Incidental Mutation 'R1823:Parp4'
| ID |
206597 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp4
|
| Ensembl Gene |
ENSMUSG00000054509 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 4 |
| Synonyms |
VPARP, Adprtl1, C030027K23Rik, VAULT3, p193, PH5P, E230037B21Rik |
| MMRRC Submission |
039851-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.146)
|
| Stock # |
R1823 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
56813076-56897251 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to C
at 56827329 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124258
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000161553]
|
| AlphaFold |
E9PYK3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161553
|
| SMART Domains |
Protein: ENSMUSP00000124258
Gene: ENSMUSG00000054509
| Domain | Start | End | E-Value | Type |
|---|
|
BRCT
|
3 |
84 |
4.32e-9 |
SMART |
|
low complexity region
|
97 |
104 |
N/A |
INTRINSIC |
|
SCOP:d1a26_1
|
252 |
352 |
2e-19 |
SMART |
|
Pfam:PARP
|
371 |
559 |
1.8e-50 |
PFAM |
|
VIT
|
600 |
728 |
1.5e-57 |
SMART |
|
VWA
|
867 |
1030 |
6.08e-13 |
SMART |
|
Blast:14_3_3
|
1149 |
1205 |
5e-10 |
BLAST |
|
low complexity region
|
1255 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1362 |
N/A |
INTRINSIC |
|
low complexity region
|
1371 |
1394 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1395 |
1416 |
4.48e-6 |
PROSPERO |
|
Pfam:Drf_FH1
|
1443 |
1542 |
3.3e-15 |
PFAM |
|
low complexity region
|
1553 |
1587 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1588 |
1608 |
2.45e-5 |
PROSPERO |
|
low complexity region
|
1695 |
1708 |
N/A |
INTRINSIC |
|
low complexity region
|
1739 |
1750 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 91.6%
|
| Validation Efficiency |
98% (87/89) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy1 |
G |
A |
11: 7,111,312 (GRCm39) |
V868I |
probably benign |
Het |
| Ahnak |
G |
T |
19: 8,982,269 (GRCm39) |
M1184I |
probably damaging |
Het |
| Akap11 |
T |
C |
14: 78,748,928 (GRCm39) |
E1153G |
probably damaging |
Het |
| Amy1 |
T |
C |
3: 113,356,376 (GRCm39) |
N260S |
probably null |
Het |
| Ankrd6 |
A |
G |
4: 32,824,427 (GRCm39) |
L129P |
probably damaging |
Het |
| Aox1 |
A |
T |
1: 58,351,518 (GRCm39) |
T702S |
probably benign |
Het |
| Apobec1 |
G |
T |
6: 122,555,845 (GRCm39) |
T204K |
possibly damaging |
Het |
| Arhgef19 |
A |
G |
4: 140,976,457 (GRCm39) |
R433G |
probably benign |
Het |
| Atf6b |
T |
A |
17: 34,867,618 (GRCm39) |
H110Q |
possibly damaging |
Het |
| Btnl4 |
C |
T |
17: 34,694,826 (GRCm39) |
|
probably null |
Het |
| Camsap2 |
T |
C |
1: 136,201,521 (GRCm39) |
T662A |
possibly damaging |
Het |
| Cbs |
G |
A |
17: 31,843,245 (GRCm39) |
H229Y |
probably damaging |
Het |
| Cct8 |
G |
A |
16: 87,287,442 (GRCm39) |
R111* |
probably null |
Het |
| Cdc42bpb |
C |
T |
12: 111,293,993 (GRCm39) |
A250T |
probably damaging |
Het |
| Chrd |
A |
G |
16: 20,560,097 (GRCm39) |
|
probably benign |
Het |
| Ckap2l |
A |
G |
2: 129,117,499 (GRCm39) |
F559L |
probably damaging |
Het |
| Cltrn |
A |
G |
X: 162,901,230 (GRCm39) |
D184G |
possibly damaging |
Het |
| D630003M21Rik |
T |
C |
2: 158,059,477 (GRCm39) |
Y141C |
probably damaging |
Het |
| Dbf4 |
T |
C |
5: 8,447,539 (GRCm39) |
N557S |
probably benign |
Het |
| Dct |
T |
G |
14: 118,273,935 (GRCm39) |
N324T |
probably benign |
Het |
| Dip2a |
A |
T |
10: 76,114,336 (GRCm39) |
L999* |
probably null |
Het |
| Dock10 |
T |
A |
1: 80,520,814 (GRCm39) |
|
probably null |
Het |
| Dync2li1 |
A |
T |
17: 84,957,225 (GRCm39) |
D330V |
probably damaging |
Het |
| Eif4g3 |
T |
A |
4: 137,907,802 (GRCm39) |
D1267E |
probably benign |
Het |
| Enc1 |
A |
G |
13: 97,382,486 (GRCm39) |
E332G |
possibly damaging |
Het |
| Fat2 |
C |
T |
11: 55,147,606 (GRCm39) |
V3879I |
probably benign |
Het |
| Fh1 |
A |
T |
1: 175,444,114 (GRCm39) |
I117K |
probably damaging |
Het |
| Fkbp15 |
A |
G |
4: 62,255,328 (GRCm39) |
L227P |
probably damaging |
Het |
| Fpr1 |
T |
A |
17: 18,097,315 (GRCm39) |
M225L |
probably benign |
Het |
| Fras1 |
A |
T |
5: 96,918,547 (GRCm39) |
I3528F |
probably damaging |
Het |
| Grm7 |
A |
G |
6: 111,184,730 (GRCm39) |
T354A |
probably benign |
Het |
| Ift27 |
T |
A |
15: 78,057,978 (GRCm39) |
I9F |
possibly damaging |
Het |
| Igf1r |
A |
G |
7: 67,844,729 (GRCm39) |
D834G |
possibly damaging |
Het |
| Igsf9b |
T |
A |
9: 27,243,028 (GRCm39) |
L738Q |
probably damaging |
Het |
| Itgam |
A |
T |
7: 127,663,904 (GRCm39) |
T44S |
probably benign |
Het |
| Ivd |
T |
A |
2: 118,692,515 (GRCm39) |
I5N |
probably benign |
Het |
| Jcad |
T |
C |
18: 4,675,780 (GRCm39) |
S1181P |
probably damaging |
Het |
| Kctd18 |
A |
G |
1: 57,995,524 (GRCm39) |
V251A |
probably benign |
Het |
| Mycbp2 |
A |
G |
14: 103,489,945 (GRCm39) |
V953A |
possibly damaging |
Het |
| Myo18a |
T |
C |
11: 77,715,923 (GRCm39) |
|
probably benign |
Het |
| Myo3a |
A |
T |
2: 22,345,091 (GRCm39) |
Y509F |
probably damaging |
Het |
| Myocd |
C |
A |
11: 65,069,496 (GRCm39) |
M909I |
probably benign |
Het |
| Ndufv3 |
G |
A |
17: 31,750,219 (GRCm39) |
R467Q |
probably damaging |
Het |
| Nkpd1 |
G |
A |
7: 19,257,177 (GRCm39) |
V319M |
probably damaging |
Het |
| Or13p4 |
T |
A |
4: 118,547,389 (GRCm39) |
N87Y |
probably damaging |
Het |
| Or1af1 |
T |
C |
2: 37,110,344 (GRCm39) |
V281A |
probably damaging |
Het |
| Or1p1c |
C |
T |
11: 74,161,043 (GRCm39) |
A276V |
probably damaging |
Het |
| Or2q1 |
G |
T |
6: 42,795,202 (GRCm39) |
A266S |
possibly damaging |
Het |
| Or2t1 |
T |
A |
14: 14,328,774 (GRCm38) |
L221Q |
probably damaging |
Het |
| Or4c111 |
A |
G |
2: 88,843,722 (GRCm39) |
S229P |
probably benign |
Het |
| Or5b101 |
C |
A |
19: 13,005,181 (GRCm39) |
V171L |
probably benign |
Het |
| Pcdhb9 |
A |
G |
18: 37,535,871 (GRCm39) |
T622A |
probably benign |
Het |
| Pdpk1 |
A |
T |
17: 24,317,150 (GRCm39) |
|
probably benign |
Het |
| Pkhd1 |
C |
A |
1: 20,417,681 (GRCm39) |
G2490V |
probably damaging |
Het |
| Plekhg1 |
G |
T |
10: 3,853,658 (GRCm39) |
|
probably null |
Het |
| Plekhh2 |
A |
G |
17: 84,882,617 (GRCm39) |
Y708C |
probably damaging |
Het |
| Pnp |
T |
C |
14: 51,187,786 (GRCm39) |
F107L |
probably damaging |
Het |
| Postn |
T |
A |
3: 54,292,708 (GRCm39) |
|
probably null |
Het |
| Prcp |
A |
T |
7: 92,577,883 (GRCm39) |
D349V |
probably damaging |
Het |
| Prl3a1 |
A |
T |
13: 27,454,177 (GRCm39) |
I52F |
probably damaging |
Het |
| Pym1 |
G |
A |
10: 128,601,913 (GRCm39) |
|
probably benign |
Het |
| Rad9a |
A |
T |
19: 4,247,241 (GRCm39) |
I248N |
probably damaging |
Het |
| Ror2 |
T |
G |
13: 53,264,341 (GRCm39) |
E917A |
probably benign |
Het |
| Rsf1 |
G |
A |
7: 97,229,117 (GRCm39) |
|
probably benign |
Het |
| Sema6d |
A |
G |
2: 124,501,476 (GRCm39) |
|
probably null |
Het |
| Shisal1 |
T |
C |
15: 84,290,669 (GRCm39) |
T213A |
probably benign |
Het |
| Slc4a2 |
C |
T |
5: 24,632,618 (GRCm39) |
A12V |
probably damaging |
Het |
| Slco6b1 |
T |
G |
1: 96,888,901 (GRCm39) |
|
noncoding transcript |
Het |
| Slf2 |
A |
T |
19: 44,923,687 (GRCm39) |
H167L |
possibly damaging |
Het |
| Snx9 |
G |
T |
17: 5,970,946 (GRCm39) |
G429V |
probably damaging |
Het |
| Sod3 |
G |
T |
5: 52,525,504 (GRCm39) |
V68L |
probably benign |
Het |
| Spta1 |
T |
A |
1: 174,074,115 (GRCm39) |
D2351E |
probably benign |
Het |
| Srpk3 |
G |
A |
X: 72,821,561 (GRCm39) |
R425Q |
possibly damaging |
Het |
| Tatdn1 |
C |
T |
15: 58,788,005 (GRCm39) |
G171E |
probably damaging |
Het |
| Tbc1d22a |
T |
C |
15: 86,119,770 (GRCm39) |
V22A |
possibly damaging |
Het |
| Tnfsf9 |
A |
G |
17: 57,412,738 (GRCm39) |
T103A |
probably benign |
Het |
| Tpm3-rs7 |
T |
C |
14: 113,552,595 (GRCm39) |
L163P |
possibly damaging |
Het |
| Trim52 |
T |
A |
14: 106,344,401 (GRCm39) |
C20S |
probably damaging |
Het |
| Ucp1 |
C |
T |
8: 84,020,661 (GRCm39) |
T157I |
probably damaging |
Het |
| Uspl1 |
T |
A |
5: 149,151,224 (GRCm39) |
L794Q |
probably benign |
Het |
| Vmn1r5 |
T |
A |
6: 56,962,580 (GRCm39) |
V85E |
probably damaging |
Het |
| Vmn1r58 |
A |
G |
7: 5,413,405 (GRCm39) |
I275T |
possibly damaging |
Het |
| Vmn2r79 |
A |
G |
7: 86,687,080 (GRCm39) |
I820M |
probably damaging |
Het |
| Wscd1 |
C |
A |
11: 71,651,044 (GRCm39) |
P124T |
probably benign |
Het |
| Zfp780b |
A |
T |
7: 27,662,525 (GRCm39) |
C677S |
possibly damaging |
Het |
|
| Other mutations in Parp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00479:Parp4
|
APN |
14 |
56,853,917 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00571:Parp4
|
APN |
14 |
56,884,810 (GRCm39) |
missense |
unknown |
|
|
IGL00737:Parp4
|
APN |
14 |
56,821,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00793:Parp4
|
APN |
14 |
56,840,334 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01108:Parp4
|
APN |
14 |
56,844,897 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01131:Parp4
|
APN |
14 |
56,823,217 (GRCm39) |
splice site |
probably benign |
|
|
IGL01485:Parp4
|
APN |
14 |
56,859,661 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01704:Parp4
|
APN |
14 |
56,839,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01993:Parp4
|
APN |
14 |
56,848,245 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02125:Parp4
|
APN |
14 |
56,827,959 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02851:Parp4
|
APN |
14 |
56,886,326 (GRCm39) |
missense |
unknown |
|
|
IGL02863:Parp4
|
APN |
14 |
56,886,243 (GRCm39) |
missense |
unknown |
|
|
IGL03065:Parp4
|
APN |
14 |
56,875,326 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03117:Parp4
|
APN |
14 |
56,840,313 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03271:Parp4
|
APN |
14 |
56,823,082 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03309:Parp4
|
APN |
14 |
56,825,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03408:Parp4
|
APN |
14 |
56,839,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
poisonous
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0515_Parp4_195
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
toxic
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
venomous
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
virulent
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0278:Parp4
|
UTSW |
14 |
56,844,980 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0320:Parp4
|
UTSW |
14 |
56,825,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0445:Parp4
|
UTSW |
14 |
56,840,205 (GRCm39) |
splice site |
probably null |
|
|
R0452:Parp4
|
UTSW |
14 |
56,886,300 (GRCm39) |
missense |
unknown |
|
|
R0511:Parp4
|
UTSW |
14 |
56,873,172 (GRCm39) |
splice site |
probably benign |
|
|
R0515:Parp4
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Parp4
|
UTSW |
14 |
56,827,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0959:Parp4
|
UTSW |
14 |
56,885,576 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1342:Parp4
|
UTSW |
14 |
56,827,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1520:Parp4
|
UTSW |
14 |
56,835,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1565:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1649:Parp4
|
UTSW |
14 |
56,827,885 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1666:Parp4
|
UTSW |
14 |
56,861,620 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1781:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R1799:Parp4
|
UTSW |
14 |
56,885,589 (GRCm39) |
missense |
unknown |
|
|
R1859:Parp4
|
UTSW |
14 |
56,886,372 (GRCm39) |
missense |
unknown |
|
|
R1919:Parp4
|
UTSW |
14 |
56,861,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2000:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2032:Parp4
|
UTSW |
14 |
56,866,553 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2034:Parp4
|
UTSW |
14 |
56,871,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2177:Parp4
|
UTSW |
14 |
56,896,746 (GRCm39) |
missense |
unknown |
|
|
R2291:Parp4
|
UTSW |
14 |
56,851,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2865:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3012:Parp4
|
UTSW |
14 |
56,832,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3841:Parp4
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3913:Parp4
|
UTSW |
14 |
56,857,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4064:Parp4
|
UTSW |
14 |
56,861,597 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4201:Parp4
|
UTSW |
14 |
56,829,848 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4288:Parp4
|
UTSW |
14 |
56,844,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4360:Parp4
|
UTSW |
14 |
56,866,661 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4506:Parp4
|
UTSW |
14 |
56,889,761 (GRCm39) |
missense |
unknown |
|
|
R4577:Parp4
|
UTSW |
14 |
56,827,867 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4633:Parp4
|
UTSW |
14 |
56,885,048 (GRCm39) |
missense |
unknown |
|
|
R4762:Parp4
|
UTSW |
14 |
56,848,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4836:Parp4
|
UTSW |
14 |
56,823,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4974:Parp4
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5049:Parp4
|
UTSW |
14 |
56,873,188 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5479:Parp4
|
UTSW |
14 |
56,861,552 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5683:Parp4
|
UTSW |
14 |
56,884,886 (GRCm39) |
nonsense |
probably null |
|
|
R5884:Parp4
|
UTSW |
14 |
56,852,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5965:Parp4
|
UTSW |
14 |
56,861,489 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6001:Parp4
|
UTSW |
14 |
56,878,740 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6027:Parp4
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6230:Parp4
|
UTSW |
14 |
56,844,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6242:Parp4
|
UTSW |
14 |
56,832,856 (GRCm39) |
nonsense |
probably null |
|
|
R6355:Parp4
|
UTSW |
14 |
56,839,757 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6414:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R6418:Parp4
|
UTSW |
14 |
56,858,108 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6477:Parp4
|
UTSW |
14 |
56,884,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6542:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R6759:Parp4
|
UTSW |
14 |
56,857,947 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6995:Parp4
|
UTSW |
14 |
56,851,196 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7002:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7026:Parp4
|
UTSW |
14 |
56,858,049 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7062:Parp4
|
UTSW |
14 |
56,852,216 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7101:Parp4
|
UTSW |
14 |
56,827,430 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7124:Parp4
|
UTSW |
14 |
56,840,256 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7162:Parp4
|
UTSW |
14 |
56,886,333 (GRCm39) |
missense |
unknown |
|
|
R7293:Parp4
|
UTSW |
14 |
56,885,303 (GRCm39) |
small deletion |
probably benign |
|
|
R7297:Parp4
|
UTSW |
14 |
56,885,138 (GRCm39) |
missense |
not run |
|
|
R7337:Parp4
|
UTSW |
14 |
56,839,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Parp4
|
UTSW |
14 |
56,873,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7575:Parp4
|
UTSW |
14 |
56,875,375 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7808:Parp4
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7854:Parp4
|
UTSW |
14 |
56,896,805 (GRCm39) |
missense |
unknown |
|
|
R7960:Parp4
|
UTSW |
14 |
56,832,708 (GRCm39) |
splice site |
probably null |
|
|
R8152:Parp4
|
UTSW |
14 |
56,884,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8344:Parp4
|
UTSW |
14 |
56,886,186 (GRCm39) |
missense |
unknown |
|
|
R8416:Parp4
|
UTSW |
14 |
56,825,271 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8726:Parp4
|
UTSW |
14 |
56,866,556 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8752:Parp4
|
UTSW |
14 |
56,886,073 (GRCm39) |
missense |
unknown |
|
|
R8804:Parp4
|
UTSW |
14 |
56,853,900 (GRCm39) |
nonsense |
probably null |
|
|
R9046:Parp4
|
UTSW |
14 |
56,864,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9176:Parp4
|
UTSW |
14 |
56,873,274 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9303:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9303:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9360:Parp4
|
UTSW |
14 |
56,878,775 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9430:Parp4
|
UTSW |
14 |
56,866,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9491:Parp4
|
UTSW |
14 |
56,832,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9729:Parp4
|
UTSW |
14 |
56,885,888 (GRCm39) |
missense |
unknown |
|
|
RF020:Parp4
|
UTSW |
14 |
56,884,806 (GRCm39) |
missense |
unknown |
|
|
Z1177:Parp4
|
UTSW |
14 |
56,829,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACCTTCGGAAGAGCAGTC -3'
(R):5'- TGAAAATGTCTCCCACAGGCC -3'
Sequencing Primer
(F):5'- GCAGTCGGGTGCTCTTAC -3'
(R):5'- CCTGGCGGCAGAGGAAAAG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation