Incidental Mutation 'R1837:Mprip'
| ID |
205420 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mprip
|
| Ensembl Gene |
ENSMUSG00000005417 |
| Gene Name |
myosin phosphatase Rho interacting protein |
| Synonyms |
p116 Rho interacting protein, p116Rip, Gm34094, RIP3, Rhoip3 |
| MMRRC Submission |
039864-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.523)
|
| Stock # |
R1837 (G1)
|
| Quality Score |
206 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
59552973-59671686 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 59657571 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 801
(V801A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000119562
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000066330]
[ENSMUST00000072031]
[ENSMUST00000108751]
[ENSMUST00000116371]
[ENSMUST00000133861]
|
| AlphaFold |
P97434 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000066330
AA Change: V2047A
PolyPhen 2
Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000071081
Gene: ENSMUSG00000005417
AA Change: V2047A
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
44 |
152 |
3.33e-10 |
SMART |
|
low complexity region
|
179 |
190 |
N/A |
INTRINSIC |
|
low complexity region
|
221 |
234 |
N/A |
INTRINSIC |
|
Blast:PH
|
249 |
320 |
1e-10 |
BLAST |
|
PH
|
351 |
448 |
3.76e-18 |
SMART |
|
low complexity region
|
492 |
501 |
N/A |
INTRINSIC |
|
low complexity region
|
536 |
555 |
N/A |
INTRINSIC |
|
coiled coil region
|
636 |
671 |
N/A |
INTRINSIC |
|
Blast:PAC
|
806 |
848 |
2e-10 |
BLAST |
|
low complexity region
|
1005 |
1023 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1059 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1128 |
N/A |
INTRINSIC |
|
low complexity region
|
1183 |
1200 |
N/A |
INTRINSIC |
|
coiled coil region
|
1267 |
1300 |
N/A |
INTRINSIC |
|
coiled coil region
|
1617 |
1642 |
N/A |
INTRINSIC |
|
coiled coil region
|
1729 |
1779 |
N/A |
INTRINSIC |
|
coiled coil region
|
1899 |
1936 |
N/A |
INTRINSIC |
|
coiled coil region
|
1960 |
2110 |
N/A |
INTRINSIC |
|
coiled coil region
|
2132 |
2206 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072031
AA Change: V815A
PolyPhen 2
Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000071914
Gene: ENSMUSG00000005417
AA Change: V815A
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
44 |
152 |
3.33e-10 |
SMART |
|
low complexity region
|
179 |
190 |
N/A |
INTRINSIC |
|
low complexity region
|
221 |
234 |
N/A |
INTRINSIC |
|
Blast:PH
|
254 |
320 |
1e-10 |
BLAST |
|
PH
|
387 |
484 |
3.76e-18 |
SMART |
|
low complexity region
|
528 |
537 |
N/A |
INTRINSIC |
|
low complexity region
|
572 |
591 |
N/A |
INTRINSIC |
|
coiled coil region
|
672 |
707 |
N/A |
INTRINSIC |
|
coiled coil region
|
728 |
878 |
N/A |
INTRINSIC |
|
coiled coil region
|
900 |
974 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000108751
AA Change: V777A
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000104382
Gene: ENSMUSG00000005417
AA Change: V777A
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
44 |
152 |
3.33e-10 |
SMART |
|
low complexity region
|
183 |
196 |
N/A |
INTRINSIC |
|
Blast:PH
|
216 |
282 |
1e-10 |
BLAST |
|
PH
|
349 |
446 |
3.76e-18 |
SMART |
|
low complexity region
|
490 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
534 |
553 |
N/A |
INTRINSIC |
|
coiled coil region
|
634 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
690 |
840 |
N/A |
INTRINSIC |
|
coiled coil region
|
862 |
936 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000116371
AA Change: V815A
PolyPhen 2
Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000112072
Gene: ENSMUSG00000005417
AA Change: V815A
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
44 |
152 |
3.33e-10 |
SMART |
|
low complexity region
|
179 |
190 |
N/A |
INTRINSIC |
|
low complexity region
|
221 |
234 |
N/A |
INTRINSIC |
|
Blast:PH
|
254 |
320 |
1e-10 |
BLAST |
|
PH
|
387 |
484 |
3.76e-18 |
SMART |
|
low complexity region
|
528 |
537 |
N/A |
INTRINSIC |
|
low complexity region
|
572 |
591 |
N/A |
INTRINSIC |
|
coiled coil region
|
672 |
707 |
N/A |
INTRINSIC |
|
coiled coil region
|
728 |
878 |
N/A |
INTRINSIC |
|
coiled coil region
|
900 |
974 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000132620
AA Change: V625A
|
| SMART Domains |
Protein: ENSMUSP00000119422
Gene: ENSMUSG00000005417
AA Change: V625A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
26 |
37 |
N/A |
INTRINSIC |
|
low complexity region
|
68 |
81 |
N/A |
INTRINSIC |
|
Blast:PH
|
101 |
167 |
9e-11 |
BLAST |
|
PH
|
198 |
295 |
3.76e-18 |
SMART |
|
low complexity region
|
339 |
348 |
N/A |
INTRINSIC |
|
low complexity region
|
383 |
402 |
N/A |
INTRINSIC |
|
coiled coil region
|
482 |
517 |
N/A |
INTRINSIC |
|
coiled coil region
|
538 |
688 |
N/A |
INTRINSIC |
|
coiled coil region
|
710 |
784 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000133861
AA Change: V801A
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000119562
Gene: ENSMUSG00000005417
AA Change: V801A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
18 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
58 |
N/A |
INTRINSIC |
|
low complexity region
|
89 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
152 |
162 |
N/A |
INTRINSIC |
|
low complexity region
|
259 |
269 |
N/A |
INTRINSIC |
|
PH
|
373 |
470 |
3.76e-18 |
SMART |
|
low complexity region
|
514 |
523 |
N/A |
INTRINSIC |
|
low complexity region
|
558 |
577 |
N/A |
INTRINSIC |
|
coiled coil region
|
658 |
693 |
N/A |
INTRINSIC |
|
coiled coil region
|
714 |
864 |
N/A |
INTRINSIC |
|
coiled coil region
|
886 |
960 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000156111
AA Change: V288A
|
| SMART Domains |
Protein: ENSMUSP00000114446
Gene: ENSMUSG00000005417
AA Change: V288A
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
5 |
38 |
1.61e-7 |
PROSPERO |
|
internal_repeat_2
|
9 |
51 |
2.4e-6 |
PROSPERO |
|
internal_repeat_1
|
59 |
92 |
1.61e-7 |
PROSPERO |
|
internal_repeat_2
|
85 |
129 |
2.4e-6 |
PROSPERO |
|
coiled coil region
|
140 |
177 |
N/A |
INTRINSIC |
|
coiled coil region
|
201 |
351 |
N/A |
INTRINSIC |
|
coiled coil region
|
373 |
447 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0896 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 94.9%
- 20x: 91.6%
|
| Validation Efficiency |
99% (86/87) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actl10 |
G |
T |
2: 154,394,962 (GRCm39) |
G305W |
probably damaging |
Het |
| Actr3b |
A |
T |
5: 26,030,157 (GRCm39) |
T74S |
probably benign |
Het |
| Add2 |
A |
G |
6: 86,095,540 (GRCm39) |
E652G |
probably damaging |
Het |
| Alg9 |
T |
A |
9: 50,717,615 (GRCm39) |
V83D |
probably damaging |
Het |
| Atp13a2 |
T |
A |
4: 140,721,643 (GRCm39) |
Y244* |
probably null |
Het |
| BB014433 |
C |
G |
8: 15,092,629 (GRCm39) |
V75L |
unknown |
Het |
| Bcr |
A |
G |
10: 75,003,932 (GRCm39) |
|
probably benign |
Het |
| Begain |
G |
A |
12: 109,001,249 (GRCm39) |
|
probably benign |
Het |
| Bzw1 |
A |
G |
1: 58,439,277 (GRCm39) |
K67E |
probably damaging |
Het |
| Ccdc141 |
T |
C |
2: 76,842,009 (GRCm39) |
E1474G |
probably benign |
Het |
| Cdc73 |
T |
A |
1: 143,543,395 (GRCm39) |
T314S |
possibly damaging |
Het |
| Cfap206 |
T |
C |
4: 34,728,813 (GRCm39) |
T31A |
probably damaging |
Het |
| Cfap58 |
G |
A |
19: 48,017,578 (GRCm39) |
E813K |
probably damaging |
Het |
| Clstn2 |
C |
A |
9: 97,465,593 (GRCm39) |
A133S |
probably benign |
Het |
| Col14a1 |
A |
T |
15: 55,245,891 (GRCm39) |
D465V |
unknown |
Het |
| Col2a1 |
C |
T |
15: 97,894,522 (GRCm39) |
|
probably benign |
Het |
| Dab2 |
A |
G |
15: 6,365,957 (GRCm39) |
|
probably benign |
Het |
| Eme1 |
T |
C |
11: 94,536,787 (GRCm39) |
D464G |
probably benign |
Het |
| Eml6 |
T |
C |
11: 29,699,802 (GRCm39) |
|
probably null |
Het |
| Ern1 |
C |
A |
11: 106,349,783 (GRCm39) |
L44F |
probably damaging |
Het |
| Fam111a |
T |
A |
19: 12,564,816 (GRCm39) |
S188R |
probably benign |
Het |
| Fam151b |
A |
T |
13: 92,610,639 (GRCm39) |
|
probably benign |
Het |
| Fmo6 |
T |
C |
1: 162,750,379 (GRCm39) |
N226D |
probably benign |
Het |
| Ggt1 |
A |
G |
10: 75,415,128 (GRCm39) |
D214G |
probably benign |
Het |
| Gm14226 |
A |
G |
2: 154,866,930 (GRCm39) |
I296V |
probably benign |
Het |
| Gm9915 |
A |
T |
1: 42,269,847 (GRCm39) |
|
noncoding transcript |
Het |
| Heatr5b |
T |
C |
17: 79,128,180 (GRCm39) |
D485G |
possibly damaging |
Het |
| Helz2 |
A |
T |
2: 180,871,082 (GRCm39) |
I2785N |
probably damaging |
Het |
| Htt |
C |
T |
5: 34,976,367 (GRCm39) |
T723M |
probably benign |
Het |
| Hydin |
C |
A |
8: 111,296,257 (GRCm39) |
H3595Q |
probably benign |
Het |
| Il6ra |
T |
C |
3: 89,797,579 (GRCm39) |
D96G |
probably benign |
Het |
| Kif5a |
G |
A |
10: 127,072,684 (GRCm39) |
Q702* |
probably null |
Het |
| Klhdc7a |
G |
T |
4: 139,694,381 (GRCm39) |
P189T |
probably benign |
Het |
| Krt7 |
A |
G |
15: 101,317,463 (GRCm39) |
D252G |
probably benign |
Het |
| Lad1 |
C |
A |
1: 135,757,444 (GRCm39) |
D394E |
probably benign |
Het |
| Lhx8 |
A |
T |
3: 154,033,692 (GRCm39) |
C38S |
possibly damaging |
Het |
| Lta4h |
C |
T |
10: 93,305,037 (GRCm39) |
T280M |
probably damaging |
Het |
| Magi2 |
A |
T |
5: 20,670,825 (GRCm39) |
T163S |
probably damaging |
Het |
| Med1 |
G |
T |
11: 98,060,238 (GRCm39) |
D230E |
probably damaging |
Het |
| Mmp1b |
A |
T |
9: 7,386,409 (GRCm39) |
F171I |
probably damaging |
Het |
| Mtrf1 |
A |
G |
14: 79,639,273 (GRCm39) |
E135G |
possibly damaging |
Het |
| Muc5ac |
T |
A |
7: 141,360,823 (GRCm39) |
M1378K |
probably benign |
Het |
| Myo3a |
A |
T |
2: 22,467,604 (GRCm39) |
Q286L |
possibly damaging |
Het |
| Ndor1 |
C |
T |
2: 25,138,408 (GRCm39) |
G391R |
probably damaging |
Het |
| Nefl |
C |
T |
14: 68,324,075 (GRCm39) |
R438C |
probably damaging |
Het |
| Nlrp3 |
G |
A |
11: 59,439,742 (GRCm39) |
V440I |
probably benign |
Het |
| Notch3 |
A |
T |
17: 32,343,296 (GRCm39) |
L1959Q |
probably damaging |
Het |
| Noto |
A |
G |
6: 85,401,159 (GRCm39) |
T63A |
probably benign |
Het |
| Oc90 |
G |
A |
15: 65,761,529 (GRCm39) |
T163M |
probably damaging |
Het |
| Or1l4 |
T |
A |
2: 37,092,114 (GRCm39) |
M287K |
probably benign |
Het |
| Or4c114 |
A |
T |
2: 88,905,176 (GRCm39) |
Y86* |
probably null |
Het |
| Or5an10 |
A |
G |
19: 12,275,740 (GRCm39) |
V252A |
probably damaging |
Het |
| Pdpr |
C |
A |
8: 111,861,366 (GRCm39) |
P787T |
probably damaging |
Het |
| Phlda1 |
A |
G |
10: 111,343,092 (GRCm39) |
Q276R |
probably benign |
Het |
| Ptpn21 |
T |
G |
12: 98,699,885 (GRCm39) |
K10Q |
probably damaging |
Het |
| Ptprb |
A |
G |
10: 116,177,531 (GRCm39) |
E1364G |
probably benign |
Het |
| Rabep1 |
T |
A |
11: 70,795,484 (GRCm39) |
W237R |
probably damaging |
Het |
| Rai1 |
A |
T |
11: 60,080,224 (GRCm39) |
K1429N |
probably damaging |
Het |
| Rapgef1 |
A |
G |
2: 29,627,438 (GRCm39) |
I1027M |
probably damaging |
Het |
| Rit1 |
C |
G |
3: 88,636,477 (GRCm39) |
T127S |
probably damaging |
Het |
| Rpap1 |
A |
C |
2: 119,600,366 (GRCm39) |
|
probably null |
Het |
| Senp7 |
T |
A |
16: 55,978,879 (GRCm39) |
C471S |
probably benign |
Het |
| Slc16a14 |
A |
G |
1: 84,890,120 (GRCm39) |
V395A |
probably benign |
Het |
| Slc45a1 |
C |
T |
4: 150,722,916 (GRCm39) |
G323S |
probably benign |
Het |
| Syne2 |
A |
T |
12: 76,014,434 (GRCm39) |
E3208D |
probably damaging |
Het |
| Tap1 |
C |
T |
17: 34,407,083 (GRCm39) |
A77V |
possibly damaging |
Het |
| Ticam1 |
T |
C |
17: 56,577,799 (GRCm39) |
E432G |
possibly damaging |
Het |
| Tmem192 |
C |
A |
8: 65,416,992 (GRCm39) |
|
probably benign |
Het |
| Trub1 |
T |
C |
19: 57,441,461 (GRCm39) |
V28A |
probably benign |
Het |
| Ttc21b |
A |
T |
2: 66,028,106 (GRCm39) |
L1121H |
probably benign |
Het |
| Ttc38 |
A |
G |
15: 85,735,764 (GRCm39) |
D290G |
probably damaging |
Het |
| Ulk1 |
C |
T |
5: 110,937,247 (GRCm39) |
G683D |
probably damaging |
Het |
| Vmn1r122 |
A |
T |
7: 20,867,291 (GRCm39) |
F255I |
probably benign |
Het |
| Vmn2r68 |
T |
A |
7: 84,882,886 (GRCm39) |
I289F |
probably damaging |
Het |
| Vps39 |
A |
T |
2: 120,155,878 (GRCm39) |
L514H |
probably damaging |
Het |
| Wdr48 |
T |
G |
9: 119,734,482 (GRCm39) |
S134A |
probably damaging |
Het |
| Yap1 |
A |
T |
9: 7,962,350 (GRCm39) |
Y139N |
probably damaging |
Het |
| Ylpm1 |
T |
C |
12: 85,076,107 (GRCm39) |
V486A |
possibly damaging |
Het |
| Zbtb38 |
T |
C |
9: 96,569,048 (GRCm39) |
T679A |
probably benign |
Het |
| Zfp292 |
A |
G |
4: 34,810,264 (GRCm39) |
S927P |
probably damaging |
Het |
| Zfp324 |
C |
T |
7: 12,704,156 (GRCm39) |
T115I |
probably benign |
Het |
| Zfp523 |
T |
A |
17: 28,413,967 (GRCm39) |
I34N |
probably damaging |
Het |
| Zfp945 |
A |
T |
17: 23,070,247 (GRCm39) |
C551S |
probably damaging |
Het |
| Zfp958 |
A |
G |
8: 4,678,590 (GRCm39) |
H205R |
probably damaging |
Het |
| Zfp974 |
G |
A |
7: 27,609,781 (GRCm39) |
P648L |
possibly damaging |
Het |
|
| Other mutations in Mprip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00334:Mprip
|
APN |
11 |
59,639,417 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL00563:Mprip
|
APN |
11 |
59,643,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00905:Mprip
|
APN |
11 |
59,662,994 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL00928:Mprip
|
APN |
11 |
59,635,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01161:Mprip
|
APN |
11 |
59,622,399 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01991:Mprip
|
APN |
11 |
59,645,838 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02491:Mprip
|
APN |
11 |
59,660,857 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03030:Mprip
|
APN |
11 |
59,631,941 (GRCm39) |
splice site |
probably null |
|
|
IGL03056:Mprip
|
APN |
11 |
59,662,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03293:Mprip
|
APN |
11 |
59,586,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0049:Mprip
|
UTSW |
11 |
59,657,571 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0097:Mprip
|
UTSW |
11 |
59,649,317 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0097:Mprip
|
UTSW |
11 |
59,649,317 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0147:Mprip
|
UTSW |
11 |
59,627,899 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0319:Mprip
|
UTSW |
11 |
59,587,864 (GRCm39) |
splice site |
probably benign |
|
|
R0471:Mprip
|
UTSW |
11 |
59,650,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Mprip
|
UTSW |
11 |
59,631,943 (GRCm39) |
splice site |
probably benign |
|
|
R0627:Mprip
|
UTSW |
11 |
59,660,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0864:Mprip
|
UTSW |
11 |
59,649,587 (GRCm39) |
missense |
probably benign |
|
|
R1218:Mprip
|
UTSW |
11 |
59,634,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Mprip
|
UTSW |
11 |
59,650,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Mprip
|
UTSW |
11 |
59,650,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1695:Mprip
|
UTSW |
11 |
59,643,357 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1698:Mprip
|
UTSW |
11 |
59,651,084 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1802:Mprip
|
UTSW |
11 |
59,645,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1862:Mprip
|
UTSW |
11 |
59,649,047 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2094:Mprip
|
UTSW |
11 |
59,640,334 (GRCm39) |
splice site |
probably benign |
|
|
R2107:Mprip
|
UTSW |
11 |
59,660,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2108:Mprip
|
UTSW |
11 |
59,660,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2510:Mprip
|
UTSW |
11 |
59,640,334 (GRCm39) |
splice site |
probably benign |
|
|
R3003:Mprip
|
UTSW |
11 |
59,618,381 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3115:Mprip
|
UTSW |
11 |
59,656,229 (GRCm39) |
splice site |
probably null |
|
|
R3941:Mprip
|
UTSW |
11 |
59,622,328 (GRCm39) |
splice site |
probably benign |
|
|
R4347:Mprip
|
UTSW |
11 |
59,650,279 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4603:Mprip
|
UTSW |
11 |
59,622,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4807:Mprip
|
UTSW |
11 |
59,648,846 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5011:Mprip
|
UTSW |
11 |
59,650,721 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5338:Mprip
|
UTSW |
11 |
59,651,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5549:Mprip
|
UTSW |
11 |
59,651,644 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5569:Mprip
|
UTSW |
11 |
59,651,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5604:Mprip
|
UTSW |
11 |
59,649,293 (GRCm39) |
missense |
probably benign |
|
|
R5615:Mprip
|
UTSW |
11 |
59,649,313 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5846:Mprip
|
UTSW |
11 |
59,649,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5970:Mprip
|
UTSW |
11 |
59,648,547 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6054:Mprip
|
UTSW |
11 |
59,649,251 (GRCm39) |
missense |
probably benign |
|
|
R6452:Mprip
|
UTSW |
11 |
59,643,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6457:Mprip
|
UTSW |
11 |
59,649,815 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6544:Mprip
|
UTSW |
11 |
59,648,552 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6750:Mprip
|
UTSW |
11 |
59,586,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6843:Mprip
|
UTSW |
11 |
59,650,554 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R6851:Mprip
|
UTSW |
11 |
59,649,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6867:Mprip
|
UTSW |
11 |
59,640,456 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7002:Mprip
|
UTSW |
11 |
59,652,016 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7023:Mprip
|
UTSW |
11 |
59,628,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7764:Mprip
|
UTSW |
11 |
59,655,242 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7765:Mprip
|
UTSW |
11 |
59,649,047 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7828:Mprip
|
UTSW |
11 |
59,627,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7866:Mprip
|
UTSW |
11 |
59,643,756 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R7911:Mprip
|
UTSW |
11 |
59,651,681 (GRCm39) |
missense |
|
|
|
R7979:Mprip
|
UTSW |
11 |
59,657,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8292:Mprip
|
UTSW |
11 |
59,650,340 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8481:Mprip
|
UTSW |
11 |
59,648,982 (GRCm39) |
nonsense |
probably null |
|
|
R8717:Mprip
|
UTSW |
11 |
59,650,526 (GRCm39) |
missense |
probably benign |
|
|
R8810:Mprip
|
UTSW |
11 |
59,587,851 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R8981:Mprip
|
UTSW |
11 |
59,622,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9214:Mprip
|
UTSW |
11 |
59,650,901 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9245:Mprip
|
UTSW |
11 |
59,628,403 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R9748:Mprip
|
UTSW |
11 |
59,656,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Mprip
|
UTSW |
11 |
59,650,310 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Mprip
|
UTSW |
11 |
59,628,230 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1177:Mprip
|
UTSW |
11 |
59,648,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGTAGCATCACCAGTGTGC -3'
(R):5'- CTTAAGTCTCAGGAAGGGCAG -3'
Sequencing Primer
(F):5'- ATCACCAGTGTGCCAGCTG -3'
(R):5'- GGTAGTATCATGGCCAGTAGC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation