Incidental Mutation 'R1844:Idh2'
| ID |
207542 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Idh2
|
| Ensembl Gene |
ENSMUSG00000030541 |
| Gene Name |
isocitrate dehydrogenase 2 (NADP+), mitochondrial |
| Synonyms |
Idh-2, IDPm |
| MMRRC Submission |
039869-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1844 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
79744594-79765140 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to C
at 79748625 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Arginine
at position 113
(T113R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145852
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000107384]
[ENSMUST00000125542]
[ENSMUST00000134328]
[ENSMUST00000164056]
[ENSMUST00000206714]
|
| AlphaFold |
P54071 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107384
AA Change: T191R
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000103007
Gene: ENSMUSG00000030541
AA Change: T191R
| Domain | Start | End | E-Value | Type |
|---|
|
Iso_dh
|
49 |
441 |
5.32e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125542
AA Change: T113R
PolyPhen 2
Score 0.308 (Sensitivity: 0.90; Specificity: 0.89)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134070
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134328
AA Change: T191R
PolyPhen 2
Score 0.242 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000118184
Gene: ENSMUSG00000030541
AA Change: T191R
| Domain | Start | End | E-Value | Type |
|---|
|
Iso_dh
|
49 |
284 |
1.59e-8 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139178
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156761
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164056
|
| SMART Domains |
Protein: ENSMUSP00000132361
Gene: ENSMUSG00000048897
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
88 |
N/A |
INTRINSIC |
|
low complexity region
|
106 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
169 |
181 |
N/A |
INTRINSIC |
|
low complexity region
|
187 |
201 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
297 |
319 |
2.71e-2 |
SMART |
|
ZnF_C2H2
|
325 |
347 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
353 |
375 |
2.71e-2 |
SMART |
|
ZnF_C2H2
|
381 |
403 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
409 |
431 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
437 |
459 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
465 |
487 |
3.83e-2 |
SMART |
|
ZnF_C2H2
|
493 |
515 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
521 |
543 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
549 |
571 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
577 |
600 |
3.69e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206714
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.2%
- 20x: 92.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit suppression of tumorigenesis from B16F10 melanoma cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aco1 |
A |
G |
4: 40,197,566 (GRCm39) |
K857E |
probably benign |
Het |
| Adam20 |
A |
G |
8: 41,249,080 (GRCm39) |
N397D |
probably benign |
Het |
| Adgrf3 |
T |
G |
5: 30,404,211 (GRCm39) |
D347A |
probably damaging |
Het |
| Ang6 |
C |
T |
14: 44,239,330 (GRCm39) |
E133K |
possibly damaging |
Het |
| Arhgap23 |
T |
A |
11: 97,354,234 (GRCm39) |
W205R |
probably damaging |
Het |
| Arhgef40 |
C |
A |
14: 52,235,080 (GRCm39) |
R1086S |
probably damaging |
Het |
| Atr |
G |
T |
9: 95,787,870 (GRCm39) |
A1488S |
probably benign |
Het |
| Cabin1 |
A |
T |
10: 75,579,184 (GRCm39) |
|
probably null |
Het |
| Cby2 |
C |
T |
14: 75,820,850 (GRCm39) |
V292I |
probably benign |
Het |
| Cdh22 |
A |
C |
2: 164,985,614 (GRCm39) |
F324C |
probably damaging |
Het |
| Cep350 |
T |
C |
1: 155,724,374 (GRCm39) |
I3075V |
probably damaging |
Het |
| Chd9 |
A |
T |
8: 91,683,323 (GRCm39) |
K588* |
probably null |
Het |
| Clns1a |
A |
T |
7: 97,346,066 (GRCm39) |
I44F |
probably damaging |
Het |
| Colgalt1 |
T |
C |
8: 72,063,995 (GRCm39) |
I51T |
possibly damaging |
Het |
| Cpt2 |
C |
T |
4: 107,761,452 (GRCm39) |
E217K |
possibly damaging |
Het |
| Ctss |
A |
G |
3: 95,454,105 (GRCm39) |
|
probably null |
Het |
| Cyp1a1 |
A |
G |
9: 57,609,980 (GRCm39) |
T465A |
probably benign |
Het |
| Dbn1 |
A |
G |
13: 55,629,160 (GRCm39) |
|
probably null |
Het |
| Dennd1b |
A |
G |
1: 139,018,143 (GRCm39) |
|
probably null |
Het |
| Dnajc1 |
A |
C |
2: 18,298,838 (GRCm39) |
Y49* |
probably null |
Het |
| Dock10 |
T |
A |
1: 80,520,918 (GRCm39) |
I1188L |
probably damaging |
Het |
| Dsg1c |
T |
G |
18: 20,416,096 (GRCm39) |
|
probably null |
Het |
| Efcab6 |
G |
A |
15: 83,851,822 (GRCm39) |
T352I |
possibly damaging |
Het |
| Eps8l3 |
T |
C |
3: 107,786,902 (GRCm39) |
L26P |
possibly damaging |
Het |
| Fbxw26 |
A |
G |
9: 109,553,946 (GRCm39) |
V231A |
probably benign |
Het |
| Fetub |
G |
A |
16: 22,754,419 (GRCm39) |
E209K |
possibly damaging |
Het |
| Galc |
A |
T |
12: 98,212,556 (GRCm39) |
|
probably null |
Het |
| Gm6871 |
A |
T |
7: 41,222,892 (GRCm39) |
N65K |
probably benign |
Het |
| Gstp3 |
A |
G |
19: 4,107,540 (GRCm39) |
I208T |
probably benign |
Het |
| Gtpbp3 |
A |
G |
8: 71,945,272 (GRCm39) |
Y448C |
probably benign |
Het |
| Hdac7 |
G |
T |
15: 97,705,857 (GRCm39) |
Q385K |
probably damaging |
Het |
| Hemgn |
C |
T |
4: 46,396,655 (GRCm39) |
V194M |
possibly damaging |
Het |
| Jarid2 |
A |
C |
13: 45,056,219 (GRCm39) |
K336T |
possibly damaging |
Het |
| Kcnj4 |
C |
T |
15: 79,369,216 (GRCm39) |
V255M |
probably damaging |
Het |
| Ldhb |
C |
A |
6: 142,439,934 (GRCm39) |
W202L |
probably damaging |
Het |
| Lmbrd2 |
T |
A |
15: 9,177,838 (GRCm39) |
Y512* |
probably null |
Het |
| Lrp1 |
A |
G |
10: 127,431,152 (GRCm39) |
|
probably null |
Het |
| Map3k12 |
G |
A |
15: 102,411,970 (GRCm39) |
P365S |
probably damaging |
Het |
| Map3k5 |
G |
A |
10: 19,979,909 (GRCm39) |
D806N |
probably benign |
Het |
| Matn3 |
A |
G |
12: 9,017,662 (GRCm39) |
E438G |
possibly damaging |
Het |
| Mcmbp |
G |
A |
7: 128,325,698 (GRCm39) |
L97F |
probably damaging |
Het |
| Mmp3 |
A |
T |
9: 7,453,662 (GRCm39) |
I428L |
probably benign |
Het |
| Mphosph8 |
T |
C |
14: 56,934,616 (GRCm39) |
V855A |
probably damaging |
Het |
| Mycbp2 |
T |
A |
14: 103,393,150 (GRCm39) |
H3027L |
possibly damaging |
Het |
| Nbea |
C |
T |
3: 55,989,857 (GRCm39) |
R333H |
probably damaging |
Het |
| Notch1 |
G |
T |
2: 26,350,446 (GRCm39) |
H2231Q |
probably benign |
Het |
| Npas2 |
A |
T |
1: 39,364,456 (GRCm39) |
H266L |
probably damaging |
Het |
| Oas3 |
A |
G |
5: 120,898,045 (GRCm39) |
S833P |
probably damaging |
Het |
| Or1j15 |
T |
C |
2: 36,458,789 (GRCm39) |
Y60H |
probably damaging |
Het |
| Or5ak24 |
T |
C |
2: 85,260,265 (GRCm39) |
T303A |
probably benign |
Het |
| Or5w17 |
A |
C |
2: 87,584,334 (GRCm39) |
M1R |
probably null |
Het |
| Or6c65 |
G |
A |
10: 129,603,725 (GRCm39) |
R120H |
probably benign |
Het |
| Pak4 |
C |
T |
7: 28,264,690 (GRCm39) |
V71I |
possibly damaging |
Het |
| Pitpnm1 |
T |
C |
19: 4,162,395 (GRCm39) |
V1075A |
probably damaging |
Het |
| Pkp3 |
G |
A |
7: 140,668,415 (GRCm39) |
V555M |
probably damaging |
Het |
| Plekhm2 |
T |
C |
4: 141,359,685 (GRCm39) |
T381A |
probably benign |
Het |
| Plppr3 |
A |
G |
10: 79,702,244 (GRCm39) |
|
probably null |
Het |
| Ppp2r5e |
A |
T |
12: 75,516,540 (GRCm39) |
F216I |
possibly damaging |
Het |
| Ppp3ca |
T |
A |
3: 136,627,672 (GRCm39) |
V412D |
probably benign |
Het |
| Prss50 |
A |
G |
9: 110,687,081 (GRCm39) |
|
probably benign |
Het |
| Psph |
A |
C |
5: 129,843,532 (GRCm39) |
I174R |
probably damaging |
Het |
| Ptov1 |
A |
G |
7: 44,514,991 (GRCm39) |
Y207H |
possibly damaging |
Het |
| Ptprs |
A |
G |
17: 56,741,510 (GRCm39) |
S585P |
probably damaging |
Het |
| Rnf146 |
A |
T |
10: 29,223,720 (GRCm39) |
H55Q |
probably damaging |
Het |
| Rnf213 |
T |
A |
11: 119,332,009 (GRCm39) |
M2407K |
probably damaging |
Het |
| Rnls |
A |
C |
19: 33,179,931 (GRCm39) |
L55R |
possibly damaging |
Het |
| Rptor |
T |
C |
11: 119,647,146 (GRCm39) |
C246R |
probably damaging |
Het |
| Rrp12 |
C |
T |
19: 41,866,222 (GRCm39) |
|
probably null |
Het |
| Samd3 |
A |
G |
10: 26,127,672 (GRCm39) |
D223G |
probably damaging |
Het |
| Sdad1 |
G |
A |
5: 92,453,155 (GRCm39) |
Q68* |
probably null |
Het |
| Selenov |
G |
A |
7: 27,989,847 (GRCm39) |
T219M |
probably damaging |
Het |
| Shd |
A |
G |
17: 56,278,554 (GRCm39) |
D39G |
possibly damaging |
Het |
| Slc26a10 |
A |
T |
10: 127,014,279 (GRCm39) |
V245E |
probably damaging |
Het |
| Slit1 |
A |
G |
19: 41,614,012 (GRCm39) |
L820P |
probably damaging |
Het |
| Snap23 |
T |
C |
2: 120,421,163 (GRCm39) |
F96L |
probably benign |
Het |
| Speer1k |
T |
C |
5: 10,998,994 (GRCm39) |
|
probably benign |
Het |
| Spef1l |
A |
T |
7: 139,556,005 (GRCm39) |
I212N |
probably benign |
Het |
| Stkld1 |
A |
G |
2: 26,840,115 (GRCm39) |
H395R |
probably damaging |
Het |
| Syt13 |
G |
A |
2: 92,771,165 (GRCm39) |
G84D |
probably damaging |
Het |
| Terb2 |
T |
A |
2: 122,016,990 (GRCm39) |
L37Q |
probably damaging |
Het |
| Themis |
A |
G |
10: 28,657,753 (GRCm39) |
Y107C |
probably damaging |
Het |
| Top2a |
T |
A |
11: 98,906,895 (GRCm39) |
T249S |
probably benign |
Het |
| Tspo2 |
A |
T |
17: 48,756,148 (GRCm39) |
F71Y |
probably damaging |
Het |
| Ttc21b |
T |
A |
2: 66,053,921 (GRCm39) |
K753* |
probably null |
Het |
| Ttk |
A |
G |
9: 83,736,915 (GRCm39) |
Y458C |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,586,017 (GRCm39) |
R21905G |
probably damaging |
Het |
| Ugt3a1 |
T |
A |
15: 9,351,254 (GRCm39) |
F88I |
probably benign |
Het |
| Vmn1r119 |
A |
G |
7: 20,746,121 (GRCm39) |
L87P |
probably damaging |
Het |
| Vmn1r36 |
A |
G |
6: 66,693,747 (GRCm39) |
F6L |
probably benign |
Het |
| Vmn2r15 |
T |
A |
5: 109,434,860 (GRCm39) |
K615* |
probably null |
Het |
| Wdr18 |
G |
A |
10: 79,802,561 (GRCm39) |
|
probably null |
Het |
| Wdr6 |
A |
T |
9: 108,453,176 (GRCm39) |
W236R |
probably damaging |
Het |
| Zbtb48 |
T |
C |
4: 152,110,955 (GRCm39) |
T187A |
probably benign |
Het |
|
| Other mutations in Idh2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01529:Idh2
|
APN |
7 |
79,747,693 (GRCm39) |
missense |
probably benign |
|
|
IGL02281:Idh2
|
APN |
7 |
79,745,550 (GRCm39) |
splice site |
probably null |
|
|
IGL02874:Idh2
|
APN |
7 |
79,747,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02892:Idh2
|
APN |
7 |
79,745,418 (GRCm39) |
missense |
probably benign |
|
|
IGL02937:Idh2
|
APN |
7 |
79,748,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02989:Idh2
|
APN |
7 |
79,748,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0040:Idh2
|
UTSW |
7 |
79,747,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0040:Idh2
|
UTSW |
7 |
79,747,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0090:Idh2
|
UTSW |
7 |
79,747,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0322:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0384:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0385:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0386:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0387:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0494:Idh2
|
UTSW |
7 |
79,748,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1603:Idh2
|
UTSW |
7 |
79,748,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1681:Idh2
|
UTSW |
7 |
79,748,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1711:Idh2
|
UTSW |
7 |
79,748,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3700:Idh2
|
UTSW |
7 |
79,748,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4941:Idh2
|
UTSW |
7 |
79,745,847 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5234:Idh2
|
UTSW |
7 |
79,745,853 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5387:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R5582:Idh2
|
UTSW |
7 |
79,748,087 (GRCm39) |
frame shift |
probably null |
|
|
R5655:Idh2
|
UTSW |
7 |
79,747,996 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6191:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6261:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R6311:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6351:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6413:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6561:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6709:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6772:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6781:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6848:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R6861:Idh2
|
UTSW |
7 |
79,747,966 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6899:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7063:Idh2
|
UTSW |
7 |
79,745,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7076:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7081:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R7090:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7254:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
frame shift |
probably null |
|
|
R7298:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7401:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R7560:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
frame shift |
probably null |
|
|
R7561:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7694:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7816:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7884:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R7919:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R7961:Idh2
|
UTSW |
7 |
79,748,001 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8009:Idh2
|
UTSW |
7 |
79,748,001 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8036:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8162:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R8321:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8451:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8488:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R8501:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8671:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8673:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8707:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R8725:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
frame shift |
probably null |
|
|
R8863:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8872:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8892:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8915:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8935:Idh2
|
UTSW |
7 |
79,764,946 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8951:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8954:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R8985:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9101:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9111:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9138:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
frame shift |
probably null |
|
|
R9138:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
R9140:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9555:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9580:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9614:Idh2
|
UTSW |
7 |
79,747,925 (GRCm39) |
nonsense |
probably null |
|
|
R9619:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9697:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9756:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
R9790:Idh2
|
UTSW |
7 |
79,748,079 (GRCm39) |
intron |
probably benign |
|
|
RF030:Idh2
|
UTSW |
7 |
79,748,077 (GRCm39) |
intron |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTGGCATGAGAATGAGGC -3'
(R):5'- CTTCAGAGAGCCAATCATCTGC -3'
Sequencing Primer
(F):5'- CATGAGAATGAGGCCAACAGAAGC -3'
(R):5'- AAACATCCCCCGCCTTGTC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation