39)	missense	probably damaging	0.97
R0811:Fat2	UTSW	11	55,144,459 (GRCm39)	missense	possibly damaging	0.75
R0812:Fat2	UTSW	11	55,144,459 (GRCm39)	missense	possibly damaging	0.75
R0869:Fat2	UTSW	11	55,202,601 (GRCm39)	missense	probably benign	0.08
R0870:Fat2	UTSW	11	55,202,601 (GRCm39)	missense	probably benign	0.08
R0899:Fat2	UTSW	11	55,147,051 (GRCm39)	missense	probably damaging	1.00
R1278:Fat2	UTSW	11	55,159,005 (GRCm39)	missense	probably damaging	1.00
R1383:Fat2	UTSW	11	55,201,599 (GRCm39)	missense	probably benign
R1428:Fat2	UTSW	11	55,186,913 (GRCm39)	missense	probably damaging	1.00
R1438:Fat2	UTSW	11	55,178,637 (GRCm39)	missense	probably damaging	1.00
R1495:Fat2	UTSW	11	55,153,499 (GRCm39)	missense	probably benign
R1506:Fat2	UTSW	11	55,175,090 (GRCm39)	missense	probably benign
R1547:Fat2	UTSW	11	55,143,081 (GRCm39)	missense	probably benign	0.01
R1554:Fat2	UTSW	11	55,144,490 (GRCm39)	missense	probably benign	0.01
R1562:Fat2	UTSW	11	55,200,800 (GRCm39)	missense	probably damaging	1.00
R1588:Fat2	UTSW	11	55,174,230 (GRCm39)	missense	probably damaging	1.00
R1592:Fat2	UTSW	11	55,182,696 (GRCm39)	splice site	probably null
R1601:Fat2	UTSW	11	55,172,836 (GRCm39)	missense	probably benign	0.01
R1610:Fat2	UTSW	11	55,169,750 (GRCm39)	missense	probably damaging	1.00
R1634:Fat2	UTSW	11	55,175,545 (GRCm39)	missense	probably benign
R1634:Fat2	UTSW	11	55,158,510 (GRCm39)	missense	probably damaging	1.00
R1644:Fat2	UTSW	11	55,187,007 (GRCm39)	missense	possibly damaging	0.94
R1644:Fat2	UTSW	11	55,178,609 (GRCm39)	missense	possibly damaging	0.91
R1691:Fat2	UTSW	11	55,202,678 (GRCm39)	missense	probably damaging	0.99
R1734:Fat2	UTSW	11	55,172,197 (GRCm39)	missense	probably benign	0.00
R1748:Fat2	UTSW	11	55,147,473 (GRCm39)	missense	probably damaging	0.97
R1771:Fat2	UTSW	11	55,201,691 (GRCm39)	missense	probably benign	0.01
R1807:Fat2	UTSW	11	55,180,085 (GRCm39)	missense	probably damaging	1.00
R1823:Fat2	UTSW	11	55,147,606 (GRCm39)	missense	probably benign	0.29
R1848:Fat2	UTSW	11	55,202,384 (GRCm39)	missense	probably damaging	1.00
R1866:Fat2	UTSW	11	55,182,840 (GRCm39)	missense	probably benign	0.00
R1899:Fat2	UTSW	11	55,153,004 (GRCm39)	missense	probably benign
R1954:Fat2	UTSW	11	55,201,910 (GRCm39)	missense	probably benign	0.06
R2010:Fat2	UTSW	11	55,144,653 (GRCm39)	missense	probably damaging	0.99
R2011:Fat2	UTSW	11	55,173,583 (GRCm39)	missense	probably damaging	1.00
R2057:Fat2	UTSW	11	55,172,686 (GRCm39)	missense	possibly damaging	0.60
R2081:Fat2	UTSW	11	55,200,503 (GRCm39)	missense	possibly damaging	0.94
R2106:Fat2	UTSW	11	55,147,390 (GRCm39)	missense	probably benign	0.00
R2165:Fat2	UTSW	11	55,194,542 (GRCm39)	missense	probably benign	0.00
R2176:Fat2	UTSW	11	55,158,401 (GRCm39)	critical splice donor site	probably null
R2284:Fat2	UTSW	11	55,173,186 (GRCm39)	missense	probably damaging	1.00
R2338:Fat2	UTSW	11	55,202,727 (GRCm39)	missense	possibly damaging	0.93
R2340:Fat2	UTSW	11	55,160,922 (GRCm39)	missense	possibly damaging	0.90
R2427:Fat2	UTSW	11	55,201,638 (GRCm39)	missense	probably benign	0.15
R2444:Fat2	UTSW	11	55,172,799 (GRCm39)	missense	probably damaging	1.00
R2858:Fat2	UTSW	11	55,174,599 (GRCm39)	missense	possibly damaging	0.94
R2882:Fat2	UTSW	11	55,202,131 (GRCm39)	missense	probably damaging	0.96
R3029:Fat2	UTSW	11	55,175,535 (GRCm39)	missense	probably damaging	1.00
R3085:Fat2	UTSW	11	55,142,997 (GRCm39)	missense	possibly damaging	0.79
R3121:Fat2	UTSW	11	55,202,622 (GRCm39)	missense	probably damaging	1.00
R3418:Fat2	UTSW	11	55,169,824 (GRCm39)	missense	probably benign	0.01
R3500:Fat2	UTSW	11	55,151,342 (GRCm39)	missense	probably damaging	0.99
R3607:Fat2	UTSW	11	55,172,511 (GRCm39)	missense	probably damaging	1.00
R3611:Fat2	UTSW	11	55,202,895 (GRCm39)	missense	probably benign
R3620:Fat2	UTSW	11	55,147,521 (GRCm39)	missense	probably damaging	0.97
R3688:Fat2	UTSW	11	55,171,927 (GRCm39)	missense	probably damaging	0.99
R3704:Fat2	UTSW	11	55,200,476 (GRCm39)	missense	probably damaging	1.00
R3784:Fat2	UTSW	11	55,147,012 (GRCm39)	missense	probably benign
R3889:Fat2	UTSW	11	55,172,589 (GRCm39)	missense	probably damaging	1.00
R3951:Fat2	UTSW	11	55,187,208 (GRCm39)	missense	probably benign	0.00
R4211:Fat2	UTSW	11	55,174,810 (GRCm39)	missense	probably damaging	1.00
R4249:Fat2	UTSW	11	55,175,127 (GRCm39)	missense	probably damaging	0.98
R4406:Fat2	UTSW	11	55,153,094 (GRCm39)	missense	probably benign	0.00
R4433:Fat2	UTSW	11	55,200,466 (GRCm39)	missense	possibly damaging	0.91
R4436:Fat2	UTSW	11	55,187,024 (GRCm39)	missense	probably damaging	1.00
R4498:Fat2	UTSW	11	55,160,923 (GRCm39)	missense	possibly damaging	0.90
R4560:Fat2	UTSW	11	55,156,777 (GRCm39)	missense	possibly damaging	0.89
R4594:Fat2	UTSW	11	55,175,578 (GRCm39)	missense	possibly damaging	0.78
R4663:Fat2	UTSW	11	55,187,039 (GRCm39)	nonsense	probably null
R4669:Fat2	UTSW	11	55,202,441 (GRCm39)	missense	probably benign	0.01
R4696:Fat2	UTSW	11	55,175,841 (GRCm39)	missense	probably benign	0.00
R4734:Fat2	UTSW	11	55,202,294 (GRCm39)	missense	probably benign	0.01
R4749:Fat2	UTSW	11	55,202,294 (GRCm39)	missense	probably benign	0.01
R4765:Fat2	UTSW	11	55,172,013 (GRCm39)	missense	probably damaging	1.00
R4803:Fat2	UTSW	11	55,175,886 (GRCm39)	missense	probably benign	0.03
R4805:Fat2	UTSW	11	55,174,805 (GRCm39)	missense	probably benign	0.01
R4822:Fat2	UTSW	11	55,202,144 (GRCm39)	missense	probably benign	0.02
R4840:Fat2	UTSW	11	55,169,844 (GRCm39)	missense	probably benign	0.21
R4849:Fat2	UTSW	11	55,201,463 (GRCm39)	missense	probably damaging	1.00
R4943:Fat2	UTSW	11	55,169,859 (GRCm39)	missense	probably benign	0.00
R4993:Fat2	UTSW	11	55,173,918 (GRCm39)	missense	probably damaging	0.99
R5097:Fat2	UTSW	11	55,201,530 (GRCm39)	missense	probably damaging	1.00
R5104:Fat2	UTSW	11	55,169,814 (GRCm39)	missense	possibly damaging	0.93
R5115:Fat2	UTSW	11	55,187,159 (GRCm39)	missense	probably damaging	1.00
R5213:Fat2	UTSW	11	55,144,658 (GRCm39)	missense	probably benign	0.00
R5254:Fat2	UTSW	11	55,172,001 (GRCm39)	missense	probably damaging	1.00
R5269:Fat2	UTSW	11	55,178,704 (GRCm39)	missense	probably benign	0.00
R5288:Fat2	UTSW	11	55,158,482 (GRCm39)	missense	probably benign	0.00
R5355:Fat2	UTSW	11	55,172,992 (GRCm39)	missense	probably damaging	1.00
R5375:Fat2	UTSW	11	55,153,646 (GRCm39)	missense	probably benign	0.00
R5379:Fat2	UTSW	11	55,194,767 (GRCm39)	missense	probably damaging	0.99
R5411:Fat2	UTSW	11	55,143,052 (GRCm39)	missense	probably benign	0.23
R5416:Fat2	UTSW	11	55,194,514 (GRCm39)	missense	possibly damaging	0.77
R5480:Fat2	UTSW	11	55,200,912 (GRCm39)	missense	probably damaging	0.99
R5486:Fat2	UTSW	11	55,144,507 (GRCm39)	missense	probably benign	0.00
R5526:Fat2	UTSW	11	55,160,187 (GRCm39)	missense	possibly damaging	0.90
R5532:Fat2	UTSW	11	55,153,163 (GRCm39)	missense	probably damaging	1.00
R5583:Fat2	UTSW	11	55,144,715 (GRCm39)	missense	probably benign	0.00
R5588:Fat2	UTSW	11	55,173,103 (GRCm39)	missense	probably damaging	1.00
R5598:Fat2	UTSW	11	55,171,956 (GRCm39)	missense	probably damaging	1.00
R5636:Fat2	UTSW	11	55,173,307 (GRCm39)	missense	probably damaging	1.00
R5653:Fat2	UTSW	11	55,201,142 (GRCm39)	missense	probably damaging	1.00
R5657:Fat2	UTSW	11	55,201,507 (GRCm39)	nonsense	probably null
R5660:Fat2	UTSW	11	55,175,002 (GRCm39)	missense	probably benign	0.00
R5752:Fat2	UTSW	11	55,180,063 (GRCm39)	missense	possibly damaging	0.48
R5757:Fat2	UTSW	11	55,143,172 (GRCm39)	missense	probably damaging	1.00
R5792:Fat2	UTSW	11	55,153,151 (GRCm39)	missense	possibly damaging	0.77
R5872:Fat2	UTSW	11	55,161,208 (GRCm39)	missense	probably damaging	1.00
R5933:Fat2	UTSW	11	55,174,877 (GRCm39)	missense	probably damaging	1.00
R6030:Fat2	UTSW	11	55,201,129 (GRCm39)	nonsense	probably null
R6030:Fat2	UTSW	11	55,201,129 (GRCm39)	nonsense	probably null
R6032:Fat2	UTSW	11	55,144,760 (GRCm39)	missense	probably damaging	1.00
R6032:Fat2	UTSW	11	55,144,760 (GRCm39)	missense	probably damaging	1.00
R6221:Fat2	UTSW	11	55,186,898 (GRCm39)	critical splice donor site	probably null
R6253:Fat2	UTSW	11	55,187,097 (GRCm39)	missense	probably damaging	1.00
R6257:Fat2	UTSW	11	55,153,407 (GRCm39)	missense	probably benign
R6307:Fat2	UTSW	11	55,172,106 (GRCm39)	missense	possibly damaging	0.63
R6450:Fat2	UTSW	11	55,180,136 (GRCm39)	missense	probably damaging	0.97
R6453:Fat2	UTSW	11	55,173,042 (GRCm39)	missense	probably benign	0.29
R6455:Fat2	UTSW	11	55,161,283 (GRCm39)	missense	probably damaging	0.96
R6483:Fat2	UTSW	11	55,187,171 (GRCm39)	missense	probably damaging	1.00
R6504:Fat2	UTSW	11	55,153,223 (GRCm39)	missense	probably benign	0.00
R6520:Fat2	UTSW	11	55,175,814 (GRCm39)	missense	probably damaging	0.99
R6525:Fat2	UTSW	11	55,174,626 (GRCm39)	missense	probably damaging	1.00
R6617:Fat2	UTSW	11	55,186,931 (GRCm39)	missense	probably benign	0.01
R6652:Fat2	UTSW	11	55,143,088 (GRCm39)	missense	probably benign
R6679:Fat2	UTSW	11	55,200,131 (GRCm39)	missense	probably damaging	1.00
R6680:Fat2	UTSW	11	55,201,684 (GRCm39)	nonsense	probably null
R6762:Fat2	UTSW	11	55,144,308 (GRCm39)	splice site	probably null
R6810:Fat2	UTSW	11	55,173,067 (GRCm39)	missense	possibly damaging	0.88
R6818:Fat2	UTSW	11	55,200,167 (GRCm39)	missense	probably benign	0.31
R6919:Fat2	UTSW	11	55,173,597 (GRCm39)	missense	possibly damaging	0.68
R6939:Fat2	UTSW	11	55,143,300 (GRCm39)	nonsense	probably null
R6941:Fat2	UTSW	11	55,152,914 (GRCm39)	missense	probably benign
R7023:Fat2	UTSW	11	55,201,328 (GRCm39)	missense	probably benign	0.00
R7027:Fat2	UTSW	11	55,160,259 (GRCm39)	missense	probably benign	0.03
R7027:Fat2	UTSW	11	55,172,677 (GRCm39)	nonsense	probably null
R7095:Fat2	UTSW	11	55,202,157 (GRCm39)	missense	probably damaging	1.00
R7102:Fat2	UTSW	11	55,174,260 (GRCm39)	missense	probably damaging	1.00
R7116:Fat2	UTSW	11	55,173,162 (GRCm39)	missense	probably damaging	1.00
R7117:Fat2	UTSW	11	55,172,088 (GRCm39)	missense	probably damaging	1.00
R7167:Fat2	UTSW	11	55,175,827 (GRCm39)	missense	possibly damaging	0.48
R7213:Fat2	UTSW	11	55,171,871 (GRCm39)	nonsense	probably null
R7246:Fat2	UTSW	11	55,187,208 (GRCm39)	missense	probably benign	0.00
R7252:Fat2	UTSW	11	55,202,088 (GRCm39)	missense	probably damaging	0.98
R7266:Fat2	UTSW	11	55,175,856 (GRCm39)	missense	probably damaging	0.99
R7316:Fat2	UTSW	11	55,176,893 (GRCm39)	missense	probably damaging	1.00
R7326:Fat2	UTSW	11	55,173,130 (GRCm39)	missense	probably damaging	0.99
R7355:Fat2	UTSW	11	55,147,377 (GRCm39)	missense	probably benign	0.00
R7431:Fat2	UTSW	11	55,199,927 (GRCm39)	missense	probably damaging	1.00
R7459:Fat2	UTSW	11	55,194,745 (GRCm39)	missense	probably damaging	1.00
R7460:Fat2	UTSW	11	55,169,789 (GRCm39)	missense	probably damaging	1.00
R7466:Fat2	UTSW	11	55,201,258 (GRCm39)	missense	probably damaging	1.00
R7475:Fat2	UTSW	11	55,194,479 (GRCm39)	missense	probably benign	0.31
R7678:Fat2	UTSW	11	55,173,156 (GRCm39)	missense	probably damaging	0.99
R7689:Fat2	UTSW	11	55,200,666 (GRCm39)	missense	probably damaging	1.00
R7704:Fat2	UTSW	11	55,175,173 (GRCm39)	missense	probably benign	0.03
R7710:Fat2	UTSW	11	55,201,589 (GRCm39)	missense	probably benign	0.35
R7724:Fat2	UTSW	11	55,175,622 (GRCm39)	missense	probably damaging	1.00
R7731:Fat2	UTSW	11	55,201,532 (GRCm39)	missense	probably damaging	1.00
R7739:Fat2	UTSW	11	55,171,957 (GRCm39)	nonsense	probably null
R7757:Fat2	UTSW	11	55,202,247 (GRCm39)	missense	probably benign	0.00
R7876:Fat2	UTSW	11	55,202,046 (GRCm39)	missense	probably benign	0.01
R7883:Fat2	UTSW	11	55,144,190 (GRCm39)	splice site	probably null
R7924:Fat2	UTSW	11	55,153,613 (GRCm39)	missense	probably benign	0.03
R7936:Fat2	UTSW	11	55,200,993 (GRCm39)	missense	probably benign
R7936:Fat2	UTSW	11	55,201,986 (GRCm39)	nonsense	probably null
R7938:Fat2	UTSW	11	55,163,922 (GRCm39)	missense	probably damaging	1.00
R7947:Fat2	UTSW	11	55,178,560 (GRCm39)	missense	probably damaging	1.00
R8049:Fat2	UTSW	11	55,202,892 (GRCm39)	missense	probably benign	0.13
R8094:Fat2	UTSW	11	55,186,965 (GRCm39)	missense	probably benign	0.06
R8157:Fat2	UTSW	11	55,142,910 (GRCm39)	missense	possibly damaging	0.90
R8170:Fat2	UTSW	11	55,161,281 (GRCm39)	missense	probably damaging	1.00
R8172:Fat2	UTSW	11	55,178,638 (GRCm39)	missense	probably damaging	1.00
R8182:Fat2	UTSW	11	55,175,223 (GRCm39)	missense	possibly damaging	0.51
R8188:Fat2	UTSW	11	55,163,997 (GRCm39)	missense	probably damaging	0.98
R8204:Fat2	UTSW	11	55,175,436 (GRCm39)	missense	probably benign	0.02
R8211:Fat2	UTSW	11	55,203,035 (GRCm39)	missense	possibly damaging	0.92
R8255:Fat2	UTSW	11	55,161,101 (GRCm39)	missense	probably benign	0.19
R8263:Fat2	UTSW	11	55,174,962 (GRCm39)	missense	probably benign
R8269:Fat2	UTSW	11	55,173,535 (GRCm39)	missense	possibly damaging	0.48
R8443:Fat2	UTSW	11	55,202,535 (GRCm39)	missense	probably damaging	1.00
R8465:Fat2	UTSW	11	55,147,530 (GRCm39)	missense	possibly damaging	0.61
R8480:Fat2	UTSW	11	55,173,794 (GRCm39)	missense	possibly damaging	0.61
R8511:Fat2	UTSW	11	55,200,063 (GRCm39)	missense	probably damaging	0.99
R8680:Fat2	UTSW	11	55,144,692 (GRCm39)	missense	probably benign
R8704:Fat2	UTSW	11	55,172,137 (GRCm39)	missense	probably damaging	1.00
R8711:Fat2	UTSW	11	55,159,129 (GRCm39)	missense	probably benign	0.22
R8724:Fat2	UTSW	11	55,173,786 (GRCm39)	missense	probably damaging	1.00
R8788:Fat2	UTSW	11	55,171,929 (GRCm39)	missense	possibly damaging	0.90
R8802:Fat2	UTSW	11	55,173,750 (GRCm39)	missense	possibly damaging	0.95
R8902:Fat2	UTSW	11	55,200,896 (GRCm39)	missense	probably damaging	1.00
R8940:Fat2	UTSW	11	55,147,636 (GRCm39)	missense	possibly damaging	0.48
R8956:Fat2	UTSW	11	55,173,729 (GRCm39)	missense	probably damaging	1.00
R9035:Fat2	UTSW	11	55,194,547 (GRCm39)	missense	probably damaging	0.99
R9100:Fat2	UTSW	11	55,153,347 (GRCm39)	missense	probably damaging	1.00
R9132:Fat2	UTSW	11	55,189,436 (GRCm39)	missense	possibly damaging	0.88
R9173:Fat2	UTSW	11	55,169,763 (GRCm39)	missense	probably damaging	1.00
R9241:Fat2	UTSW	11	55,147,566 (GRCm39)	missense	probably benign	0.00
R9253:Fat2	UTSW	11	55,201,397 (GRCm39)	missense	probably damaging	1.00
R9280:Fat2	UTSW	11	55,201,523 (GRCm39)	missense	probably benign	0.36
R9351:Fat2	UTSW	11	55,172,127 (GRCm39)	missense	probably damaging	1.00
R9369:Fat2	UTSW	11	55,201,514 (GRCm39)	missense	possibly damaging	0.67
R9404:Fat2	UTSW	11	55,144,348 (GRCm39)	critical splice donor site	probably null
R9431:Fat2	UTSW	11	55,142,838 (GRCm39)	missense	probably damaging	1.00
R9484:Fat2	UTSW	11	55,200,752 (GRCm39)	missense	probably damaging	0.99
R9509:Fat2	UTSW	11	55,200,713 (GRCm39)	missense	possibly damaging	0.51
R9514:Fat2	UTSW	11	55,175,808 (GRCm39)	missense	probably damaging	0.98
R9606:Fat2	UTSW	11	55,180,093 (GRCm39)	missense	probably damaging	1.00
R9630:Fat2	UTSW	11	55,147,605 (GRCm39)	missense	probably benign	0.29
R9727:Fat2	UTSW	11	55,159,137 (GRCm39)	missense	probably damaging	1.00
R9736:Fat2	UTSW	11	55,194,751 (GRCm39)	missense	probably damaging	1.00
X0010:Fat2	UTSW	11	55,143,086 (GRCm39)	missense	probably benign	0.00
X0011:Fat2	UTSW	11	55,201,257 (GRCm39)	missense	probably damaging	0.98
X0018:Fat2	UTSW	11	55,187,036 (GRCm39)	missense	probably damaging	1.00
X0028:Fat2	UTSW	11	55,200,240 (GRCm39)	missense	possibly damaging	0.84
X0067:Fat2	UTSW	11	55,174,060 (GRCm39)	missense	possibly damaging	0.48
Z1176:Fat2	UTSW	11	55,175,817 (GRCm39)	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55,173,621 (GRCm39)	missense	probably damaging	1.00
Z1176:Fat2	UTSW	11	55,200,947 (GRCm39)	missense	probably damaging	0.96
Z1176:Fat2	UTSW	11	55,194,526 (GRCm39)	missense	probably damaging	1.00
Z1177:Fat2	UTSW	11	55,169,792 (GRCm39)	nonsense	probably null
Z1186:Fat2	UTSW	11	55,200,625 (GRCm39)	missense	probably benign
Z1186:Fat2	UTSW	11	55,199,796 (GRCm39)	frame shift	probably null
Z1187:Fat2	UTSW	11	55,200,625 (GRCm39)	missense	probably benign
Z1187:Fat2	UTSW	11	55,199,796 (GRCm39)	frame shift	probably null
Z1188:Fat2	UTSW	11	55,200,625 (GRCm39)	missense	probably benign
Z1188:Fat2	UTSW	11	55,199,796 (GRCm39)	frame shift	probably null
Z1189:Fat2	UTSW	11	55,200,625 (GRCm39)	missense	probably benign
Z1189:Fat2	UTSW	11	55,199,796 (GRCm39)	frame shift	probably null
Z1190:Fat2	UTSW	11	55,200,625 (GRCm39)	missense	probably benign
Z1190:Fat2	UTSW	11	55,199,796 (GRCm39)	frame shift	probably null
Z1191:Fat2	UTSW	11	55,200,625 (GRCm39)	missense	probably benign
Z1191:Fat2	UTSW	11	55,199,796 (GRCm39)	frame shift	probably null
Z1192:Fat2	UTSW	11	55,200,625 (GRCm39)	missense	probably benign
Z1192:Fat2	UTSW	11	55,199,796 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- GGCAGATGCTGAAACTCAGG -3'
(R):5'- AGCTCAATATTAGGGCTTTTGATGG -3'

Sequencing Primer
(F):5'- GAAACTCAGGGATGTTGTCATTGAC -3'
(R):5'- GATGGTCTGTATCAAGATACTGCAG -3'

Posted On

2014-06-23