Incidental Mutation 'R0114:Sema6a'
| ID |
20683 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sema6a
|
| Ensembl Gene |
ENSMUSG00000019647 |
| Gene Name |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
| Synonyms |
VIa, Semaq, Sema6A-1, sema, A730020P05Rik |
| MMRRC Submission |
038400-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0114 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
18 |
| Chromosomal Location |
47378321-47504267 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 47423244 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 254
(V254A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000121442
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019791]
[ENSMUST00000076043]
[ENSMUST00000115449]
[ENSMUST00000126684]
[ENSMUST00000135790]
[ENSMUST00000156422]
|
| AlphaFold |
O35464 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000019791
AA Change: V254A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000019791
Gene: ENSMUSG00000019647
AA Change: V254A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000076043
AA Change: V254A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000075420
Gene: ENSMUSG00000019647
AA Change: V254A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
593 |
615 |
N/A |
INTRINSIC |
|
low complexity region
|
877 |
896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115449
AA Change: V254A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000111109
Gene: ENSMUSG00000019647
AA Change: V254A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
461 |
1.24e-168 |
SMART |
|
PSI
|
488 |
543 |
9.57e-1 |
SMART |
|
transmembrane domain
|
622 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
925 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126684
|
| SMART Domains |
Protein: ENSMUSP00000118655
Gene: ENSMUSG00000019647
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Sema
|
56 |
216 |
2.5e-51 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135790
AA Change: V254A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000120011
Gene: ENSMUSG00000019647
AA Change: V254A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
665 |
687 |
N/A |
INTRINSIC |
|
low complexity region
|
949 |
968 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141224
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151382
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000156422
AA Change: V254A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000121442
Gene: ENSMUSG00000019647
AA Change: V254A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.3403 |
| Coding Region Coverage |
- 1x: 98.6%
- 3x: 97.4%
- 10x: 93.2%
- 20x: 79.2%
|
| Validation Efficiency |
100% (99/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit defects in lamina-specific neurite stratification of specific retinal neuron subtypes and disruption of the dendritic plexus organization of On but not Off starburst amacrine cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310057J18Rik |
T |
C |
10: 28,861,978 (GRCm39) |
|
probably benign |
Het |
| 4933427D14Rik |
T |
C |
11: 72,086,625 (GRCm39) |
Y262C |
probably damaging |
Het |
| Adamts1 |
C |
A |
16: 85,596,502 (GRCm39) |
V379L |
probably benign |
Het |
| Akt3 |
T |
C |
1: 176,894,817 (GRCm39) |
D260G |
probably damaging |
Het |
| Alms1 |
T |
C |
6: 85,596,785 (GRCm39) |
L537P |
probably benign |
Het |
| Anln |
A |
T |
9: 22,264,642 (GRCm39) |
I876N |
probably damaging |
Het |
| Ano9 |
A |
T |
7: 140,683,152 (GRCm39) |
|
probably benign |
Het |
| Arhgef10l |
T |
C |
4: 140,311,194 (GRCm39) |
E218G |
probably benign |
Het |
| Arnt2 |
G |
A |
7: 83,996,738 (GRCm39) |
R63C |
probably damaging |
Het |
| Atp9a |
G |
T |
2: 168,552,776 (GRCm39) |
Y63* |
probably null |
Het |
| Bmpr2 |
G |
T |
1: 59,854,499 (GRCm39) |
C116F |
probably damaging |
Het |
| Cand1 |
T |
C |
10: 119,052,427 (GRCm39) |
D233G |
probably benign |
Het |
| Cftr |
A |
T |
6: 18,282,447 (GRCm39) |
H1049L |
probably damaging |
Het |
| Ckap5 |
A |
T |
2: 91,450,457 (GRCm39) |
D1975V |
possibly damaging |
Het |
| Cyp26c1 |
T |
C |
19: 37,675,081 (GRCm39) |
V134A |
probably benign |
Het |
| Dnai1 |
T |
C |
4: 41,605,686 (GRCm39) |
|
probably benign |
Het |
| Dpp10 |
T |
C |
1: 123,413,821 (GRCm39) |
I163V |
probably benign |
Het |
| Fam151a |
A |
T |
4: 106,591,201 (GRCm39) |
I15F |
possibly damaging |
Het |
| Fanca |
A |
T |
8: 124,015,230 (GRCm39) |
|
probably null |
Het |
| Fes |
A |
G |
7: 80,027,783 (GRCm39) |
V787A |
probably damaging |
Het |
| Fnip1 |
C |
T |
11: 54,378,627 (GRCm39) |
|
probably benign |
Het |
| Gabpb1 |
A |
G |
2: 126,495,494 (GRCm39) |
I86T |
probably damaging |
Het |
| Gmds |
A |
T |
13: 32,411,264 (GRCm39) |
S57T |
probably benign |
Het |
| Gnpat |
T |
G |
8: 125,610,096 (GRCm39) |
D426E |
probably benign |
Het |
| Gnptab |
C |
A |
10: 88,269,262 (GRCm39) |
P655Q |
possibly damaging |
Het |
| Gpi-ps |
A |
G |
8: 5,690,359 (GRCm39) |
|
noncoding transcript |
Het |
| Herc1 |
T |
A |
9: 66,369,128 (GRCm39) |
F2941I |
probably damaging |
Het |
| Herc2 |
T |
C |
7: 55,803,522 (GRCm39) |
|
probably benign |
Het |
| Ino80 |
G |
A |
2: 119,213,441 (GRCm39) |
R1249C |
probably damaging |
Het |
| Itga11 |
T |
G |
9: 62,642,575 (GRCm39) |
V166G |
probably damaging |
Het |
| Itga11 |
T |
C |
9: 62,667,584 (GRCm39) |
V639A |
possibly damaging |
Het |
| Itpr2 |
A |
G |
6: 146,214,377 (GRCm39) |
F1490S |
probably damaging |
Het |
| Lama2 |
C |
A |
10: 26,869,064 (GRCm39) |
E802* |
probably null |
Het |
| Lgi3 |
C |
T |
14: 70,768,469 (GRCm39) |
|
probably benign |
Het |
| Limch1 |
C |
T |
5: 67,193,427 (GRCm39) |
|
probably benign |
Het |
| Lipc |
T |
C |
9: 70,711,063 (GRCm39) |
N363S |
probably damaging |
Het |
| Lrit2 |
A |
G |
14: 36,790,002 (GRCm39) |
|
probably null |
Het |
| Mfsd13a |
C |
T |
19: 46,354,943 (GRCm39) |
T40I |
probably benign |
Het |
| Mug2 |
A |
G |
6: 122,017,607 (GRCm39) |
Y448C |
probably damaging |
Het |
| Mybpc3 |
A |
G |
2: 90,954,839 (GRCm39) |
E450G |
probably damaging |
Het |
| Myo5b |
A |
T |
18: 74,875,242 (GRCm39) |
T1549S |
probably benign |
Het |
| Naa15 |
T |
C |
3: 51,355,859 (GRCm39) |
|
probably null |
Het |
| Nckap1l |
T |
A |
15: 103,363,455 (GRCm39) |
C54S |
probably benign |
Het |
| Nlrp9b |
A |
G |
7: 19,757,981 (GRCm39) |
D406G |
probably benign |
Het |
| Nprl3 |
T |
A |
11: 32,189,784 (GRCm39) |
|
probably benign |
Het |
| Nvl |
A |
G |
1: 180,947,956 (GRCm39) |
V429A |
probably benign |
Het |
| Opa1 |
A |
T |
16: 29,448,453 (GRCm39) |
N912Y |
probably benign |
Het |
| Or14j3 |
A |
T |
17: 37,900,306 (GRCm39) |
*313K |
probably null |
Het |
| Or1x2 |
G |
A |
11: 50,918,431 (GRCm39) |
V201I |
probably benign |
Het |
| Or52b4i |
A |
T |
7: 102,191,938 (GRCm39) |
Q265L |
probably benign |
Het |
| Or6c211 |
T |
A |
10: 129,505,467 (GRCm39) |
Y307F |
probably benign |
Het |
| Pcnx1 |
T |
C |
12: 82,042,869 (GRCm39) |
V2317A |
possibly damaging |
Het |
| Phf3 |
A |
T |
1: 30,844,524 (GRCm39) |
N1478K |
possibly damaging |
Het |
| Phykpl |
G |
A |
11: 51,477,480 (GRCm39) |
D91N |
probably benign |
Het |
| Polr2b |
T |
A |
5: 77,491,110 (GRCm39) |
C984S |
probably damaging |
Het |
| Ppfibp1 |
A |
G |
6: 146,899,731 (GRCm39) |
R141G |
probably benign |
Het |
| Ppm1d |
G |
A |
11: 85,217,731 (GRCm39) |
G20R |
probably damaging |
Het |
| Ppp1r16a |
C |
T |
15: 76,574,999 (GRCm39) |
|
probably benign |
Het |
| Ppp2r5b |
C |
A |
19: 6,278,461 (GRCm39) |
V483F |
probably benign |
Het |
| Ppp4r4 |
T |
A |
12: 103,542,633 (GRCm39) |
C132S |
probably benign |
Het |
| Prg2 |
A |
G |
2: 84,813,800 (GRCm39) |
|
probably benign |
Het |
| Prpf4b |
G |
A |
13: 35,074,471 (GRCm39) |
|
probably benign |
Het |
| Rad54l2 |
T |
C |
9: 106,590,654 (GRCm39) |
T491A |
probably damaging |
Het |
| Rnf213 |
G |
T |
11: 119,305,413 (GRCm39) |
W548L |
probably damaging |
Het |
| Rusc2 |
G |
T |
4: 43,422,055 (GRCm39) |
C825F |
probably damaging |
Het |
| Sema4b |
A |
G |
7: 79,868,826 (GRCm39) |
|
probably benign |
Het |
| Slc13a3 |
A |
G |
2: 165,266,501 (GRCm39) |
F346L |
probably damaging |
Het |
| Slc25a17 |
T |
C |
15: 81,222,160 (GRCm39) |
D104G |
probably damaging |
Het |
| Specc1 |
A |
T |
11: 62,037,139 (GRCm39) |
N707Y |
possibly damaging |
Het |
| Tex48 |
T |
A |
4: 63,526,696 (GRCm39) |
E76V |
probably damaging |
Het |
| Tfr2 |
T |
C |
5: 137,575,727 (GRCm39) |
V281A |
probably benign |
Het |
| Tgfb1i1 |
A |
C |
7: 127,848,666 (GRCm39) |
Q238H |
probably damaging |
Het |
| Thoc6 |
G |
A |
17: 23,889,213 (GRCm39) |
T122I |
probably benign |
Het |
| Tmtc1 |
G |
A |
6: 148,314,328 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf8 |
T |
C |
4: 145,014,617 (GRCm39) |
D264G |
possibly damaging |
Het |
| Trim43a |
T |
A |
9: 88,466,213 (GRCm39) |
I178N |
probably damaging |
Het |
| Ttn |
G |
C |
2: 76,537,437 (GRCm39) |
I26503M |
possibly damaging |
Het |
| Usp28 |
C |
A |
9: 48,950,323 (GRCm39) |
D589E |
probably benign |
Het |
| Utp23 |
T |
C |
15: 51,745,907 (GRCm39) |
S242P |
probably damaging |
Het |
| Vwa3a |
A |
G |
7: 120,374,603 (GRCm39) |
Y305C |
probably benign |
Het |
| Vwa5b1 |
C |
A |
4: 138,336,169 (GRCm39) |
E142* |
probably null |
Het |
| Xrn2 |
A |
T |
2: 146,871,699 (GRCm39) |
T374S |
probably damaging |
Het |
| Zfp735 |
A |
T |
11: 73,601,488 (GRCm39) |
Q144L |
probably benign |
Het |
|
| Other mutations in Sema6a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Sema6a
|
APN |
18 |
47,423,042 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01351:Sema6a
|
APN |
18 |
47,414,369 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01594:Sema6a
|
APN |
18 |
47,381,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01953:Sema6a
|
APN |
18 |
47,423,187 (GRCm39) |
nonsense |
probably null |
|
|
IGL02077:Sema6a
|
APN |
18 |
47,416,465 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02632:Sema6a
|
APN |
18 |
47,423,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02957:Sema6a
|
APN |
18 |
47,382,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03013:Sema6a
|
APN |
18 |
47,381,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03279:Sema6a
|
APN |
18 |
47,433,157 (GRCm39) |
nonsense |
probably null |
|
|
saphire
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
IGL02988:Sema6a
|
UTSW |
18 |
47,431,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0312:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0347:Sema6a
|
UTSW |
18 |
47,424,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0350:Sema6a
|
UTSW |
18 |
47,403,785 (GRCm39) |
missense |
probably benign |
|
|
R0366:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0368:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0391:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0403:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0466:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0515:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0517:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0542:Sema6a
|
UTSW |
18 |
47,381,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0557:Sema6a
|
UTSW |
18 |
47,382,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0569:Sema6a
|
UTSW |
18 |
47,403,872 (GRCm39) |
splice site |
probably null |
|
|
R0650:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0689:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0694:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0726:Sema6a
|
UTSW |
18 |
47,425,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0741:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0821:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0824:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0924:Sema6a
|
UTSW |
18 |
47,381,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1108:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1255:Sema6a
|
UTSW |
18 |
47,382,366 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1422:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1531:Sema6a
|
UTSW |
18 |
47,382,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1707:Sema6a
|
UTSW |
18 |
47,416,512 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1746:Sema6a
|
UTSW |
18 |
47,439,416 (GRCm39) |
splice site |
probably benign |
|
|
R1807:Sema6a
|
UTSW |
18 |
47,409,491 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1974:Sema6a
|
UTSW |
18 |
47,403,696 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1987:Sema6a
|
UTSW |
18 |
47,433,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2044:Sema6a
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
R3719:Sema6a
|
UTSW |
18 |
47,382,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4491:Sema6a
|
UTSW |
18 |
47,439,524 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4552:Sema6a
|
UTSW |
18 |
47,424,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Sema6a
|
UTSW |
18 |
47,381,779 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4710:Sema6a
|
UTSW |
18 |
47,403,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4713:Sema6a
|
UTSW |
18 |
47,382,363 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4963:Sema6a
|
UTSW |
18 |
47,431,318 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5088:Sema6a
|
UTSW |
18 |
47,382,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5133:Sema6a
|
UTSW |
18 |
47,433,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Sema6a
|
UTSW |
18 |
47,424,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5141:Sema6a
|
UTSW |
18 |
47,381,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Sema6a
|
UTSW |
18 |
47,409,611 (GRCm39) |
intron |
probably benign |
|
|
R5551:Sema6a
|
UTSW |
18 |
47,381,595 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5618:Sema6a
|
UTSW |
18 |
47,415,015 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5717:Sema6a
|
UTSW |
18 |
47,382,330 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5729:Sema6a
|
UTSW |
18 |
47,414,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Sema6a
|
UTSW |
18 |
47,381,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Sema6a
|
UTSW |
18 |
47,414,405 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6054:Sema6a
|
UTSW |
18 |
47,416,470 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6142:Sema6a
|
UTSW |
18 |
47,414,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6209:Sema6a
|
UTSW |
18 |
47,431,369 (GRCm39) |
splice site |
probably null |
|
|
R6307:Sema6a
|
UTSW |
18 |
47,382,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6734:Sema6a
|
UTSW |
18 |
47,412,236 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7014:Sema6a
|
UTSW |
18 |
47,431,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Sema6a
|
UTSW |
18 |
47,381,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7574:Sema6a
|
UTSW |
18 |
47,424,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8054:Sema6a
|
UTSW |
18 |
47,424,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8250:Sema6a
|
UTSW |
18 |
47,423,182 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8408:Sema6a
|
UTSW |
18 |
47,381,958 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8411:Sema6a
|
UTSW |
18 |
47,382,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8900:Sema6a
|
UTSW |
18 |
47,424,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9140:Sema6a
|
UTSW |
18 |
47,415,009 (GRCm39) |
missense |
probably benign |
|
|
R9158:Sema6a
|
UTSW |
18 |
47,431,330 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9488:Sema6a
|
UTSW |
18 |
47,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Sema6a
|
UTSW |
18 |
47,382,594 (GRCm39) |
missense |
probably null |
1.00 |
|
R9652:Sema6a
|
UTSW |
18 |
47,382,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9732:Sema6a
|
UTSW |
18 |
47,381,925 (GRCm39) |
missense |
probably damaging |
0.96 |
|
X0065:Sema6a
|
UTSW |
18 |
47,416,386 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCGAATCACATCTGTAACTGCCTG -3'
(R):5'- TGGTAGAGGGACTCACACTCCAAG -3'
Sequencing Primer
(F):5'- CATCTGTAACTGCCTGGAGTATATTG -3'
(R):5'- TCTGCTGAGTTtttttttttttttcc -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation