Incidental Mutation 'R1887:Vmn2r115'
| ID |
209687 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r115
|
| Ensembl Gene |
ENSMUSG00000091076 |
| Gene Name |
vomeronasal 2, receptor 115 |
| Synonyms |
V2Rp4, EG638102 |
| MMRRC Submission |
039908-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.084)
|
| Stock # |
R1887 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
23562951-23579102 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23565007 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 298
(I298T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131447
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168175]
|
| AlphaFold |
E9Q0E7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168175
AA Change: I298T
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076
AA Change: I298T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
471 |
1.4e-28 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
2.9e-20 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
5e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 97.1%
- 3x: 96.1%
- 10x: 93.2%
- 20x: 86.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700034J05Rik |
T |
C |
6: 146,853,909 (GRCm39) |
I249M |
possibly damaging |
Het |
| 1700102P08Rik |
T |
A |
9: 108,270,809 (GRCm39) |
D124E |
possibly damaging |
Het |
| 4930544D05Rik |
A |
G |
11: 70,507,249 (GRCm39) |
E98G |
probably damaging |
Het |
| Abca8a |
A |
T |
11: 109,980,768 (GRCm39) |
M90K |
probably damaging |
Het |
| Adamts9 |
A |
G |
6: 92,849,769 (GRCm39) |
|
probably null |
Het |
| Adora3 |
A |
C |
3: 105,812,152 (GRCm39) |
N13H |
possibly damaging |
Het |
| Aen |
A |
T |
7: 78,557,073 (GRCm39) |
D307V |
probably damaging |
Het |
| Akr1c18 |
T |
A |
13: 4,193,287 (GRCm39) |
N126I |
probably benign |
Het |
| Ankmy2 |
T |
A |
12: 36,220,467 (GRCm39) |
M51K |
possibly damaging |
Het |
| Antkmt |
C |
A |
17: 26,010,319 (GRCm39) |
|
probably null |
Het |
| Apc |
A |
G |
18: 34,405,521 (GRCm39) |
E159G |
probably damaging |
Het |
| Arhgef28 |
G |
T |
13: 98,282,081 (GRCm39) |
S4R |
probably damaging |
Het |
| Atg2b |
G |
A |
12: 105,620,351 (GRCm39) |
T784M |
probably benign |
Het |
| Atp11a |
A |
G |
8: 12,862,324 (GRCm39) |
N59D |
probably damaging |
Het |
| Cacna1h |
T |
C |
17: 25,595,861 (GRCm39) |
Y1875C |
probably benign |
Het |
| Capza1 |
A |
T |
3: 104,747,096 (GRCm39) |
|
probably null |
Het |
| Ccdc81 |
T |
C |
7: 89,515,819 (GRCm39) |
E620G |
possibly damaging |
Het |
| Cdcp2 |
T |
C |
4: 106,959,899 (GRCm39) |
F105L |
probably damaging |
Het |
| Cdhr18 |
A |
C |
14: 13,828,607 (GRCm38) |
Y718D |
probably damaging |
Het |
| Cep152 |
A |
T |
2: 125,462,225 (GRCm39) |
M58K |
probably benign |
Het |
| Comtd1 |
A |
G |
14: 21,897,809 (GRCm39) |
L108P |
probably damaging |
Het |
| Cyp2b13 |
A |
G |
7: 25,788,075 (GRCm39) |
Y401C |
probably damaging |
Het |
| Dap3 |
A |
G |
3: 88,838,281 (GRCm39) |
L86P |
probably damaging |
Het |
| Dmxl1 |
G |
A |
18: 49,992,202 (GRCm39) |
R316H |
probably benign |
Het |
| Eea1 |
T |
A |
10: 95,854,073 (GRCm39) |
|
probably null |
Het |
| Eeig1 |
T |
A |
2: 32,450,140 (GRCm39) |
N129K |
possibly damaging |
Het |
| Ezhip |
GTCATCATCATCATC |
GTCATCATCATCATCATC |
X: 5,994,645 (GRCm39) |
|
probably benign |
Het |
| Fam171a1 |
T |
C |
2: 3,221,380 (GRCm39) |
V157A |
probably damaging |
Het |
| Fat3 |
T |
A |
9: 15,878,357 (GRCm39) |
I3375F |
probably damaging |
Het |
| Fmod |
A |
G |
1: 133,968,551 (GRCm39) |
E197G |
possibly damaging |
Het |
| Fsd1l |
T |
C |
4: 53,696,984 (GRCm39) |
|
probably null |
Het |
| Gbp2b |
A |
G |
3: 142,314,063 (GRCm39) |
T448A |
probably benign |
Het |
| Gpatch1 |
A |
T |
7: 35,002,813 (GRCm39) |
N232K |
probably damaging |
Het |
| H2-Q4 |
A |
G |
17: 35,599,113 (GRCm39) |
R128G |
possibly damaging |
Het |
| Hc |
T |
C |
2: 34,924,623 (GRCm39) |
I435V |
probably benign |
Het |
| Hmgxb3 |
A |
G |
18: 61,270,473 (GRCm39) |
|
probably null |
Het |
| Il23r |
A |
T |
6: 67,450,785 (GRCm39) |
D231E |
possibly damaging |
Het |
| Irag1 |
A |
G |
7: 110,523,740 (GRCm39) |
|
probably null |
Het |
| Kcnt2 |
T |
A |
1: 140,511,985 (GRCm39) |
S1023T |
probably damaging |
Het |
| Klc2 |
A |
G |
19: 5,158,640 (GRCm39) |
V618A |
probably benign |
Het |
| Lzts1 |
T |
C |
8: 69,591,485 (GRCm39) |
D221G |
probably damaging |
Het |
| Mdn1 |
G |
C |
4: 32,742,540 (GRCm39) |
R3926P |
probably damaging |
Het |
| Med24 |
A |
G |
11: 98,609,642 (GRCm39) |
|
probably benign |
Het |
| Mga |
T |
A |
2: 119,754,098 (GRCm39) |
L869Q |
probably damaging |
Het |
| Mob3a |
G |
A |
10: 80,527,068 (GRCm39) |
Q86* |
probably null |
Het |
| Ncoa7 |
T |
C |
10: 30,524,448 (GRCm39) |
N823S |
possibly damaging |
Het |
| Nlrp5 |
T |
A |
7: 23,116,909 (GRCm39) |
V211D |
probably damaging |
Het |
| Nr1h4 |
A |
T |
10: 89,290,729 (GRCm39) |
M433K |
possibly damaging |
Het |
| Ofcc1 |
T |
C |
13: 40,360,100 (GRCm39) |
S310G |
possibly damaging |
Het |
| Or4k49 |
G |
T |
2: 111,495,099 (GRCm39) |
S176I |
probably damaging |
Het |
| Or5p57 |
T |
C |
7: 107,665,985 (GRCm39) |
N7D |
probably benign |
Het |
| Or8k22 |
A |
G |
2: 86,163,617 (GRCm39) |
F28L |
possibly damaging |
Het |
| Pdlim7 |
C |
T |
13: 55,653,981 (GRCm39) |
G212D |
probably benign |
Het |
| Pdzd4 |
G |
A |
X: 72,839,052 (GRCm39) |
R419C |
probably damaging |
Het |
| Pik3cd |
T |
A |
4: 149,737,091 (GRCm39) |
I902F |
probably damaging |
Het |
| Pip5kl1 |
A |
G |
2: 32,468,517 (GRCm39) |
T198A |
probably damaging |
Het |
| Prkdc |
T |
C |
16: 15,647,499 (GRCm39) |
V3641A |
probably benign |
Het |
| Rp1l1 |
T |
C |
14: 64,265,839 (GRCm39) |
V475A |
probably benign |
Het |
| Rpl37 |
C |
T |
15: 5,148,072 (GRCm39) |
T83M |
possibly damaging |
Het |
| Scml4 |
A |
G |
10: 42,788,223 (GRCm39) |
Y51C |
probably damaging |
Het |
| Serinc5 |
A |
T |
13: 92,838,214 (GRCm39) |
D340V |
possibly damaging |
Het |
| Stambpl1 |
A |
G |
19: 34,213,808 (GRCm39) |
I346V |
probably benign |
Het |
| Syna |
G |
A |
5: 134,588,106 (GRCm39) |
S281L |
probably benign |
Het |
| Tcstv2a |
G |
T |
13: 120,725,604 (GRCm39) |
K89N |
probably damaging |
Het |
| Tet2 |
T |
C |
3: 133,193,094 (GRCm39) |
T447A |
possibly damaging |
Het |
| Tgfbr3 |
A |
G |
5: 107,284,874 (GRCm39) |
F592L |
probably damaging |
Het |
| Tmc7 |
A |
T |
7: 118,160,310 (GRCm39) |
F176I |
possibly damaging |
Het |
| Trip4 |
T |
A |
9: 65,782,163 (GRCm39) |
I190F |
probably null |
Het |
| Ttc6 |
T |
A |
12: 57,720,044 (GRCm39) |
S872T |
probably benign |
Het |
| Ttc7b |
C |
T |
12: 100,381,389 (GRCm39) |
|
probably null |
Het |
| Ubap2 |
C |
T |
4: 41,199,872 (GRCm39) |
A752T |
probably benign |
Het |
| Ubr4 |
T |
C |
4: 139,182,871 (GRCm39) |
L419P |
probably damaging |
Het |
| Ush2a |
C |
A |
1: 188,132,177 (GRCm39) |
Q800K |
probably benign |
Het |
| Vmn2r28 |
T |
C |
7: 5,491,288 (GRCm39) |
T320A |
possibly damaging |
Het |
| Zfp804b |
T |
C |
5: 6,820,376 (GRCm39) |
R860G |
probably damaging |
Het |
|
| Other mutations in Vmn2r115 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00990:Vmn2r115
|
APN |
17 |
23,575,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,345 (GRCm39) |
nonsense |
probably null |
|
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,135 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,252 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,323 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,150 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,180 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,567,008 (GRCm39) |
nonsense |
probably null |
|
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,578,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,238 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL00990:Vmn2r115
|
APN |
17 |
23,565,346 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01073:Vmn2r115
|
APN |
17 |
23,564,971 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01101:Vmn2r115
|
APN |
17 |
23,564,971 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01300:Vmn2r115
|
APN |
17 |
23,578,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01415:Vmn2r115
|
APN |
17 |
23,578,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02309:Vmn2r115
|
APN |
17 |
23,564,113 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02863:Vmn2r115
|
APN |
17 |
23,578,257 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0023:Vmn2r115
|
UTSW |
17 |
23,565,252 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0197:Vmn2r115
|
UTSW |
17 |
23,578,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0361:Vmn2r115
|
UTSW |
17 |
23,564,196 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0601:Vmn2r115
|
UTSW |
17 |
23,579,074 (GRCm39) |
missense |
probably null |
0.51 |
|
R0676:Vmn2r115
|
UTSW |
17 |
23,565,238 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0685:Vmn2r115
|
UTSW |
17 |
23,578,249 (GRCm39) |
missense |
probably benign |
|
|
R0865:Vmn2r115
|
UTSW |
17 |
23,565,382 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1124:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1145:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1146:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1207:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1266:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1318:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1367:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1376:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1376:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1420:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1469:Vmn2r115
|
UTSW |
17 |
23,564,992 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Vmn2r115
|
UTSW |
17 |
23,564,992 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1604:Vmn2r115
|
UTSW |
17 |
23,564,245 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1645:Vmn2r115
|
UTSW |
17 |
23,565,192 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1646:Vmn2r115
|
UTSW |
17 |
23,578,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1650:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1678:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1716:Vmn2r115
|
UTSW |
17 |
23,566,795 (GRCm39) |
missense |
probably benign |
|
|
R1846:Vmn2r115
|
UTSW |
17 |
23,578,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1847:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1885:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R1937:Vmn2r115
|
UTSW |
17 |
23,578,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2007:Vmn2r115
|
UTSW |
17 |
23,566,927 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2120:Vmn2r115
|
UTSW |
17 |
23,578,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3161:Vmn2r115
|
UTSW |
17 |
23,575,998 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3780:Vmn2r115
|
UTSW |
17 |
23,564,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3806:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R3982:Vmn2r115
|
UTSW |
17 |
23,578,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4019:Vmn2r115
|
UTSW |
17 |
23,579,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4039:Vmn2r115
|
UTSW |
17 |
23,564,077 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4087:Vmn2r115
|
UTSW |
17 |
23,565,358 (GRCm39) |
missense |
probably benign |
0.35 |
|
R4089:Vmn2r115
|
UTSW |
17 |
23,565,358 (GRCm39) |
missense |
probably benign |
0.35 |
|
R4379:Vmn2r115
|
UTSW |
17 |
23,564,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4417:Vmn2r115
|
UTSW |
17 |
23,564,854 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4601:Vmn2r115
|
UTSW |
17 |
23,565,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4874:Vmn2r115
|
UTSW |
17 |
23,578,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5466:Vmn2r115
|
UTSW |
17 |
23,579,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5613:Vmn2r115
|
UTSW |
17 |
23,564,307 (GRCm39) |
missense |
probably benign |
|
|
R5821:Vmn2r115
|
UTSW |
17 |
23,566,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6120:Vmn2r115
|
UTSW |
17 |
23,565,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6193:Vmn2r115
|
UTSW |
17 |
23,575,983 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6213:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R6290:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
R6319:Vmn2r115
|
UTSW |
17 |
23,566,877 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6495:Vmn2r115
|
UTSW |
17 |
23,578,572 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6599:Vmn2r115
|
UTSW |
17 |
23,565,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6764:Vmn2r115
|
UTSW |
17 |
23,565,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6970:Vmn2r115
|
UTSW |
17 |
23,564,989 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7023:Vmn2r115
|
UTSW |
17 |
23,578,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7236:Vmn2r115
|
UTSW |
17 |
23,578,576 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7353:Vmn2r115
|
UTSW |
17 |
23,564,887 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7483:Vmn2r115
|
UTSW |
17 |
23,565,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7743:Vmn2r115
|
UTSW |
17 |
23,564,772 (GRCm39) |
nonsense |
probably null |
|
|
R8005:Vmn2r115
|
UTSW |
17 |
23,563,124 (GRCm39) |
nonsense |
probably null |
|
|
R8191:Vmn2r115
|
UTSW |
17 |
23,578,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Vmn2r115
|
UTSW |
17 |
23,564,773 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8890:Vmn2r115
|
UTSW |
17 |
23,578,497 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9098:Vmn2r115
|
UTSW |
17 |
23,564,803 (GRCm39) |
missense |
probably benign |
|
|
R9114:Vmn2r115
|
UTSW |
17 |
23,564,307 (GRCm39) |
missense |
probably benign |
|
|
R9189:Vmn2r115
|
UTSW |
17 |
23,564,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9351:Vmn2r115
|
UTSW |
17 |
23,578,482 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9397:Vmn2r115
|
UTSW |
17 |
23,564,152 (GRCm39) |
nonsense |
probably null |
|
|
R9410:Vmn2r115
|
UTSW |
17 |
23,578,915 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9593:Vmn2r115
|
UTSW |
17 |
23,578,184 (GRCm39) |
missense |
probably damaging |
0.99 |
|
V5622:Vmn2r115
|
UTSW |
17 |
23,578,333 (GRCm39) |
missense |
probably benign |
|
|
V5622:Vmn2r115
|
UTSW |
17 |
23,565,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
X0033:Vmn2r115
|
UTSW |
17 |
23,578,962 (GRCm39) |
small deletion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGGTTGGTCATCTCAGACAATG -3'
(R):5'- AGTGCATCCATTCCAGCTTTAC -3'
Sequencing Primer
(F):5'- TGGTCATCTCAGACAATGATCAAGG -3'
(R):5'- GCATCCATTCCAGCTTTACCAGATAC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation