Mutagenetix > Incidental Mutation

Incidental Mutation 'R1828:Xirp2'

206975

Institutional Source

Beutler Lab

Gene Symbol

Xirp2

Ensembl Gene

ENSMUSG00000027022

Gene Name

xin actin-binding repeat containing 2

Synonyms

mXin beta, 2310008C07Rik, 2310003D02Rik, Cmya3, myomaxin, A530024P18Rik

MMRRC Submission

039855-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.321) question?

Stock #

R1828 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

67276343-67356964 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 67345582 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 2608 (N2608D)

Ref Sequence

ENSEMBL: ENSMUSP00000107966 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028410] [ENSMUST00000112347]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000028410
AA Change: N2608D

PolyPhen 2 Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000028410
Gene: ENSMUSG00000027022
AA Change: N2608D

Domain	Start	End	E-Value	Type
low complexity region	176	188	N/A	INTRINSIC
low complexity region	194	208	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
Pfam:Xin	343	358	4e-9	PFAM
Pfam:Xin	384	398	7.6e-10	PFAM
Pfam:Xin	420	435	6.4e-9	PFAM
Pfam:Xin	458	473	5.3e-9	PFAM
Pfam:Xin	536	551	4.1e-12	PFAM
Pfam:Xin	574	588	2.1e-8	PFAM
Pfam:Xin	609	623	6e-9	PFAM
Pfam:Xin	642	656	5.6e-8	PFAM
Pfam:Xin	679	693	5.9e-8	PFAM
Pfam:Xin	784	799	1.1e-10	PFAM
Pfam:Xin	822	837	3.9e-11	PFAM
Pfam:Xin	861	875	8.6e-12	PFAM
Pfam:Xin	894	909	2.8e-10	PFAM
Pfam:Xin	1006	1021	3.1e-9	PFAM
Pfam:Xin	1079	1094	6.7e-10	PFAM
Pfam:Xin	1117	1132	1.5e-10	PFAM
Pfam:Xin	1154	1169	2.4e-8	PFAM
Pfam:Xin	1256	1271	4.6e-8	PFAM
Pfam:Xin	1292	1305	1.6e-8	PFAM
low complexity region	1314	1325	N/A	INTRINSIC
low complexity region	1547	1559	N/A	INTRINSIC
coiled coil region	1683	1704	N/A	INTRINSIC
low complexity region	1862	1871	N/A	INTRINSIC
low complexity region	2031	2043	N/A	INTRINSIC
low complexity region	2052	2063	N/A	INTRINSIC
low complexity region	2087	2093	N/A	INTRINSIC
low complexity region	2105	2123	N/A	INTRINSIC
low complexity region	2159	2177	N/A	INTRINSIC
coiled coil region	2288	2311	N/A	INTRINSIC
coiled coil region	2738	2767	N/A	INTRINSIC
low complexity region	2794	2804	N/A	INTRINSIC
low complexity region	2906	2919	N/A	INTRINSIC
LIM	3256	3308	4.45e-12	SMART
low complexity region	3356	3367	N/A	INTRINSIC
low complexity region	3549	3565	N/A	INTRINSIC
low complexity region	3614	3625	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000112347
AA Change: N2608D

PolyPhen 2 Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000107966
Gene: ENSMUSG00000027022
AA Change: N2608D

Domain	Start	End	E-Value	Type
low complexity region	176	188	N/A	INTRINSIC
low complexity region	194	208	N/A	INTRINSIC
low complexity region	289	298	N/A	INTRINSIC
Pfam:Xin	343	358	4.3e-8	PFAM
Pfam:Xin	383	398	6.9e-9	PFAM
Pfam:Xin	420	435	1.8e-8	PFAM
Pfam:Xin	458	473	6.9e-8	PFAM
Pfam:Xin	536	551	2.8e-10	PFAM
Pfam:Xin	608	623	2.4e-8	PFAM
Pfam:Xin	642	657	1.7e-7	PFAM
Pfam:Xin	784	799	3.5e-9	PFAM
Pfam:Xin	822	837	8.9e-10	PFAM
Pfam:Xin	861	876	3.9e-10	PFAM
Pfam:Xin	894	909	5.4e-9	PFAM
Pfam:Xin	1006	1021	6.2e-8	PFAM
Pfam:Xin	1079	1094	2.4e-8	PFAM
Pfam:Xin	1117	1132	9.5e-9	PFAM
Pfam:Xin	1291	1306	5.8e-8	PFAM
low complexity region	1314	1325	N/A	INTRINSIC
low complexity region	1547	1559	N/A	INTRINSIC
coiled coil region	1683	1704	N/A	INTRINSIC
low complexity region	1862	1871	N/A	INTRINSIC
low complexity region	2031	2043	N/A	INTRINSIC
low complexity region	2052	2063	N/A	INTRINSIC
low complexity region	2087	2093	N/A	INTRINSIC
low complexity region	2105	2123	N/A	INTRINSIC
low complexity region	2159	2177	N/A	INTRINSIC
coiled coil region	2288	2311	N/A	INTRINSIC
coiled coil region	2738	2767	N/A	INTRINSIC
low complexity region	2794	2804	N/A	INTRINSIC
low complexity region	2906	2919	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142314

Coding Region Coverage

1x: 97.4%
3x: 96.9%
10x: 95.2%
20x: 92.0%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice have an abnormal heart shape, ventricular septal defects, a failure of mature intercalated disc formation, severe growth retardation, and postnatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(5) : Targeted(5)

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9130008F23Rik	T	C	17: 41,190,962 (GRCm39)	T156A	probably benign	Het
9230106D20Rik	A	T	10: 19,536,065 (GRCm39)		noncoding transcript	Het
Abca3	A	G	17: 24,585,171 (GRCm39)	D144G	probably benign	Het
Anxa2	T	A	9: 69,390,260 (GRCm39)	L121Q	probably damaging	Het
Anxa7	A	T	14: 20,512,732 (GRCm39)	I267N	probably damaging	Het
Asb14	A	T	14: 26,633,797 (GRCm39)	D334V	possibly damaging	Het
Batf3	A	G	1: 190,830,714 (GRCm39)	N20S	probably benign	Het
Bub1b	A	G	2: 118,468,920 (GRCm39)	H895R	probably benign	Het
C1qtnf12	G	A	4: 156,050,160 (GRCm39)		probably null	Het
Cars1	T	C	7: 143,130,385 (GRCm39)	I294V	probably damaging	Het
Ccdc142	G	A	6: 83,084,462 (GRCm39)	A527T	probably damaging	Het
Ccdc168	A	T	1: 44,096,234 (GRCm39)	N1621K	possibly damaging	Het
Ccdc92	T	C	5: 124,913,242 (GRCm39)	N96D	probably benign	Het
Ceacam18	T	A	7: 43,288,880 (GRCm39)	D210E	probably benign	Het
Cenpe	A	G	3: 134,952,257 (GRCm39)	T1373A	probably damaging	Het
Cfap161	T	G	7: 83,440,932 (GRCm39)		probably null	Het
Cimip4	T	C	15: 78,270,588 (GRCm39)	Y60C	possibly damaging	Het
Cldn19	A	G	4: 119,112,990 (GRCm39)	D74G	probably benign	Het
Clec12a	A	G	6: 129,330,762 (GRCm39)	T115A	probably damaging	Het
Cox7a2l	T	A	17: 83,811,397 (GRCm39)	Q78L	probably benign	Het
Crot	T	C	5: 9,019,080 (GRCm39)	N491S	probably benign	Het
Cspg4b	T	A	13: 113,505,342 (GRCm39)	L2157Q	probably damaging	Het
Ctr9	A	G	7: 110,643,165 (GRCm39)		probably null	Het
Cyp4f14	T	G	17: 33,130,209 (GRCm39)	D190A	probably damaging	Het
D630039A03Rik	C	T	4: 57,910,240 (GRCm39)	V191I	probably benign	Het
Dnah10	A	T	5: 124,838,343 (GRCm39)	N1124I	probably benign	Het
Duox1	T	A	2: 122,177,861 (GRCm39)	Y1548*	probably null	Het
Epdr1	G	A	13: 19,778,773 (GRCm39)	Q6*	probably null	Het
Erbin	A	G	13: 103,996,577 (GRCm39)		probably null	Het
Ero1a	A	T	14: 45,525,217 (GRCm39)	I436K	probably damaging	Het
Exph5	A	T	9: 53,287,941 (GRCm39)	Q1674L	possibly damaging	Het
Fat4	A	T	3: 39,037,607 (GRCm39)	Y3753F	probably damaging	Het
Gaa	T	C	11: 119,174,098 (GRCm39)	V763A	probably damaging	Het
Golim4	G	A	3: 75,809,745 (GRCm39)	T216I	probably damaging	Het
Gpr83	G	T	9: 14,779,629 (GRCm39)	C269F	possibly damaging	Het
Gtf2f2	A	G	14: 76,245,143 (GRCm39)		probably null	Het
Gtf3c5	T	C	2: 28,469,694 (GRCm39)	Y70C	probably damaging	Het
Hao1	T	A	2: 134,372,584 (GRCm39)	R141S	probably benign	Het
Hecw2	T	C	1: 53,965,182 (GRCm39)	D548G	probably benign	Het
Hr	G	A	14: 70,809,477 (GRCm39)		probably null	Het
Hrg	A	C	16: 22,774,853 (GRCm39)	E161A	probably damaging	Het
Hydin	A	T	8: 111,237,526 (GRCm39)	N1933I	probably benign	Het
Itpr2	A	G	6: 146,229,830 (GRCm39)	L1255P	probably damaging	Het
Kcnma1	C	A	14: 23,380,997 (GRCm39)	D903Y	probably damaging	Het
Kif5c	T	C	2: 49,570,252 (GRCm39)		probably null	Het
Mgat5b	C	A	11: 116,868,614 (GRCm39)	H512Q	probably damaging	Het
Mtmr4	T	C	11: 87,502,943 (GRCm39)	V999A	probably benign	Het
Mttp	G	T	3: 137,813,041 (GRCm39)	Q545K	probably damaging	Het
Ncstn	CAGCTCCACGAAG	CAG	1: 171,899,038 (GRCm39)		probably null	Het
Nexn	A	G	3: 151,948,405 (GRCm39)	I386T	probably damaging	Het
Nrip3	A	G	7: 109,365,763 (GRCm39)	S85P	probably benign	Het
Nxpe2	T	C	9: 48,237,914 (GRCm39)	T114A	probably damaging	Het
Olr1	T	C	6: 129,465,895 (GRCm39)	N37S	possibly damaging	Het
Or14j5	C	T	17: 38,161,966 (GRCm39)	A161V	probably benign	Het
Or4b1d	A	G	2: 89,968,931 (GRCm39)	L184S	probably damaging	Het
Or4c105	A	T	2: 88,648,402 (GRCm39)	I296F	probably benign	Het
Or55b3	A	G	7: 102,126,720 (GRCm39)	L119P	probably damaging	Het
Or5p80	G	T	7: 108,229,855 (GRCm39)	V219F	possibly damaging	Het
Pax4	T	C	6: 28,443,446 (GRCm39)	Y290C	probably benign	Het
Pcdhb2	T	A	18: 37,429,038 (GRCm39)	V337D	probably damaging	Het
Pglyrp4	T	C	3: 90,640,310 (GRCm39)	Y187H	probably damaging	Het
Pi4ka	A	G	16: 17,098,614 (GRCm39)	M2017T	probably benign	Het
Pkdrej	T	C	15: 85,703,483 (GRCm39)	T818A	possibly damaging	Het
Pxk	C	T	14: 8,151,507 (GRCm38)	R441*	probably null	Het
Pygm	T	C	19: 6,447,637 (GRCm39)	I648T	possibly damaging	Het
Rab4a	A	T	8: 124,550,565 (GRCm39)	K15I	probably damaging	Het
Rasa3	T	C	8: 13,635,035 (GRCm39)	E428G	probably benign	Het
Rnf182	G	A	13: 43,822,010 (GRCm39)	W187*	probably null	Het
Rpl3	C	T	15: 79,964,591 (GRCm39)	V222M	possibly damaging	Het
Rtl9	C	T	X: 141,886,011 (GRCm39)	S1141F	possibly damaging	Het
S100a11	A	T	3: 93,433,428 (GRCm39)	I91F	probably benign	Het
Sfswap	C	T	5: 129,590,148 (GRCm39)	T215I	probably damaging	Het
Slit2	A	G	5: 48,461,372 (GRCm39)	D1456G	probably damaging	Het
Tex19.2	C	T	11: 121,008,317 (GRCm39)	V44I	probably benign	Het
Tmem127	G	A	2: 127,098,094 (GRCm39)		probably null	Het
Tpd52	G	T	3: 9,012,579 (GRCm39)	N59K	probably damaging	Het
Trpc3	G	A	3: 36,692,695 (GRCm39)	P766S	possibly damaging	Het
Usp17la	T	A	7: 104,510,331 (GRCm39)	V312D	probably damaging	Het
Zfp764l1	T	A	7: 126,991,081 (GRCm39)	H302L	probably damaging	Het
Zscan25	C	A	5: 145,227,858 (GRCm39)	H507Q	possibly damaging	Het

Other mutations in Xirp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Xirp2	APN	2	67,343,719 (GRCm39)	missense	probably benign	0.37
IGL00336:Xirp2	APN	2	67,342,942 (GRCm39)	missense	possibly damaging	0.93
IGL00596:Xirp2	APN	2	67,345,226 (GRCm39)	missense	probably benign	0.08
IGL00862:Xirp2	APN	2	67,347,247 (GRCm39)	missense	probably benign	0.00
IGL01124:Xirp2	APN	2	67,338,959 (GRCm39)	missense	probably damaging	0.99
IGL01289:Xirp2	APN	2	67,343,525 (GRCm39)	missense	probably damaging	0.99
IGL01293:Xirp2	APN	2	67,345,528 (GRCm39)	missense	possibly damaging	0.51
IGL01372:Xirp2	APN	2	67,344,334 (GRCm39)	missense	possibly damaging	0.93
IGL01385:Xirp2	APN	2	67,340,021 (GRCm39)	missense	probably damaging	0.99
IGL01411:Xirp2	APN	2	67,344,427 (GRCm39)	missense	probably benign	0.00
IGL01413:Xirp2	APN	2	67,340,270 (GRCm39)	missense	probably damaging	1.00
IGL01551:Xirp2	APN	2	67,343,849 (GRCm39)	missense	probably benign
IGL01672:Xirp2	APN	2	67,338,846 (GRCm39)	missense	probably benign
IGL01724:Xirp2	APN	2	67,356,411 (GRCm39)	missense	probably benign
IGL01739:Xirp2	APN	2	67,345,482 (GRCm39)	missense	probably benign	0.15
IGL01807:Xirp2	APN	2	67,345,375 (GRCm39)	missense	probably benign
IGL02006:Xirp2	APN	2	67,342,306 (GRCm39)	missense	possibly damaging	0.85
IGL02030:Xirp2	APN	2	67,339,325 (GRCm39)	missense	probably benign	0.06
IGL02066:Xirp2	APN	2	67,356,415 (GRCm39)	missense	probably benign
IGL02138:Xirp2	APN	2	67,347,300 (GRCm39)	missense	probably benign	0.15
IGL02250:Xirp2	APN	2	67,344,356 (GRCm39)	missense	probably benign	0.03
IGL02265:Xirp2	APN	2	67,347,494 (GRCm39)	missense	possibly damaging	0.94
IGL02274:Xirp2	APN	2	67,338,995 (GRCm39)	missense	probably benign	0.12
IGL02322:Xirp2	APN	2	67,339,082 (GRCm39)	missense	probably benign	0.00
IGL02327:Xirp2	APN	2	67,340,444 (GRCm39)	missense	probably damaging	1.00
IGL02378:Xirp2	APN	2	67,344,112 (GRCm39)	missense	probably benign	0.00
IGL02492:Xirp2	APN	2	67,346,511 (GRCm39)	missense	probably damaging	0.99
IGL02549:Xirp2	APN	2	67,343,446 (GRCm39)	missense	probably benign	0.03
IGL02578:Xirp2	APN	2	67,341,591 (GRCm39)	missense	probably damaging	0.96
IGL02635:Xirp2	APN	2	67,338,254 (GRCm39)	missense	possibly damaging	0.86
IGL02654:Xirp2	APN	2	67,345,015 (GRCm39)	missense	possibly damaging	0.86
IGL02663:Xirp2	APN	2	67,339,802 (GRCm39)	missense	possibly damaging	0.92
IGL02795:Xirp2	APN	2	67,339,480 (GRCm39)	missense	probably damaging	1.00
IGL02934:Xirp2	APN	2	67,346,020 (GRCm39)	missense	probably benign	0.33
IGL03003:Xirp2	APN	2	67,345,906 (GRCm39)	missense	possibly damaging	0.93
IGL03069:Xirp2	APN	2	67,339,876 (GRCm39)	missense	possibly damaging	0.91
IGL03286:Xirp2	APN	2	67,346,654 (GRCm39)	missense	probably damaging	0.99
IGL03326:Xirp2	APN	2	67,312,590 (GRCm39)	missense	probably benign	0.01
IGL03381:Xirp2	APN	2	67,344,570 (GRCm39)	missense	probably benign	0.34
IGL03394:Xirp2	APN	2	67,345,538 (GRCm39)	missense	probably damaging	0.99
Ordovician	UTSW	2	67,312,707 (GRCm39)	missense	possibly damaging	0.72
silurian	UTSW	2	67,349,609 (GRCm39)	missense	probably damaging	0.99
3-1:Xirp2	UTSW	2	67,338,542 (GRCm39)	missense	possibly damaging	0.95
H8562:Xirp2	UTSW	2	67,345,801 (GRCm39)	missense	probably benign
PIT4142001:Xirp2	UTSW	2	67,349,706 (GRCm39)	splice site	probably benign
PIT4260001:Xirp2	UTSW	2	67,341,941 (GRCm39)	missense	possibly damaging	0.96
PIT4445001:Xirp2	UTSW	2	67,340,116 (GRCm39)	missense	possibly damaging	0.84
PIT4531001:Xirp2	UTSW	2	67,345,826 (GRCm39)	missense	possibly damaging	0.73
R0015:Xirp2	UTSW	2	67,341,243 (GRCm39)	nonsense	probably null
R0063:Xirp2	UTSW	2	67,339,427 (GRCm39)	missense	probably damaging	0.99
R0063:Xirp2	UTSW	2	67,339,427 (GRCm39)	missense	probably damaging	0.99
R0066:Xirp2	UTSW	2	67,342,484 (GRCm39)	missense	possibly damaging	0.85
R0109:Xirp2	UTSW	2	67,349,622 (GRCm39)	missense	probably damaging	1.00
R0111:Xirp2	UTSW	2	67,338,722 (GRCm39)	missense	probably damaging	0.99
R0115:Xirp2	UTSW	2	67,340,253 (GRCm39)	missense	possibly damaging	0.92
R0117:Xirp2	UTSW	2	67,347,464 (GRCm39)	missense	possibly damaging	0.94
R0133:Xirp2	UTSW	2	67,347,468 (GRCm39)	missense	probably benign
R0282:Xirp2	UTSW	2	67,343,724 (GRCm39)	missense	probably damaging	0.96
R0463:Xirp2	UTSW	2	67,345,262 (GRCm39)	missense	probably benign	0.02
R0481:Xirp2	UTSW	2	67,340,253 (GRCm39)	missense	possibly damaging	0.92
R0488:Xirp2	UTSW	2	67,345,165 (GRCm39)	missense	possibly damaging	0.90
R0548:Xirp2	UTSW	2	67,344,758 (GRCm39)	missense	probably benign	0.00
R0557:Xirp2	UTSW	2	67,346,695 (GRCm39)	missense	probably benign	0.33
R0582:Xirp2	UTSW	2	67,339,210 (GRCm39)	missense	probably benign
R0723:Xirp2	UTSW	2	67,342,559 (GRCm39)	missense	probably damaging	0.98
R0835:Xirp2	UTSW	2	67,338,254 (GRCm39)	missense	possibly damaging	0.86
R1160:Xirp2	UTSW	2	67,340,231 (GRCm39)	missense	possibly damaging	0.92
R1189:Xirp2	UTSW	2	67,343,805 (GRCm39)	missense	probably damaging	0.96
R1474:Xirp2	UTSW	2	67,355,411 (GRCm39)	missense	probably benign	0.00
R1513:Xirp2	UTSW	2	67,341,874 (GRCm39)	missense	probably benign	0.00
R1514:Xirp2	UTSW	2	67,344,667 (GRCm39)	nonsense	probably null
R1519:Xirp2	UTSW	2	67,346,023 (GRCm39)	missense	probably benign	0.44
R1532:Xirp2	UTSW	2	67,344,283 (GRCm39)	missense	probably benign	0.00
R1537:Xirp2	UTSW	2	67,340,357 (GRCm39)	missense	probably damaging	0.98
R1541:Xirp2	UTSW	2	67,342,634 (GRCm39)	missense	possibly damaging	0.70
R1543:Xirp2	UTSW	2	67,338,383 (GRCm39)	missense	probably benign
R1607:Xirp2	UTSW	2	67,340,639 (GRCm39)	nonsense	probably null
R1620:Xirp2	UTSW	2	67,341,179 (GRCm39)	missense	probably damaging	0.98
R1709:Xirp2	UTSW	2	67,340,215 (GRCm39)	missense	probably benign	0.33
R1713:Xirp2	UTSW	2	67,342,762 (GRCm39)	missense	probably benign	0.25
R1834:Xirp2	UTSW	2	67,341,484 (GRCm39)	missense	probably damaging	0.99
R1905:Xirp2	UTSW	2	67,346,700 (GRCm39)	missense	probably damaging	0.98
R1907:Xirp2	UTSW	2	67,346,700 (GRCm39)	missense	probably damaging	0.98
R1943:Xirp2	UTSW	2	67,342,959 (GRCm39)	missense	probably benign	0.34
R1971:Xirp2	UTSW	2	67,342,039 (GRCm39)	missense	possibly damaging	0.48
R1998:Xirp2	UTSW	2	67,339,393 (GRCm39)	missense	probably damaging	0.97
R2075:Xirp2	UTSW	2	67,340,545 (GRCm39)	missense	probably benign	0.33
R2132:Xirp2	UTSW	2	67,338,392 (GRCm39)	missense	possibly damaging	0.72
R2175:Xirp2	UTSW	2	67,340,258 (GRCm39)	missense	probably damaging	0.99
R2310:Xirp2	UTSW	2	67,356,591 (GRCm39)	missense	probably benign	0.19
R2338:Xirp2	UTSW	2	67,341,114 (GRCm39)	missense	probably damaging	0.98
R2426:Xirp2	UTSW	2	67,344,815 (GRCm39)	missense	probably benign	0.02
R2483:Xirp2	UTSW	2	67,355,336 (GRCm39)	missense	probably benign
R3084:Xirp2	UTSW	2	67,339,393 (GRCm39)	missense	probably damaging	0.97
R3113:Xirp2	UTSW	2	67,340,491 (GRCm39)	missense	probably benign	0.33
R3903:Xirp2	UTSW	2	67,338,380 (GRCm39)	missense	probably benign	0.40
R3916:Xirp2	UTSW	2	67,341,766 (GRCm39)	missense	probably benign	0.25
R3928:Xirp2	UTSW	2	67,342,013 (GRCm39)	missense	possibly damaging	0.85
R4025:Xirp2	UTSW	2	67,341,746 (GRCm39)	missense	probably benign	0.12
R4135:Xirp2	UTSW	2	67,355,741 (GRCm39)	missense	probably benign	0.00
R4223:Xirp2	UTSW	2	67,346,837 (GRCm39)	missense	possibly damaging	0.66
R4257:Xirp2	UTSW	2	67,346,383 (GRCm39)	missense	probably benign	0.31
R4499:Xirp2	UTSW	2	67,343,782 (GRCm39)	missense	probably benign	0.08
R4577:Xirp2	UTSW	2	67,344,241 (GRCm39)	missense	probably damaging	0.99
R4739:Xirp2	UTSW	2	67,349,609 (GRCm39)	missense	probably damaging	0.99
R4758:Xirp2	UTSW	2	67,346,879 (GRCm39)	missense	probably damaging	0.98
R4834:Xirp2	UTSW	2	67,346,750 (GRCm39)	missense	probably benign	0.26
R4855:Xirp2	UTSW	2	67,341,408 (GRCm39)	missense	possibly damaging	0.96
R4923:Xirp2	UTSW	2	67,343,237 (GRCm39)	missense	probably benign
R4936:Xirp2	UTSW	2	67,340,163 (GRCm39)	missense	possibly damaging	0.85
R5032:Xirp2	UTSW	2	67,356,014 (GRCm39)	missense	possibly damaging	0.84
R5049:Xirp2	UTSW	2	67,347,478 (GRCm39)	missense	probably benign	0.03
R5077:Xirp2	UTSW	2	67,344,821 (GRCm39)	missense	probably benign
R5090:Xirp2	UTSW	2	67,355,814 (GRCm39)	missense	possibly damaging	0.83
R5107:Xirp2	UTSW	2	67,340,054 (GRCm39)	missense	probably damaging	0.99
R5107:Xirp2	UTSW	2	67,342,205 (GRCm39)	missense	probably damaging	1.00
R5187:Xirp2	UTSW	2	67,345,711 (GRCm39)	missense	probably benign	0.01
R5241:Xirp2	UTSW	2	67,312,704 (GRCm39)	nonsense	probably null
R5307:Xirp2	UTSW	2	67,341,506 (GRCm39)	missense	probably damaging	0.99
R5342:Xirp2	UTSW	2	67,343,805 (GRCm39)	missense	probably damaging	0.96
R5370:Xirp2	UTSW	2	67,342,496 (GRCm39)	missense	possibly damaging	0.72
R5375:Xirp2	UTSW	2	67,342,250 (GRCm39)	missense	probably damaging	0.99
R5407:Xirp2	UTSW	2	67,341,313 (GRCm39)	missense	probably benign	0.33
R5514:Xirp2	UTSW	2	67,335,465 (GRCm39)	missense	probably benign	0.03
R5531:Xirp2	UTSW	2	67,345,646 (GRCm39)	missense	probably benign	0.42
R5590:Xirp2	UTSW	2	67,344,379 (GRCm39)	missense	probably benign	0.23
R5646:Xirp2	UTSW	2	67,341,134 (GRCm39)	missense	probably damaging	0.99
R5649:Xirp2	UTSW	2	67,347,239 (GRCm39)	missense	probably benign	0.00
R5686:Xirp2	UTSW	2	67,312,642 (GRCm39)	missense	probably damaging	0.99
R5761:Xirp2	UTSW	2	67,341,311 (GRCm39)	missense	probably benign	0.00
R5777:Xirp2	UTSW	2	67,340,348 (GRCm39)	missense	possibly damaging	0.92
R5785:Xirp2	UTSW	2	67,340,006 (GRCm39)	missense	probably damaging	0.96
R5843:Xirp2	UTSW	2	67,307,129 (GRCm39)	start gained	probably benign
R5846:Xirp2	UTSW	2	67,339,587 (GRCm39)	missense	probably damaging	0.98
R5875:Xirp2	UTSW	2	67,335,424 (GRCm39)	missense	probably benign	0.00
R5896:Xirp2	UTSW	2	67,340,290 (GRCm39)	missense	possibly damaging	0.91
R5896:Xirp2	UTSW	2	67,339,042 (GRCm39)	missense	probably benign	0.32
R5901:Xirp2	UTSW	2	67,343,410 (GRCm39)	missense	possibly damaging	0.91
R5934:Xirp2	UTSW	2	67,355,148 (GRCm39)	missense	possibly damaging	0.92
R5950:Xirp2	UTSW	2	67,341,664 (GRCm39)	missense	possibly damaging	0.95
R5996:Xirp2	UTSW	2	67,341,994 (GRCm39)	missense	possibly damaging	0.91
R6013:Xirp2	UTSW	2	67,341,287 (GRCm39)	missense	possibly damaging	0.48
R6048:Xirp2	UTSW	2	67,338,587 (GRCm39)	missense	possibly damaging	0.96
R6111:Xirp2	UTSW	2	67,342,161 (GRCm39)	missense	possibly damaging	0.86
R6180:Xirp2	UTSW	2	67,335,921 (GRCm39)	critical splice donor site	probably null
R6342:Xirp2	UTSW	2	67,341,994 (GRCm39)	missense	possibly damaging	0.91
R6346:Xirp2	UTSW	2	67,346,425 (GRCm39)	missense	probably benign	0.00
R6603:Xirp2	UTSW	2	67,346,888 (GRCm39)	missense	probably benign
R6604:Xirp2	UTSW	2	67,340,189 (GRCm39)	missense	possibly damaging	0.86
R6669:Xirp2	UTSW	2	67,343,699 (GRCm39)	missense	possibly damaging	0.78
R6701:Xirp2	UTSW	2	67,346,569 (GRCm39)	missense	possibly damaging	0.94
R6726:Xirp2	UTSW	2	67,343,212 (GRCm39)	missense	possibly damaging	0.88
R6833:Xirp2	UTSW	2	67,340,294 (GRCm39)	missense	probably benign	0.12
R6897:Xirp2	UTSW	2	67,338,911 (GRCm39)	missense	probably damaging	1.00
R6933:Xirp2	UTSW	2	67,345,201 (GRCm39)	missense	probably benign	0.34
R7020:Xirp2	UTSW	2	67,355,913 (GRCm39)	missense	probably benign
R7042:Xirp2	UTSW	2	67,343,633 (GRCm39)	missense	probably benign	0.12
R7060:Xirp2	UTSW	2	67,345,952 (GRCm39)	missense	probably damaging	1.00
R7179:Xirp2	UTSW	2	67,340,177 (GRCm39)	missense	probably benign	0.00
R7229:Xirp2	UTSW	2	67,355,895 (GRCm39)	missense	probably damaging	0.99
R7253:Xirp2	UTSW	2	67,343,826 (GRCm39)	missense	probably benign
R7284:Xirp2	UTSW	2	67,347,173 (GRCm39)	missense	probably benign
R7450:Xirp2	UTSW	2	67,340,159 (GRCm39)	missense	possibly damaging	0.86
R7476:Xirp2	UTSW	2	67,340,978 (GRCm39)	missense	probably benign	0.01
R7489:Xirp2	UTSW	2	67,355,904 (GRCm39)	missense	possibly damaging	0.83
R7513:Xirp2	UTSW	2	67,341,108 (GRCm39)	missense	possibly damaging	0.86
R7549:Xirp2	UTSW	2	67,339,241 (GRCm39)	missense	possibly damaging	0.91
R7563:Xirp2	UTSW	2	67,340,245 (GRCm39)	missense	probably damaging	0.99
R7567:Xirp2	UTSW	2	67,346,326 (GRCm39)	missense	probably benign	0.02
R7577:Xirp2	UTSW	2	67,345,309 (GRCm39)	missense	possibly damaging	0.65
R7597:Xirp2	UTSW	2	67,356,099 (GRCm39)	missense	possibly damaging	0.84
R7610:Xirp2	UTSW	2	67,356,306 (GRCm39)	missense	possibly damaging	0.92
R7613:Xirp2	UTSW	2	67,344,842 (GRCm39)	missense	probably benign	0.00
R7669:Xirp2	UTSW	2	67,342,521 (GRCm39)	missense	probably benign	0.00
R7670:Xirp2	UTSW	2	67,340,917 (GRCm39)	missense	possibly damaging	0.91
R7673:Xirp2	UTSW	2	67,347,431 (GRCm39)	missense	probably damaging	1.00
R7682:Xirp2	UTSW	2	67,339,193 (GRCm39)	missense	probably damaging	0.99
R7755:Xirp2	UTSW	2	67,345,526 (GRCm39)	missense	probably benign
R7805:Xirp2	UTSW	2	67,340,325 (GRCm39)	missense	probably benign	0.23
R7815:Xirp2	UTSW	2	67,339,756 (GRCm39)	missense	probably damaging	1.00
R7823:Xirp2	UTSW	2	67,342,118 (GRCm39)	missense	probably damaging	1.00
R7842:Xirp2	UTSW	2	67,355,289 (GRCm39)	missense	probably benign	0.00
R7863:Xirp2	UTSW	2	67,343,074 (GRCm39)	missense	probably benign	0.03
R7895:Xirp2	UTSW	2	67,339,841 (GRCm39)	missense	probably damaging	0.96
R7948:Xirp2	UTSW	2	67,349,658 (GRCm39)	missense	possibly damaging	0.95
R8083:Xirp2	UTSW	2	67,339,043 (GRCm39)	missense	possibly damaging	0.71
R8125:Xirp2	UTSW	2	67,342,379 (GRCm39)	missense	probably benign	0.25
R8154:Xirp2	UTSW	2	67,342,017 (GRCm39)	missense	possibly damaging	0.48
R8169:Xirp2	UTSW	2	67,343,543 (GRCm39)	missense	probably benign	0.00
R8213:Xirp2	UTSW	2	67,307,210 (GRCm39)	missense	probably damaging	0.96
R8215:Xirp2	UTSW	2	67,346,853 (GRCm39)	missense	probably benign	0.08
R8230:Xirp2	UTSW	2	67,346,009 (GRCm39)	missense	probably damaging	0.99
R8266:Xirp2	UTSW	2	67,338,918 (GRCm39)	missense	probably damaging	0.98
R8350:Xirp2	UTSW	2	67,355,713 (GRCm39)	missense	probably benign
R8432:Xirp2	UTSW	2	67,340,962 (GRCm39)	missense	probably benign
R8441:Xirp2	UTSW	2	67,343,159 (GRCm39)	missense	possibly damaging	0.85
R8677:Xirp2	UTSW	2	67,346,978 (GRCm39)	missense	probably damaging	0.98
R8773:Xirp2	UTSW	2	67,355,527 (GRCm39)	missense	probably benign
R8794:Xirp2	UTSW	2	67,341,557 (GRCm39)	missense	probably damaging	0.98
R8930:Xirp2	UTSW	2	67,312,707 (GRCm39)	missense	possibly damaging	0.72
R8932:Xirp2	UTSW	2	67,312,707 (GRCm39)	missense	possibly damaging	0.72
R8939:Xirp2	UTSW	2	67,346,488 (GRCm39)	missense	probably benign	0.04
R9263:Xirp2	UTSW	2	67,345,289 (GRCm39)	missense	possibly damaging	0.76
R9313:Xirp2	UTSW	2	67,347,322 (GRCm39)	missense	probably damaging	0.99
R9350:Xirp2	UTSW	2	67,349,653 (GRCm39)	missense	probably damaging	1.00
R9375:Xirp2	UTSW	2	67,342,118 (GRCm39)	missense	probably damaging	1.00
R9442:Xirp2	UTSW	2	67,342,235 (GRCm39)	nonsense	probably null
R9447:Xirp2	UTSW	2	67,338,950 (GRCm39)	missense	probably damaging	0.98
R9457:Xirp2	UTSW	2	67,345,976 (GRCm39)	missense	probably benign	0.03
R9507:Xirp2	UTSW	2	67,344,280 (GRCm39)	missense	possibly damaging	0.95
R9529:Xirp2	UTSW	2	67,355,540 (GRCm39)	missense	possibly damaging	0.93
R9569:Xirp2	UTSW	2	67,341,242 (GRCm39)	missense	probably damaging	1.00
R9607:Xirp2	UTSW	2	67,341,106 (GRCm39)	missense	possibly damaging	0.72
R9648:Xirp2	UTSW	2	67,346,599 (GRCm39)	missense	probably benign
R9651:Xirp2	UTSW	2	67,344,167 (GRCm39)	missense	possibly damaging	0.72
R9678:Xirp2	UTSW	2	67,339,788 (GRCm39)	missense	possibly damaging	0.91
R9691:Xirp2	UTSW	2	67,340,539 (GRCm39)	missense	possibly damaging	0.91
R9777:Xirp2	UTSW	2	67,347,379 (GRCm39)	missense	possibly damaging	0.85
RF035:Xirp2	UTSW	2	67,355,888 (GRCm39)	utr 3 prime	probably benign
RF040:Xirp2	UTSW	2	67,355,888 (GRCm39)	utr 3 prime	probably benign
X0063:Xirp2	UTSW	2	67,346,467 (GRCm39)	missense	probably benign	0.04
X0065:Xirp2	UTSW	2	67,345,462 (GRCm39)	missense	probably benign	0.34
Z1088:Xirp2	UTSW	2	67,343,665 (GRCm39)	missense	probably benign	0.03
Z1176:Xirp2	UTSW	2	67,344,923 (GRCm39)	missense	probably benign	0.17
Z1176:Xirp2	UTSW	2	67,341,737 (GRCm39)	missense	probably damaging	0.99
Z1176:Xirp2	UTSW	2	67,355,576 (GRCm39)	missense	probably damaging	1.00
Z1177:Xirp2	UTSW	2	67,355,715 (GRCm39)	missense	probably benign
Z1177:Xirp2	UTSW	2	67,340,537 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- AGCTCCAGACAGTTCCCAAG -3'
(R):5'- CACAGAGGAAAATGCAGATTGGTTC -3'

Sequencing Primer
(F):5'- TTCCCAAGAAGCAAGGAATATTTGG -3'
(R):5'- CAGATTGGTTCTGTCTTAGCTCTTGC -3'

Posted On

2014-06-23