Incidental Mutation 'R1889:Kcnt2'
| ID |
209790 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kcnt2
|
| Ensembl Gene |
ENSMUSG00000052726 |
| Gene Name |
potassium channel, subfamily T, member 2 |
| Synonyms |
E330038N15Rik |
| MMRRC Submission |
039910-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R1889 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
140173896-140539805 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 140512031 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 995
(H995L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113535
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119786]
[ENSMUST00000120709]
[ENSMUST00000120796]
|
| AlphaFold |
D3Z649 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000060201
AA Change: H1069L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000054623
Gene: ENSMUSG00000052726
AA Change: H1069L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.8e-15 |
PFAM |
|
Pfam:BK_channel_a
|
424 |
533 |
1.3e-31 |
PFAM |
|
low complexity region
|
655 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
689 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119786
AA Change: H995L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000113535
Gene: ENSMUSG00000052726
AA Change: H995L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.6e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
476 |
2.3e-16 |
PFAM |
|
low complexity region
|
598 |
613 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
699 |
714 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120709
AA Change: H1038L
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000112887
Gene: ENSMUSG00000052726
AA Change: H1038L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.7e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
764 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120796
AA Change: H1062L
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000113333
Gene: ENSMUSG00000052726
AA Change: H1062L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.8e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193820
|
| Meta Mutation Damage Score |
0.1738 |
| Coding Region Coverage |
- 1x: 97.1%
- 3x: 96.2%
- 10x: 93.6%
- 20x: 88.0%
|
| Validation Efficiency |
97% (103/106) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele are viable with normal pain and itch responses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930579C12Rik |
A |
G |
9: 89,034,815 (GRCm39) |
|
noncoding transcript |
Het |
| 9130008F23Rik |
T |
C |
17: 41,191,193 (GRCm39) |
R79G |
probably damaging |
Het |
| Aco1 |
A |
T |
4: 40,164,607 (GRCm39) |
|
probably null |
Het |
| Acp6 |
C |
T |
3: 97,073,201 (GRCm39) |
R81W |
probably damaging |
Het |
| Agbl1 |
A |
C |
7: 76,239,129 (GRCm39) |
Y543S |
probably damaging |
Het |
| Anapc7 |
T |
C |
5: 122,571,539 (GRCm39) |
W205R |
probably damaging |
Het |
| Ap1g2 |
T |
A |
14: 55,338,886 (GRCm39) |
M532L |
probably damaging |
Het |
| Appl1 |
A |
G |
14: 26,647,470 (GRCm39) |
|
probably benign |
Het |
| Arhgef19 |
T |
C |
4: 140,976,624 (GRCm39) |
F462S |
probably damaging |
Het |
| Astn1 |
A |
G |
1: 158,332,886 (GRCm39) |
|
probably null |
Het |
| AU015836 |
T |
C |
X: 93,012,985 (GRCm39) |
|
probably benign |
Het |
| Cacna1c |
C |
T |
6: 118,589,586 (GRCm39) |
R1446H |
probably damaging |
Het |
| Cadm2 |
T |
C |
16: 66,679,683 (GRCm39) |
D50G |
probably damaging |
Het |
| Ccdc81 |
G |
A |
7: 89,531,502 (GRCm39) |
Q324* |
probably null |
Het |
| Cd300lf |
A |
G |
11: 115,011,206 (GRCm39) |
V178A |
probably benign |
Het |
| Cdt1 |
T |
C |
8: 123,298,791 (GRCm39) |
V476A |
possibly damaging |
Het |
| Cenpj |
A |
G |
14: 56,796,182 (GRCm39) |
V225A |
probably benign |
Het |
| Cep295 |
T |
C |
9: 15,243,399 (GRCm39) |
T1686A |
possibly damaging |
Het |
| Cfap54 |
A |
G |
10: 92,870,572 (GRCm39) |
S684P |
possibly damaging |
Het |
| Clip1 |
C |
A |
5: 123,791,559 (GRCm39) |
V204F |
probably damaging |
Het |
| Cnpy4 |
A |
G |
5: 138,191,102 (GRCm39) |
E226G |
probably benign |
Het |
| Col6a3 |
T |
A |
1: 90,731,433 (GRCm39) |
M1000L |
probably benign |
Het |
| Cpsf1 |
T |
C |
15: 76,486,356 (GRCm39) |
M335V |
probably benign |
Het |
| Dnmt3b |
C |
A |
2: 153,518,679 (GRCm39) |
A614E |
probably benign |
Het |
| Dpm1 |
C |
T |
2: 168,059,655 (GRCm39) |
R147Q |
possibly damaging |
Het |
| Dpp7 |
G |
T |
2: 25,243,691 (GRCm39) |
|
probably null |
Het |
| Engase |
T |
C |
11: 118,369,759 (GRCm39) |
F57S |
probably damaging |
Het |
| Epb41l5 |
T |
C |
1: 119,476,902 (GRCm39) |
D718G |
possibly damaging |
Het |
| Fam20a |
T |
C |
11: 109,564,380 (GRCm39) |
K458E |
probably benign |
Het |
| Fbxo44 |
C |
G |
4: 148,240,726 (GRCm39) |
R220S |
probably damaging |
Het |
| Gkn2 |
T |
A |
6: 87,355,137 (GRCm39) |
Y115* |
probably null |
Het |
| Gtdc1 |
A |
G |
2: 44,481,926 (GRCm39) |
S246P |
probably damaging |
Het |
| H2-Q2 |
A |
G |
17: 35,564,152 (GRCm39) |
D302G |
probably benign |
Het |
| Herc2 |
C |
T |
7: 55,839,561 (GRCm39) |
S3357L |
possibly damaging |
Het |
| Herc6 |
T |
A |
6: 57,639,060 (GRCm39) |
Y840* |
probably null |
Het |
| Hoxa10 |
GGCTGCTGCTGCTGCTGCTG |
GGCTGCTGCTGCTGCTG |
6: 52,211,472 (GRCm39) |
|
probably benign |
Het |
| Ift122 |
T |
C |
6: 115,871,382 (GRCm39) |
|
probably null |
Het |
| Ilf3 |
T |
A |
9: 21,316,063 (GRCm39) |
|
probably benign |
Het |
| Itgb2 |
A |
T |
10: 77,384,457 (GRCm39) |
N193Y |
possibly damaging |
Het |
| Itgb5 |
T |
G |
16: 33,730,839 (GRCm39) |
I65S |
probably damaging |
Het |
| Jpt2 |
T |
C |
17: 25,179,585 (GRCm39) |
M1V |
probably null |
Het |
| Kif20b |
T |
C |
19: 34,918,608 (GRCm39) |
|
probably benign |
Het |
| Kif7 |
T |
C |
7: 79,360,211 (GRCm39) |
Y342C |
probably damaging |
Het |
| Klhl21 |
T |
C |
4: 152,099,877 (GRCm39) |
V529A |
possibly damaging |
Het |
| Klhl26 |
T |
C |
8: 70,904,383 (GRCm39) |
D475G |
probably damaging |
Het |
| Lcor |
T |
C |
19: 41,547,567 (GRCm39) |
Y384H |
probably damaging |
Het |
| Lrp1b |
A |
T |
2: 40,809,179 (GRCm39) |
C2463* |
probably null |
Het |
| Marchf6 |
T |
C |
15: 31,459,339 (GRCm39) |
E909G |
possibly damaging |
Het |
| Mrc1 |
A |
T |
2: 14,313,488 (GRCm39) |
|
probably null |
Het |
| Mtrex |
T |
C |
13: 113,024,024 (GRCm39) |
N707S |
probably benign |
Het |
| Nipal4 |
T |
A |
11: 46,041,560 (GRCm39) |
I212F |
probably damaging |
Het |
| Nup98 |
T |
A |
7: 101,809,923 (GRCm39) |
T536S |
probably damaging |
Het |
| Nwd2 |
A |
G |
5: 63,965,009 (GRCm39) |
E1531G |
possibly damaging |
Het |
| Nxpe2 |
T |
C |
9: 48,237,914 (GRCm39) |
T114A |
probably damaging |
Het |
| Oosp1 |
C |
T |
19: 11,645,158 (GRCm39) |
V169I |
possibly damaging |
Het |
| Opa1 |
T |
C |
16: 29,444,403 (GRCm39) |
V863A |
possibly damaging |
Het |
| Or5ac22 |
T |
G |
16: 59,135,326 (GRCm39) |
Y148S |
probably damaging |
Het |
| Pabpc4l |
A |
T |
3: 46,400,798 (GRCm39) |
M282K |
probably benign |
Het |
| Parp14 |
G |
A |
16: 35,677,130 (GRCm39) |
A946V |
probably benign |
Het |
| Pcnx3 |
T |
C |
19: 5,722,684 (GRCm39) |
D1336G |
probably damaging |
Het |
| Phlpp1 |
T |
C |
1: 106,246,580 (GRCm39) |
V590A |
possibly damaging |
Het |
| Rbck1 |
T |
A |
2: 152,160,276 (GRCm39) |
T468S |
probably damaging |
Het |
| Ripor2 |
T |
A |
13: 24,877,870 (GRCm39) |
I290N |
probably damaging |
Het |
| Rnf139 |
T |
C |
15: 58,771,346 (GRCm39) |
L457P |
probably damaging |
Het |
| Rtn1 |
C |
A |
12: 72,351,184 (GRCm39) |
A342S |
possibly damaging |
Het |
| Sema3d |
A |
G |
5: 12,534,988 (GRCm39) |
|
probably null |
Het |
| Serpinb2 |
T |
A |
1: 107,452,337 (GRCm39) |
V305D |
probably damaging |
Het |
| Sez6l2 |
T |
C |
7: 126,552,668 (GRCm39) |
V148A |
probably damaging |
Het |
| Shank2 |
C |
A |
7: 143,740,595 (GRCm39) |
S568* |
probably null |
Het |
| Slc10a4 |
T |
C |
5: 73,169,490 (GRCm39) |
S372P |
possibly damaging |
Het |
| Slc10a5 |
T |
C |
3: 10,400,550 (GRCm39) |
T37A |
probably benign |
Het |
| Slc14a1 |
T |
C |
18: 78,152,912 (GRCm39) |
I276V |
possibly damaging |
Het |
| Slc6a20b |
G |
T |
9: 123,461,269 (GRCm39) |
D52E |
probably benign |
Het |
| Slc6a5 |
T |
C |
7: 49,601,182 (GRCm39) |
M661T |
probably benign |
Het |
| Ssh2 |
C |
G |
11: 77,340,571 (GRCm39) |
D574E |
probably damaging |
Het |
| Steap4 |
G |
T |
5: 8,025,892 (GRCm39) |
R151L |
probably damaging |
Het |
| Sun5 |
T |
A |
2: 153,707,915 (GRCm39) |
I107L |
probably benign |
Het |
| Tacc1 |
C |
T |
8: 25,665,269 (GRCm39) |
V488M |
probably damaging |
Het |
| Tgs1 |
A |
G |
4: 3,614,928 (GRCm39) |
T829A |
probably benign |
Het |
| Tnxb |
A |
G |
17: 34,914,799 (GRCm39) |
E1929G |
probably damaging |
Het |
| Tssc4 |
A |
C |
7: 142,624,292 (GRCm39) |
Q200P |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,588,876 (GRCm39) |
W21398R |
probably damaging |
Het |
| Usp50 |
C |
T |
2: 126,619,818 (GRCm39) |
|
probably null |
Het |
| Usp9y |
A |
T |
Y: 1,448,829 (GRCm39) |
|
probably null |
Het |
| V1rd19 |
T |
A |
7: 23,702,632 (GRCm39) |
F33I |
probably benign |
Het |
| Zfat |
T |
C |
15: 67,973,388 (GRCm39) |
T1118A |
probably benign |
Het |
|
| Other mutations in Kcnt2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00561:Kcnt2
|
APN |
1 |
140,450,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00673:Kcnt2
|
APN |
1 |
140,523,789 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL00806:Kcnt2
|
APN |
1 |
140,450,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01135:Kcnt2
|
APN |
1 |
140,282,293 (GRCm39) |
critical splice donor site |
probably null |
0.00 |
|
IGL01412:Kcnt2
|
APN |
1 |
140,498,155 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01777:Kcnt2
|
APN |
1 |
140,523,736 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01780:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02134:Kcnt2
|
APN |
1 |
140,304,121 (GRCm39) |
missense |
probably benign |
|
|
IGL02350:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02357:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02481:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02483:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02866:Kcnt2
|
APN |
1 |
140,352,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02891:Kcnt2
|
APN |
1 |
140,502,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03007:Kcnt2
|
APN |
1 |
140,282,245 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03024:Kcnt2
|
APN |
1 |
140,498,193 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03231:Kcnt2
|
APN |
1 |
140,461,740 (GRCm39) |
intron |
probably benign |
|
|
BB002:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
BB012:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R0230:Kcnt2
|
UTSW |
1 |
140,174,083 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0367:Kcnt2
|
UTSW |
1 |
140,278,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Kcnt2
|
UTSW |
1 |
140,437,218 (GRCm39) |
nonsense |
probably null |
|
|
R0543:Kcnt2
|
UTSW |
1 |
140,537,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0849:Kcnt2
|
UTSW |
1 |
140,435,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1123:Kcnt2
|
UTSW |
1 |
140,501,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1156:Kcnt2
|
UTSW |
1 |
140,356,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1425:Kcnt2
|
UTSW |
1 |
140,310,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1530:Kcnt2
|
UTSW |
1 |
140,411,970 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Kcnt2
|
UTSW |
1 |
140,359,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1728:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1739:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1762:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1783:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1785:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1862:Kcnt2
|
UTSW |
1 |
140,353,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1887:Kcnt2
|
UTSW |
1 |
140,511,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1894:Kcnt2
|
UTSW |
1 |
140,353,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2005:Kcnt2
|
UTSW |
1 |
140,480,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2044:Kcnt2
|
UTSW |
1 |
140,302,892 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2115:Kcnt2
|
UTSW |
1 |
140,480,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2135:Kcnt2
|
UTSW |
1 |
140,356,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Kcnt2
|
UTSW |
1 |
140,437,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2212:Kcnt2
|
UTSW |
1 |
140,458,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2267:Kcnt2
|
UTSW |
1 |
140,501,421 (GRCm39) |
splice site |
probably null |
|
|
R2442:Kcnt2
|
UTSW |
1 |
140,304,091 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R3121:Kcnt2
|
UTSW |
1 |
140,356,622 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3176:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3276:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3704:Kcnt2
|
UTSW |
1 |
140,461,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Kcnt2
|
UTSW |
1 |
140,512,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Kcnt2
|
UTSW |
1 |
140,537,368 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4201:Kcnt2
|
UTSW |
1 |
140,353,070 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4501:Kcnt2
|
UTSW |
1 |
140,480,718 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4502:Kcnt2
|
UTSW |
1 |
140,435,485 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4632:Kcnt2
|
UTSW |
1 |
140,450,886 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4758:Kcnt2
|
UTSW |
1 |
140,446,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4790:Kcnt2
|
UTSW |
1 |
140,282,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4892:Kcnt2
|
UTSW |
1 |
140,440,763 (GRCm39) |
nonsense |
probably null |
|
|
R4973:Kcnt2
|
UTSW |
1 |
140,537,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5154:Kcnt2
|
UTSW |
1 |
140,278,994 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5296:Kcnt2
|
UTSW |
1 |
140,537,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5353:Kcnt2
|
UTSW |
1 |
140,354,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Kcnt2
|
UTSW |
1 |
140,502,481 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5806:Kcnt2
|
UTSW |
1 |
140,437,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5887:Kcnt2
|
UTSW |
1 |
140,353,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Kcnt2
|
UTSW |
1 |
140,461,666 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5961:Kcnt2
|
UTSW |
1 |
140,435,440 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6123:Kcnt2
|
UTSW |
1 |
140,290,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6225:Kcnt2
|
UTSW |
1 |
140,354,661 (GRCm39) |
nonsense |
probably null |
|
|
R6248:Kcnt2
|
UTSW |
1 |
140,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6351:Kcnt2
|
UTSW |
1 |
140,302,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6380:Kcnt2
|
UTSW |
1 |
140,437,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6532:Kcnt2
|
UTSW |
1 |
140,511,844 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6693:Kcnt2
|
UTSW |
1 |
140,278,965 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6817:Kcnt2
|
UTSW |
1 |
140,173,931 (GRCm39) |
unclassified |
probably benign |
|
|
R6856:Kcnt2
|
UTSW |
1 |
140,523,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6944:Kcnt2
|
UTSW |
1 |
140,511,803 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6971:Kcnt2
|
UTSW |
1 |
140,440,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7052:Kcnt2
|
UTSW |
1 |
140,310,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7138:Kcnt2
|
UTSW |
1 |
140,523,778 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7261:Kcnt2
|
UTSW |
1 |
140,282,255 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7474:Kcnt2
|
UTSW |
1 |
140,498,216 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7524:Kcnt2
|
UTSW |
1 |
140,511,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7541:Kcnt2
|
UTSW |
1 |
140,304,122 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7558:Kcnt2
|
UTSW |
1 |
140,450,928 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7651:Kcnt2
|
UTSW |
1 |
140,498,199 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7730:Kcnt2
|
UTSW |
1 |
140,446,686 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7875:Kcnt2
|
UTSW |
1 |
140,501,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7883:Kcnt2
|
UTSW |
1 |
140,450,888 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7925:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R8040:Kcnt2
|
UTSW |
1 |
140,377,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8041:Kcnt2
|
UTSW |
1 |
140,537,398 (GRCm39) |
missense |
probably benign |
|
|
R8171:Kcnt2
|
UTSW |
1 |
140,437,203 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8268:Kcnt2
|
UTSW |
1 |
140,450,954 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8905:Kcnt2
|
UTSW |
1 |
140,435,467 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8927:Kcnt2
|
UTSW |
1 |
140,356,535 (GRCm39) |
splice site |
probably null |
|
|
R8988:Kcnt2
|
UTSW |
1 |
140,356,587 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9020:Kcnt2
|
UTSW |
1 |
140,512,049 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9109:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9167:Kcnt2
|
UTSW |
1 |
140,506,200 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9232:Kcnt2
|
UTSW |
1 |
140,411,931 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9297:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9298:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9318:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9404:Kcnt2
|
UTSW |
1 |
140,353,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Kcnt2
|
UTSW |
1 |
140,440,729 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
Z1088:Kcnt2
|
UTSW |
1 |
140,511,896 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Kcnt2
|
UTSW |
1 |
140,501,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Kcnt2
|
UTSW |
1 |
140,304,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Kcnt2
|
UTSW |
1 |
140,537,386 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGTGACCAGTCGGACCATC -3'
(R):5'- ATGCTGGGTCCAAACATTGC -3'
Sequencing Primer
(F):5'- AGTCGGACCATCCCTTGCTG -3'
(R):5'- TGGGTCCAAACATTGCCTAATGAAC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation