Incidental Mutation 'R1866:Cacna2d3'
ID |
208763 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cacna2d3
|
Ensembl Gene |
ENSMUSG00000021991 |
Gene Name |
calcium channel, voltage-dependent, alpha2/delta subunit 3 |
Synonyms |
alpha 2 delta-3, alpha2delta3 |
MMRRC Submission |
039889-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R1866 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
14 |
Chromosomal Location |
28626900-29443821 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 28691171 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Leucine
at position 51
(F51L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000152967
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022567]
[ENSMUST00000225668]
[ENSMUST00000225985]
|
AlphaFold |
Q9Z1L5 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000022567
AA Change: F878L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
SMART Domains |
Protein: ENSMUSP00000022567 Gene: ENSMUSG00000021991 AA Change: F878L
Domain | Start | End | E-Value | Type |
low complexity region
|
14 |
27 |
N/A |
INTRINSIC |
Blast:WNT1
|
28 |
103 |
2e-33 |
BLAST |
Pfam:VWA_N
|
113 |
229 |
6.8e-40 |
PFAM |
VWA
|
254 |
439 |
4.13e-24 |
SMART |
Pfam:Cache_1
|
452 |
548 |
3e-32 |
PFAM |
low complexity region
|
1070 |
1088 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000225668
AA Change: F51L
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000225985
AA Change: F51L
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.3%
- 20x: 92.6%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for disruptions in this gene have a decreased startle reflex and occasional animals show increased aggression and hyperactivity. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 92 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Apba1 |
A |
T |
19: 23,870,195 (GRCm39) |
E9V |
probably benign |
Het |
Armc8 |
T |
A |
9: 99,418,333 (GRCm39) |
T32S |
probably benign |
Het |
Atr |
T |
A |
9: 95,752,658 (GRCm39) |
|
probably null |
Het |
Blm |
A |
G |
7: 80,143,862 (GRCm39) |
L859P |
probably benign |
Het |
Cdcp2 |
A |
G |
4: 106,964,197 (GRCm39) |
N349S |
probably damaging |
Het |
Cfap57 |
G |
A |
4: 118,457,124 (GRCm39) |
H442Y |
possibly damaging |
Het |
Chrm3 |
A |
G |
13: 9,928,517 (GRCm39) |
L173P |
probably damaging |
Het |
Cpb1 |
C |
G |
3: 20,317,920 (GRCm39) |
M201I |
probably benign |
Het |
Dgcr8 |
A |
T |
16: 18,076,178 (GRCm39) |
N2K |
probably damaging |
Het |
Dnah3 |
A |
T |
7: 119,528,079 (GRCm39) |
|
probably null |
Het |
Dnah6 |
T |
A |
6: 73,077,071 (GRCm39) |
Q2398L |
probably benign |
Het |
Dpep2 |
A |
T |
8: 106,716,080 (GRCm39) |
|
probably null |
Het |
Eif2ak4 |
C |
A |
2: 118,303,142 (GRCm39) |
T1504K |
probably damaging |
Het |
Exoc6b |
A |
G |
6: 84,828,896 (GRCm39) |
V496A |
probably damaging |
Het |
Fam174a |
A |
C |
1: 95,241,620 (GRCm39) |
S27R |
probably benign |
Het |
Fat2 |
T |
A |
11: 55,182,840 (GRCm39) |
Q1339L |
probably benign |
Het |
Fkbpl |
T |
A |
17: 34,864,797 (GRCm39) |
D188E |
possibly damaging |
Het |
Focad |
A |
G |
4: 88,325,402 (GRCm39) |
D89G |
possibly damaging |
Het |
Fstl4 |
C |
A |
11: 53,077,225 (GRCm39) |
Q661K |
probably benign |
Het |
Gck |
T |
C |
11: 5,853,253 (GRCm39) |
Y289C |
probably benign |
Het |
Gm16181 |
T |
A |
17: 35,442,913 (GRCm39) |
|
probably benign |
Het |
Herc1 |
G |
A |
9: 66,358,073 (GRCm39) |
G2385S |
probably damaging |
Het |
Igfn1 |
T |
C |
1: 135,902,606 (GRCm39) |
|
probably null |
Het |
Il12b |
T |
C |
11: 44,299,353 (GRCm39) |
W141R |
probably damaging |
Het |
Itga6 |
T |
A |
2: 71,664,414 (GRCm39) |
S517T |
probably benign |
Het |
Kank1 |
A |
G |
19: 25,388,813 (GRCm39) |
S801G |
probably benign |
Het |
Klrh1 |
A |
G |
6: 129,752,343 (GRCm39) |
|
probably null |
Het |
Lctl |
A |
G |
9: 64,039,003 (GRCm39) |
D205G |
probably damaging |
Het |
Lhx3 |
A |
C |
2: 26,093,986 (GRCm39) |
V79G |
probably damaging |
Het |
Lrrc9 |
T |
C |
12: 72,543,912 (GRCm39) |
I1127T |
probably damaging |
Het |
Ltbp3 |
A |
T |
19: 5,797,877 (GRCm39) |
E505D |
probably benign |
Het |
Man1c1 |
G |
C |
4: 134,430,749 (GRCm39) |
P11R |
probably damaging |
Het |
Map6 |
A |
G |
7: 98,965,083 (GRCm39) |
S291G |
probably damaging |
Het |
Mapk7 |
A |
G |
11: 61,380,239 (GRCm39) |
F671L |
probably benign |
Het |
Mau2 |
A |
G |
8: 70,484,142 (GRCm39) |
W149R |
probably damaging |
Het |
Mb21d2 |
C |
T |
16: 28,647,267 (GRCm39) |
V236I |
possibly damaging |
Het |
Mc5r |
C |
G |
18: 68,471,741 (GRCm39) |
|
probably null |
Het |
Mical1 |
C |
A |
10: 41,361,466 (GRCm39) |
P797Q |
probably benign |
Het |
Mnx1 |
G |
A |
5: 29,679,043 (GRCm39) |
R347C |
unknown |
Het |
Mslnl |
G |
A |
17: 25,961,908 (GRCm39) |
V128M |
probably damaging |
Het |
Nlrp2 |
G |
T |
7: 5,330,715 (GRCm39) |
C560* |
probably null |
Het |
Npat |
T |
A |
9: 53,474,416 (GRCm39) |
L736H |
probably damaging |
Het |
Nup155 |
T |
A |
15: 8,145,010 (GRCm39) |
V147E |
probably damaging |
Het |
Nxpe2 |
A |
G |
9: 48,238,121 (GRCm39) |
F45L |
probably benign |
Het |
Obscn |
T |
C |
11: 58,951,741 (GRCm39) |
D4370G |
probably benign |
Het |
Or2d3b |
A |
G |
7: 106,514,273 (GRCm39) |
I289M |
probably damaging |
Het |
Or4a79 |
T |
C |
2: 89,551,550 (GRCm39) |
K302E |
probably benign |
Het |
Or4c35 |
T |
C |
2: 89,808,671 (GRCm39) |
L183S |
probably damaging |
Het |
Or4d10 |
A |
G |
19: 12,051,183 (GRCm39) |
V271A |
probably benign |
Het |
Or52n4 |
A |
G |
7: 104,294,004 (GRCm39) |
S190P |
probably benign |
Het |
Or5g23 |
T |
A |
2: 85,439,188 (GRCm39) |
H22L |
probably benign |
Het |
Or8k3 |
A |
C |
2: 86,059,072 (GRCm39) |
M81R |
probably damaging |
Het |
Pcx |
T |
C |
19: 4,671,249 (GRCm39) |
I1157T |
possibly damaging |
Het |
Pias2 |
T |
A |
18: 77,240,412 (GRCm39) |
S589R |
probably benign |
Het |
Plcb1 |
T |
C |
2: 135,186,093 (GRCm39) |
F687L |
probably benign |
Het |
Plk5 |
G |
T |
10: 80,196,403 (GRCm39) |
|
probably null |
Het |
Pnpla2 |
T |
A |
7: 141,035,329 (GRCm39) |
Y44N |
probably damaging |
Het |
Ppp1r12a |
T |
A |
10: 108,098,292 (GRCm39) |
D337E |
possibly damaging |
Het |
Prl2c5 |
G |
T |
13: 13,365,358 (GRCm39) |
|
probably null |
Het |
Prom2 |
T |
C |
2: 127,378,514 (GRCm39) |
D460G |
probably damaging |
Het |
Pros1 |
A |
G |
16: 62,748,498 (GRCm39) |
H657R |
possibly damaging |
Het |
Prune2 |
A |
G |
19: 17,100,856 (GRCm39) |
E2120G |
probably damaging |
Het |
Rap2a |
T |
A |
14: 120,716,347 (GRCm39) |
L70Q |
probably damaging |
Het |
Rbl2 |
A |
T |
8: 91,839,157 (GRCm39) |
E858D |
probably benign |
Het |
Rbm48 |
T |
C |
5: 3,645,997 (GRCm39) |
Y69C |
probably damaging |
Het |
Rgs12 |
T |
A |
5: 35,123,018 (GRCm39) |
I267N |
probably damaging |
Het |
Rpusd2 |
G |
T |
2: 118,865,728 (GRCm39) |
A142S |
probably benign |
Het |
Rspo2 |
A |
T |
15: 42,939,332 (GRCm39) |
W153R |
probably damaging |
Het |
Sdk2 |
C |
T |
11: 113,729,472 (GRCm39) |
|
silent |
Het |
Serinc5 |
T |
A |
13: 92,842,771 (GRCm39) |
M407K |
probably damaging |
Het |
Slain2 |
T |
C |
5: 73,114,665 (GRCm39) |
S299P |
probably damaging |
Het |
Slc17a4 |
A |
G |
13: 24,084,528 (GRCm39) |
Y419H |
possibly damaging |
Het |
Slc1a6 |
T |
A |
10: 78,627,183 (GRCm39) |
D173E |
probably damaging |
Het |
Slc22a19 |
A |
T |
19: 7,688,506 (GRCm39) |
I18N |
probably damaging |
Het |
Slc37a3 |
A |
T |
6: 39,336,902 (GRCm39) |
F91L |
probably damaging |
Het |
Spag5 |
C |
A |
11: 78,195,281 (GRCm39) |
T196K |
possibly damaging |
Het |
Susd2 |
G |
T |
10: 75,475,566 (GRCm39) |
A326D |
probably damaging |
Het |
Syna |
G |
T |
5: 134,588,769 (GRCm39) |
A60D |
probably damaging |
Het |
Tchh |
A |
T |
3: 93,355,067 (GRCm39) |
E1502D |
unknown |
Het |
Tecta |
T |
C |
9: 42,303,320 (GRCm39) |
H104R |
probably damaging |
Het |
Tmed1 |
T |
C |
9: 21,420,387 (GRCm39) |
D102G |
probably damaging |
Het |
Trip12 |
T |
C |
1: 84,722,781 (GRCm39) |
D128G |
probably damaging |
Het |
Uroc1 |
A |
G |
6: 90,338,506 (GRCm39) |
M656V |
probably benign |
Het |
Usp47 |
T |
A |
7: 111,701,077 (GRCm39) |
V1096D |
possibly damaging |
Het |
Utp20 |
T |
A |
10: 88,598,632 (GRCm39) |
K115* |
probably null |
Het |
Vmn2r19 |
G |
T |
6: 123,308,597 (GRCm39) |
|
probably null |
Het |
Vmn2r86 |
A |
T |
10: 130,282,255 (GRCm39) |
V787D |
probably damaging |
Het |
Vmn2r87 |
A |
T |
10: 130,308,441 (GRCm39) |
I599N |
possibly damaging |
Het |
Vwf |
A |
G |
6: 125,644,492 (GRCm39) |
D2449G |
possibly damaging |
Het |
Zbtb7c |
T |
A |
18: 76,269,977 (GRCm39) |
C22S |
probably benign |
Het |
Zc3h7a |
A |
G |
16: 10,965,168 (GRCm39) |
I655T |
possibly damaging |
Het |
Zfp764l1 |
A |
G |
7: 126,992,503 (GRCm39) |
W36R |
probably damaging |
Het |
|
Other mutations in Cacna2d3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01113:Cacna2d3
|
APN |
14 |
29,022,688 (GRCm39) |
splice site |
probably benign |
|
IGL01150:Cacna2d3
|
APN |
14 |
28,905,598 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL01390:Cacna2d3
|
APN |
14 |
28,665,548 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL01626:Cacna2d3
|
APN |
14 |
28,665,564 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL02127:Cacna2d3
|
APN |
14 |
28,785,832 (GRCm39) |
unclassified |
probably benign |
|
IGL02237:Cacna2d3
|
APN |
14 |
29,068,954 (GRCm39) |
missense |
probably benign |
0.09 |
IGL02274:Cacna2d3
|
APN |
14 |
28,678,827 (GRCm39) |
splice site |
probably null |
|
IGL02604:Cacna2d3
|
APN |
14 |
29,015,066 (GRCm39) |
missense |
possibly damaging |
0.61 |
IGL02806:Cacna2d3
|
APN |
14 |
29,073,907 (GRCm39) |
splice site |
probably null |
|
IGL02838:Cacna2d3
|
APN |
14 |
29,022,785 (GRCm39) |
critical splice acceptor site |
probably null |
|
IGL02894:Cacna2d3
|
APN |
14 |
28,786,276 (GRCm39) |
critical splice acceptor site |
probably null |
|
IGL03061:Cacna2d3
|
APN |
14 |
28,780,388 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL03117:Cacna2d3
|
APN |
14 |
29,189,909 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03265:Cacna2d3
|
APN |
14 |
28,674,243 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL03266:Cacna2d3
|
APN |
14 |
29,022,705 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03396:Cacna2d3
|
APN |
14 |
29,442,834 (GRCm39) |
nonsense |
probably null |
|
R0094:Cacna2d3
|
UTSW |
14 |
28,892,460 (GRCm39) |
critical splice donor site |
probably null |
|
R0326:Cacna2d3
|
UTSW |
14 |
28,767,601 (GRCm39) |
missense |
probably damaging |
0.96 |
R0485:Cacna2d3
|
UTSW |
14 |
29,256,476 (GRCm39) |
missense |
possibly damaging |
0.89 |
R0669:Cacna2d3
|
UTSW |
14 |
29,189,906 (GRCm39) |
missense |
probably benign |
0.40 |
R0730:Cacna2d3
|
UTSW |
14 |
28,704,322 (GRCm39) |
missense |
probably benign |
0.02 |
R0736:Cacna2d3
|
UTSW |
14 |
28,780,585 (GRCm39) |
missense |
probably benign |
0.02 |
R1073:Cacna2d3
|
UTSW |
14 |
28,767,580 (GRCm39) |
missense |
probably damaging |
0.99 |
R1116:Cacna2d3
|
UTSW |
14 |
28,786,278 (GRCm39) |
splice site |
probably benign |
|
R1312:Cacna2d3
|
UTSW |
14 |
28,767,625 (GRCm39) |
missense |
probably benign |
0.00 |
R1467:Cacna2d3
|
UTSW |
14 |
29,055,736 (GRCm39) |
missense |
possibly damaging |
0.67 |
R1467:Cacna2d3
|
UTSW |
14 |
29,055,736 (GRCm39) |
missense |
possibly damaging |
0.67 |
R1501:Cacna2d3
|
UTSW |
14 |
28,703,137 (GRCm39) |
missense |
probably damaging |
1.00 |
R1525:Cacna2d3
|
UTSW |
14 |
28,694,199 (GRCm39) |
missense |
probably benign |
0.01 |
R1574:Cacna2d3
|
UTSW |
14 |
29,073,779 (GRCm39) |
missense |
probably damaging |
1.00 |
R1574:Cacna2d3
|
UTSW |
14 |
29,073,779 (GRCm39) |
missense |
probably damaging |
1.00 |
R2403:Cacna2d3
|
UTSW |
14 |
28,627,259 (GRCm39) |
missense |
probably benign |
0.38 |
R2981:Cacna2d3
|
UTSW |
14 |
28,785,875 (GRCm39) |
missense |
probably damaging |
1.00 |
R3715:Cacna2d3
|
UTSW |
14 |
29,068,880 (GRCm39) |
missense |
probably damaging |
1.00 |
R3791:Cacna2d3
|
UTSW |
14 |
28,905,538 (GRCm39) |
missense |
probably benign |
0.03 |
R3847:Cacna2d3
|
UTSW |
14 |
29,069,077 (GRCm39) |
critical splice donor site |
probably null |
|
R3849:Cacna2d3
|
UTSW |
14 |
29,069,077 (GRCm39) |
critical splice donor site |
probably null |
|
R3850:Cacna2d3
|
UTSW |
14 |
29,069,077 (GRCm39) |
critical splice donor site |
probably null |
|
R4558:Cacna2d3
|
UTSW |
14 |
28,825,670 (GRCm39) |
missense |
possibly damaging |
0.70 |
R4594:Cacna2d3
|
UTSW |
14 |
28,704,303 (GRCm39) |
missense |
probably benign |
0.13 |
R4681:Cacna2d3
|
UTSW |
14 |
29,015,092 (GRCm39) |
missense |
probably damaging |
1.00 |
R4868:Cacna2d3
|
UTSW |
14 |
28,678,743 (GRCm39) |
splice site |
probably null |
|
R4965:Cacna2d3
|
UTSW |
14 |
28,704,289 (GRCm39) |
missense |
probably benign |
0.07 |
R5133:Cacna2d3
|
UTSW |
14 |
29,015,135 (GRCm39) |
missense |
possibly damaging |
0.75 |
R5311:Cacna2d3
|
UTSW |
14 |
29,068,987 (GRCm39) |
missense |
probably damaging |
0.99 |
R5432:Cacna2d3
|
UTSW |
14 |
28,665,512 (GRCm39) |
critical splice donor site |
probably null |
|
R5873:Cacna2d3
|
UTSW |
14 |
29,442,891 (GRCm39) |
missense |
probably benign |
0.31 |
R6103:Cacna2d3
|
UTSW |
14 |
29,118,446 (GRCm39) |
missense |
probably damaging |
1.00 |
R6197:Cacna2d3
|
UTSW |
14 |
28,630,278 (GRCm39) |
missense |
probably benign |
0.38 |
R6396:Cacna2d3
|
UTSW |
14 |
29,118,522 (GRCm39) |
missense |
probably benign |
0.03 |
R6626:Cacna2d3
|
UTSW |
14 |
28,786,143 (GRCm39) |
unclassified |
probably benign |
|
R6632:Cacna2d3
|
UTSW |
14 |
28,627,222 (GRCm39) |
makesense |
probably null |
|
R6706:Cacna2d3
|
UTSW |
14 |
28,846,642 (GRCm39) |
critical splice acceptor site |
probably null |
|
R6765:Cacna2d3
|
UTSW |
14 |
28,777,934 (GRCm39) |
missense |
probably damaging |
1.00 |
R6945:Cacna2d3
|
UTSW |
14 |
28,691,275 (GRCm39) |
intron |
probably benign |
|
R7009:Cacna2d3
|
UTSW |
14 |
28,691,322 (GRCm39) |
start codon destroyed |
probably null |
|
R7069:Cacna2d3
|
UTSW |
14 |
28,691,260 (GRCm39) |
intron |
probably benign |
|
R7146:Cacna2d3
|
UTSW |
14 |
29,443,654 (GRCm39) |
missense |
unknown |
|
R7427:Cacna2d3
|
UTSW |
14 |
28,786,232 (GRCm39) |
missense |
probably damaging |
1.00 |
R7428:Cacna2d3
|
UTSW |
14 |
28,786,232 (GRCm39) |
missense |
probably damaging |
1.00 |
R7445:Cacna2d3
|
UTSW |
14 |
28,780,575 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7505:Cacna2d3
|
UTSW |
14 |
28,767,501 (GRCm39) |
splice site |
probably null |
|
R7560:Cacna2d3
|
UTSW |
14 |
28,780,378 (GRCm39) |
missense |
probably benign |
0.18 |
R7703:Cacna2d3
|
UTSW |
14 |
28,765,503 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8042:Cacna2d3
|
UTSW |
14 |
28,826,995 (GRCm39) |
splice site |
probably benign |
|
R8096:Cacna2d3
|
UTSW |
14 |
28,825,657 (GRCm39) |
missense |
possibly damaging |
0.62 |
R8280:Cacna2d3
|
UTSW |
14 |
28,704,328 (GRCm39) |
missense |
probably benign |
0.25 |
R8814:Cacna2d3
|
UTSW |
14 |
28,819,772 (GRCm39) |
missense |
probably damaging |
1.00 |
R8838:Cacna2d3
|
UTSW |
14 |
28,691,220 (GRCm39) |
missense |
probably benign |
0.03 |
R8864:Cacna2d3
|
UTSW |
14 |
29,055,735 (GRCm39) |
missense |
probably damaging |
1.00 |
R9103:Cacna2d3
|
UTSW |
14 |
29,068,971 (GRCm39) |
missense |
probably damaging |
1.00 |
R9341:Cacna2d3
|
UTSW |
14 |
28,704,315 (GRCm39) |
missense |
possibly damaging |
0.92 |
R9343:Cacna2d3
|
UTSW |
14 |
28,704,315 (GRCm39) |
missense |
possibly damaging |
0.92 |
R9567:Cacna2d3
|
UTSW |
14 |
28,627,268 (GRCm39) |
missense |
probably benign |
0.38 |
Z1088:Cacna2d3
|
UTSW |
14 |
28,786,265 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1177:Cacna2d3
|
UTSW |
14 |
29,069,120 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
Predicted Primers |
PCR Primer
(F):5'- AGTACCCATGCACAGAGTTC -3'
(R):5'- ACTGTTTCAGCCATTCCCAG -3'
Sequencing Primer
(F):5'- TCAACAAGTGGGATTGGCTCC -3'
(R):5'- GGAATCTTAAAAACCTGCCTCTG -3'
|
Posted On |
2014-06-30 |