Incidental Mutation 'R1824:Dscam'
| ID |
206725 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dscam
|
| Ensembl Gene |
ENSMUSG00000050272 |
| Gene Name |
DS cell adhesion molecule |
| Synonyms |
4932410A21Rik, Down syndrome cell adhesion molecule |
| MMRRC Submission |
039852-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1824 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
96392040-96971952 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 96626781 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 376
(V376G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000056040
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000056102]
|
| AlphaFold |
Q9ERC8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000056102
AA Change: V376G
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000056040
Gene: ENSMUSG00000050272
AA Change: V376G
| Domain | Start | End | E-Value | Type |
|---|
|
IG_like
|
37 |
109 |
1.47e0 |
SMART |
|
IG
|
130 |
218 |
8.33e-1 |
SMART |
|
IGc2
|
237 |
300 |
8.7e-13 |
SMART |
|
IGc2
|
326 |
392 |
1.24e-8 |
SMART |
|
IGc2
|
419 |
491 |
1.1e-9 |
SMART |
|
IGc2
|
516 |
582 |
1.99e-7 |
SMART |
|
IGc2
|
608 |
676 |
1.84e-11 |
SMART |
|
IGc2
|
702 |
773 |
6.01e-16 |
SMART |
|
IG
|
794 |
883 |
1.73e-7 |
SMART |
|
FN3
|
885 |
969 |
7.34e-9 |
SMART |
|
FN3
|
985 |
1073 |
4.06e-11 |
SMART |
|
FN3
|
1088 |
1174 |
7.23e-8 |
SMART |
|
FN3
|
1189 |
1270 |
2.6e-9 |
SMART |
|
IGc2
|
1301 |
1366 |
2.05e-9 |
SMART |
|
FN3
|
1380 |
1460 |
7.17e-12 |
SMART |
|
FN3
|
1477 |
1557 |
4.35e1 |
SMART |
|
transmembrane domain
|
1595 |
1617 |
N/A |
INTRINSIC |
|
low complexity region
|
1799 |
1809 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.2%
- 20x: 92.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mice homozygous for a null allele exhibit background-sensitive perinatal lethality associated with respiratory distress, altered C4 ventral root and pre-inspiratory neuron signaling, and abnormal response to hypercapnia. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(9) : Targeted(6) Gene trapped(1) Spontaneous(2)
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930533K18Rik |
T |
C |
10: 70,708,086 (GRCm39) |
|
noncoding transcript |
Het |
| Aadacl2fm1 |
C |
A |
3: 59,840,001 (GRCm39) |
Y24* |
probably null |
Het |
| Abl1 |
T |
A |
2: 31,690,656 (GRCm39) |
M706K |
probably benign |
Het |
| Abtb1 |
T |
C |
6: 88,813,536 (GRCm39) |
T401A |
probably benign |
Het |
| Acd |
A |
G |
8: 106,427,122 (GRCm39) |
L96P |
probably damaging |
Het |
| Arsi |
T |
A |
18: 61,045,369 (GRCm39) |
W20R |
probably damaging |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Asic3 |
C |
T |
5: 24,618,749 (GRCm39) |
Q14* |
probably null |
Het |
| Asxl3 |
T |
A |
18: 22,655,125 (GRCm39) |
I1045N |
probably damaging |
Het |
| Atr |
T |
C |
9: 95,818,474 (GRCm39) |
I2149T |
probably damaging |
Het |
| Begain |
A |
G |
12: 108,999,025 (GRCm39) |
|
probably null |
Het |
| Brca2 |
C |
T |
5: 150,460,387 (GRCm39) |
T554I |
possibly damaging |
Het |
| Brd10 |
T |
C |
19: 29,693,814 (GRCm39) |
N1960S |
probably damaging |
Het |
| C1s2 |
C |
T |
6: 124,612,641 (GRCm39) |
V11I |
probably benign |
Het |
| Cacna1i |
T |
C |
15: 80,260,990 (GRCm39) |
F1333L |
possibly damaging |
Het |
| Camsap2 |
T |
C |
1: 136,201,521 (GRCm39) |
T662A |
possibly damaging |
Het |
| Cep164 |
C |
T |
9: 45,690,226 (GRCm39) |
V1367M |
probably damaging |
Het |
| Cfap46 |
C |
A |
7: 139,219,518 (GRCm39) |
A1316S |
probably benign |
Het |
| Cic |
T |
C |
7: 24,987,691 (GRCm39) |
S553P |
probably damaging |
Het |
| Cilk1 |
T |
A |
9: 78,065,144 (GRCm39) |
D351E |
probably benign |
Het |
| Clcn2 |
C |
T |
16: 20,534,712 (GRCm39) |
A12T |
probably benign |
Het |
| Clip2 |
A |
G |
5: 134,532,081 (GRCm39) |
Y540H |
probably benign |
Het |
| Coil |
A |
G |
11: 88,872,923 (GRCm39) |
N428S |
possibly damaging |
Het |
| Cpxm1 |
A |
C |
2: 130,237,617 (GRCm39) |
V196G |
probably damaging |
Het |
| Cr2 |
A |
G |
1: 194,839,624 (GRCm39) |
V601A |
probably damaging |
Het |
| Cyp3a25 |
T |
A |
5: 145,921,763 (GRCm39) |
K390N |
probably damaging |
Het |
| Dclre1a |
T |
C |
19: 56,535,150 (GRCm39) |
|
probably null |
Het |
| Dennd4a |
G |
C |
9: 64,766,640 (GRCm39) |
|
probably null |
Het |
| Dlg5 |
T |
C |
14: 24,199,512 (GRCm39) |
H1464R |
probably benign |
Het |
| Dmac2 |
T |
G |
7: 25,324,217 (GRCm39) |
M225R |
probably damaging |
Het |
| Dnah8 |
T |
C |
17: 30,950,154 (GRCm39) |
V1991A |
possibly damaging |
Het |
| Dync1li1 |
A |
G |
9: 114,538,252 (GRCm39) |
D203G |
probably benign |
Het |
| Eva1c |
A |
G |
16: 90,663,331 (GRCm39) |
T22A |
probably benign |
Het |
| Fam110b |
A |
G |
4: 5,799,029 (GRCm39) |
D149G |
probably benign |
Het |
| Fras1 |
A |
T |
5: 96,918,547 (GRCm39) |
I3528F |
probably damaging |
Het |
| Fsip1 |
T |
C |
2: 118,063,389 (GRCm39) |
D360G |
probably damaging |
Het |
| Galnt14 |
T |
C |
17: 74,016,934 (GRCm39) |
T41A |
probably benign |
Het |
| Gdf3 |
T |
A |
6: 122,586,921 (GRCm39) |
Q2L |
probably benign |
Het |
| Glrp1 |
A |
G |
1: 88,437,511 (GRCm39) |
|
probably null |
Het |
| Gm3336 |
C |
G |
8: 71,173,066 (GRCm39) |
|
probably null |
Het |
| Gm8674 |
C |
T |
13: 50,054,844 (GRCm39) |
|
noncoding transcript |
Het |
| Gnat1 |
A |
G |
9: 107,553,774 (GRCm39) |
Y226H |
probably damaging |
Het |
| Grk5 |
T |
C |
19: 61,078,410 (GRCm39) |
V489A |
probably damaging |
Het |
| H1f8 |
A |
G |
6: 115,925,719 (GRCm39) |
Y1C |
probably null |
Het |
| Igfbpl1 |
C |
A |
4: 45,826,406 (GRCm39) |
A130S |
probably benign |
Het |
| Impdh1 |
T |
A |
6: 29,205,087 (GRCm39) |
D261V |
probably benign |
Het |
| Itgal |
T |
A |
7: 126,913,232 (GRCm39) |
S610T |
probably damaging |
Het |
| Jcad |
A |
G |
18: 4,649,293 (GRCm39) |
T55A |
probably benign |
Het |
| Jup |
G |
A |
11: 100,264,963 (GRCm39) |
R663* |
probably null |
Het |
| Kalrn |
C |
T |
16: 34,114,585 (GRCm39) |
G556D |
probably damaging |
Het |
| Krt81 |
T |
C |
15: 101,358,020 (GRCm39) |
E411G |
probably damaging |
Het |
| Lcat |
T |
C |
8: 106,666,520 (GRCm39) |
E334G |
probably damaging |
Het |
| Lhcgr |
T |
C |
17: 89,057,585 (GRCm39) |
E302G |
probably benign |
Het |
| Magi1 |
A |
G |
6: 93,676,620 (GRCm39) |
V913A |
possibly damaging |
Het |
| Mrpl19 |
A |
T |
6: 81,941,060 (GRCm39) |
|
probably null |
Het |
| Muc4 |
G |
T |
16: 32,576,307 (GRCm39) |
|
probably benign |
Het |
| Mycbp2 |
A |
G |
14: 103,489,945 (GRCm39) |
V953A |
possibly damaging |
Het |
| Myo3a |
G |
A |
2: 22,401,054 (GRCm39) |
V600I |
probably benign |
Het |
| Ndufv3 |
G |
A |
17: 31,750,219 (GRCm39) |
R467Q |
probably damaging |
Het |
| Ngef |
A |
G |
1: 87,430,986 (GRCm39) |
|
probably null |
Het |
| Nisch |
A |
T |
14: 30,898,389 (GRCm39) |
|
probably benign |
Het |
| Nlrp4c |
G |
A |
7: 6,069,955 (GRCm39) |
|
probably null |
Het |
| Nup153 |
A |
T |
13: 46,867,223 (GRCm39) |
S154T |
probably damaging |
Het |
| Obscn |
A |
G |
11: 58,885,658 (GRCm39) |
|
probably benign |
Het |
| Or2t1 |
T |
A |
14: 14,328,774 (GRCm38) |
L221Q |
probably damaging |
Het |
| Or4a74 |
G |
T |
2: 89,439,693 (GRCm39) |
P251H |
probably damaging |
Het |
| Or6c219 |
T |
C |
10: 129,781,206 (GRCm39) |
M242V |
possibly damaging |
Het |
| Otogl |
T |
C |
10: 107,615,692 (GRCm39) |
N1869S |
probably benign |
Het |
| Phf24 |
G |
T |
4: 42,934,661 (GRCm39) |
C136F |
probably damaging |
Het |
| Phldb2 |
A |
T |
16: 45,646,374 (GRCm39) |
V65E |
probably benign |
Het |
| Pkhd1 |
C |
A |
1: 20,417,681 (GRCm39) |
G2490V |
probably damaging |
Het |
| Prl8a8 |
A |
T |
13: 27,692,433 (GRCm39) |
M186K |
probably damaging |
Het |
| Qars1 |
T |
C |
9: 108,391,809 (GRCm39) |
V70A |
probably damaging |
Het |
| Rac1 |
C |
T |
5: 143,502,980 (GRCm39) |
V14I |
probably benign |
Het |
| Rapgef5 |
T |
A |
12: 117,652,419 (GRCm39) |
|
probably null |
Het |
| Slc16a12 |
G |
A |
19: 34,648,278 (GRCm39) |
T405M |
possibly damaging |
Het |
| Slc17a6 |
A |
G |
7: 51,311,294 (GRCm39) |
Y336C |
probably damaging |
Het |
| Slc30a9 |
T |
C |
5: 67,505,395 (GRCm39) |
L441P |
probably damaging |
Het |
| Slc45a2 |
T |
C |
15: 11,022,172 (GRCm39) |
S305P |
probably damaging |
Het |
| Sod3 |
G |
T |
5: 52,525,504 (GRCm39) |
V68L |
probably benign |
Het |
| Sp1 |
T |
G |
15: 102,339,438 (GRCm39) |
S773A |
possibly damaging |
Het |
| Spen |
C |
A |
4: 141,200,096 (GRCm39) |
G2821C |
probably damaging |
Het |
| Tagap1 |
A |
G |
17: 7,223,425 (GRCm39) |
S424P |
probably benign |
Het |
| Tbc1d22a |
T |
C |
15: 86,119,770 (GRCm39) |
V22A |
possibly damaging |
Het |
| Tfec |
C |
T |
6: 16,840,467 (GRCm39) |
|
probably null |
Het |
| Thsd7a |
A |
T |
6: 12,409,041 (GRCm39) |
|
probably null |
Het |
| Tnfsf15 |
C |
A |
4: 63,651,588 (GRCm39) |
G112V |
probably benign |
Het |
| Tnfsf9 |
A |
G |
17: 57,412,738 (GRCm39) |
T103A |
probably benign |
Het |
| Tnxb |
C |
T |
17: 34,911,307 (GRCm39) |
R1537* |
probably null |
Het |
| Tpra1 |
A |
G |
6: 88,888,805 (GRCm39) |
N329S |
probably benign |
Het |
| Ttc12 |
A |
G |
9: 49,368,184 (GRCm39) |
F281S |
probably damaging |
Het |
| Unc79 |
A |
G |
12: 103,025,579 (GRCm39) |
N322S |
probably damaging |
Het |
| Unk |
G |
T |
11: 115,921,268 (GRCm39) |
|
probably benign |
Het |
| Usp4 |
G |
T |
9: 108,225,207 (GRCm39) |
G31W |
probably damaging |
Het |
| Vcan |
G |
T |
13: 89,853,331 (GRCm39) |
A543D |
possibly damaging |
Het |
| Vil1 |
A |
C |
1: 74,457,606 (GRCm39) |
I80L |
probably benign |
Het |
| Vmn2r27 |
C |
T |
6: 124,208,593 (GRCm39) |
G51S |
probably benign |
Het |
| Vpreb1a |
A |
G |
16: 16,686,935 (GRCm39) |
|
probably null |
Het |
| Zbtb6 |
C |
T |
2: 37,319,829 (GRCm39) |
C33Y |
probably damaging |
Het |
| Zfp330 |
A |
T |
8: 83,492,644 (GRCm39) |
C189* |
probably null |
Het |
| Zfp942 |
T |
A |
17: 22,147,522 (GRCm39) |
H369L |
probably damaging |
Het |
| Zfp943 |
T |
A |
17: 22,211,361 (GRCm39) |
I149K |
probably benign |
Het |
| Zfyve19 |
G |
A |
2: 119,042,016 (GRCm39) |
V162M |
probably benign |
Het |
|
| Other mutations in Dscam |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00515:Dscam
|
APN |
16 |
96,409,265 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL00841:Dscam
|
APN |
16 |
96,621,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01289:Dscam
|
APN |
16 |
96,445,082 (GRCm39) |
nonsense |
probably null |
|
|
IGL01358:Dscam
|
APN |
16 |
96,411,543 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL01431:Dscam
|
APN |
16 |
96,453,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01444:Dscam
|
APN |
16 |
96,474,909 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01767:Dscam
|
APN |
16 |
96,456,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01866:Dscam
|
APN |
16 |
96,486,550 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02020:Dscam
|
APN |
16 |
96,517,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02023:Dscam
|
APN |
16 |
96,602,397 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02057:Dscam
|
APN |
16 |
96,517,273 (GRCm39) |
nonsense |
probably null |
|
|
IGL02389:Dscam
|
APN |
16 |
96,442,097 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL02409:Dscam
|
APN |
16 |
96,621,088 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL02694:Dscam
|
APN |
16 |
96,394,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02899:Dscam
|
APN |
16 |
96,510,447 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02956:Dscam
|
APN |
16 |
96,602,472 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03035:Dscam
|
APN |
16 |
96,621,170 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03191:Dscam
|
APN |
16 |
96,621,969 (GRCm39) |
missense |
probably benign |
0.36 |
|
growler
|
UTSW |
16 |
96,622,197 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Twostep
|
UTSW |
16 |
96,626,982 (GRCm39) |
splice site |
probably null |
|
|
F6893:Dscam
|
UTSW |
16 |
96,857,660 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
K3955:Dscam
|
UTSW |
16 |
96,474,887 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0024:Dscam
|
UTSW |
16 |
96,394,585 (GRCm39) |
nonsense |
probably null |
|
|
R0057:Dscam
|
UTSW |
16 |
96,474,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0057:Dscam
|
UTSW |
16 |
96,474,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0117:Dscam
|
UTSW |
16 |
96,474,878 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0211:Dscam
|
UTSW |
16 |
96,517,279 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0280:Dscam
|
UTSW |
16 |
96,840,206 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R0355:Dscam
|
UTSW |
16 |
96,456,105 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0380:Dscam
|
UTSW |
16 |
96,857,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0445:Dscam
|
UTSW |
16 |
96,573,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0492:Dscam
|
UTSW |
16 |
96,626,982 (GRCm39) |
splice site |
probably null |
|
|
R0534:Dscam
|
UTSW |
16 |
96,453,372 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0593:Dscam
|
UTSW |
16 |
96,573,608 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0707:Dscam
|
UTSW |
16 |
96,626,982 (GRCm39) |
splice site |
probably null |
|
|
R0738:Dscam
|
UTSW |
16 |
96,620,981 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1017:Dscam
|
UTSW |
16 |
96,634,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1377:Dscam
|
UTSW |
16 |
96,573,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1440:Dscam
|
UTSW |
16 |
96,621,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1442:Dscam
|
UTSW |
16 |
96,409,274 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1464:Dscam
|
UTSW |
16 |
96,602,453 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1464:Dscam
|
UTSW |
16 |
96,602,453 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1478:Dscam
|
UTSW |
16 |
96,592,110 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1530:Dscam
|
UTSW |
16 |
96,621,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Dscam
|
UTSW |
16 |
96,621,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1765:Dscam
|
UTSW |
16 |
96,486,579 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1933:Dscam
|
UTSW |
16 |
96,394,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2005:Dscam
|
UTSW |
16 |
96,840,120 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2006:Dscam
|
UTSW |
16 |
96,621,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2101:Dscam
|
UTSW |
16 |
96,411,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2177:Dscam
|
UTSW |
16 |
96,411,524 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2342:Dscam
|
UTSW |
16 |
96,420,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2851:Dscam
|
UTSW |
16 |
96,423,915 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2929:Dscam
|
UTSW |
16 |
96,486,612 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3055:Dscam
|
UTSW |
16 |
96,602,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3157:Dscam
|
UTSW |
16 |
96,479,710 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3159:Dscam
|
UTSW |
16 |
96,479,710 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3944:Dscam
|
UTSW |
16 |
96,622,197 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4080:Dscam
|
UTSW |
16 |
96,484,972 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4285:Dscam
|
UTSW |
16 |
96,510,309 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4384:Dscam
|
UTSW |
16 |
96,510,416 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4460:Dscam
|
UTSW |
16 |
96,411,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4575:Dscam
|
UTSW |
16 |
96,626,823 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4594:Dscam
|
UTSW |
16 |
96,519,196 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R4643:Dscam
|
UTSW |
16 |
96,486,501 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4698:Dscam
|
UTSW |
16 |
96,411,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4716:Dscam
|
UTSW |
16 |
96,420,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4743:Dscam
|
UTSW |
16 |
96,631,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4766:Dscam
|
UTSW |
16 |
96,445,188 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4899:Dscam
|
UTSW |
16 |
96,485,018 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4987:Dscam
|
UTSW |
16 |
96,498,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4990:Dscam
|
UTSW |
16 |
96,626,715 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5123:Dscam
|
UTSW |
16 |
96,573,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5130:Dscam
|
UTSW |
16 |
96,620,979 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5328:Dscam
|
UTSW |
16 |
96,474,878 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5666:Dscam
|
UTSW |
16 |
96,519,364 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5670:Dscam
|
UTSW |
16 |
96,519,364 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5678:Dscam
|
UTSW |
16 |
96,592,100 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5827:Dscam
|
UTSW |
16 |
96,451,191 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5907:Dscam
|
UTSW |
16 |
96,622,120 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6032:Dscam
|
UTSW |
16 |
96,451,191 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6032:Dscam
|
UTSW |
16 |
96,451,191 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6103:Dscam
|
UTSW |
16 |
96,626,781 (GRCm39) |
missense |
probably benign |
|
|
R6240:Dscam
|
UTSW |
16 |
96,420,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6257:Dscam
|
UTSW |
16 |
96,474,914 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6361:Dscam
|
UTSW |
16 |
96,424,011 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6405:Dscam
|
UTSW |
16 |
96,479,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6444:Dscam
|
UTSW |
16 |
96,420,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6560:Dscam
|
UTSW |
16 |
96,626,935 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6598:Dscam
|
UTSW |
16 |
96,620,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6622:Dscam
|
UTSW |
16 |
96,446,273 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6792:Dscam
|
UTSW |
16 |
96,449,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6792:Dscam
|
UTSW |
16 |
96,394,455 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6827:Dscam
|
UTSW |
16 |
96,840,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6868:Dscam
|
UTSW |
16 |
96,631,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6898:Dscam
|
UTSW |
16 |
96,631,100 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6903:Dscam
|
UTSW |
16 |
96,621,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7051:Dscam
|
UTSW |
16 |
96,620,986 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7146:Dscam
|
UTSW |
16 |
96,631,117 (GRCm39) |
nonsense |
probably null |
|
|
R7180:Dscam
|
UTSW |
16 |
96,626,764 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7209:Dscam
|
UTSW |
16 |
96,451,544 (GRCm39) |
splice site |
probably null |
|
|
R7247:Dscam
|
UTSW |
16 |
96,622,008 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7269:Dscam
|
UTSW |
16 |
96,479,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7301:Dscam
|
UTSW |
16 |
96,857,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7328:Dscam
|
UTSW |
16 |
96,446,235 (GRCm39) |
nonsense |
probably null |
|
|
R7368:Dscam
|
UTSW |
16 |
96,445,131 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7425:Dscam
|
UTSW |
16 |
96,430,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7474:Dscam
|
UTSW |
16 |
96,621,089 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7536:Dscam
|
UTSW |
16 |
96,442,226 (GRCm39) |
splice site |
probably null |
|
|
R7624:Dscam
|
UTSW |
16 |
96,411,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7766:Dscam
|
UTSW |
16 |
96,592,101 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7817:Dscam
|
UTSW |
16 |
96,442,064 (GRCm39) |
missense |
probably benign |
|
|
R7843:Dscam
|
UTSW |
16 |
96,626,830 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7911:Dscam
|
UTSW |
16 |
96,445,122 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8108:Dscam
|
UTSW |
16 |
96,445,079 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8128:Dscam
|
UTSW |
16 |
96,602,374 (GRCm39) |
splice site |
probably null |
|
|
R8770:Dscam
|
UTSW |
16 |
96,456,106 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8876:Dscam
|
UTSW |
16 |
96,420,828 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9005:Dscam
|
UTSW |
16 |
96,602,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9009:Dscam
|
UTSW |
16 |
96,840,116 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9168:Dscam
|
UTSW |
16 |
96,420,768 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9176:Dscam
|
UTSW |
16 |
96,486,553 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9244:Dscam
|
UTSW |
16 |
96,486,429 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9339:Dscam
|
UTSW |
16 |
96,517,263 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9374:Dscam
|
UTSW |
16 |
96,857,857 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9385:Dscam
|
UTSW |
16 |
96,840,203 (GRCm39) |
missense |
probably benign |
|
|
R9674:Dscam
|
UTSW |
16 |
96,442,036 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0025:Dscam
|
UTSW |
16 |
96,510,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Dscam
|
UTSW |
16 |
96,573,761 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Dscam
|
UTSW |
16 |
96,409,389 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGTGACTCTGCATGGCTC -3'
(R):5'- TTTCAACAGTGTCAATACCTTGTGG -3'
Sequencing Primer
(F):5'- GTGACTCTGCATGGCTCTCTCC -3'
(R):5'- TATTTAACTCCCCAGAGCCACTG -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation