Incidental Mutation 'R1817:Vmn2r56'
ID 204495
Institutional Source Beutler Lab
Gene Symbol Vmn2r56
Ensembl Gene ENSMUSG00000090762
Gene Name vomeronasal 2, receptor 56
Synonyms EG629079
MMRRC Submission 039845-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R1817 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 12427787-12468785 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 12449542 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 232 (M232K)
Ref Sequence ENSEMBL: ENSMUSP00000129566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163852]
AlphaFold A0A3B2WBA1
Predicted Effect probably benign
Transcript: ENSMUST00000163852
AA Change: M232K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000129566
Gene: ENSMUSG00000090762
AA Change: M232K

DomainStartEndE-ValueType
Pfam:ANF_receptor 5 397 1.9e-55 PFAM
Pfam:NCD3G 439 492 6.4e-20 PFAM
Pfam:7tm_3 523 760 1.3e-53 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.9%
  • 10x: 95.2%
  • 20x: 91.9%
Validation Efficiency 95% (90/95)
Allele List at MGI
Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,110,144 (GRCm39) S600T probably benign Het
Acly T A 11: 100,386,717 (GRCm39) Q615L probably benign Het
Adgrf1 C A 17: 43,620,924 (GRCm39) T387K probably benign Het
Afg3l1 G T 8: 124,228,670 (GRCm39) K745N probably damaging Het
Armc8 T C 9: 99,418,312 (GRCm39) T39A possibly damaging Het
Atm C A 9: 53,403,533 (GRCm39) probably benign Het
Babam2 A G 5: 32,214,890 (GRCm39) T324A probably damaging Het
Btd C A 14: 31,384,246 (GRCm39) D77E possibly damaging Het
Cadm1 T A 9: 47,740,668 (GRCm39) probably benign Het
Card11 A T 5: 140,871,315 (GRCm39) D729E probably benign Het
Ccni G T 5: 93,335,967 (GRCm39) T144K possibly damaging Het
Ceacam23 C T 7: 17,607,255 (GRCm39) noncoding transcript Het
Cecr2 A G 6: 120,708,228 (GRCm39) T77A probably damaging Het
Cgas A G 9: 78,341,593 (GRCm39) probably null Het
Cpsf7 T C 19: 10,512,803 (GRCm39) F296L possibly damaging Het
Cyfip1 C A 7: 55,523,196 (GRCm39) N70K possibly damaging Het
Cyp4a12b A G 4: 115,271,259 (GRCm39) probably benign Het
Ddx20 A T 3: 105,585,896 (GRCm39) Y816* probably null Het
Ddx59 A G 1: 136,360,245 (GRCm39) I420V probably damaging Het
Dgat1 T A 15: 76,386,703 (GRCm39) M445L probably damaging Het
Dnah5 T A 15: 28,246,546 (GRCm39) L628* probably null Het
Dnah7a A C 1: 53,598,307 (GRCm39) D1409E probably benign Het
Dnmt1 T C 9: 20,838,422 (GRCm39) T215A probably benign Het
Dsg4 C T 18: 20,604,302 (GRCm39) T923M probably damaging Het
Enox1 A G 14: 77,852,915 (GRCm39) I394V possibly damaging Het
Esrp2 A T 8: 106,861,250 (GRCm39) M183K probably damaging Het
Fam171a1 C T 2: 3,179,410 (GRCm39) P79S probably benign Het
Fga A G 3: 82,939,082 (GRCm39) T486A probably benign Het
Fkbp10 G T 11: 100,306,715 (GRCm39) A36S probably benign Het
Fnip1 A G 11: 54,393,279 (GRCm39) T572A probably benign Het
Fxn A C 19: 24,257,765 (GRCm39) probably null Het
Gaa C T 11: 119,175,324 (GRCm39) Q901* probably null Het
Gabrg1 A G 5: 70,911,594 (GRCm39) M344T probably benign Het
Galnt7 C T 8: 57,991,212 (GRCm39) V433M probably damaging Het
Gin1 A G 1: 97,712,951 (GRCm39) probably null Het
Hydin A C 8: 111,259,459 (GRCm39) D2477A probably benign Het
Igsf6 T C 7: 120,670,031 (GRCm39) Y37C probably damaging Het
Il18rap A G 1: 40,570,687 (GRCm39) I210V probably benign Het
Kif3a T C 11: 53,489,561 (GRCm39) Y138H probably damaging Het
Klra17 A G 6: 129,845,681 (GRCm39) probably null Het
Lcorl A T 5: 45,952,688 (GRCm39) I55N probably damaging Het
Lrrc49 A G 9: 60,510,059 (GRCm39) S398P possibly damaging Het
Ltv1 A G 10: 13,055,018 (GRCm39) L384S probably damaging Het
Mageb3 A T 2: 121,784,918 (GRCm39) Y261* probably null Het
Mical3 T G 6: 121,019,196 (GRCm39) T9P probably benign Het
Myrip C T 9: 120,217,228 (GRCm39) S49L probably damaging Het
Nrap T C 19: 56,372,487 (GRCm39) probably benign Het
Or2m12 T C 16: 19,104,627 (GRCm39) N289D probably damaging Het
Or4k5 A G 14: 50,385,728 (GRCm39) V201A probably benign Het
Otoa A T 7: 120,759,753 (GRCm39) probably benign Het
Pals2 T G 6: 50,140,411 (GRCm39) F144V probably benign Het
Parp11 T A 6: 127,467,008 (GRCm39) I133N probably damaging Het
Pcnx1 A G 12: 81,965,416 (GRCm39) T528A probably benign Het
Pde4c A G 8: 71,179,638 (GRCm39) H63R probably benign Het
Pdpk1 T C 17: 24,329,878 (GRCm39) K53E probably damaging Het
Pdzd7 A T 19: 45,024,615 (GRCm39) M468K probably damaging Het
Perm1 C A 4: 156,303,061 (GRCm39) P535Q possibly damaging Het
Pgap1 C A 1: 54,575,128 (GRCm39) A265S probably benign Het
Pik3c2a A T 7: 115,975,747 (GRCm39) probably null Het
Plxnd1 T C 6: 115,957,562 (GRCm39) T491A possibly damaging Het
Pms1 A T 1: 53,246,128 (GRCm39) D470E probably benign Het
Prf1 C A 10: 61,138,762 (GRCm39) T240N probably damaging Het
Prune2 A G 19: 17,099,445 (GRCm39) T1650A probably benign Het
Ptprf A G 4: 118,080,462 (GRCm39) L1264P probably benign Het
Ptprs A G 17: 56,726,527 (GRCm39) S948P probably damaging Het
Rapgef1 T C 2: 29,576,268 (GRCm39) V117A probably damaging Het
Rnf123 A G 9: 107,940,125 (GRCm39) V756A probably benign Het
Sez6l2 A G 7: 126,566,291 (GRCm39) E741G probably damaging Het
Shc3 A T 13: 51,626,888 (GRCm39) I125K possibly damaging Het
Smr3a A T 5: 88,155,917 (GRCm39) probably benign Het
Spef2 C T 15: 9,584,194 (GRCm39) E1624K probably damaging Het
St6gal1 A T 16: 23,140,083 (GRCm39) K85* probably null Het
Taf1b T G 12: 24,597,121 (GRCm39) D353E possibly damaging Het
Tcp10b C T 17: 13,286,590 (GRCm39) P180S possibly damaging Het
Tlr9 A T 9: 106,102,142 (GRCm39) M478L probably benign Het
Tpr A T 1: 150,295,654 (GRCm39) E892D probably damaging Het
Trio C T 15: 27,742,581 (GRCm39) W22* probably null Het
Usp14 A G 18: 10,024,673 (GRCm39) V8A probably damaging Het
Vmn2r19 A T 6: 123,307,011 (GRCm39) K506N possibly damaging Het
Vmn2r45 T A 7: 8,475,372 (GRCm39) N552I probably damaging Het
Vps13b T A 15: 35,910,788 (GRCm39) F3517L possibly damaging Het
Yif1a C T 19: 5,142,333 (GRCm39) R247* probably null Het
Zbtb5 A G 4: 44,993,767 (GRCm39) V539A probably benign Het
Zfp180 G A 7: 23,804,652 (GRCm39) R357Q probably damaging Het
Zfp536 A G 7: 37,268,042 (GRCm39) L458P probably damaging Het
Zfp646 G A 7: 127,482,292 (GRCm39) G1490S probably benign Het
Zfp970 C T 2: 177,167,976 (GRCm39) H517Y probably damaging Het
Zranb3 A T 1: 127,945,293 (GRCm39) probably null Het
Other mutations in Vmn2r56
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Vmn2r56 APN 7 12,449,426 (GRCm39) missense probably benign 0.38
IGL01060:Vmn2r56 APN 7 12,447,016 (GRCm39) missense probably damaging 0.97
IGL01433:Vmn2r56 APN 7 12,449,541 (GRCm39) missense probably benign
IGL01859:Vmn2r56 APN 7 12,449,932 (GRCm39) missense probably damaging 1.00
IGL01874:Vmn2r56 APN 7 12,449,602 (GRCm39) missense probably benign 0.03
IGL02208:Vmn2r56 APN 7 12,449,408 (GRCm39) missense probably benign 0.01
PIT4445001:Vmn2r56 UTSW 7 12,449,153 (GRCm39) critical splice donor site probably null
R0077:Vmn2r56 UTSW 7 12,449,332 (GRCm39) missense probably benign 0.01
R0278:Vmn2r56 UTSW 7 12,449,644 (GRCm39) missense probably damaging 0.99
R0512:Vmn2r56 UTSW 7 12,449,350 (GRCm39) missense probably benign
R0658:Vmn2r56 UTSW 7 12,444,235 (GRCm39) missense probably benign 0.10
R0789:Vmn2r56 UTSW 7 12,466,762 (GRCm39) missense probably damaging 1.00
R1534:Vmn2r56 UTSW 7 12,427,954 (GRCm39) missense probably benign
R1731:Vmn2r56 UTSW 7 12,466,972 (GRCm39) missense probably benign
R2047:Vmn2r56 UTSW 7 12,466,918 (GRCm39) missense probably damaging 1.00
R2139:Vmn2r56 UTSW 7 12,446,890 (GRCm39) nonsense probably null
R2160:Vmn2r56 UTSW 7 12,428,146 (GRCm39) missense probably benign 0.43
R2449:Vmn2r56 UTSW 7 12,428,082 (GRCm39) missense possibly damaging 0.67
R2877:Vmn2r56 UTSW 7 12,444,954 (GRCm39) missense probably benign
R2878:Vmn2r56 UTSW 7 12,444,954 (GRCm39) missense probably benign
R4910:Vmn2r56 UTSW 7 12,449,462 (GRCm39) missense possibly damaging 0.64
R5072:Vmn2r56 UTSW 7 12,427,983 (GRCm39) missense probably benign 0.40
R5340:Vmn2r56 UTSW 7 12,449,799 (GRCm39) missense probably damaging 1.00
R5697:Vmn2r56 UTSW 7 12,449,917 (GRCm39) missense probably damaging 1.00
R5798:Vmn2r56 UTSW 7 12,446,892 (GRCm39) missense probably benign 0.00
R6166:Vmn2r56 UTSW 7 12,427,947 (GRCm39) missense probably damaging 1.00
R6290:Vmn2r56 UTSW 7 12,428,809 (GRCm39) missense probably damaging 1.00
R6458:Vmn2r56 UTSW 7 12,427,984 (GRCm39) missense probably damaging 0.99
R6751:Vmn2r56 UTSW 7 12,428,719 (GRCm39) missense probably benign
R6978:Vmn2r56 UTSW 7 12,449,333 (GRCm39) missense probably benign 0.01
R7090:Vmn2r56 UTSW 7 12,449,254 (GRCm39) missense probably damaging 1.00
R7200:Vmn2r56 UTSW 7 12,444,259 (GRCm39) missense probably damaging 1.00
R7861:Vmn2r56 UTSW 7 12,449,351 (GRCm39) missense probably benign 0.00
R8222:Vmn2r56 UTSW 7 12,444,960 (GRCm39) missense probably benign
R8282:Vmn2r56 UTSW 7 12,449,601 (GRCm39) nonsense probably null
R8786:Vmn2r56 UTSW 7 12,449,393 (GRCm39) missense probably damaging 1.00
R8970:Vmn2r56 UTSW 7 12,428,632 (GRCm39) missense probably damaging 1.00
R9230:Vmn2r56 UTSW 7 12,444,237 (GRCm39) missense possibly damaging 0.70
RF002:Vmn2r56 UTSW 7 12,428,757 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- ACACCCTCTGTCACTGTGATG -3'
(R):5'- GGGGTTTGCATTGAATTCTACC -3'

Sequencing Primer
(F):5'- GTTCTGGTAGGGCCACATACAATC -3'
(R):5'- GGTTTGCATTGAATTCTACCTCTATG -3'
Posted On 2014-06-23