Incidental Mutation 'R1826:Ttc6'
| ID |
206825 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc6
|
| Ensembl Gene |
ENSMUSG00000046782 |
| Gene Name |
tetratricopeptide repeat domain 6 |
| Synonyms |
LOC217602, Gm9813, EG639426, 4921506M07Rik, AU024163 |
| MMRRC Submission |
039853-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.119)
|
| Stock # |
R1826 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
57610899-57784714 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 57707033 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 647
(S647P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134273
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172939]
|
| AlphaFold |
G3UYY4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172939
AA Change: S647P
PolyPhen 2
Score 0.100 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000134273
Gene: ENSMUSG00000046782
AA Change: S647P
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
18 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
146 |
162 |
N/A |
INTRINSIC |
|
low complexity region
|
188 |
212 |
N/A |
INTRINSIC |
|
low complexity region
|
227 |
238 |
N/A |
INTRINSIC |
|
low complexity region
|
486 |
495 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
733 |
740 |
N/A |
INTRINSIC |
|
TPR
|
889 |
922 |
2e-4 |
SMART |
|
TPR
|
957 |
989 |
2.36e1 |
SMART |
|
TPR
|
990 |
1022 |
2.63e1 |
SMART |
|
TPR
|
1023 |
1056 |
9.39e-1 |
SMART |
|
TPR
|
1057 |
1090 |
3.78e-5 |
SMART |
|
Blast:TPR
|
1126 |
1157 |
1e-11 |
BLAST |
|
SEL1
|
1160 |
1192 |
3.39e1 |
SMART |
|
TPR
|
1160 |
1194 |
4.44e1 |
SMART |
|
TPR
|
1195 |
1228 |
7.87e0 |
SMART |
|
Blast:TPR
|
1229 |
1262 |
1e-11 |
BLAST |
|
TPR
|
1297 |
1330 |
1.24e0 |
SMART |
|
SEL1
|
1341 |
1372 |
9.26e-1 |
SMART |
|
TPR
|
1341 |
1374 |
3.45e-8 |
SMART |
|
TPR
|
1375 |
1407 |
8.76e-1 |
SMART |
|
TPR
|
1408 |
1441 |
1.45e-1 |
SMART |
|
TPR
|
1442 |
1475 |
1.36e1 |
SMART |
|
TPR
|
1476 |
1509 |
7.34e-3 |
SMART |
|
TPR
|
1513 |
1546 |
1.01e0 |
SMART |
|
TPR
|
1547 |
1580 |
2.55e-2 |
SMART |
|
TPR
|
1581 |
1617 |
2.43e1 |
SMART |
|
Blast:TPR
|
1618 |
1651 |
4e-12 |
BLAST |
|
TPR
|
1652 |
1685 |
7.87e0 |
SMART |
|
TPR
|
1686 |
1718 |
2.35e-1 |
SMART |
|
SEL1
|
1719 |
1750 |
1.21e2 |
SMART |
|
TPR
|
1719 |
1752 |
1.65e-5 |
SMART |
|
TPR
|
1753 |
1786 |
1.66e-1 |
SMART |
|
TPR
|
1787 |
1820 |
1.45e-1 |
SMART |
|
TPR
|
1821 |
1854 |
3.27e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218344
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 92.0%
|
| Validation Efficiency |
95% (116/122) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
T |
C |
19: 43,810,453 (GRCm39) |
S917P |
probably benign |
Het |
| Acsbg1 |
C |
T |
9: 54,529,840 (GRCm39) |
V256M |
possibly damaging |
Het |
| Adam34 |
T |
A |
8: 44,104,379 (GRCm39) |
D422V |
probably damaging |
Het |
| Adam6a |
T |
A |
12: 113,509,742 (GRCm39) |
V705E |
possibly damaging |
Het |
| Adamts12 |
C |
A |
15: 11,071,606 (GRCm39) |
P50Q |
probably benign |
Het |
| Arfgap3 |
C |
T |
15: 83,187,303 (GRCm39) |
|
probably null |
Het |
| Aspg |
T |
A |
12: 112,089,852 (GRCm39) |
D463E |
probably damaging |
Het |
| Atad2b |
G |
A |
12: 5,024,094 (GRCm39) |
S73N |
probably benign |
Het |
| Atp11a |
T |
C |
8: 12,896,154 (GRCm39) |
L788P |
probably damaging |
Het |
| B3gnt8 |
T |
C |
7: 25,328,188 (GRCm39) |
F206S |
probably damaging |
Het |
| Baz2b |
T |
C |
2: 59,799,077 (GRCm39) |
E349G |
probably benign |
Het |
| Bmp2k |
A |
T |
5: 97,209,261 (GRCm39) |
|
probably benign |
Het |
| Camta2 |
A |
G |
11: 70,574,134 (GRCm39) |
F128L |
probably damaging |
Het |
| Ccdc88a |
A |
T |
11: 29,439,637 (GRCm39) |
Q30L |
possibly damaging |
Het |
| Cdh1 |
T |
C |
8: 107,392,898 (GRCm39) |
M794T |
probably benign |
Het |
| Cdh5 |
A |
G |
8: 104,857,723 (GRCm39) |
N383S |
possibly damaging |
Het |
| Cep85l |
T |
C |
10: 53,224,908 (GRCm39) |
D227G |
possibly damaging |
Het |
| Clec4e |
A |
G |
6: 123,260,591 (GRCm39) |
S156P |
probably damaging |
Het |
| Col10a1 |
G |
T |
10: 34,270,645 (GRCm39) |
G206C |
probably damaging |
Het |
| Col4a2 |
T |
C |
8: 11,363,509 (GRCm39) |
|
probably null |
Het |
| Copg2 |
A |
G |
6: 30,789,777 (GRCm39) |
M517T |
probably benign |
Het |
| Cyp2f2 |
T |
A |
7: 26,831,987 (GRCm39) |
L414Q |
probably damaging |
Het |
| Dact1 |
G |
A |
12: 71,365,118 (GRCm39) |
G596D |
probably damaging |
Het |
| Dcaf13 |
T |
C |
15: 38,982,294 (GRCm39) |
C87R |
probably damaging |
Het |
| Dchs1 |
T |
G |
7: 105,406,834 (GRCm39) |
T2224P |
probably damaging |
Het |
| Dnah12 |
A |
G |
14: 26,432,174 (GRCm39) |
M429V |
probably benign |
Het |
| Dppa2 |
G |
A |
16: 48,137,711 (GRCm39) |
R231H |
probably damaging |
Het |
| Elavl4 |
T |
C |
4: 110,108,489 (GRCm39) |
D78G |
probably damaging |
Het |
| Enthd1 |
T |
C |
15: 80,358,482 (GRCm39) |
E346G |
probably damaging |
Het |
| Exoc3l |
A |
T |
8: 106,020,250 (GRCm39) |
I225N |
probably damaging |
Het |
| Fasn |
C |
T |
11: 120,699,325 (GRCm39) |
|
probably benign |
Het |
| Fbxl7 |
G |
A |
15: 26,552,851 (GRCm39) |
R139C |
possibly damaging |
Het |
| Fbxw15 |
C |
A |
9: 109,388,782 (GRCm39) |
|
probably null |
Het |
| Flnc |
A |
G |
6: 29,455,184 (GRCm39) |
T1971A |
probably damaging |
Het |
| Fnip1 |
T |
G |
11: 54,356,990 (GRCm39) |
V33G |
probably damaging |
Het |
| Foxn2 |
A |
G |
17: 88,794,233 (GRCm39) |
E390G |
possibly damaging |
Het |
| Fry |
C |
T |
5: 150,360,174 (GRCm39) |
S1940L |
possibly damaging |
Het |
| Fzd3 |
A |
T |
14: 65,490,555 (GRCm39) |
D9E |
probably benign |
Het |
| Gabrd |
T |
C |
4: 155,470,943 (GRCm39) |
Y255C |
probably damaging |
Het |
| Garem1 |
A |
T |
18: 21,262,509 (GRCm39) |
F768L |
probably benign |
Het |
| Gas2 |
T |
A |
7: 51,593,421 (GRCm39) |
L167Q |
probably damaging |
Het |
| Gm16391 |
A |
G |
17: 76,591,418 (GRCm39) |
|
noncoding transcript |
Het |
| Gm1979 |
A |
T |
5: 26,206,240 (GRCm39) |
N113K |
probably damaging |
Het |
| Gpr83 |
G |
T |
9: 14,779,629 (GRCm39) |
C269F |
possibly damaging |
Het |
| Hdac4 |
T |
A |
1: 91,912,421 (GRCm39) |
N352Y |
probably damaging |
Het |
| Hdac9 |
A |
G |
12: 34,479,491 (GRCm39) |
|
probably benign |
Het |
| Hhipl2 |
G |
A |
1: 183,217,253 (GRCm39) |
S673N |
probably benign |
Het |
| Iffo2 |
T |
A |
4: 139,341,376 (GRCm39) |
S417T |
probably benign |
Het |
| Itgb5 |
G |
T |
16: 33,685,930 (GRCm39) |
R90L |
possibly damaging |
Het |
| Jade1 |
T |
G |
3: 41,567,648 (GRCm39) |
L572W |
probably damaging |
Het |
| Kcnh1 |
T |
A |
1: 192,095,376 (GRCm39) |
M478K |
possibly damaging |
Het |
| Kcnma1 |
C |
A |
14: 23,380,997 (GRCm39) |
D903Y |
probably damaging |
Het |
| Kcnq4 |
T |
A |
4: 120,561,701 (GRCm39) |
H456L |
probably benign |
Het |
| Kif9 |
C |
A |
9: 110,346,701 (GRCm39) |
T613K |
probably benign |
Het |
| Krt36 |
T |
G |
11: 99,993,856 (GRCm39) |
|
probably benign |
Het |
| Kyat3 |
A |
T |
3: 142,428,940 (GRCm39) |
D89V |
possibly damaging |
Het |
| Lnpep |
A |
T |
17: 17,783,098 (GRCm39) |
F568I |
probably damaging |
Het |
| Lpl |
T |
C |
8: 69,354,943 (GRCm39) |
F444L |
possibly damaging |
Het |
| Lrp1 |
A |
T |
10: 127,389,576 (GRCm39) |
V3153E |
probably damaging |
Het |
| Lrrn1 |
A |
T |
6: 107,544,529 (GRCm39) |
N109I |
probably benign |
Het |
| Ltn1 |
A |
G |
16: 87,212,504 (GRCm39) |
Y686H |
probably damaging |
Het |
| Mcoln2 |
A |
C |
3: 145,881,227 (GRCm39) |
D166A |
possibly damaging |
Het |
| Ms4a6b |
A |
T |
19: 11,501,298 (GRCm39) |
I103F |
probably damaging |
Het |
| Mtmr10 |
T |
G |
7: 63,987,214 (GRCm39) |
S585A |
probably benign |
Het |
| Mx1 |
T |
C |
16: 97,256,837 (GRCm39) |
N114S |
possibly damaging |
Het |
| Mysm1 |
A |
T |
4: 94,858,923 (GRCm39) |
N75K |
probably benign |
Het |
| Nkx1-1 |
A |
G |
5: 33,591,277 (GRCm39) |
V15A |
unknown |
Het |
| Nlrp1a |
G |
A |
11: 71,013,573 (GRCm39) |
T559I |
possibly damaging |
Het |
| Nlrp1a |
T |
A |
11: 70,998,806 (GRCm39) |
|
probably benign |
Het |
| Oas1f |
A |
G |
5: 120,993,652 (GRCm39) |
K288R |
probably benign |
Het |
| Or10q1 |
T |
A |
19: 13,726,711 (GRCm39) |
D80E |
probably benign |
Het |
| Or55b3 |
A |
G |
7: 102,126,720 (GRCm39) |
L119P |
probably damaging |
Het |
| Or9e1 |
T |
A |
11: 58,732,257 (GRCm39) |
C106S |
probably benign |
Het |
| Pcdhb2 |
T |
A |
18: 37,429,038 (GRCm39) |
V337D |
probably damaging |
Het |
| Pcdhb5 |
C |
T |
18: 37,454,522 (GRCm39) |
R301* |
probably null |
Het |
| Phf12 |
T |
C |
11: 77,915,780 (GRCm39) |
|
probably benign |
Het |
| Pik3c2a |
C |
T |
7: 115,967,352 (GRCm39) |
D862N |
probably benign |
Het |
| Pkhd1l1 |
T |
A |
15: 44,366,741 (GRCm39) |
L740I |
possibly damaging |
Het |
| Ppp1r9a |
A |
T |
6: 5,111,060 (GRCm39) |
|
probably benign |
Het |
| Prg4 |
T |
C |
1: 150,327,760 (GRCm39) |
D820G |
probably benign |
Het |
| Prmt9 |
C |
T |
8: 78,282,303 (GRCm39) |
Q67* |
probably null |
Het |
| Prob1 |
T |
C |
18: 35,786,628 (GRCm39) |
E542G |
possibly damaging |
Het |
| Pttg1 |
A |
G |
11: 43,311,193 (GRCm39) |
V188A |
probably damaging |
Het |
| Rassf1 |
T |
A |
9: 107,435,392 (GRCm39) |
L260H |
probably damaging |
Het |
| Rbm5 |
T |
A |
9: 107,619,613 (GRCm39) |
Q766L |
probably damaging |
Het |
| Rbms3 |
T |
A |
9: 116,651,936 (GRCm39) |
Y137F |
probably damaging |
Het |
| Rccd1 |
T |
C |
7: 79,969,966 (GRCm39) |
|
probably benign |
Het |
| Rnf182 |
G |
A |
13: 43,822,010 (GRCm39) |
W187* |
probably null |
Het |
| S100a11 |
A |
T |
3: 93,433,428 (GRCm39) |
I91F |
probably benign |
Het |
| Setd4 |
T |
A |
16: 93,388,187 (GRCm39) |
K100* |
probably null |
Het |
| Simc1 |
T |
A |
13: 54,672,452 (GRCm39) |
C267S |
probably benign |
Het |
| Slc16a1 |
G |
T |
3: 104,558,255 (GRCm39) |
A91S |
probably benign |
Het |
| Slc36a1 |
A |
G |
11: 55,111,279 (GRCm39) |
N133S |
probably benign |
Het |
| Ssxb16 |
T |
A |
X: 8,746,944 (GRCm39) |
Y133* |
probably null |
Het |
| Svil |
C |
T |
18: 5,063,383 (GRCm39) |
P885S |
probably benign |
Het |
| Svop |
A |
T |
5: 114,198,117 (GRCm39) |
|
probably null |
Het |
| Taar7d |
T |
C |
10: 23,903,474 (GRCm39) |
Y119H |
probably damaging |
Het |
| Tasor2 |
T |
A |
13: 3,631,759 (GRCm39) |
N914I |
probably damaging |
Het |
| Tgfb3 |
T |
C |
12: 86,108,818 (GRCm39) |
T304A |
probably benign |
Het |
| Tmem94 |
C |
A |
11: 115,684,039 (GRCm39) |
C786* |
probably null |
Het |
| Tnfrsf4 |
T |
A |
4: 156,100,736 (GRCm39) |
|
probably null |
Het |
| Tns1 |
C |
A |
1: 73,992,793 (GRCm39) |
M1I |
probably null |
Het |
| Trappc13 |
C |
T |
13: 104,306,327 (GRCm39) |
|
probably null |
Het |
| Trim72 |
T |
C |
7: 127,607,016 (GRCm39) |
F182L |
possibly damaging |
Het |
| Tulp1 |
A |
G |
17: 28,575,341 (GRCm39) |
L400P |
possibly damaging |
Het |
| Vegfc |
C |
T |
8: 54,634,347 (GRCm39) |
T342M |
possibly damaging |
Het |
| Vit |
T |
A |
17: 78,842,105 (GRCm39) |
V15E |
probably benign |
Het |
| Vps13d |
A |
T |
4: 144,881,573 (GRCm39) |
M1334K |
probably damaging |
Het |
| Zfp280d |
T |
C |
9: 72,206,062 (GRCm39) |
V23A |
probably damaging |
Het |
| Zfp608 |
A |
G |
18: 55,031,648 (GRCm39) |
I764T |
probably benign |
Het |
| Zfp94 |
T |
C |
7: 24,008,540 (GRCm39) |
Y33C |
probably damaging |
Het |
| Zfyve26 |
T |
A |
12: 79,315,823 (GRCm39) |
I1218F |
probably damaging |
Het |
|
| Other mutations in Ttc6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03278:Ttc6
|
APN |
12 |
57,668,812 (GRCm39) |
missense |
probably damaging |
0.99 |
|
polonius
|
UTSW |
12 |
57,704,928 (GRCm39) |
splice site |
probably null |
|
|
tybalt
|
UTSW |
12 |
57,720,542 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02802:Ttc6
|
UTSW |
12 |
57,622,654 (GRCm39) |
missense |
probably benign |
0.14 |
|
PIT4802001:Ttc6
|
UTSW |
12 |
57,772,462 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0698:Ttc6
|
UTSW |
12 |
57,720,002 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0988:Ttc6
|
UTSW |
12 |
57,735,435 (GRCm39) |
splice site |
probably benign |
|
|
R1290:Ttc6
|
UTSW |
12 |
57,707,199 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1338:Ttc6
|
UTSW |
12 |
57,663,155 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1468:Ttc6
|
UTSW |
12 |
57,721,463 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1468:Ttc6
|
UTSW |
12 |
57,721,463 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1481:Ttc6
|
UTSW |
12 |
57,783,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1488:Ttc6
|
UTSW |
12 |
57,696,301 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1558:Ttc6
|
UTSW |
12 |
57,733,132 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1570:Ttc6
|
UTSW |
12 |
57,721,549 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1619:Ttc6
|
UTSW |
12 |
57,784,454 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1819:Ttc6
|
UTSW |
12 |
57,741,286 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1863:Ttc6
|
UTSW |
12 |
57,760,881 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1872:Ttc6
|
UTSW |
12 |
57,751,338 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1887:Ttc6
|
UTSW |
12 |
57,720,044 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1937:Ttc6
|
UTSW |
12 |
57,663,109 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2014:Ttc6
|
UTSW |
12 |
57,623,003 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2056:Ttc6
|
UTSW |
12 |
57,784,479 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2058:Ttc6
|
UTSW |
12 |
57,784,479 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2059:Ttc6
|
UTSW |
12 |
57,784,479 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2152:Ttc6
|
UTSW |
12 |
57,752,338 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2179:Ttc6
|
UTSW |
12 |
57,719,904 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2275:Ttc6
|
UTSW |
12 |
57,749,084 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2432:Ttc6
|
UTSW |
12 |
57,668,821 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2474:Ttc6
|
UTSW |
12 |
57,622,713 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2853:Ttc6
|
UTSW |
12 |
57,622,967 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3848:Ttc6
|
UTSW |
12 |
57,723,932 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3853:Ttc6
|
UTSW |
12 |
57,775,335 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3950:Ttc6
|
UTSW |
12 |
57,696,292 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3953:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3954:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3955:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3957:Ttc6
|
UTSW |
12 |
57,744,238 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4135:Ttc6
|
UTSW |
12 |
57,679,581 (GRCm39) |
intron |
probably benign |
|
|
R4387:Ttc6
|
UTSW |
12 |
57,689,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4577:Ttc6
|
UTSW |
12 |
57,623,441 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4747:Ttc6
|
UTSW |
12 |
57,721,478 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4779:Ttc6
|
UTSW |
12 |
57,776,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4803:Ttc6
|
UTSW |
12 |
57,775,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4871:Ttc6
|
UTSW |
12 |
57,749,142 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4898:Ttc6
|
UTSW |
12 |
57,707,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4930:Ttc6
|
UTSW |
12 |
57,720,609 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4946:Ttc6
|
UTSW |
12 |
57,689,926 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5257:Ttc6
|
UTSW |
12 |
57,749,061 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5303:Ttc6
|
UTSW |
12 |
57,622,606 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5385:Ttc6
|
UTSW |
12 |
57,689,821 (GRCm39) |
splice site |
probably null |
|
|
R5402:Ttc6
|
UTSW |
12 |
57,783,817 (GRCm39) |
nonsense |
probably null |
|
|
R5428:Ttc6
|
UTSW |
12 |
57,736,620 (GRCm39) |
missense |
probably null |
0.98 |
|
R5436:Ttc6
|
UTSW |
12 |
57,721,380 (GRCm39) |
splice site |
probably null |
|
|
R5646:Ttc6
|
UTSW |
12 |
57,622,805 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5697:Ttc6
|
UTSW |
12 |
57,724,000 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5792:Ttc6
|
UTSW |
12 |
57,719,990 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5808:Ttc6
|
UTSW |
12 |
57,664,397 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5842:Ttc6
|
UTSW |
12 |
57,783,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5935:Ttc6
|
UTSW |
12 |
57,720,590 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6144:Ttc6
|
UTSW |
12 |
57,719,886 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6155:Ttc6
|
UTSW |
12 |
57,784,402 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6283:Ttc6
|
UTSW |
12 |
57,749,048 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6371:Ttc6
|
UTSW |
12 |
57,775,249 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6715:Ttc6
|
UTSW |
12 |
57,721,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6738:Ttc6
|
UTSW |
12 |
57,735,426 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6795:Ttc6
|
UTSW |
12 |
57,751,199 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6959:Ttc6
|
UTSW |
12 |
57,704,928 (GRCm39) |
splice site |
probably null |
|
|
R7053:Ttc6
|
UTSW |
12 |
57,707,318 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7125:Ttc6
|
UTSW |
12 |
57,623,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7259:Ttc6
|
UTSW |
12 |
57,622,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7304:Ttc6
|
UTSW |
12 |
57,622,837 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7369:Ttc6
|
UTSW |
12 |
57,719,717 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7409:Ttc6
|
UTSW |
12 |
57,743,772 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7429:Ttc6
|
UTSW |
12 |
57,704,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7430:Ttc6
|
UTSW |
12 |
57,704,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7492:Ttc6
|
UTSW |
12 |
57,719,922 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7535:Ttc6
|
UTSW |
12 |
57,623,305 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7866:Ttc6
|
UTSW |
12 |
57,721,435 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7901:Ttc6
|
UTSW |
12 |
57,735,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7944:Ttc6
|
UTSW |
12 |
57,707,229 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7945:Ttc6
|
UTSW |
12 |
57,707,229 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7965:Ttc6
|
UTSW |
12 |
57,720,542 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8062:Ttc6
|
UTSW |
12 |
57,783,764 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8119:Ttc6
|
UTSW |
12 |
57,752,429 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8142:Ttc6
|
UTSW |
12 |
57,744,258 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8154:Ttc6
|
UTSW |
12 |
57,776,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8171:Ttc6
|
UTSW |
12 |
57,720,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8335:Ttc6
|
UTSW |
12 |
57,707,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8343:Ttc6
|
UTSW |
12 |
57,707,282 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8696:Ttc6
|
UTSW |
12 |
57,784,492 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8875:Ttc6
|
UTSW |
12 |
57,776,194 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8875:Ttc6
|
UTSW |
12 |
57,751,199 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8876:Ttc6
|
UTSW |
12 |
57,784,489 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8924:Ttc6
|
UTSW |
12 |
57,697,790 (GRCm39) |
nonsense |
probably null |
|
|
R8944:Ttc6
|
UTSW |
12 |
57,689,826 (GRCm39) |
missense |
|
|
|
R8956:Ttc6
|
UTSW |
12 |
57,775,196 (GRCm39) |
nonsense |
probably null |
|
|
R9009:Ttc6
|
UTSW |
12 |
57,744,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9020:Ttc6
|
UTSW |
12 |
57,752,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9051:Ttc6
|
UTSW |
12 |
57,783,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9232:Ttc6
|
UTSW |
12 |
57,776,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9291:Ttc6
|
UTSW |
12 |
57,622,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9304:Ttc6
|
UTSW |
12 |
57,776,117 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9309:Ttc6
|
UTSW |
12 |
57,753,649 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9331:Ttc6
|
UTSW |
12 |
57,720,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9398:Ttc6
|
UTSW |
12 |
57,784,404 (GRCm39) |
nonsense |
probably null |
|
|
R9430:Ttc6
|
UTSW |
12 |
57,733,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9632:Ttc6
|
UTSW |
12 |
57,664,299 (GRCm39) |
missense |
probably benign |
|
|
R9688:Ttc6
|
UTSW |
12 |
57,720,602 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9732:Ttc6
|
UTSW |
12 |
57,775,335 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9740:Ttc6
|
UTSW |
12 |
57,736,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9749:Ttc6
|
UTSW |
12 |
57,701,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0021:Ttc6
|
UTSW |
12 |
57,622,904 (GRCm39) |
missense |
probably damaging |
0.96 |
|
X0058:Ttc6
|
UTSW |
12 |
57,753,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Ttc6
|
UTSW |
12 |
57,744,161 (GRCm39) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATACGTGCCTGAGAATGTCACG -3'
(R):5'- TGTCTTCTGAGCCCTGAAGG -3'
Sequencing Primer
(F):5'- CCTGAGAATGTCACGATAGAAAATG -3'
(R):5'- CCTGAAGGCTTTCCAGGC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation