Incidental Mutation 'R1809:Arhgef4'
| ID |
203647 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef4
|
| Ensembl Gene |
ENSMUSG00000037509 |
| Gene Name |
Rho guanine nucleotide exchange factor 4 |
| Synonyms |
Asef, 9330140K16Rik, C230030N03Rik |
| MMRRC Submission |
039838-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1809 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
34717263-34851819 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (1 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 34849636 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124906
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047534]
[ENSMUST00000047664]
[ENSMUST00000159021]
[ENSMUST00000159747]
[ENSMUST00000160855]
[ENSMUST00000162599]
[ENSMUST00000167518]
|
| AlphaFold |
Q7TNR9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047534
|
| SMART Domains |
Protein: ENSMUSP00000042212
Gene: ENSMUSG00000037503
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TCRP1
|
1 |
194 |
1e-108 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000047664
|
| SMART Domains |
Protein: ENSMUSP00000035980
Gene: ENSMUSG00000037509
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
1 |
45 |
6.97e-7 |
SMART |
|
RhoGEF
|
82 |
261 |
3.86e-56 |
SMART |
|
PH
|
294 |
402 |
2.33e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159021
|
| SMART Domains |
Protein: ENSMUSP00000124467
Gene: ENSMUSG00000037509
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
1 |
45 |
6.97e-7 |
SMART |
|
Pfam:RhoGEF
|
82 |
190 |
3.4e-29 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159059
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000159747
|
| SMART Domains |
Protein: ENSMUSP00000124213
Gene: ENSMUSG00000037509
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
584 |
N/A |
INTRINSIC |
|
low complexity region
|
686 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
926 |
N/A |
INTRINSIC |
|
low complexity region
|
1119 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1240 |
1254 |
N/A |
INTRINSIC |
|
SH3
|
1361 |
1416 |
3.73e-16 |
SMART |
|
RhoGEF
|
1453 |
1632 |
3.86e-56 |
SMART |
|
PH
|
1665 |
1773 |
2.33e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160855
|
| SMART Domains |
Protein: ENSMUSP00000124207
Gene: ENSMUSG00000037509
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
1 |
45 |
6.97e-7 |
SMART |
|
Pfam:RhoGEF
|
82 |
187 |
1.2e-21 |
PFAM |
|
low complexity region
|
194 |
211 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000162599
|
| SMART Domains |
Protein: ENSMUSP00000124906
Gene: ENSMUSG00000037509
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
73 |
87 |
N/A |
INTRINSIC |
|
SH3
|
194 |
249 |
3.73e-16 |
SMART |
|
Pfam:RhoGEF
|
304 |
405 |
1.2e-25 |
PFAM |
|
PH
|
438 |
546 |
2.33e-14 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193040
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162760
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167518
|
| SMART Domains |
Protein: ENSMUSP00000131720
Gene: ENSMUSG00000037503
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TCRP1
|
1 |
62 |
3.3e-26 |
PFAM |
|
Pfam:TCRP1
|
54 |
206 |
1.1e-89 |
PFAM |
|
| Meta Mutation Damage Score |
0.9488 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.8%
- 10x: 94.9%
- 20x: 91.2%
|
| Validation Efficiency |
96% (107/111) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1) : Targeted, other(1) |
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim2 |
A |
G |
5: 36,000,614 (GRCm39) |
|
probably benign |
Het |
| Adamts20 |
C |
T |
15: 94,238,968 (GRCm39) |
S750N |
probably damaging |
Het |
| Adh6a |
G |
A |
3: 138,036,722 (GRCm39) |
R370H |
possibly damaging |
Het |
| Akr1b7 |
A |
G |
6: 34,396,046 (GRCm39) |
N183D |
probably damaging |
Het |
| Aktip |
A |
T |
8: 91,856,348 (GRCm39) |
I43N |
probably damaging |
Het |
| Ankrd26 |
A |
T |
6: 118,502,883 (GRCm39) |
|
probably benign |
Het |
| Ano9 |
G |
A |
7: 140,688,717 (GRCm39) |
T144I |
possibly damaging |
Het |
| Anpep |
G |
T |
7: 79,491,571 (GRCm39) |
D143E |
probably benign |
Het |
| Aox1 |
C |
A |
1: 58,333,484 (GRCm39) |
Q234K |
probably benign |
Het |
| Ap1g1 |
C |
G |
8: 110,559,814 (GRCm39) |
|
probably benign |
Het |
| Arsj |
A |
G |
3: 126,231,944 (GRCm39) |
Y230C |
possibly damaging |
Het |
| Asmt |
C |
T |
X: 169,109,480 (GRCm39) |
|
probably benign |
Het |
| Astl |
A |
T |
2: 127,187,405 (GRCm39) |
K72N |
probably damaging |
Het |
| Atp2b2 |
G |
A |
6: 113,780,704 (GRCm39) |
|
probably benign |
Het |
| Baiap2l1 |
A |
C |
5: 144,261,365 (GRCm39) |
|
probably null |
Het |
| C7 |
A |
T |
15: 5,063,821 (GRCm39) |
N193K |
probably damaging |
Het |
| Cacna2d4 |
G |
T |
6: 119,247,785 (GRCm39) |
R362L |
probably damaging |
Het |
| Cct4 |
T |
A |
11: 22,947,615 (GRCm39) |
D189E |
probably benign |
Het |
| Cd300lg |
G |
A |
11: 101,933,938 (GRCm39) |
G62S |
probably benign |
Het |
| Cdk14 |
T |
A |
5: 5,060,901 (GRCm39) |
M307L |
probably damaging |
Het |
| Cfi |
G |
A |
3: 129,666,768 (GRCm39) |
|
probably null |
Het |
| Clec2g |
G |
T |
6: 128,957,273 (GRCm39) |
|
probably null |
Het |
| Cntnap2 |
T |
C |
6: 46,965,609 (GRCm39) |
S807P |
probably damaging |
Het |
| Col6a3 |
T |
A |
1: 90,755,671 (GRCm39) |
H206L |
probably damaging |
Het |
| Ct55 |
A |
G |
X: 52,735,716 (GRCm39) |
E99G |
probably benign |
Het |
| Cyp2c23 |
A |
T |
19: 44,009,997 (GRCm39) |
|
probably benign |
Het |
| Degs1l |
T |
C |
1: 180,887,252 (GRCm39) |
I279T |
probably damaging |
Het |
| Dlec1 |
T |
C |
9: 118,965,767 (GRCm39) |
V1058A |
probably benign |
Het |
| Dpp9 |
A |
G |
17: 56,506,038 (GRCm39) |
Y454H |
probably damaging |
Het |
| Drosha |
G |
A |
15: 12,890,198 (GRCm39) |
G920R |
probably null |
Het |
| Duox2 |
A |
G |
2: 122,114,378 (GRCm39) |
S1142P |
possibly damaging |
Het |
| Fam13a |
C |
T |
6: 58,942,045 (GRCm39) |
|
probably null |
Het |
| Filip1l |
A |
G |
16: 57,327,023 (GRCm39) |
R18G |
probably benign |
Het |
| Foxa1 |
A |
G |
12: 57,589,527 (GRCm39) |
V231A |
probably damaging |
Het |
| Gm4787 |
A |
T |
12: 81,425,303 (GRCm39) |
M285K |
possibly damaging |
Het |
| Gm5084 |
T |
A |
13: 60,360,320 (GRCm39) |
|
noncoding transcript |
Het |
| Gm6788 |
G |
A |
19: 28,740,586 (GRCm39) |
|
noncoding transcript |
Het |
| Gm9922 |
G |
T |
14: 101,966,841 (GRCm39) |
|
probably benign |
Het |
| Gtf3c4 |
A |
T |
2: 28,723,988 (GRCm39) |
Y440* |
probably null |
Het |
| Helq |
A |
G |
5: 100,921,820 (GRCm39) |
S795P |
probably damaging |
Het |
| Helz |
T |
A |
11: 107,489,997 (GRCm39) |
S151T |
possibly damaging |
Het |
| Irgm1 |
T |
C |
11: 48,757,440 (GRCm39) |
T124A |
probably benign |
Het |
| Itgam |
C |
T |
7: 127,670,109 (GRCm39) |
P134S |
possibly damaging |
Het |
| Kdm6a |
T |
C |
X: 18,102,923 (GRCm39) |
Y217H |
probably benign |
Het |
| Kif6 |
T |
C |
17: 50,208,812 (GRCm39) |
L744P |
probably benign |
Het |
| Kmt2c |
C |
T |
5: 25,489,190 (GRCm39) |
R1203H |
probably damaging |
Het |
| Ksr2 |
A |
G |
5: 117,693,535 (GRCm39) |
T328A |
probably damaging |
Het |
| Lig1 |
T |
C |
7: 13,034,281 (GRCm39) |
|
probably benign |
Het |
| Lpar3 |
G |
A |
3: 145,946,303 (GRCm39) |
|
probably benign |
Het |
| Lrrk2 |
T |
C |
15: 91,584,095 (GRCm39) |
F285S |
possibly damaging |
Het |
| Marchf7 |
A |
G |
2: 60,062,637 (GRCm39) |
D148G |
probably benign |
Het |
| Mcee |
T |
C |
7: 64,050,049 (GRCm39) |
L60S |
probably damaging |
Het |
| Mob2 |
A |
G |
7: 141,570,111 (GRCm39) |
I81T |
probably damaging |
Het |
| Mphosph8 |
T |
A |
14: 56,909,909 (GRCm39) |
D87E |
probably damaging |
Het |
| Msantd5f9 |
A |
G |
4: 73,835,754 (GRCm39) |
F237L |
probably benign |
Het |
| Myo1g |
T |
C |
11: 6,462,283 (GRCm39) |
T560A |
probably benign |
Het |
| Nagk |
C |
T |
6: 83,774,169 (GRCm39) |
T42I |
probably benign |
Het |
| Naip1 |
G |
T |
13: 100,562,747 (GRCm39) |
T806K |
probably benign |
Het |
| Ncor2 |
A |
G |
5: 125,195,857 (GRCm39) |
|
probably benign |
Het |
| Ocln |
G |
T |
13: 100,647,967 (GRCm39) |
Y401* |
probably null |
Het |
| Odad2 |
T |
A |
18: 7,211,630 (GRCm39) |
Y748F |
probably benign |
Het |
| Oma1 |
T |
A |
4: 103,182,374 (GRCm39) |
N292K |
probably damaging |
Het |
| Or8b55 |
G |
A |
9: 38,727,443 (GRCm39) |
V215I |
probably benign |
Het |
| Ovch2 |
T |
A |
7: 107,389,412 (GRCm39) |
|
probably null |
Het |
| Pcdhb16 |
T |
C |
18: 37,611,441 (GRCm39) |
F134L |
probably damaging |
Het |
| Pipox |
A |
T |
11: 77,772,360 (GRCm39) |
Y337N |
probably benign |
Het |
| Polr3b |
A |
G |
10: 84,528,865 (GRCm39) |
D763G |
probably damaging |
Het |
| Pygo1 |
T |
A |
9: 72,852,078 (GRCm39) |
N88K |
probably damaging |
Het |
| Rab3gap1 |
T |
C |
1: 127,862,251 (GRCm39) |
M674T |
probably damaging |
Het |
| Rbm25 |
T |
C |
12: 83,719,501 (GRCm39) |
|
probably benign |
Het |
| Rbm26 |
C |
T |
14: 105,354,542 (GRCm39) |
|
probably benign |
Het |
| Rbms2 |
G |
A |
10: 127,974,055 (GRCm39) |
T187I |
possibly damaging |
Het |
| Rnase11 |
T |
A |
14: 51,287,184 (GRCm39) |
R123S |
probably benign |
Het |
| Rngtt |
A |
G |
4: 33,443,614 (GRCm39) |
N485D |
probably benign |
Het |
| Rp1l1 |
A |
T |
14: 64,265,415 (GRCm39) |
M334L |
probably benign |
Het |
| Rps9 |
T |
A |
7: 3,707,726 (GRCm39) |
L56Q |
probably damaging |
Het |
| Saysd1 |
C |
A |
14: 20,133,170 (GRCm39) |
|
probably benign |
Het |
| Sema4d |
C |
T |
13: 51,867,727 (GRCm39) |
|
probably null |
Het |
| Shisa5 |
A |
T |
9: 108,869,998 (GRCm39) |
D34V |
probably damaging |
Het |
| Skil |
A |
G |
3: 31,171,655 (GRCm39) |
D547G |
probably damaging |
Het |
| Slc2a5 |
T |
A |
4: 150,227,514 (GRCm39) |
F444L |
probably damaging |
Het |
| Slc9b2 |
T |
G |
3: 135,022,892 (GRCm39) |
C10G |
possibly damaging |
Het |
| Sorcs2 |
G |
T |
5: 36,386,564 (GRCm39) |
|
probably benign |
Het |
| Stk17b |
T |
G |
1: 53,805,140 (GRCm39) |
K140N |
possibly damaging |
Het |
| Stradb |
T |
A |
1: 59,033,549 (GRCm39) |
L404Q |
possibly damaging |
Het |
| Synj2 |
T |
C |
17: 6,076,826 (GRCm39) |
M432T |
possibly damaging |
Het |
| Tanc1 |
G |
T |
2: 59,630,441 (GRCm39) |
R800L |
probably damaging |
Het |
| Tenm4 |
A |
G |
7: 96,522,987 (GRCm39) |
M1473V |
probably benign |
Het |
| Tesc |
A |
G |
5: 118,199,667 (GRCm39) |
I190V |
probably benign |
Het |
| Tex15 |
T |
C |
8: 34,064,262 (GRCm39) |
F1231L |
probably benign |
Het |
| Thrsp |
T |
C |
7: 97,066,332 (GRCm39) |
I127V |
probably benign |
Het |
| Tlr6 |
A |
T |
5: 65,111,055 (GRCm39) |
C617* |
probably null |
Het |
| Trank1 |
A |
T |
9: 111,221,893 (GRCm39) |
I2877F |
probably benign |
Het |
| Tut4 |
T |
A |
4: 108,406,552 (GRCm39) |
H1373Q |
probably damaging |
Het |
| Ucp1 |
T |
C |
8: 84,024,496 (GRCm39) |
S274P |
probably damaging |
Het |
| Ucp2 |
T |
A |
7: 100,147,606 (GRCm39) |
V195E |
probably damaging |
Het |
| Vars2 |
T |
C |
17: 35,973,108 (GRCm39) |
T394A |
probably damaging |
Het |
| Vmn1r1 |
A |
G |
1: 181,985,371 (GRCm39) |
V98A |
possibly damaging |
Het |
| Vmn1r225 |
A |
G |
17: 20,722,918 (GRCm39) |
I120V |
probably benign |
Het |
| Vmn2r102 |
A |
T |
17: 19,897,881 (GRCm39) |
M299L |
probably benign |
Het |
| Vmn2r25 |
A |
G |
6: 123,802,337 (GRCm39) |
V522A |
probably benign |
Het |
| Vmn2r70 |
T |
C |
7: 85,215,130 (GRCm39) |
I135V |
probably benign |
Het |
| Vwf |
T |
C |
6: 125,567,138 (GRCm39) |
|
probably benign |
Het |
| Zfp446 |
T |
C |
7: 12,713,048 (GRCm39) |
F29L |
probably damaging |
Het |
|
| Other mutations in Arhgef4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00896:Arhgef4
|
APN |
1 |
34,850,777 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02376:Arhgef4
|
APN |
1 |
34,845,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02604:Arhgef4
|
APN |
1 |
34,850,804 (GRCm39) |
nonsense |
probably null |
|
|
IGL03240:Arhgef4
|
APN |
1 |
34,845,107 (GRCm39) |
missense |
probably benign |
0.03 |
|
BB004:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0095:Arhgef4
|
UTSW |
1 |
34,771,451 (GRCm39) |
nonsense |
probably null |
|
|
R0157:Arhgef4
|
UTSW |
1 |
34,845,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0243:Arhgef4
|
UTSW |
1 |
34,846,080 (GRCm39) |
splice site |
probably null |
|
|
R0383:Arhgef4
|
UTSW |
1 |
34,849,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0440:Arhgef4
|
UTSW |
1 |
34,784,529 (GRCm39) |
splice site |
probably null |
|
|
R0452:Arhgef4
|
UTSW |
1 |
34,771,403 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0893:Arhgef4
|
UTSW |
1 |
34,846,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1429:Arhgef4
|
UTSW |
1 |
34,849,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Arhgef4
|
UTSW |
1 |
34,763,026 (GRCm39) |
missense |
unknown |
|
|
R1669:Arhgef4
|
UTSW |
1 |
34,771,239 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1780:Arhgef4
|
UTSW |
1 |
34,763,241 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1879:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R1908:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1919:Arhgef4
|
UTSW |
1 |
34,850,221 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2020:Arhgef4
|
UTSW |
1 |
34,762,891 (GRCm39) |
missense |
unknown |
|
|
R2058:Arhgef4
|
UTSW |
1 |
34,761,458 (GRCm39) |
missense |
unknown |
|
|
R2213:Arhgef4
|
UTSW |
1 |
34,846,230 (GRCm39) |
splice site |
probably null |
|
|
R2851:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2852:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2853:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R3697:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R4012:Arhgef4
|
UTSW |
1 |
34,764,187 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4118:Arhgef4
|
UTSW |
1 |
34,771,428 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4133:Arhgef4
|
UTSW |
1 |
34,845,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4535:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4581:Arhgef4
|
UTSW |
1 |
34,771,205 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4665:Arhgef4
|
UTSW |
1 |
34,845,113 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4678:Arhgef4
|
UTSW |
1 |
34,761,749 (GRCm39) |
missense |
unknown |
|
|
R4684:Arhgef4
|
UTSW |
1 |
34,850,866 (GRCm39) |
splice site |
probably null |
|
|
R4706:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4745:Arhgef4
|
UTSW |
1 |
34,846,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4747:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R4988:Arhgef4
|
UTSW |
1 |
34,762,535 (GRCm39) |
missense |
unknown |
|
|
R5063:Arhgef4
|
UTSW |
1 |
34,763,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5154:Arhgef4
|
UTSW |
1 |
34,771,455 (GRCm39) |
missense |
probably benign |
0.43 |
|
R5156:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R5263:Arhgef4
|
UTSW |
1 |
34,764,078 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5450:Arhgef4
|
UTSW |
1 |
34,846,405 (GRCm39) |
intron |
probably benign |
|
|
R5807:Arhgef4
|
UTSW |
1 |
34,846,696 (GRCm39) |
intron |
probably benign |
|
|
R5863:Arhgef4
|
UTSW |
1 |
34,761,926 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6311:Arhgef4
|
UTSW |
1 |
34,763,062 (GRCm39) |
missense |
unknown |
|
|
R6315:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6316:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6318:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6323:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6324:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6325:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6340:Arhgef4
|
UTSW |
1 |
34,771,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Arhgef4
|
UTSW |
1 |
34,845,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6981:Arhgef4
|
UTSW |
1 |
34,761,533 (GRCm39) |
missense |
unknown |
|
|
R7087:Arhgef4
|
UTSW |
1 |
34,850,767 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7297:Arhgef4
|
UTSW |
1 |
34,846,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Arhgef4
|
UTSW |
1 |
34,848,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7614:Arhgef4
|
UTSW |
1 |
34,771,316 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7693:Arhgef4
|
UTSW |
1 |
34,763,222 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7892:Arhgef4
|
UTSW |
1 |
34,760,885 (GRCm39) |
missense |
unknown |
|
|
R7895:Arhgef4
|
UTSW |
1 |
34,845,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Arhgef4
|
UTSW |
1 |
34,850,762 (GRCm39) |
missense |
probably benign |
|
|
R7973:Arhgef4
|
UTSW |
1 |
34,763,518 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7979:Arhgef4
|
UTSW |
1 |
34,760,978 (GRCm39) |
missense |
unknown |
|
|
R8160:Arhgef4
|
UTSW |
1 |
34,762,655 (GRCm39) |
missense |
unknown |
|
|
R8175:Arhgef4
|
UTSW |
1 |
34,849,455 (GRCm39) |
missense |
probably benign |
|
|
R8178:Arhgef4
|
UTSW |
1 |
34,761,983 (GRCm39) |
missense |
unknown |
|
|
R9046:Arhgef4
|
UTSW |
1 |
34,850,846 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9077:Arhgef4
|
UTSW |
1 |
34,760,824 (GRCm39) |
missense |
unknown |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,849,576 (GRCm39) |
missense |
probably benign |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,764,241 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9355:Arhgef4
|
UTSW |
1 |
34,849,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9489:Arhgef4
|
UTSW |
1 |
34,761,745 (GRCm39) |
missense |
unknown |
|
|
R9509:Arhgef4
|
UTSW |
1 |
34,762,772 (GRCm39) |
missense |
unknown |
|
|
R9605:Arhgef4
|
UTSW |
1 |
34,761,745 (GRCm39) |
missense |
unknown |
|
|
R9665:Arhgef4
|
UTSW |
1 |
34,849,518 (GRCm39) |
missense |
probably benign |
|
|
R9675:Arhgef4
|
UTSW |
1 |
34,845,108 (GRCm39) |
missense |
probably benign |
|
|
R9790:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9791:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF012:Arhgef4
|
UTSW |
1 |
34,763,565 (GRCm39) |
small deletion |
probably benign |
|
|
X0062:Arhgef4
|
UTSW |
1 |
34,763,308 (GRCm39) |
missense |
probably benign |
0.35 |
|
YA93:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,844,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,762,810 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,447 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,002 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGACATGGATGACCTGGAG -3'
(R):5'- AAGGATGGGAAAGGCTTCTC -3'
Sequencing Primer
(F):5'- CCTGGAGGTGGTAGATGTGGAAG -3'
(R):5'- GGAAAGGCTTCTCTAGTTAGTACCC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation