Incidental Mutation 'R0116:Dapk1'
| ID |
20834 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, D13Ucla1, 2810425C21Rik, 2310039H24Rik |
| MMRRC Submission |
038402-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0116 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
13 |
| Chromosomal Location |
60749761-60911005 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 60908914 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 1176
(I1176V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153607
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044083
AA Change: I1176V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
AA Change: I1176V
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077453
AA Change: I1176V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
AA Change: I1176V
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225952
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226059
AA Change: I1176V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 94.2%
|
| Validation Efficiency |
94% (95/101) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931406C07Rik |
A |
T |
9: 15,202,066 (GRCm39) |
V152E |
probably damaging |
Het |
| Abca5 |
T |
G |
11: 110,167,331 (GRCm39) |
E1495A |
probably damaging |
Het |
| Abcc12 |
G |
A |
8: 87,261,627 (GRCm39) |
S668F |
probably benign |
Het |
| Adgrl4 |
A |
T |
3: 151,223,247 (GRCm39) |
T608S |
probably benign |
Het |
| Angel2 |
G |
A |
1: 190,673,187 (GRCm39) |
D255N |
probably benign |
Het |
| Apob |
T |
A |
12: 8,039,113 (GRCm39) |
|
probably benign |
Het |
| Arfgef2 |
A |
T |
2: 166,715,603 (GRCm39) |
R1349S |
probably damaging |
Het |
| Atp2b2 |
C |
T |
6: 113,770,656 (GRCm39) |
V418I |
probably damaging |
Het |
| Birc6 |
C |
A |
17: 74,930,741 (GRCm39) |
|
probably benign |
Het |
| Capn13 |
T |
A |
17: 73,658,519 (GRCm39) |
Y183F |
probably damaging |
Het |
| Cngb1 |
A |
G |
8: 95,987,266 (GRCm39) |
S352P |
probably damaging |
Het |
| Col6a3 |
A |
G |
1: 90,741,273 (GRCm39) |
S720P |
probably damaging |
Het |
| Cpa4 |
C |
T |
6: 30,579,657 (GRCm39) |
R155W |
probably damaging |
Het |
| Dnah17 |
T |
C |
11: 117,949,132 (GRCm39) |
E2959G |
probably benign |
Het |
| Dnah7b |
T |
A |
1: 46,252,520 (GRCm39) |
I1734N |
possibly damaging |
Het |
| Dnajb7 |
A |
G |
15: 81,291,555 (GRCm39) |
Y261H |
probably benign |
Het |
| Dock2 |
T |
C |
11: 34,579,392 (GRCm39) |
|
probably benign |
Het |
| Dyrk3 |
A |
T |
1: 131,057,576 (GRCm39) |
V199E |
probably damaging |
Het |
| F2r |
G |
T |
13: 95,740,994 (GRCm39) |
C180* |
probably null |
Het |
| F5 |
A |
G |
1: 164,012,483 (GRCm39) |
S466G |
probably benign |
Het |
| Fbn2 |
A |
T |
18: 58,235,445 (GRCm39) |
C677* |
probably null |
Het |
| Fbxo41 |
A |
G |
6: 85,454,890 (GRCm39) |
S673P |
probably damaging |
Het |
| Fhad1 |
G |
T |
4: 141,667,406 (GRCm39) |
H639N |
probably benign |
Het |
| Fmnl3 |
G |
C |
15: 99,220,619 (GRCm39) |
|
probably benign |
Het |
| Foxa2 |
A |
G |
2: 147,885,481 (GRCm39) |
S270P |
probably damaging |
Het |
| Fxyd7 |
C |
T |
7: 30,746,793 (GRCm39) |
|
probably null |
Het |
| Gm5225 |
A |
G |
17: 24,243,032 (GRCm39) |
D67G |
probably benign |
Het |
| Grik3 |
G |
A |
4: 125,564,349 (GRCm39) |
E444K |
probably benign |
Het |
| Gsdma2 |
A |
G |
11: 98,540,009 (GRCm39) |
K44E |
probably damaging |
Het |
| Haus1 |
T |
A |
18: 77,849,770 (GRCm39) |
K130* |
probably null |
Het |
| Heg1 |
A |
G |
16: 33,556,028 (GRCm39) |
|
probably benign |
Het |
| Hormad2 |
A |
G |
11: 4,362,206 (GRCm39) |
|
probably benign |
Het |
| Hsd17b3 |
G |
A |
13: 64,206,403 (GRCm39) |
R300C |
possibly damaging |
Het |
| Irf5 |
T |
C |
6: 29,536,108 (GRCm39) |
F374S |
probably damaging |
Het |
| Itch |
A |
G |
2: 155,059,903 (GRCm39) |
|
probably benign |
Het |
| Jade2 |
A |
T |
11: 51,722,136 (GRCm39) |
L139Q |
probably damaging |
Het |
| Kif5c |
G |
A |
2: 49,642,251 (GRCm39) |
|
probably benign |
Het |
| Lama1 |
T |
C |
17: 68,083,918 (GRCm39) |
Y1387H |
probably benign |
Het |
| Larp4b |
A |
G |
13: 9,220,724 (GRCm39) |
R658G |
probably damaging |
Het |
| Mcph1 |
C |
T |
8: 18,838,264 (GRCm39) |
L729F |
probably benign |
Het |
| Me1 |
A |
T |
9: 86,536,720 (GRCm39) |
N118K |
probably benign |
Het |
| Med13 |
A |
G |
11: 86,210,723 (GRCm39) |
L473S |
probably damaging |
Het |
| Mgam |
T |
A |
6: 40,635,921 (GRCm39) |
Y359N |
probably damaging |
Het |
| Morc2b |
A |
G |
17: 33,356,015 (GRCm39) |
S586P |
probably damaging |
Het |
| Mthfr |
A |
G |
4: 148,135,980 (GRCm39) |
D310G |
probably benign |
Het |
| Mtmr7 |
A |
T |
8: 41,034,447 (GRCm39) |
|
probably benign |
Het |
| Mtus1 |
A |
G |
8: 41,451,514 (GRCm39) |
|
probably benign |
Het |
| Mus81 |
G |
T |
19: 5,536,552 (GRCm39) |
A138D |
probably damaging |
Het |
| Myom2 |
A |
T |
8: 15,167,633 (GRCm39) |
I1073F |
probably damaging |
Het |
| Nhsl1 |
A |
T |
10: 18,400,990 (GRCm39) |
K739* |
probably null |
Het |
| Nlrp4d |
T |
A |
7: 10,108,818 (GRCm39) |
K762N |
probably benign |
Het |
| Nrap |
T |
C |
19: 56,343,978 (GRCm39) |
Y724C |
probably damaging |
Het |
| Ogn |
A |
T |
13: 49,774,514 (GRCm39) |
Y219F |
possibly damaging |
Het |
| Or6c212 |
T |
A |
10: 129,558,846 (GRCm39) |
D189V |
probably damaging |
Het |
| Or8b56 |
T |
C |
9: 38,739,860 (GRCm39) |
L291P |
probably damaging |
Het |
| Or8g30 |
A |
T |
9: 39,230,160 (GRCm39) |
I250N |
probably damaging |
Het |
| Padi2 |
T |
C |
4: 140,653,550 (GRCm39) |
V180A |
probably benign |
Het |
| Papss2 |
C |
T |
19: 32,615,768 (GRCm39) |
R167* |
probably null |
Het |
| Pcbp2 |
T |
C |
15: 102,382,670 (GRCm39) |
|
probably benign |
Het |
| Per1 |
T |
A |
11: 68,992,706 (GRCm39) |
|
probably benign |
Het |
| Pik3ca |
T |
C |
3: 32,514,094 (GRCm39) |
I860T |
probably damaging |
Het |
| Pkdrej |
G |
A |
15: 85,701,746 (GRCm39) |
Q1397* |
probably null |
Het |
| Plce1 |
T |
C |
19: 38,710,265 (GRCm39) |
V1133A |
probably benign |
Het |
| Pnma8a |
T |
G |
7: 16,694,625 (GRCm39) |
V160G |
probably damaging |
Het |
| Prss12 |
T |
C |
3: 123,276,423 (GRCm39) |
C351R |
probably damaging |
Het |
| Qprt |
A |
T |
7: 126,708,269 (GRCm39) |
L54Q |
probably damaging |
Het |
| Raf1 |
C |
T |
6: 115,603,344 (GRCm39) |
S165N |
probably damaging |
Het |
| Rere |
A |
G |
4: 150,701,433 (GRCm39) |
N1271S |
probably benign |
Het |
| Rnasel |
T |
A |
1: 153,630,258 (GRCm39) |
L258H |
probably damaging |
Het |
| Ryr2 |
T |
C |
13: 11,724,807 (GRCm39) |
D2502G |
probably damaging |
Het |
| Ryr3 |
G |
A |
2: 112,633,510 (GRCm39) |
S2081L |
probably damaging |
Het |
| Sc5d |
G |
T |
9: 42,171,155 (GRCm39) |
Y11* |
probably null |
Het |
| Slc25a29 |
A |
C |
12: 108,793,017 (GRCm39) |
L187R |
possibly damaging |
Het |
| Slc2a7 |
G |
A |
4: 150,252,721 (GRCm39) |
V454M |
probably benign |
Het |
| Slco1b2 |
A |
T |
6: 141,615,114 (GRCm39) |
T340S |
probably benign |
Het |
| Smarcc1 |
A |
G |
9: 109,976,172 (GRCm39) |
N153S |
possibly damaging |
Het |
| Snx1 |
C |
A |
9: 65,995,821 (GRCm39) |
E516* |
probably null |
Het |
| Sptlc2 |
T |
C |
12: 87,403,454 (GRCm39) |
D115G |
probably benign |
Het |
| Stard9 |
A |
G |
2: 120,464,736 (GRCm39) |
N67S |
probably damaging |
Het |
| Styxl2 |
A |
C |
1: 165,927,270 (GRCm39) |
S781A |
probably benign |
Het |
| Swap70 |
G |
A |
7: 109,872,489 (GRCm39) |
R368H |
probably benign |
Het |
| Tcaf3 |
T |
C |
6: 42,568,284 (GRCm39) |
K691E |
probably benign |
Het |
| Tmco4 |
T |
C |
4: 138,781,231 (GRCm39) |
F465S |
probably damaging |
Het |
| Tmem245 |
A |
G |
4: 56,926,213 (GRCm39) |
S290P |
probably benign |
Het |
| Top2a |
T |
C |
11: 98,894,416 (GRCm39) |
T972A |
probably benign |
Het |
| Tpr |
T |
A |
1: 150,285,898 (GRCm39) |
S527R |
probably damaging |
Het |
| Traf2 |
T |
C |
2: 25,409,621 (GRCm39) |
D443G |
probably damaging |
Het |
| Trim40 |
A |
T |
17: 37,194,039 (GRCm39) |
|
probably null |
Het |
| Trim42 |
A |
T |
9: 97,245,456 (GRCm39) |
I448N |
possibly damaging |
Het |
| Ttll9 |
G |
A |
2: 152,825,054 (GRCm39) |
V78M |
probably damaging |
Het |
| Vav1 |
C |
T |
17: 57,603,039 (GRCm39) |
L88F |
probably damaging |
Het |
| Vps13b |
A |
G |
15: 35,423,301 (GRCm39) |
D207G |
probably damaging |
Het |
| Wdsub1 |
A |
G |
2: 59,707,009 (GRCm39) |
|
probably null |
Het |
| Zfp799 |
A |
G |
17: 33,040,009 (GRCm39) |
W85R |
possibly damaging |
Het |
| Zfp839 |
A |
T |
12: 110,825,203 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,908,854 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,908,618 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,909,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,909,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,908,612 (GRCm39) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,878,845 (GRCm39) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,908,990 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,908,989 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,874,424 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,884,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,878,696 (GRCm39) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,844,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,867,584 (GRCm39) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,897,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,909,621 (GRCm39) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,844,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,899,031 (GRCm39) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,896,134 (GRCm39) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,864,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,909,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,865,963 (GRCm39) |
splice site |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,909,407 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,877,372 (GRCm39) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,873,101 (GRCm39) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,909,198 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,865,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,905,262 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,878,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,869,679 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,864,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,901,957 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,866,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,867,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Dapk1
|
UTSW |
13 |
60,869,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,899,022 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,909,481 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,877,317 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,909,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,905,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,878,745 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,900,030 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,864,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,867,564 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,896,014 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,908,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,909,403 (GRCm39) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,865,942 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,869,636 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,865,861 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,898,961 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4717:Dapk1
|
UTSW |
13 |
60,874,476 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4775:Dapk1
|
UTSW |
13 |
60,897,156 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4790:Dapk1
|
UTSW |
13 |
60,870,919 (GRCm39) |
frame shift |
probably null |
|
|
R4897:Dapk1
|
UTSW |
13 |
60,909,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,908,774 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,869,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,873,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,877,209 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,909,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,909,580 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,909,140 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,877,256 (GRCm39) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,908,975 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,909,161 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,897,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,864,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,908,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,873,154 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,900,049 (GRCm39) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,899,103 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,844,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,884,138 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,896,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,844,209 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,909,599 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7199:Dapk1
|
UTSW |
13 |
60,902,024 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7203:Dapk1
|
UTSW |
13 |
60,844,149 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7404:Dapk1
|
UTSW |
13 |
60,867,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7448:Dapk1
|
UTSW |
13 |
60,898,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,905,311 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,878,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Dapk1
|
UTSW |
13 |
60,908,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,909,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,899,007 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,873,153 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,873,715 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,909,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,897,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,909,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,878,710 (GRCm39) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,870,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,887,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,908,734 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,866,264 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,909,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,866,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,866,125 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,898,991 (GRCm39) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,877,369 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,910,203 (GRCm39) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,895,937 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,898,948 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,909,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,908,618 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGAAGACATCCAGCGTCTGGTC -3'
(R):5'- TGCTTCACCGTCAACAACCCTG -3'
Sequencing Primer
(F):5'- TCTGGTCCCAGACAGTGAC -3'
(R):5'- ACAACCCTGGCAAGGTG -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation