Incidental Mutation 'R1903:Myo18b'
| ID |
209926 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo18b
|
| Ensembl Gene |
ENSMUSG00000072720 |
| Gene Name |
myosin XVIIIb |
| Synonyms |
4932408L24Rik, 4933411E19Rik |
| MMRRC Submission |
039923-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1903 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
112836742-113044228 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 112840624 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Cysteine
at position 2390
(R2390C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083810
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086617]
|
| AlphaFold |
E9PV66 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000086617
AA Change: R2390C
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000083810
Gene: ENSMUSG00000072720
AA Change: R2390C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
20 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
59 |
N/A |
INTRINSIC |
|
low complexity region
|
86 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
185 |
200 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
355 |
372 |
N/A |
INTRINSIC |
|
low complexity region
|
377 |
419 |
N/A |
INTRINSIC |
|
MYSc
|
605 |
1374 |
8.78e-30 |
SMART |
|
IQ
|
1375 |
1397 |
5.92e-4 |
SMART |
|
Pfam:Myosin_tail_1
|
1423 |
1875 |
5e-12 |
PFAM |
|
low complexity region
|
1965 |
1985 |
N/A |
INTRINSIC |
|
coiled coil region
|
2052 |
2126 |
N/A |
INTRINSIC |
|
low complexity region
|
2184 |
2199 |
N/A |
INTRINSIC |
|
low complexity region
|
2325 |
2336 |
N/A |
INTRINSIC |
|
low complexity region
|
2408 |
2424 |
N/A |
INTRINSIC |
|
low complexity region
|
2544 |
2558 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000182189
|
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.7%
- 10x: 95.0%
- 20x: 91.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis with internal hemorrhage, pericaridal effusion, enlargement of the right atrium, and cardiac myofibril abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 120 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
A |
C |
9: 57,165,635 (GRCm39) |
S246R |
possibly damaging |
Het |
| Abca13 |
C |
T |
11: 9,416,411 (GRCm39) |
R4058C |
probably benign |
Het |
| Acacb |
A |
T |
5: 114,303,795 (GRCm39) |
R73* |
probably null |
Het |
| Adam22 |
C |
T |
5: 8,184,525 (GRCm39) |
C489Y |
probably damaging |
Het |
| Agap3 |
A |
T |
5: 24,698,011 (GRCm39) |
K460I |
probably damaging |
Het |
| Ak4 |
T |
C |
4: 101,320,833 (GRCm39) |
I214T |
possibly damaging |
Het |
| Anpep |
C |
T |
7: 79,488,004 (GRCm39) |
E518K |
probably benign |
Het |
| Arrb2 |
T |
A |
11: 70,328,808 (GRCm39) |
H221Q |
probably damaging |
Het |
| Atl1 |
T |
G |
12: 70,006,049 (GRCm39) |
F452V |
probably damaging |
Het |
| Atp8b5 |
A |
G |
4: 43,357,063 (GRCm39) |
T604A |
probably damaging |
Het |
| Bglap3 |
T |
C |
3: 88,276,068 (GRCm39) |
I95V |
probably benign |
Het |
| Ccdc88a |
G |
T |
11: 29,411,788 (GRCm39) |
M532I |
probably benign |
Het |
| Ccnl1 |
A |
G |
3: 65,854,332 (GRCm39) |
S430P |
possibly damaging |
Het |
| Cdhr18 |
C |
T |
14: 13,829,657 (GRCm38) |
S695N |
possibly damaging |
Het |
| Cdk5rap2 |
A |
T |
4: 70,321,791 (GRCm39) |
|
probably null |
Het |
| Cep126 |
A |
T |
9: 8,120,748 (GRCm39) |
Y92N |
possibly damaging |
Het |
| Cfap44 |
A |
C |
16: 44,242,737 (GRCm39) |
T714P |
probably benign |
Het |
| Cnga1 |
T |
G |
5: 72,774,068 (GRCm39) |
D90A |
possibly damaging |
Het |
| Cnot1 |
T |
C |
8: 96,469,749 (GRCm39) |
I1369V |
possibly damaging |
Het |
| Coq3 |
T |
C |
4: 21,910,466 (GRCm39) |
S314P |
probably damaging |
Het |
| Crhr1 |
A |
G |
11: 104,060,675 (GRCm39) |
R151G |
probably damaging |
Het |
| Crybg2 |
A |
G |
4: 133,806,167 (GRCm39) |
I930V |
probably damaging |
Het |
| Ctcf |
T |
A |
8: 106,402,620 (GRCm39) |
|
probably null |
Het |
| Dct |
T |
C |
14: 118,271,690 (GRCm39) |
N380S |
probably benign |
Het |
| Decr2 |
A |
T |
17: 26,306,387 (GRCm39) |
L83Q |
probably damaging |
Het |
| Depdc5 |
CTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCT |
CTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCT |
5: 33,067,751 (GRCm39) |
|
probably benign |
Het |
| Dgkb |
T |
C |
12: 38,216,776 (GRCm39) |
|
probably null |
Het |
| Dnah1 |
T |
C |
14: 31,041,716 (GRCm39) |
D85G |
probably damaging |
Het |
| Dnah7a |
T |
C |
1: 53,574,637 (GRCm39) |
D1709G |
probably damaging |
Het |
| Dnajc13 |
A |
C |
9: 104,106,136 (GRCm39) |
L346R |
probably damaging |
Het |
| Dsc1 |
A |
T |
18: 20,229,045 (GRCm39) |
V415D |
probably damaging |
Het |
| Duox2 |
T |
A |
2: 122,125,832 (GRCm39) |
I296F |
probably damaging |
Het |
| Ece2 |
T |
A |
16: 20,463,922 (GRCm39) |
L890H |
probably damaging |
Het |
| Ecsit |
A |
G |
9: 21,987,815 (GRCm39) |
S75P |
possibly damaging |
Het |
| Enpp3 |
A |
G |
10: 24,654,687 (GRCm39) |
C664R |
probably damaging |
Het |
| Evpl |
G |
T |
11: 116,117,854 (GRCm39) |
D778E |
probably damaging |
Het |
| Eya3 |
T |
A |
4: 132,448,663 (GRCm39) |
|
probably null |
Het |
| Fam217b |
A |
T |
2: 178,062,374 (GRCm39) |
I113F |
probably benign |
Het |
| Galnt6 |
G |
A |
15: 100,613,999 (GRCm39) |
P101S |
possibly damaging |
Het |
| Gm379 |
G |
A |
X: 107,707,870 (GRCm39) |
Q210* |
probably null |
Het |
| Grk4 |
A |
T |
5: 34,833,531 (GRCm39) |
|
probably null |
Het |
| Gtf3c4 |
A |
G |
2: 28,729,968 (GRCm39) |
V91A |
probably benign |
Het |
| Hcfc2 |
G |
T |
10: 82,538,392 (GRCm39) |
G143V |
probably damaging |
Het |
| Heatr4 |
A |
C |
12: 84,005,221 (GRCm39) |
H710Q |
probably damaging |
Het |
| Htr3a |
A |
T |
9: 48,817,681 (GRCm39) |
D97E |
probably damaging |
Het |
| Htr4 |
T |
G |
18: 62,561,193 (GRCm39) |
F151L |
probably benign |
Het |
| Il22ra1 |
A |
T |
4: 135,478,219 (GRCm39) |
Q430L |
probably damaging |
Het |
| Invs |
T |
A |
4: 48,402,824 (GRCm39) |
|
probably null |
Het |
| Ip6k1 |
G |
A |
9: 107,918,195 (GRCm39) |
E77K |
possibly damaging |
Het |
| Irs1 |
T |
C |
1: 82,267,182 (GRCm39) |
S345G |
probably damaging |
Het |
| Kdm4a |
A |
G |
4: 118,017,596 (GRCm39) |
V490A |
probably benign |
Het |
| Kif26a |
C |
T |
12: 112,141,974 (GRCm39) |
R743C |
probably damaging |
Het |
| Kif28 |
A |
G |
1: 179,530,088 (GRCm39) |
V691A |
possibly damaging |
Het |
| Klhl5 |
T |
A |
5: 65,324,330 (GRCm39) |
L696Q |
probably benign |
Het |
| Krtap5-1 |
T |
C |
7: 141,850,084 (GRCm39) |
|
probably benign |
Het |
| Lama2 |
A |
C |
10: 27,064,395 (GRCm39) |
D1195E |
probably damaging |
Het |
| Lamb1 |
T |
G |
12: 31,379,209 (GRCm39) |
L1722R |
probably damaging |
Het |
| Lrp11 |
T |
A |
10: 7,499,544 (GRCm39) |
L245Q |
probably damaging |
Het |
| Ltbp2 |
T |
C |
12: 84,876,879 (GRCm39) |
E422G |
probably benign |
Het |
| Man2b1 |
T |
A |
8: 85,813,451 (GRCm39) |
D214E |
probably damaging |
Het |
| Mlxipl |
A |
T |
5: 135,162,422 (GRCm39) |
D628V |
possibly damaging |
Het |
| Msantd5f6 |
T |
A |
4: 73,321,675 (GRCm39) |
Y120F |
probably damaging |
Het |
| Mypn |
T |
A |
10: 62,959,176 (GRCm39) |
R1048S |
probably benign |
Het |
| Napepld |
A |
G |
5: 21,870,270 (GRCm39) |
S383P |
probably damaging |
Het |
| Napsa |
A |
G |
7: 44,231,160 (GRCm39) |
T130A |
probably damaging |
Het |
| Nbr1 |
T |
C |
11: 101,465,978 (GRCm39) |
I716T |
probably damaging |
Het |
| Nexn |
A |
T |
3: 151,953,818 (GRCm39) |
M212K |
probably damaging |
Het |
| Nlrp9b |
T |
A |
7: 19,757,182 (GRCm39) |
S140T |
probably benign |
Het |
| Nxpe2 |
T |
C |
9: 48,230,906 (GRCm39) |
T488A |
probably benign |
Het |
| Or10g3 |
T |
G |
14: 52,610,174 (GRCm39) |
Q112P |
possibly damaging |
Het |
| Or10v1 |
A |
T |
19: 11,873,913 (GRCm39) |
Y176F |
probably benign |
Het |
| Or5ac25 |
A |
T |
16: 59,182,526 (GRCm39) |
D18E |
probably benign |
Het |
| Or7g12 |
A |
T |
9: 18,900,192 (GRCm39) |
K303* |
probably null |
Het |
| Or8k20 |
C |
T |
2: 86,106,190 (GRCm39) |
V214I |
probably benign |
Het |
| Osbpl5 |
T |
C |
7: 143,256,918 (GRCm39) |
D404G |
possibly damaging |
Het |
| Pan2 |
T |
G |
10: 128,144,237 (GRCm39) |
L162R |
probably damaging |
Het |
| Parp1 |
G |
T |
1: 180,416,235 (GRCm39) |
V545F |
probably damaging |
Het |
| Pcdh18 |
A |
G |
3: 49,709,896 (GRCm39) |
V473A |
probably benign |
Het |
| Plb1 |
A |
T |
5: 32,448,582 (GRCm39) |
N350I |
probably damaging |
Het |
| Polr1a |
A |
G |
6: 71,944,898 (GRCm39) |
K1318R |
probably benign |
Het |
| Ppp1r18 |
C |
T |
17: 36,184,738 (GRCm39) |
P130S |
probably damaging |
Het |
| Prss48 |
C |
T |
3: 85,905,614 (GRCm39) |
W86* |
probably null |
Het |
| Rab3c |
A |
T |
13: 110,220,744 (GRCm39) |
I137N |
probably damaging |
Het |
| Rab3gap2 |
G |
C |
1: 184,954,099 (GRCm39) |
R57P |
probably benign |
Het |
| Rad54l2 |
A |
C |
9: 106,570,916 (GRCm39) |
|
probably null |
Het |
| Ralgapb |
C |
A |
2: 158,337,483 (GRCm39) |
N1147K |
probably benign |
Het |
| Rfx7 |
C |
T |
9: 72,524,093 (GRCm39) |
R428C |
probably damaging |
Het |
| Robo1 |
A |
G |
16: 72,757,092 (GRCm39) |
Q351R |
probably null |
Het |
| Samd4 |
T |
C |
14: 47,311,585 (GRCm39) |
F81S |
probably damaging |
Het |
| Shprh |
T |
A |
10: 11,059,541 (GRCm39) |
Y1097* |
probably null |
Het |
| Sik3 |
C |
G |
9: 46,132,387 (GRCm39) |
H1276Q |
probably benign |
Het |
| Slc24a4 |
T |
A |
12: 102,097,876 (GRCm39) |
D79E |
probably benign |
Het |
| Slc7a13 |
A |
T |
4: 19,839,254 (GRCm39) |
I286F |
probably benign |
Het |
| Smarca1 |
G |
A |
X: 46,938,840 (GRCm39) |
Q723* |
probably null |
Het |
| Spata31d1b |
T |
C |
13: 59,865,882 (GRCm39) |
L1010P |
probably damaging |
Het |
| Sult2a1 |
T |
C |
7: 13,569,900 (GRCm39) |
S111G |
possibly damaging |
Het |
| Tecpr2 |
C |
T |
12: 110,914,346 (GRCm39) |
T1219M |
probably damaging |
Het |
| Tesk1 |
T |
C |
4: 43,446,998 (GRCm39) |
M462T |
probably benign |
Het |
| Thoc2l |
T |
A |
5: 104,666,196 (GRCm39) |
S239R |
probably benign |
Het |
| Tmem171 |
C |
A |
13: 98,822,924 (GRCm39) |
G292* |
probably null |
Het |
| Tmtc2 |
G |
T |
10: 105,025,969 (GRCm39) |
T833N |
probably benign |
Het |
| Tnc |
G |
T |
4: 63,918,299 (GRCm39) |
T1204K |
probably benign |
Het |
| Tnfaip3 |
T |
C |
10: 18,883,937 (GRCm39) |
K148E |
probably benign |
Het |
| Tnrc18 |
G |
A |
5: 142,800,895 (GRCm39) |
S21F |
probably damaging |
Het |
| Tns4 |
T |
C |
11: 98,966,401 (GRCm39) |
T425A |
probably damaging |
Het |
| Tox |
T |
A |
4: 6,688,948 (GRCm39) |
Y472F |
probably damaging |
Het |
| Trak2 |
A |
T |
1: 58,958,014 (GRCm39) |
|
probably null |
Het |
| Trim33 |
T |
A |
3: 103,244,760 (GRCm39) |
Y716N |
probably damaging |
Het |
| Trrap |
T |
G |
5: 144,752,863 (GRCm39) |
I1813R |
probably damaging |
Het |
| Ttc29 |
A |
G |
8: 78,978,361 (GRCm39) |
E137G |
probably benign |
Het |
| Ube2j2 |
A |
G |
4: 156,033,483 (GRCm39) |
K19R |
probably benign |
Het |
| Ubxn2b |
T |
C |
4: 6,208,889 (GRCm39) |
I206T |
possibly damaging |
Het |
| Usp40 |
A |
G |
1: 87,909,778 (GRCm39) |
F559L |
probably benign |
Het |
| Utp4 |
T |
A |
8: 107,638,982 (GRCm39) |
|
probably null |
Het |
| Vac14 |
A |
G |
8: 111,409,166 (GRCm39) |
N524S |
probably benign |
Het |
| Vps13c |
T |
C |
9: 67,801,334 (GRCm39) |
S605P |
probably damaging |
Het |
| Vwa5b2 |
G |
T |
16: 20,423,582 (GRCm39) |
S1165I |
possibly damaging |
Het |
| Zdhhc19 |
C |
T |
16: 32,317,231 (GRCm39) |
R28* |
probably null |
Het |
| Zfp106 |
T |
C |
2: 120,357,329 (GRCm39) |
I1189V |
probably benign |
Het |
| Zfp189 |
C |
T |
4: 49,529,511 (GRCm39) |
Q205* |
probably null |
Het |
|
| Other mutations in Myo18b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Myo18b
|
APN |
5 |
113,021,997 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL00847:Myo18b
|
APN |
5 |
112,978,255 (GRCm39) |
splice site |
probably benign |
|
|
IGL00848:Myo18b
|
APN |
5 |
113,019,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00969:Myo18b
|
APN |
5 |
113,022,873 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01018:Myo18b
|
APN |
5 |
112,957,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01448:Myo18b
|
APN |
5 |
112,959,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01490:Myo18b
|
APN |
5 |
112,957,566 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01556:Myo18b
|
APN |
5 |
112,905,315 (GRCm39) |
splice site |
probably benign |
|
|
IGL01637:Myo18b
|
APN |
5 |
112,988,495 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01819:Myo18b
|
APN |
5 |
113,025,916 (GRCm39) |
missense |
unknown |
|
|
IGL02007:Myo18b
|
APN |
5 |
113,022,838 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02146:Myo18b
|
APN |
5 |
112,991,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02229:Myo18b
|
APN |
5 |
113,025,976 (GRCm39) |
missense |
unknown |
|
|
IGL02319:Myo18b
|
APN |
5 |
112,939,005 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02398:Myo18b
|
APN |
5 |
112,978,178 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02420:Myo18b
|
APN |
5 |
112,975,852 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02626:Myo18b
|
APN |
5 |
113,025,951 (GRCm39) |
missense |
unknown |
|
|
IGL02815:Myo18b
|
APN |
5 |
112,957,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02822:Myo18b
|
APN |
5 |
112,923,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02852:Myo18b
|
APN |
5 |
112,863,377 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02995:Myo18b
|
APN |
5 |
112,923,279 (GRCm39) |
splice site |
probably benign |
|
|
IGL03019:Myo18b
|
APN |
5 |
112,840,263 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL03039:Myo18b
|
APN |
5 |
112,988,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03112:Myo18b
|
APN |
5 |
113,021,856 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03123:Myo18b
|
APN |
5 |
113,022,804 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03288:Myo18b
|
APN |
5 |
112,937,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03391:Myo18b
|
APN |
5 |
113,022,345 (GRCm39) |
unclassified |
probably benign |
|
|
klippel
|
UTSW |
5 |
112,905,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
PIT4651001:Myo18b
|
UTSW |
5 |
112,982,301 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0271:Myo18b
|
UTSW |
5 |
112,957,551 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0277:Myo18b
|
UTSW |
5 |
112,841,213 (GRCm39) |
splice site |
probably benign |
|
|
R0352:Myo18b
|
UTSW |
5 |
113,022,389 (GRCm39) |
unclassified |
probably benign |
|
|
R0504:Myo18b
|
UTSW |
5 |
113,021,442 (GRCm39) |
unclassified |
probably benign |
|
|
R0539:Myo18b
|
UTSW |
5 |
112,871,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0599:Myo18b
|
UTSW |
5 |
113,013,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Myo18b
|
UTSW |
5 |
112,946,700 (GRCm39) |
missense |
probably benign |
0.38 |
|
R0659:Myo18b
|
UTSW |
5 |
112,908,193 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0671:Myo18b
|
UTSW |
5 |
112,840,632 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0847:Myo18b
|
UTSW |
5 |
113,022,354 (GRCm39) |
unclassified |
probably benign |
|
|
R1082:Myo18b
|
UTSW |
5 |
112,908,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1116:Myo18b
|
UTSW |
5 |
112,951,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1264:Myo18b
|
UTSW |
5 |
112,978,185 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1280:Myo18b
|
UTSW |
5 |
112,871,671 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1444:Myo18b
|
UTSW |
5 |
112,923,117 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1446:Myo18b
|
UTSW |
5 |
112,905,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1470:Myo18b
|
UTSW |
5 |
112,840,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1470:Myo18b
|
UTSW |
5 |
112,840,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1590:Myo18b
|
UTSW |
5 |
113,023,132 (GRCm39) |
nonsense |
probably null |
|
|
R1601:Myo18b
|
UTSW |
5 |
113,019,364 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1935:Myo18b
|
UTSW |
5 |
112,908,222 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1936:Myo18b
|
UTSW |
5 |
112,908,222 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2008:Myo18b
|
UTSW |
5 |
113,021,423 (GRCm39) |
missense |
probably benign |
|
|
R2127:Myo18b
|
UTSW |
5 |
112,978,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Myo18b
|
UTSW |
5 |
112,978,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2141:Myo18b
|
UTSW |
5 |
113,021,892 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2170:Myo18b
|
UTSW |
5 |
112,871,724 (GRCm39) |
missense |
probably benign |
0.23 |
|
R2258:Myo18b
|
UTSW |
5 |
113,022,529 (GRCm39) |
unclassified |
probably benign |
|
|
R2265:Myo18b
|
UTSW |
5 |
112,930,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2483:Myo18b
|
UTSW |
5 |
113,006,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2931:Myo18b
|
UTSW |
5 |
112,840,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3160:Myo18b
|
UTSW |
5 |
112,840,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3162:Myo18b
|
UTSW |
5 |
112,840,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3777:Myo18b
|
UTSW |
5 |
112,905,462 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4240:Myo18b
|
UTSW |
5 |
112,951,053 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4243:Myo18b
|
UTSW |
5 |
112,840,261 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4245:Myo18b
|
UTSW |
5 |
112,840,261 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4533:Myo18b
|
UTSW |
5 |
112,840,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4631:Myo18b
|
UTSW |
5 |
112,994,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4661:Myo18b
|
UTSW |
5 |
113,023,041 (GRCm39) |
unclassified |
probably benign |
|
|
R4755:Myo18b
|
UTSW |
5 |
113,022,340 (GRCm39) |
nonsense |
probably null |
|
|
R4771:Myo18b
|
UTSW |
5 |
112,840,093 (GRCm39) |
nonsense |
probably null |
|
|
R4812:Myo18b
|
UTSW |
5 |
112,957,584 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4840:Myo18b
|
UTSW |
5 |
113,021,895 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4888:Myo18b
|
UTSW |
5 |
113,022,346 (GRCm39) |
unclassified |
probably benign |
|
|
R4995:Myo18b
|
UTSW |
5 |
112,908,258 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5001:Myo18b
|
UTSW |
5 |
112,909,206 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5015:Myo18b
|
UTSW |
5 |
112,937,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5055:Myo18b
|
UTSW |
5 |
113,023,083 (GRCm39) |
unclassified |
probably benign |
|
|
R5070:Myo18b
|
UTSW |
5 |
112,909,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5105:Myo18b
|
UTSW |
5 |
112,988,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5121:Myo18b
|
UTSW |
5 |
113,022,346 (GRCm39) |
unclassified |
probably benign |
|
|
R5130:Myo18b
|
UTSW |
5 |
113,021,769 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5186:Myo18b
|
UTSW |
5 |
113,019,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5437:Myo18b
|
UTSW |
5 |
112,905,439 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5535:Myo18b
|
UTSW |
5 |
112,937,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5560:Myo18b
|
UTSW |
5 |
113,016,161 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5810:Myo18b
|
UTSW |
5 |
112,982,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5898:Myo18b
|
UTSW |
5 |
112,950,196 (GRCm39) |
splice site |
probably null |
|
|
R6065:Myo18b
|
UTSW |
5 |
112,840,647 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6104:Myo18b
|
UTSW |
5 |
113,022,157 (GRCm39) |
unclassified |
probably benign |
|
|
R6113:Myo18b
|
UTSW |
5 |
113,014,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6158:Myo18b
|
UTSW |
5 |
113,022,038 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6167:Myo18b
|
UTSW |
5 |
113,020,373 (GRCm39) |
splice site |
probably null |
|
|
R6220:Myo18b
|
UTSW |
5 |
112,905,373 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6276:Myo18b
|
UTSW |
5 |
112,959,508 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6290:Myo18b
|
UTSW |
5 |
113,013,601 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6291:Myo18b
|
UTSW |
5 |
113,013,601 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6795:Myo18b
|
UTSW |
5 |
112,994,230 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6798:Myo18b
|
UTSW |
5 |
112,909,252 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6817:Myo18b
|
UTSW |
5 |
112,978,104 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6937:Myo18b
|
UTSW |
5 |
112,950,258 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7034:Myo18b
|
UTSW |
5 |
112,871,770 (GRCm39) |
nonsense |
probably null |
|
|
R7097:Myo18b
|
UTSW |
5 |
113,022,271 (GRCm39) |
missense |
unknown |
|
|
R7145:Myo18b
|
UTSW |
5 |
112,965,545 (GRCm39) |
nonsense |
probably null |
|
|
R7201:Myo18b
|
UTSW |
5 |
112,863,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7260:Myo18b
|
UTSW |
5 |
112,923,154 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7265:Myo18b
|
UTSW |
5 |
112,959,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7409:Myo18b
|
UTSW |
5 |
113,021,971 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7466:Myo18b
|
UTSW |
5 |
112,871,758 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7487:Myo18b
|
UTSW |
5 |
112,982,299 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7571:Myo18b
|
UTSW |
5 |
112,978,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7600:Myo18b
|
UTSW |
5 |
113,025,969 (GRCm39) |
missense |
unknown |
|
|
R7612:Myo18b
|
UTSW |
5 |
113,013,168 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7617:Myo18b
|
UTSW |
5 |
112,905,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7696:Myo18b
|
UTSW |
5 |
112,840,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7710:Myo18b
|
UTSW |
5 |
113,022,891 (GRCm39) |
missense |
unknown |
|
|
R8047:Myo18b
|
UTSW |
5 |
112,871,681 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8070:Myo18b
|
UTSW |
5 |
112,938,986 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8088:Myo18b
|
UTSW |
5 |
113,027,376 (GRCm39) |
start gained |
probably benign |
|
|
R8247:Myo18b
|
UTSW |
5 |
112,840,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8276:Myo18b
|
UTSW |
5 |
112,943,273 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8313:Myo18b
|
UTSW |
5 |
113,023,045 (GRCm39) |
missense |
unknown |
|
|
R8375:Myo18b
|
UTSW |
5 |
112,908,259 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8432:Myo18b
|
UTSW |
5 |
112,912,378 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8475:Myo18b
|
UTSW |
5 |
113,021,422 (GRCm39) |
nonsense |
probably null |
|
|
R8482:Myo18b
|
UTSW |
5 |
113,019,489 (GRCm39) |
nonsense |
probably null |
|
|
R8671:Myo18b
|
UTSW |
5 |
113,022,609 (GRCm39) |
missense |
unknown |
|
|
R8681:Myo18b
|
UTSW |
5 |
113,021,429 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8918:Myo18b
|
UTSW |
5 |
113,022,873 (GRCm39) |
unclassified |
probably benign |
|
|
R8941:Myo18b
|
UTSW |
5 |
113,022,795 (GRCm39) |
unclassified |
probably benign |
|
|
R8962:Myo18b
|
UTSW |
5 |
113,006,346 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8972:Myo18b
|
UTSW |
5 |
112,841,164 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9116:Myo18b
|
UTSW |
5 |
112,975,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9209:Myo18b
|
UTSW |
5 |
113,022,927 (GRCm39) |
missense |
unknown |
|
|
R9358:Myo18b
|
UTSW |
5 |
112,943,269 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9469:Myo18b
|
UTSW |
5 |
112,994,247 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9607:Myo18b
|
UTSW |
5 |
113,022,544 (GRCm39) |
missense |
unknown |
|
|
R9659:Myo18b
|
UTSW |
5 |
113,022,382 (GRCm39) |
missense |
unknown |
|
|
Z1088:Myo18b
|
UTSW |
5 |
112,905,350 (GRCm39) |
missense |
probably benign |
0.25 |
|
Z1088:Myo18b
|
UTSW |
5 |
112,840,809 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Z1176:Myo18b
|
UTSW |
5 |
112,979,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myo18b
|
UTSW |
5 |
112,957,604 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1176:Myo18b
|
UTSW |
5 |
112,910,587 (GRCm39) |
missense |
not run |
|
|
Z1177:Myo18b
|
UTSW |
5 |
113,021,407 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Myo18b
|
UTSW |
5 |
112,910,587 (GRCm39) |
missense |
not run |
|
|
Z1177:Myo18b
|
UTSW |
5 |
112,840,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Myo18b
|
UTSW |
5 |
113,023,018 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CATCAGGTGAGAAAATTGTCGATTC -3'
(R):5'- AGGGTTCCACTCTGCATCTG -3'
Sequencing Primer
(F):5'- GAAAATTGTCGATTCTGGAAGACC -3'
(R):5'- CTCACTTAGGAGAGGCAGAGC -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation