Incidental Mutation 'R1859:Msh4'
| ID |
204196 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Msh4
|
| Ensembl Gene |
ENSMUSG00000005493 |
| Gene Name |
mutS homolog 4 |
| Synonyms |
mMsh4, 4930485C04Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.507)
|
| Stock # |
R1859 (G1)
|
| Quality Score |
124 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
153562783-153611495 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 153611517 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 35
(H35Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005630
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005630]
[ENSMUST00000089950]
[ENSMUST00000167111]
[ENSMUST00000188338]
[ENSMUST00000190449]
[ENSMUST00000196266]
[ENSMUST00000200631]
[ENSMUST00000196956]
[ENSMUST00000197438]
[ENSMUST00000200209]
[ENSMUST00000196565]
|
| AlphaFold |
Q99MT2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000005630
AA Change: H35Q
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000005630
Gene: ENSMUSG00000005493
AA Change: H35Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
91 |
107 |
N/A |
INTRINSIC |
|
Pfam:MutS_II
|
177 |
321 |
2.3e-20 |
PFAM |
|
MUTSd
|
352 |
679 |
3.77e-37 |
SMART |
|
MUTSac
|
695 |
888 |
1.6e-81 |
SMART |
|
Blast:MUTSac
|
912 |
956 |
1e-9 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000082797
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000089950
|
| SMART Domains |
Protein: ENSMUSP00000087396
Gene: ENSMUSG00000038975
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Prenyltrans
|
66 |
109 |
3e-11 |
PFAM |
|
Pfam:Prenyltrans_2
|
72 |
183 |
1.1e-19 |
PFAM |
|
Pfam:Prenyltrans
|
114 |
157 |
2.2e-14 |
PFAM |
|
Pfam:Prenyltrans_1
|
116 |
214 |
1.7e-9 |
PFAM |
|
Pfam:Prenyltrans
|
162 |
205 |
8.1e-18 |
PFAM |
|
Pfam:Prenyltrans
|
210 |
253 |
3.1e-15 |
PFAM |
|
Pfam:Prenyltrans
|
258 |
302 |
3.3e-15 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167111
|
| SMART Domains |
Protein: ENSMUSP00000129481
Gene: ENSMUSG00000038975
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Prenyltrans
|
74 |
117 |
5.9e-12 |
PFAM |
|
Pfam:Prenyltrans
|
122 |
165 |
8.4e-15 |
PFAM |
|
Pfam:Prenyltrans
|
170 |
213 |
2.2e-18 |
PFAM |
|
Pfam:Prenyltrans
|
218 |
261 |
1.2e-15 |
PFAM |
|
Pfam:Prenyltrans
|
266 |
310 |
2.1e-15 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188338
|
| SMART Domains |
Protein: ENSMUSP00000140190
Gene: ENSMUSG00000005493
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MutS_II
|
89 |
233 |
5.3e-19 |
PFAM |
|
MUTSd
|
264 |
591 |
9.4e-40 |
SMART |
|
MUTSac
|
607 |
800 |
4.2e-84 |
SMART |
|
Blast:MUTSac
|
808 |
866 |
4e-17 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190449
|
| SMART Domains |
Protein: ENSMUSP00000140265
Gene: ENSMUSG00000005493
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MutS_II
|
1 |
127 |
3.3e-15 |
PFAM |
|
MUTSd
|
158 |
485 |
9.4e-40 |
SMART |
|
MUTSac
|
501 |
694 |
4.2e-84 |
SMART |
|
Blast:MUTSac
|
702 |
760 |
5e-17 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196266
|
| SMART Domains |
Protein: ENSMUSP00000142682
Gene: ENSMUSG00000038975
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Prenyltrans_2
|
32 |
143 |
9e-10 |
PFAM |
|
Pfam:Prenyltrans
|
74 |
117 |
8.4e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200631
|
| SMART Domains |
Protein: ENSMUSP00000142999
Gene: ENSMUSG00000038975
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Prenyltrans
|
74 |
112 |
5.3e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196956
|
| SMART Domains |
Protein: ENSMUSP00000143458
Gene: ENSMUSG00000038975
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Prenyltrans
|
74 |
117 |
2e-9 |
PFAM |
|
Pfam:Prenyltrans_2
|
80 |
191 |
3.8e-18 |
PFAM |
|
Pfam:Prenyltrans
|
122 |
165 |
1.4e-12 |
PFAM |
|
Pfam:Prenyltrans_1
|
124 |
202 |
4.8e-7 |
PFAM |
|
Pfam:Prenyltrans
|
170 |
201 |
9.5e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000198094
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197438
|
| SMART Domains |
Protein: ENSMUSP00000143551
Gene: ENSMUSG00000038975
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Prenyltrans
|
74 |
112 |
1.8e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000198350
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200209
|
| SMART Domains |
Protein: ENSMUSP00000143452
Gene: ENSMUSG00000038975
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Prenyltrans_2
|
32 |
143 |
9e-10 |
PFAM |
|
Pfam:Prenyltrans
|
74 |
117 |
8.4e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197829
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196565
|
| SMART Domains |
Protein: ENSMUSP00000143258
Gene: ENSMUSG00000038975
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
23 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit male and female sterility associated with failure to undergo pairing during meiosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001K19Rik |
C |
T |
12: 110,637,268 (GRCm39) |
|
probably benign |
Het |
| Adcy10 |
A |
G |
1: 165,349,530 (GRCm39) |
E467G |
probably damaging |
Het |
| Alkbh8 |
A |
G |
9: 3,385,499 (GRCm39) |
D597G |
probably benign |
Het |
| Alpk1 |
T |
A |
3: 127,474,749 (GRCm39) |
H418L |
possibly damaging |
Het |
| Ano5 |
G |
T |
7: 51,196,581 (GRCm39) |
V138L |
probably damaging |
Het |
| Aspg |
T |
A |
12: 112,087,606 (GRCm39) |
I319K |
possibly damaging |
Het |
| Atp9b |
T |
C |
18: 80,793,135 (GRCm39) |
T970A |
possibly damaging |
Het |
| Brd10 |
A |
C |
19: 29,732,323 (GRCm39) |
C230G |
possibly damaging |
Het |
| C4b |
T |
A |
17: 34,954,527 (GRCm39) |
M881L |
probably benign |
Het |
| Cd209c |
A |
T |
8: 3,994,953 (GRCm39) |
N70K |
probably benign |
Het |
| Cdca5 |
T |
C |
19: 6,140,124 (GRCm39) |
V95A |
possibly damaging |
Het |
| Cds2 |
A |
G |
2: 132,144,115 (GRCm39) |
Y297C |
probably damaging |
Het |
| Celsr2 |
C |
T |
3: 108,303,946 (GRCm39) |
G2371S |
probably damaging |
Het |
| Cemip2 |
T |
C |
19: 21,825,341 (GRCm39) |
V1213A |
possibly damaging |
Het |
| Chd5 |
T |
A |
4: 152,464,980 (GRCm39) |
I1557N |
probably benign |
Het |
| Cntn5 |
C |
T |
9: 9,972,839 (GRCm39) |
E266K |
probably damaging |
Het |
| Crtam |
G |
A |
9: 40,884,900 (GRCm39) |
T363M |
possibly damaging |
Het |
| Dnah2 |
A |
G |
11: 69,328,712 (GRCm39) |
S3298P |
probably damaging |
Het |
| Dok1 |
A |
T |
6: 83,009,226 (GRCm39) |
Y209N |
probably damaging |
Het |
| Dpp10 |
T |
C |
1: 123,281,333 (GRCm39) |
D561G |
possibly damaging |
Het |
| Drosha |
A |
G |
15: 12,878,804 (GRCm39) |
K710R |
probably benign |
Het |
| Dse |
T |
C |
10: 34,029,225 (GRCm39) |
T622A |
probably benign |
Het |
| Duxf4 |
A |
G |
10: 58,071,602 (GRCm39) |
V204A |
probably benign |
Het |
| Ercc6 |
T |
C |
14: 32,248,735 (GRCm39) |
S429P |
probably damaging |
Het |
| Fam135a |
A |
T |
1: 24,069,306 (GRCm39) |
V521E |
probably damaging |
Het |
| Fbxl7 |
A |
T |
15: 26,543,279 (GRCm39) |
L456Q |
probably damaging |
Het |
| Fbxo38 |
A |
G |
18: 62,648,489 (GRCm39) |
I683T |
probably damaging |
Het |
| Foxc2 |
G |
T |
8: 121,843,364 (GRCm39) |
R4L |
probably damaging |
Het |
| Glyctk |
C |
T |
9: 106,034,731 (GRCm39) |
V112I |
probably benign |
Het |
| Guf1 |
G |
T |
5: 69,725,803 (GRCm39) |
G481* |
probably null |
Het |
| Heatr1 |
T |
C |
13: 12,418,040 (GRCm39) |
L324S |
probably damaging |
Het |
| Hectd1 |
A |
G |
12: 51,853,350 (GRCm39) |
L57P |
probably damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,532,944 (GRCm39) |
C3080S |
probably damaging |
Het |
| Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
| Ifit1 |
T |
A |
19: 34,624,944 (GRCm39) |
F27I |
probably benign |
Het |
| Ift20 |
G |
T |
11: 78,430,860 (GRCm39) |
E68* |
probably null |
Het |
| Itsn1 |
A |
G |
16: 91,686,042 (GRCm39) |
|
probably benign |
Het |
| Ksr2 |
T |
A |
5: 117,553,006 (GRCm39) |
L38Q |
probably damaging |
Het |
| Lama2 |
A |
T |
10: 26,907,078 (GRCm39) |
M2361K |
possibly damaging |
Het |
| Lrrc56 |
A |
G |
7: 140,787,421 (GRCm39) |
M353V |
probably benign |
Het |
| Lsmem1 |
GTACATACATACATACATACATACATACA |
GTACATACATACATACATACATACATACATACA |
12: 40,235,260 (GRCm39) |
|
probably null |
Het |
| Map3k9 |
A |
T |
12: 81,771,256 (GRCm39) |
S800R |
possibly damaging |
Het |
| Mef2a |
A |
G |
7: 66,915,766 (GRCm39) |
S179P |
probably damaging |
Het |
| Micall1 |
A |
G |
15: 79,007,145 (GRCm39) |
|
probably benign |
Het |
| Mpg |
A |
G |
11: 32,181,957 (GRCm39) |
|
probably null |
Het |
| Mpp7 |
A |
T |
18: 7,350,967 (GRCm39) |
*577K |
probably null |
Het |
| Mst1 |
G |
A |
9: 107,961,545 (GRCm39) |
V601I |
probably benign |
Het |
| Myh10 |
T |
A |
11: 68,636,239 (GRCm39) |
N246K |
probably benign |
Het |
| Myom3 |
C |
A |
4: 135,506,707 (GRCm39) |
N493K |
probably benign |
Het |
| Mypn |
T |
C |
10: 62,981,969 (GRCm39) |
D537G |
probably benign |
Het |
| Ncan |
A |
T |
8: 70,567,998 (GRCm39) |
M38K |
possibly damaging |
Het |
| Ndufaf6 |
G |
T |
4: 11,053,474 (GRCm39) |
H277Q |
probably benign |
Het |
| Nos1 |
A |
T |
5: 118,043,527 (GRCm39) |
N601Y |
possibly damaging |
Het |
| Nrxn2 |
G |
A |
19: 6,538,825 (GRCm39) |
V794I |
probably benign |
Het |
| Or10q12 |
T |
A |
19: 13,746,088 (GRCm39) |
Y127* |
probably null |
Het |
| Or13a17 |
T |
A |
7: 140,271,571 (GRCm39) |
V251E |
possibly damaging |
Het |
| Or13c7b |
A |
T |
4: 43,820,779 (GRCm39) |
I194N |
possibly damaging |
Het |
| Or2y17 |
T |
C |
11: 49,232,211 (GRCm39) |
L284P |
probably damaging |
Het |
| Or8h9 |
T |
C |
2: 86,789,425 (GRCm39) |
I126V |
probably damaging |
Het |
| Parp4 |
T |
C |
14: 56,886,372 (GRCm39) |
V1817A |
unknown |
Het |
| Pfdn1 |
C |
A |
18: 36,584,153 (GRCm39) |
M60I |
probably benign |
Het |
| Ppp1r3c |
T |
C |
19: 36,711,011 (GRCm39) |
N253S |
probably damaging |
Het |
| Prdm5 |
A |
G |
6: 65,808,263 (GRCm39) |
I42V |
probably benign |
Het |
| Prom2 |
T |
G |
2: 127,383,017 (GRCm39) |
Q75P |
probably damaging |
Het |
| Ptpn23 |
T |
C |
9: 110,217,938 (GRCm39) |
D669G |
possibly damaging |
Het |
| Rag1 |
T |
C |
2: 101,474,407 (GRCm39) |
D245G |
probably benign |
Het |
| Rpl22l1 |
T |
A |
3: 28,860,747 (GRCm39) |
|
probably null |
Het |
| Sars2 |
T |
C |
7: 28,443,737 (GRCm39) |
V113A |
probably damaging |
Het |
| Sbno2 |
T |
A |
10: 79,894,473 (GRCm39) |
K1067* |
probably null |
Het |
| Sec61g |
A |
G |
11: 16,456,371 (GRCm39) |
|
probably null |
Het |
| Slc4a11 |
A |
T |
2: 130,529,932 (GRCm39) |
M282K |
probably benign |
Het |
| Slc5a4a |
T |
C |
10: 76,002,569 (GRCm39) |
S242P |
probably benign |
Het |
| Sparc |
A |
T |
11: 55,297,334 (GRCm39) |
|
probably null |
Het |
| Thra |
T |
A |
11: 98,646,977 (GRCm39) |
C33S |
probably damaging |
Het |
| Trrap |
A |
T |
5: 144,767,761 (GRCm39) |
T2293S |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,724,989 (GRCm39) |
|
probably benign |
Het |
| Vat1l |
T |
A |
8: 114,998,041 (GRCm39) |
V195E |
probably damaging |
Het |
| Vmn1r60 |
T |
A |
7: 5,547,549 (GRCm39) |
I184F |
possibly damaging |
Het |
| Wdfy4 |
A |
G |
14: 32,825,940 (GRCm39) |
I1192T |
probably damaging |
Het |
| Zbtb10 |
T |
C |
3: 9,345,446 (GRCm39) |
S737P |
possibly damaging |
Het |
| Zfp553 |
A |
G |
7: 126,834,517 (GRCm39) |
E24G |
probably benign |
Het |
| Zscan30 |
A |
G |
18: 24,104,524 (GRCm39) |
|
noncoding transcript |
Het |
|
| Other mutations in Msh4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00862:Msh4
|
APN |
3 |
153,589,372 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01098:Msh4
|
APN |
3 |
153,583,619 (GRCm39) |
splice site |
probably benign |
|
|
IGL01609:Msh4
|
APN |
3 |
153,603,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01785:Msh4
|
APN |
3 |
153,563,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Msh4
|
APN |
3 |
153,563,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02022:Msh4
|
APN |
3 |
153,592,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02209:Msh4
|
APN |
3 |
153,594,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02224:Msh4
|
APN |
3 |
153,595,822 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02240:Msh4
|
APN |
3 |
153,579,311 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02493:Msh4
|
APN |
3 |
153,583,545 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02576:Msh4
|
APN |
3 |
153,573,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02616:Msh4
|
APN |
3 |
153,563,160 (GRCm39) |
missense |
probably benign |
|
|
IGL02812:Msh4
|
APN |
3 |
153,607,037 (GRCm39) |
splice site |
probably benign |
|
|
IGL02888:Msh4
|
APN |
3 |
153,602,550 (GRCm39) |
nonsense |
probably null |
|
|
IGL02992:Msh4
|
APN |
3 |
153,577,962 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03191:Msh4
|
APN |
3 |
153,575,245 (GRCm39) |
missense |
probably damaging |
0.97 |
|
P0021:Msh4
|
UTSW |
3 |
153,594,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0057:Msh4
|
UTSW |
3 |
153,575,318 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0057:Msh4
|
UTSW |
3 |
153,575,318 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0368:Msh4
|
UTSW |
3 |
153,594,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0377:Msh4
|
UTSW |
3 |
153,602,527 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0631:Msh4
|
UTSW |
3 |
153,572,057 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0632:Msh4
|
UTSW |
3 |
153,602,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0677:Msh4
|
UTSW |
3 |
153,585,004 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0909:Msh4
|
UTSW |
3 |
153,569,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1081:Msh4
|
UTSW |
3 |
153,577,995 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1463:Msh4
|
UTSW |
3 |
153,563,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1476:Msh4
|
UTSW |
3 |
153,569,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1669:Msh4
|
UTSW |
3 |
153,582,357 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1733:Msh4
|
UTSW |
3 |
153,573,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2168:Msh4
|
UTSW |
3 |
153,573,472 (GRCm39) |
nonsense |
probably null |
|
|
R2378:Msh4
|
UTSW |
3 |
153,569,114 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2991:Msh4
|
UTSW |
3 |
153,611,497 (GRCm39) |
missense |
probably benign |
|
|
R3025:Msh4
|
UTSW |
3 |
153,569,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4604:Msh4
|
UTSW |
3 |
153,577,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4757:Msh4
|
UTSW |
3 |
153,585,024 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5205:Msh4
|
UTSW |
3 |
153,572,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5285:Msh4
|
UTSW |
3 |
153,579,350 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5766:Msh4
|
UTSW |
3 |
153,573,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5777:Msh4
|
UTSW |
3 |
153,569,076 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5888:Msh4
|
UTSW |
3 |
153,573,360 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7384:Msh4
|
UTSW |
3 |
153,594,385 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7408:Msh4
|
UTSW |
3 |
153,582,382 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7487:Msh4
|
UTSW |
3 |
153,569,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7503:Msh4
|
UTSW |
3 |
153,573,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7726:Msh4
|
UTSW |
3 |
153,571,957 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7990:Msh4
|
UTSW |
3 |
153,602,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8097:Msh4
|
UTSW |
3 |
153,583,545 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8805:Msh4
|
UTSW |
3 |
153,563,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8814:Msh4
|
UTSW |
3 |
153,577,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8861:Msh4
|
UTSW |
3 |
153,607,105 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8970:Msh4
|
UTSW |
3 |
153,575,369 (GRCm39) |
nonsense |
probably null |
|
|
R9010:Msh4
|
UTSW |
3 |
153,595,819 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9338:Msh4
|
UTSW |
3 |
153,573,444 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9598:Msh4
|
UTSW |
3 |
153,607,148 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9780:Msh4
|
UTSW |
3 |
153,582,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Msh4
|
UTSW |
3 |
153,607,080 (GRCm39) |
start gained |
probably benign |
|
|
Z1177:Msh4
|
UTSW |
3 |
153,585,005 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCCTGGCCAGACTGCTTTC -3'
(R):5'- TCACGTGATGAGAATAAACCGGC -3'
Sequencing Primer
(F):5'- GGCCAGACTGCTTTCTCCAG -3'
(R):5'- GTGATGAGAATAAACCGGCACAACC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation