Incidental Mutation 'R1819:Tcf12'
| ID |
204715 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tcf12
|
| Ensembl Gene |
ENSMUSG00000032228 |
| Gene Name |
transcription factor 12 |
| Synonyms |
REB, HTF-4, HTF4, HEB, ALF1, HEBAlt, bHLHb20, ME1 |
| MMRRC Submission |
039847-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1819 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
71751534-72019611 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 72016999 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Methionine
at position 36
(T36M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138939
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034755]
[ENSMUST00000183404]
[ENSMUST00000183492]
[ENSMUST00000183594]
[ENSMUST00000183992]
[ENSMUST00000184072]
[ENSMUST00000184107]
[ENSMUST00000184867]
[ENSMUST00000184783]
[ENSMUST00000185117]
[ENSMUST00000184523]
|
| AlphaFold |
Q61286 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000034755
AA Change: T36M
PolyPhen 2
Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000034755
Gene: ENSMUSG00000032228
AA Change: T36M
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4JOL|H
|
177 |
200 |
7e-8 |
PDB |
|
low complexity region
|
208 |
219 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
272 |
N/A |
INTRINSIC |
|
low complexity region
|
352 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
558 |
572 |
N/A |
INTRINSIC |
|
HLH
|
607 |
660 |
7.54e-10 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000183404
AA Change: T36M
PolyPhen 2
Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000139365
Gene: ENSMUSG00000032228
AA Change: T36M
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4JOL|H
|
177 |
200 |
7e-8 |
PDB |
|
low complexity region
|
208 |
219 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
272 |
N/A |
INTRINSIC |
|
low complexity region
|
352 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
558 |
572 |
N/A |
INTRINSIC |
|
HLH
|
607 |
660 |
7.54e-10 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000183492
AA Change: T36M
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000138939
Gene: ENSMUSG00000032228
AA Change: T36M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
89 |
100 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000183594
AA Change: T36M
PolyPhen 2
Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000183992
AA Change: T36M
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000139084
Gene: ENSMUSG00000032228
AA Change: T36M
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4JOL|H
|
177 |
200 |
5e-8 |
PDB |
|
low complexity region
|
208 |
219 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
272 |
N/A |
INTRINSIC |
|
low complexity region
|
352 |
363 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000184072
AA Change: T3M
PolyPhen 2
Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000139284
Gene: ENSMUSG00000032228
AA Change: T3M
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4JOL|H
|
85 |
108 |
4e-8 |
PDB |
|
low complexity region
|
116 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
164 |
180 |
N/A |
INTRINSIC |
|
low complexity region
|
260 |
271 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000184107
AA Change: T36M
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000184867
AA Change: T36M
PolyPhen 2
Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000184783
AA Change: T36M
PolyPhen 2
Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000139364
Gene: ENSMUSG00000032228
AA Change: T36M
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4JOL|H
|
177 |
200 |
7e-8 |
PDB |
|
low complexity region
|
208 |
219 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
272 |
N/A |
INTRINSIC |
|
low complexity region
|
352 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
558 |
572 |
N/A |
INTRINSIC |
|
HLH
|
607 |
660 |
7.54e-10 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000185117
AA Change: T36M
PolyPhen 2
Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000138925
Gene: ENSMUSG00000032228
AA Change: T36M
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4JOL|H
|
177 |
200 |
7e-8 |
PDB |
|
low complexity region
|
208 |
219 |
N/A |
INTRINSIC |
|
low complexity region
|
256 |
272 |
N/A |
INTRINSIC |
|
low complexity region
|
352 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
534 |
548 |
N/A |
INTRINSIC |
|
HLH
|
583 |
636 |
7.54e-10 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000184523
AA Change: T36M
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000138832
Gene: ENSMUSG00000032228
AA Change: T36M
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4JOL|H
|
173 |
196 |
6e-8 |
PDB |
|
low complexity region
|
204 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
252 |
268 |
N/A |
INTRINSIC |
|
low complexity region
|
348 |
359 |
N/A |
INTRINSIC |
|
low complexity region
|
554 |
568 |
N/A |
INTRINSIC |
|
HLH
|
603 |
656 |
7.54e-10 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184806
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184196
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 91.9%
|
| Validation Efficiency |
100% (91/91) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
T |
C |
11: 109,871,882 (GRCm39) |
|
probably null |
Het |
| Abhd17a |
T |
C |
10: 80,422,470 (GRCm39) |
T71A |
probably benign |
Het |
| Acad11 |
G |
A |
9: 103,991,738 (GRCm39) |
|
probably null |
Het |
| Adgrf1 |
C |
A |
17: 43,620,924 (GRCm39) |
T387K |
probably benign |
Het |
| Afdn |
A |
G |
17: 14,071,110 (GRCm39) |
T783A |
probably damaging |
Het |
| Akap13 |
T |
A |
7: 75,258,453 (GRCm39) |
M359K |
probably benign |
Het |
| Asxl3 |
A |
T |
18: 22,655,433 (GRCm39) |
N1148Y |
probably damaging |
Het |
| Atl1 |
T |
C |
12: 70,010,074 (GRCm39) |
S547P |
probably benign |
Het |
| Bace1 |
A |
T |
9: 45,768,460 (GRCm39) |
T252S |
possibly damaging |
Het |
| BC034090 |
A |
G |
1: 155,101,575 (GRCm39) |
S230P |
possibly damaging |
Het |
| Bnc2 |
A |
G |
4: 84,210,111 (GRCm39) |
F778L |
possibly damaging |
Het |
| Capn2 |
T |
A |
1: 182,300,162 (GRCm39) |
K609N |
probably benign |
Het |
| Capn8 |
T |
A |
1: 182,426,391 (GRCm39) |
I242N |
probably damaging |
Het |
| Car9 |
G |
T |
4: 43,512,439 (GRCm39) |
|
probably null |
Het |
| Ccdc180 |
A |
G |
4: 45,926,195 (GRCm39) |
E1135G |
possibly damaging |
Het |
| Ccdc181 |
C |
T |
1: 164,110,047 (GRCm39) |
Q385* |
probably null |
Het |
| Cdh10 |
G |
T |
15: 18,992,051 (GRCm39) |
G437* |
probably null |
Het |
| Ceacam1 |
T |
A |
7: 25,163,285 (GRCm39) |
Q316L |
possibly damaging |
Het |
| Cecr2 |
A |
G |
6: 120,708,228 (GRCm39) |
T77A |
probably damaging |
Het |
| Cers4 |
T |
A |
8: 4,571,232 (GRCm39) |
M267K |
probably benign |
Het |
| Csmd3 |
T |
C |
15: 47,617,131 (GRCm39) |
D1930G |
possibly damaging |
Het |
| Cyp2j11 |
A |
T |
4: 96,185,976 (GRCm39) |
V403D |
probably damaging |
Het |
| Cyp4v3 |
G |
A |
8: 45,768,673 (GRCm39) |
R296C |
possibly damaging |
Het |
| Ddx59 |
A |
G |
1: 136,360,245 (GRCm39) |
I420V |
probably damaging |
Het |
| Dnah5 |
T |
A |
15: 28,246,546 (GRCm39) |
L628* |
probably null |
Het |
| Dnah7a |
A |
C |
1: 53,598,307 (GRCm39) |
D1409E |
probably benign |
Het |
| Dus2 |
T |
A |
8: 106,778,480 (GRCm39) |
W377R |
probably damaging |
Het |
| E330034G19Rik |
A |
G |
14: 24,348,081 (GRCm39) |
D111G |
probably damaging |
Het |
| Erich4 |
C |
T |
7: 25,314,715 (GRCm39) |
R66Q |
possibly damaging |
Het |
| Fcgbp |
G |
T |
7: 27,784,708 (GRCm39) |
R256L |
probably benign |
Het |
| Fdxr |
A |
T |
11: 115,166,930 (GRCm39) |
F53Y |
probably damaging |
Het |
| Fkbp10 |
G |
T |
11: 100,306,715 (GRCm39) |
A36S |
probably benign |
Het |
| Foxo3 |
A |
T |
10: 42,073,607 (GRCm39) |
D84E |
probably benign |
Het |
| Gin1 |
A |
G |
1: 97,712,951 (GRCm39) |
|
probably null |
Het |
| Gli3 |
C |
T |
13: 15,900,377 (GRCm39) |
Q1255* |
probably null |
Het |
| Gm4847 |
T |
A |
1: 166,465,788 (GRCm39) |
H267L |
probably damaging |
Het |
| Gpr171 |
T |
C |
3: 59,005,341 (GRCm39) |
I145V |
probably benign |
Het |
| Gpr68 |
T |
A |
12: 100,844,662 (GRCm39) |
H294L |
possibly damaging |
Het |
| Gys2 |
T |
C |
6: 142,406,912 (GRCm39) |
E148G |
probably damaging |
Het |
| Heatr5b |
T |
C |
17: 79,098,940 (GRCm39) |
D1320G |
probably damaging |
Het |
| Ifnlr1 |
G |
T |
4: 135,413,834 (GRCm39) |
|
probably benign |
Het |
| Ift88 |
G |
A |
14: 57,692,976 (GRCm39) |
E392K |
probably damaging |
Het |
| Igsf9b |
T |
A |
9: 27,222,889 (GRCm39) |
S97T |
probably damaging |
Het |
| Il18rap |
A |
G |
1: 40,570,687 (GRCm39) |
I210V |
probably benign |
Het |
| Kcnj11 |
C |
T |
7: 45,748,580 (GRCm39) |
G248S |
probably benign |
Het |
| Kif28 |
T |
C |
1: 179,533,319 (GRCm39) |
K541E |
possibly damaging |
Het |
| Lilrb4a |
A |
G |
10: 51,372,124 (GRCm39) |
Y205C |
probably damaging |
Het |
| Lima1 |
T |
A |
15: 99,717,817 (GRCm39) |
H63L |
probably benign |
Het |
| Lonrf3 |
A |
G |
X: 35,622,361 (GRCm39) |
I687V |
probably damaging |
Het |
| Lrba |
A |
G |
3: 86,449,941 (GRCm39) |
T2099A |
possibly damaging |
Het |
| Morn5 |
C |
T |
2: 35,942,987 (GRCm39) |
T29M |
probably damaging |
Het |
| Neurl1b |
G |
A |
17: 26,657,674 (GRCm39) |
R22H |
probably benign |
Het |
| Nr2e3 |
T |
C |
9: 59,850,720 (GRCm39) |
I380V |
probably damaging |
Het |
| Oas1c |
G |
A |
5: 120,946,800 (GRCm39) |
A10V |
possibly damaging |
Het |
| Or1e35 |
T |
C |
11: 73,797,505 (GRCm39) |
E271G |
probably benign |
Het |
| Or52e8 |
C |
T |
7: 104,624,605 (GRCm39) |
V196I |
probably benign |
Het |
| P3h3 |
T |
C |
6: 124,831,895 (GRCm39) |
T297A |
probably benign |
Het |
| Pdpk1 |
T |
C |
17: 24,329,878 (GRCm39) |
K53E |
probably damaging |
Het |
| Plec |
C |
T |
15: 76,064,106 (GRCm39) |
R2056Q |
probably damaging |
Het |
| Plxna2 |
T |
A |
1: 194,472,494 (GRCm39) |
N1079K |
probably benign |
Het |
| Prr12 |
G |
C |
7: 44,698,121 (GRCm39) |
|
probably benign |
Het |
| Psip1 |
A |
G |
4: 83,376,400 (GRCm39) |
S480P |
probably benign |
Het |
| Ptpre |
A |
G |
7: 135,270,722 (GRCm39) |
|
probably benign |
Het |
| Pvalb |
A |
C |
15: 78,086,784 (GRCm39) |
V44G |
probably damaging |
Het |
| Rab3c |
T |
G |
13: 110,220,669 (GRCm39) |
Q164P |
possibly damaging |
Het |
| Rubcn |
T |
C |
16: 32,647,284 (GRCm39) |
K703R |
possibly damaging |
Het |
| Setd7 |
T |
G |
3: 51,450,060 (GRCm39) |
H122P |
probably benign |
Het |
| Slc26a8 |
A |
T |
17: 28,903,808 (GRCm39) |
F19I |
probably benign |
Het |
| Slc6a14 |
A |
G |
X: 21,607,286 (GRCm39) |
D625G |
probably benign |
Het |
| Snx6 |
C |
T |
12: 54,830,259 (GRCm39) |
V67I |
possibly damaging |
Het |
| Syngr3 |
A |
G |
17: 24,906,696 (GRCm39) |
F40L |
possibly damaging |
Het |
| Syt8 |
G |
A |
7: 141,991,971 (GRCm39) |
G21R |
possibly damaging |
Het |
| Tagln |
A |
G |
9: 45,842,138 (GRCm39) |
F152L |
probably benign |
Het |
| Tdrd6 |
C |
T |
17: 43,937,442 (GRCm39) |
S1202N |
probably benign |
Het |
| Tekt2 |
T |
C |
4: 126,217,529 (GRCm39) |
K179E |
probably damaging |
Het |
| Tekt4 |
G |
T |
17: 25,692,785 (GRCm39) |
|
probably null |
Het |
| Tmprss5 |
G |
T |
9: 49,018,464 (GRCm39) |
R98L |
probably benign |
Het |
| Tns1 |
G |
T |
1: 73,955,635 (GRCm39) |
|
probably benign |
Het |
| Tpcn1 |
A |
C |
5: 120,674,292 (GRCm39) |
|
probably null |
Het |
| Ttc6 |
T |
C |
12: 57,741,286 (GRCm39) |
|
probably null |
Het |
| Ttf1 |
A |
G |
2: 28,964,796 (GRCm39) |
N706S |
possibly damaging |
Het |
| Washc4 |
C |
T |
10: 83,386,748 (GRCm39) |
T124I |
probably benign |
Het |
| Wdr17 |
A |
T |
8: 55,143,159 (GRCm39) |
S140T |
probably benign |
Het |
| Wdr19 |
A |
T |
5: 65,370,234 (GRCm39) |
I123F |
possibly damaging |
Het |
| Zer1 |
C |
T |
2: 30,000,230 (GRCm39) |
A317T |
probably benign |
Het |
| Zfp474 |
A |
G |
18: 52,771,872 (GRCm39) |
D175G |
probably damaging |
Het |
| Zfp598 |
T |
C |
17: 24,900,104 (GRCm39) |
|
probably benign |
Het |
| Zfp646 |
G |
A |
7: 127,482,292 (GRCm39) |
G1490S |
probably benign |
Het |
| Zranb3 |
A |
T |
1: 127,945,293 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Tcf12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00671:Tcf12
|
APN |
9 |
71,775,400 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01311:Tcf12
|
APN |
9 |
71,765,938 (GRCm39) |
splice site |
probably benign |
|
|
IGL01734:Tcf12
|
APN |
9 |
71,829,930 (GRCm39) |
splice site |
probably null |
|
|
IGL01768:Tcf12
|
APN |
9 |
71,776,278 (GRCm39) |
splice site |
probably null |
|
|
IGL02625:Tcf12
|
APN |
9 |
71,830,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02671:Tcf12
|
APN |
9 |
72,016,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03395:Tcf12
|
APN |
9 |
71,783,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Beneath
|
UTSW |
9 |
71,790,385 (GRCm39) |
splice site |
probably null |
|
|
depauperate
|
UTSW |
9 |
71,775,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Poorly
|
UTSW |
9 |
71,851,298 (GRCm39) |
nonsense |
probably null |
|
|
Poorly2
|
UTSW |
9 |
71,766,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Poorly3
|
UTSW |
9 |
71,922,918 (GRCm39) |
critical splice donor site |
probably null |
|
|
Substandard
|
UTSW |
9 |
71,766,122 (GRCm39) |
missense |
probably null |
0.54 |
|
R0183:Tcf12
|
UTSW |
9 |
71,824,309 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0257:Tcf12
|
UTSW |
9 |
71,765,904 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1126:Tcf12
|
UTSW |
9 |
71,907,715 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1520:Tcf12
|
UTSW |
9 |
71,790,388 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1690:Tcf12
|
UTSW |
9 |
71,777,354 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1850:Tcf12
|
UTSW |
9 |
71,775,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Tcf12
|
UTSW |
9 |
71,765,816 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1888:Tcf12
|
UTSW |
9 |
71,765,816 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2402:Tcf12
|
UTSW |
9 |
71,763,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4445:Tcf12
|
UTSW |
9 |
71,776,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4693:Tcf12
|
UTSW |
9 |
71,776,249 (GRCm39) |
intron |
probably benign |
|
|
R4814:Tcf12
|
UTSW |
9 |
71,777,323 (GRCm39) |
intron |
probably benign |
|
|
R4860:Tcf12
|
UTSW |
9 |
71,766,122 (GRCm39) |
missense |
probably null |
0.54 |
|
R4860:Tcf12
|
UTSW |
9 |
71,766,122 (GRCm39) |
missense |
probably null |
0.54 |
|
R4885:Tcf12
|
UTSW |
9 |
71,766,122 (GRCm39) |
missense |
probably null |
0.54 |
|
R5347:Tcf12
|
UTSW |
9 |
71,792,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5422:Tcf12
|
UTSW |
9 |
71,776,320 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5650:Tcf12
|
UTSW |
9 |
71,792,584 (GRCm39) |
splice site |
probably null |
|
|
R5713:Tcf12
|
UTSW |
9 |
71,792,545 (GRCm39) |
makesense |
probably null |
|
|
R5789:Tcf12
|
UTSW |
9 |
71,792,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5964:Tcf12
|
UTSW |
9 |
71,775,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6012:Tcf12
|
UTSW |
9 |
71,766,229 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6119:Tcf12
|
UTSW |
9 |
71,775,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6240:Tcf12
|
UTSW |
9 |
71,851,298 (GRCm39) |
nonsense |
probably null |
|
|
R6299:Tcf12
|
UTSW |
9 |
71,766,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6449:Tcf12
|
UTSW |
9 |
71,775,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6489:Tcf12
|
UTSW |
9 |
71,922,918 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6984:Tcf12
|
UTSW |
9 |
71,914,041 (GRCm39) |
nonsense |
probably null |
|
|
R7146:Tcf12
|
UTSW |
9 |
71,790,385 (GRCm39) |
splice site |
probably null |
|
|
R7734:Tcf12
|
UTSW |
9 |
71,829,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8007:Tcf12
|
UTSW |
9 |
71,841,905 (GRCm39) |
intron |
probably benign |
|
|
R8161:Tcf12
|
UTSW |
9 |
71,922,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8709:Tcf12
|
UTSW |
9 |
71,830,069 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8709:Tcf12
|
UTSW |
9 |
71,765,787 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8711:Tcf12
|
UTSW |
9 |
71,757,097 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9444:Tcf12
|
UTSW |
9 |
72,018,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9667:Tcf12
|
UTSW |
9 |
71,792,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0021:Tcf12
|
UTSW |
9 |
71,790,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0022:Tcf12
|
UTSW |
9 |
72,017,025 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Tcf12
|
UTSW |
9 |
71,907,742 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCAAGTTTGAGGCGCTAGTAG -3'
(R):5'- TGTCACCGGTTCTCTCAAGC -3'
Sequencing Primer
(F):5'- GCGCTAGTAGTTTATAATTGTAACCG -3'
(R):5'- CACCGGTTCTCTCAAGCAATATTAG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation