Incidental Mutation 'R1855:Mtcl1'
| ID |
206064 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mtcl1
|
| Ensembl Gene |
ENSMUSG00000052105 |
| Gene Name |
microtubule crosslinking factor 1 |
| Synonyms |
1110012J17Rik, Soga2, t8219b25 |
| MMRRC Submission |
039879-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.154)
|
| Stock # |
R1855 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
66643977-66756745 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 66686509 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 447
(V447A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135690
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086693]
[ENSMUST00000097291]
[ENSMUST00000145347]
[ENSMUST00000177034]
|
| AlphaFold |
Q3UHU5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086693
AA Change: V799A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000083899
Gene: ENSMUSG00000052105
AA Change: V799A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
493 |
587 |
1.8e-34 |
PFAM |
|
Pfam:DUF3166
|
622 |
714 |
3.8e-39 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1344 |
3e-40 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
low complexity region
|
1912 |
1924 |
N/A |
INTRINSIC |
|
low complexity region
|
1931 |
1943 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097291
AA Change: V799A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000094894
Gene: ENSMUSG00000052105
AA Change: V799A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
492 |
588 |
1.8e-43 |
PFAM |
|
Pfam:DUF3166
|
621 |
716 |
5e-19 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1392 |
3.9e-49 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129841
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134139
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142154
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144492
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145347
AA Change: V350A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000121387
Gene: ENSMUSG00000052105
AA Change: V350A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
43 |
139 |
9.1e-44 |
PFAM |
|
Pfam:DUF3166
|
172 |
267 |
2.5e-19 |
PFAM |
|
low complexity region
|
394 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
447 |
461 |
N/A |
INTRINSIC |
|
low complexity region
|
513 |
524 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
613 |
N/A |
INTRINSIC |
|
coiled coil region
|
671 |
710 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
771 |
910 |
4.6e-49 |
PFAM |
|
low complexity region
|
1015 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1232 |
N/A |
INTRINSIC |
|
low complexity region
|
1463 |
1475 |
N/A |
INTRINSIC |
|
low complexity region
|
1482 |
1494 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177034
AA Change: V447A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000135690
Gene: ENSMUSG00000052105
AA Change: V447A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
140 |
236 |
1.5e-43 |
PFAM |
|
Pfam:DUF3166
|
269 |
364 |
4e-19 |
PFAM |
|
low complexity region
|
491 |
507 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
558 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
coiled coil region
|
642 |
674 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
809 |
848 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
909 |
1042 |
4e-49 |
PFAM |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
low complexity region
|
1369 |
1378 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.9%
- 10x: 95.3%
- 20x: 92.4%
|
| Validation Efficiency |
97% (72/74) |
| MGI Phenotype |
PHENOTYPE: Global or Purkinje cell-specific homozygous knockout affects Purkinje cell axon and dendrite morphology, resulting in abnormal motor function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A830018L16Rik |
T |
A |
1: 11,818,195 (GRCm39) |
L285Q |
probably damaging |
Het |
| Acaca |
T |
C |
11: 84,262,380 (GRCm39) |
L1994P |
probably damaging |
Het |
| Adamts9 |
A |
G |
6: 92,878,350 (GRCm39) |
|
probably benign |
Het |
| Aff3 |
T |
C |
1: 38,249,385 (GRCm39) |
E574G |
probably benign |
Het |
| Ankrd1 |
T |
C |
19: 36,096,635 (GRCm39) |
K64R |
probably damaging |
Het |
| Arhgap23 |
T |
C |
11: 97,339,523 (GRCm39) |
I163T |
probably damaging |
Het |
| Ascc3 |
A |
T |
10: 50,494,018 (GRCm39) |
Q151L |
probably benign |
Het |
| Atad2 |
G |
A |
15: 57,960,685 (GRCm39) |
P971L |
possibly damaging |
Het |
| C1s1 |
A |
C |
6: 124,511,315 (GRCm39) |
|
probably null |
Het |
| Ccdc150 |
T |
C |
1: 54,407,069 (GRCm39) |
|
probably benign |
Het |
| Cdhr3 |
A |
T |
12: 33,110,351 (GRCm39) |
I311N |
probably damaging |
Het |
| Chad |
T |
A |
11: 94,456,303 (GRCm39) |
L127H |
probably damaging |
Het |
| Clasp1 |
G |
A |
1: 118,436,624 (GRCm39) |
A303T |
probably damaging |
Het |
| Clptm1 |
A |
G |
7: 19,372,134 (GRCm39) |
V234A |
probably benign |
Het |
| Cnih3 |
C |
A |
1: 181,282,186 (GRCm39) |
S140* |
probably null |
Het |
| Col24a1 |
G |
A |
3: 145,164,895 (GRCm39) |
G1033D |
probably damaging |
Het |
| Csnk1a1 |
T |
A |
18: 61,708,498 (GRCm39) |
|
probably null |
Het |
| Cttnbp2 |
T |
A |
6: 18,378,412 (GRCm39) |
I1475L |
probably benign |
Het |
| Dnah5 |
T |
C |
15: 28,411,815 (GRCm39) |
V3728A |
possibly damaging |
Het |
| Dock9 |
C |
A |
14: 121,877,571 (GRCm39) |
V391F |
probably damaging |
Het |
| Ehmt2 |
A |
T |
17: 35,129,752 (GRCm39) |
I949F |
probably damaging |
Het |
| Eif4g1 |
C |
A |
16: 20,505,911 (GRCm39) |
T1025K |
possibly damaging |
Het |
| Enpp2 |
C |
T |
15: 54,709,219 (GRCm39) |
E803K |
probably damaging |
Het |
| Esrrg |
A |
T |
1: 187,943,295 (GRCm39) |
M423L |
probably damaging |
Het |
| Etnppl |
A |
T |
3: 130,414,371 (GRCm39) |
I89F |
probably benign |
Het |
| Fabp3 |
C |
T |
4: 130,206,180 (GRCm39) |
T57I |
probably benign |
Het |
| Fbln7 |
A |
G |
2: 128,735,755 (GRCm39) |
T248A |
possibly damaging |
Het |
| Galnt9 |
C |
T |
5: 110,763,390 (GRCm39) |
T465M |
probably damaging |
Het |
| Grcc10 |
A |
G |
6: 124,717,541 (GRCm39) |
V57A |
probably benign |
Het |
| Herc1 |
T |
A |
9: 66,298,708 (GRCm39) |
M614K |
possibly damaging |
Het |
| Itch |
C |
T |
2: 155,014,374 (GRCm39) |
|
probably benign |
Het |
| Kdm6b |
C |
A |
11: 69,298,112 (GRCm39) |
A167S |
probably damaging |
Het |
| Kidins220 |
C |
T |
12: 25,106,590 (GRCm39) |
R1348C |
probably damaging |
Het |
| Kif17 |
T |
C |
4: 138,015,582 (GRCm39) |
L577P |
probably benign |
Het |
| Krt25 |
A |
T |
11: 99,209,141 (GRCm39) |
L258Q |
probably damaging |
Het |
| Marchf10 |
T |
C |
11: 105,281,218 (GRCm39) |
T356A |
probably benign |
Het |
| Mical2 |
G |
A |
7: 111,944,489 (GRCm39) |
A940T |
probably benign |
Het |
| Mrpl4 |
A |
G |
9: 20,914,667 (GRCm39) |
E81G |
possibly damaging |
Het |
| Mtor |
C |
A |
4: 148,637,546 (GRCm39) |
N2502K |
probably benign |
Het |
| Notch4 |
G |
A |
17: 34,799,936 (GRCm39) |
D966N |
probably benign |
Het |
| Oip5 |
C |
A |
2: 119,442,271 (GRCm39) |
K214N |
probably benign |
Het |
| Or8a1b |
A |
T |
9: 37,623,266 (GRCm39) |
F103Y |
possibly damaging |
Het |
| Pabir2 |
T |
A |
X: 52,342,933 (GRCm39) |
Q201H |
probably benign |
Het |
| Pak5 |
A |
T |
2: 135,929,429 (GRCm39) |
S585T |
probably benign |
Het |
| Pard3 |
T |
A |
8: 128,174,293 (GRCm39) |
|
probably null |
Het |
| Pcnx2 |
A |
T |
8: 126,534,735 (GRCm39) |
|
probably benign |
Het |
| Pcsk5 |
T |
C |
19: 17,492,556 (GRCm39) |
Y939C |
possibly damaging |
Het |
| Pde1a |
A |
G |
2: 79,728,408 (GRCm39) |
|
probably null |
Het |
| Pde9a |
C |
T |
17: 31,674,094 (GRCm39) |
P60S |
probably damaging |
Het |
| Pikfyve |
C |
A |
1: 65,297,957 (GRCm39) |
T1562K |
probably benign |
Het |
| Plekhg6 |
A |
T |
6: 125,352,802 (GRCm39) |
M115K |
probably damaging |
Het |
| Pogz |
C |
T |
3: 94,786,160 (GRCm39) |
T863I |
probably benign |
Het |
| Ppp1r3a |
A |
T |
6: 14,754,993 (GRCm39) |
W85R |
probably damaging |
Het |
| Rnf123 |
C |
A |
9: 107,938,990 (GRCm39) |
R826L |
probably damaging |
Het |
| Slc1a6 |
T |
A |
10: 78,648,758 (GRCm39) |
V493E |
probably damaging |
Het |
| Slc22a2 |
A |
G |
17: 12,805,699 (GRCm39) |
D150G |
probably damaging |
Het |
| Snap47 |
C |
T |
11: 59,319,159 (GRCm39) |
|
probably benign |
Het |
| Spata22 |
A |
G |
11: 73,231,385 (GRCm39) |
D213G |
probably benign |
Het |
| St6galnac2 |
T |
A |
11: 116,581,141 (GRCm39) |
R60S |
probably benign |
Het |
| Stk32c |
A |
G |
7: 138,701,363 (GRCm39) |
F263S |
probably damaging |
Het |
| Supt6 |
T |
C |
11: 78,123,366 (GRCm39) |
I104V |
possibly damaging |
Het |
| Tex2 |
T |
C |
11: 106,437,702 (GRCm39) |
E158G |
possibly damaging |
Het |
| Tiam2 |
C |
T |
17: 3,465,410 (GRCm39) |
R380C |
probably damaging |
Het |
| Trim25 |
C |
T |
11: 88,906,407 (GRCm39) |
T410I |
probably benign |
Het |
| Usp18 |
T |
A |
6: 121,239,076 (GRCm39) |
C212S |
probably benign |
Het |
| Vmn1r2 |
A |
G |
4: 3,172,588 (GRCm39) |
Y169C |
probably damaging |
Het |
| Wdr33 |
A |
T |
18: 32,039,909 (GRCm39) |
|
probably benign |
Het |
| Xpr1 |
A |
G |
1: 155,159,002 (GRCm39) |
Y597H |
probably benign |
Het |
| Yy1 |
CGGG |
CGGGGGGGGG |
12: 108,759,916 (GRCm39) |
|
probably benign |
Het |
| Zfp54 |
T |
A |
17: 21,654,404 (GRCm39) |
Y299* |
probably null |
Het |
| Zfp566 |
T |
G |
7: 29,777,927 (GRCm39) |
S85R |
probably benign |
Het |
|
| Other mutations in Mtcl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Mtcl1
|
APN |
17 |
66,651,314 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01774:Mtcl1
|
APN |
17 |
66,692,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01918:Mtcl1
|
APN |
17 |
66,675,263 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02000:Mtcl1
|
APN |
17 |
66,661,185 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02074:Mtcl1
|
APN |
17 |
66,673,463 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02338:Mtcl1
|
APN |
17 |
66,686,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02597:Mtcl1
|
APN |
17 |
66,645,016 (GRCm39) |
missense |
probably benign |
|
|
IGL03034:Mtcl1
|
APN |
17 |
66,651,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Mtcl1
|
APN |
17 |
66,686,378 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03184:Mtcl1
|
APN |
17 |
66,661,209 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03240:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Mtcl1
|
UTSW |
17 |
66,745,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4520001:Mtcl1
|
UTSW |
17 |
66,692,907 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R0110:Mtcl1
|
UTSW |
17 |
66,665,109 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R0113:Mtcl1
|
UTSW |
17 |
66,661,237 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0321:Mtcl1
|
UTSW |
17 |
66,686,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Mtcl1
|
UTSW |
17 |
66,645,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Mtcl1
|
UTSW |
17 |
66,645,137 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Mtcl1
|
UTSW |
17 |
66,686,143 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1650:Mtcl1
|
UTSW |
17 |
66,692,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1754:Mtcl1
|
UTSW |
17 |
66,687,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1882:Mtcl1
|
UTSW |
17 |
66,686,315 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1935:Mtcl1
|
UTSW |
17 |
66,686,409 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2063:Mtcl1
|
UTSW |
17 |
66,653,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Mtcl1
|
UTSW |
17 |
66,650,618 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2197:Mtcl1
|
UTSW |
17 |
66,673,427 (GRCm39) |
missense |
probably benign |
|
|
R3196:Mtcl1
|
UTSW |
17 |
66,650,829 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3877:Mtcl1
|
UTSW |
17 |
66,649,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4116:Mtcl1
|
UTSW |
17 |
66,673,476 (GRCm39) |
missense |
probably benign |
|
|
R4204:Mtcl1
|
UTSW |
17 |
66,745,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4373:Mtcl1
|
UTSW |
17 |
66,687,074 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4396:Mtcl1
|
UTSW |
17 |
66,651,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4591:Mtcl1
|
UTSW |
17 |
66,655,506 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4610:Mtcl1
|
UTSW |
17 |
66,684,882 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4681:Mtcl1
|
UTSW |
17 |
66,756,139 (GRCm39) |
missense |
unknown |
|
|
R4922:Mtcl1
|
UTSW |
17 |
66,655,474 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4992:Mtcl1
|
UTSW |
17 |
66,649,834 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5169:Mtcl1
|
UTSW |
17 |
66,650,818 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5542:Mtcl1
|
UTSW |
17 |
66,691,354 (GRCm39) |
intron |
probably benign |
|
|
R5804:Mtcl1
|
UTSW |
17 |
66,650,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5998:Mtcl1
|
UTSW |
17 |
66,675,275 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6163:Mtcl1
|
UTSW |
17 |
66,686,326 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6191:Mtcl1
|
UTSW |
17 |
66,650,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Mtcl1
|
UTSW |
17 |
66,665,129 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6260:Mtcl1
|
UTSW |
17 |
66,650,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6524:Mtcl1
|
UTSW |
17 |
66,655,280 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6884:Mtcl1
|
UTSW |
17 |
66,745,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7199:Mtcl1
|
UTSW |
17 |
66,647,534 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7431:Mtcl1
|
UTSW |
17 |
66,649,901 (GRCm39) |
nonsense |
probably null |
|
|
R7479:Mtcl1
|
UTSW |
17 |
66,686,485 (GRCm39) |
missense |
probably benign |
|
|
R7564:Mtcl1
|
UTSW |
17 |
66,678,322 (GRCm39) |
missense |
probably benign |
|
|
R7608:Mtcl1
|
UTSW |
17 |
66,650,300 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7691:Mtcl1
|
UTSW |
17 |
66,687,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7847:Mtcl1
|
UTSW |
17 |
66,651,328 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Mtcl1
|
UTSW |
17 |
66,678,325 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8262:Mtcl1
|
UTSW |
17 |
66,650,653 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8324:Mtcl1
|
UTSW |
17 |
66,743,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8477:Mtcl1
|
UTSW |
17 |
66,684,942 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8927:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8928:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9016:Mtcl1
|
UTSW |
17 |
66,651,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9048:Mtcl1
|
UTSW |
17 |
66,678,331 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9059:Mtcl1
|
UTSW |
17 |
66,650,606 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Mtcl1
|
UTSW |
17 |
66,650,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9327:Mtcl1
|
UTSW |
17 |
66,645,130 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9398:Mtcl1
|
UTSW |
17 |
66,755,462 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9762:Mtcl1
|
UTSW |
17 |
66,673,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Mtcl1
|
UTSW |
17 |
66,686,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mtcl1
|
UTSW |
17 |
66,650,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
Z1176:Mtcl1
|
UTSW |
17 |
66,686,455 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Mtcl1
|
UTSW |
17 |
66,651,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGCCTTCATCCTCACATTGATGG -3'
(R):5'- ACAGTGATGCCGAGAGTGAC -3'
Sequencing Primer
(F):5'- CACATTGATGGTCTCCAACAAGTGG -3'
(R):5'- AGAGTGACGCGGGCAAG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation