Incidental Mutation 'R1903:Kif26a'
ID 209983
Institutional Source Beutler Lab
Gene Symbol Kif26a
Ensembl Gene ENSMUSG00000021294
Gene Name kinesin family member 26A
Synonyms N-11 kinesin
MMRRC Submission 039923-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1903 (G1)
Quality Score 215
Status Not validated
Chromosome 12
Chromosomal Location 112112642-112148181 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 112141974 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 743 (R743C)
Ref Sequence ENSEMBL: ENSMUSP00000119482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000128402]
AlphaFold Q52KG5
Predicted Effect probably damaging
Transcript: ENSMUST00000128402
AA Change: R743C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000119482
Gene: ENSMUSG00000021294
AA Change: R743C

DomainStartEndE-ValueType
low complexity region 238 248 N/A INTRINSIC
low complexity region 279 297 N/A INTRINSIC
KISc 362 726 9.57e-35 SMART
low complexity region 727 739 N/A INTRINSIC
low complexity region 740 754 N/A INTRINSIC
low complexity region 932 957 N/A INTRINSIC
low complexity region 1005 1012 N/A INTRINSIC
low complexity region 1044 1054 N/A INTRINSIC
low complexity region 1084 1095 N/A INTRINSIC
low complexity region 1328 1360 N/A INTRINSIC
low complexity region 1458 1471 N/A INTRINSIC
low complexity region 1477 1493 N/A INTRINSIC
low complexity region 1519 1538 N/A INTRINSIC
low complexity region 1574 1587 N/A INTRINSIC
low complexity region 1664 1675 N/A INTRINSIC
low complexity region 1699 1713 N/A INTRINSIC
coiled coil region 1780 1812 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183816
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.7%
  • 10x: 95.0%
  • 20x: 91.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit premature death associated with megacolon and hyperganglionosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 120 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik A C 9: 57,165,635 (GRCm39) S246R possibly damaging Het
Abca13 C T 11: 9,416,411 (GRCm39) R4058C probably benign Het
Acacb A T 5: 114,303,795 (GRCm39) R73* probably null Het
Adam22 C T 5: 8,184,525 (GRCm39) C489Y probably damaging Het
Agap3 A T 5: 24,698,011 (GRCm39) K460I probably damaging Het
Ak4 T C 4: 101,320,833 (GRCm39) I214T possibly damaging Het
Anpep C T 7: 79,488,004 (GRCm39) E518K probably benign Het
Arrb2 T A 11: 70,328,808 (GRCm39) H221Q probably damaging Het
Atl1 T G 12: 70,006,049 (GRCm39) F452V probably damaging Het
Atp8b5 A G 4: 43,357,063 (GRCm39) T604A probably damaging Het
Bglap3 T C 3: 88,276,068 (GRCm39) I95V probably benign Het
Ccdc88a G T 11: 29,411,788 (GRCm39) M532I probably benign Het
Ccnl1 A G 3: 65,854,332 (GRCm39) S430P possibly damaging Het
Cdhr18 C T 14: 13,829,657 (GRCm38) S695N possibly damaging Het
Cdk5rap2 A T 4: 70,321,791 (GRCm39) probably null Het
Cep126 A T 9: 8,120,748 (GRCm39) Y92N possibly damaging Het
Cfap44 A C 16: 44,242,737 (GRCm39) T714P probably benign Het
Cnga1 T G 5: 72,774,068 (GRCm39) D90A possibly damaging Het
Cnot1 T C 8: 96,469,749 (GRCm39) I1369V possibly damaging Het
Coq3 T C 4: 21,910,466 (GRCm39) S314P probably damaging Het
Crhr1 A G 11: 104,060,675 (GRCm39) R151G probably damaging Het
Crybg2 A G 4: 133,806,167 (GRCm39) I930V probably damaging Het
Ctcf T A 8: 106,402,620 (GRCm39) probably null Het
Dct T C 14: 118,271,690 (GRCm39) N380S probably benign Het
Decr2 A T 17: 26,306,387 (GRCm39) L83Q probably damaging Het
Depdc5 CTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCT CTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCT 5: 33,067,751 (GRCm39) probably benign Het
Dgkb T C 12: 38,216,776 (GRCm39) probably null Het
Dnah1 T C 14: 31,041,716 (GRCm39) D85G probably damaging Het
Dnah7a T C 1: 53,574,637 (GRCm39) D1709G probably damaging Het
Dnajc13 A C 9: 104,106,136 (GRCm39) L346R probably damaging Het
Dsc1 A T 18: 20,229,045 (GRCm39) V415D probably damaging Het
Duox2 T A 2: 122,125,832 (GRCm39) I296F probably damaging Het
Ece2 T A 16: 20,463,922 (GRCm39) L890H probably damaging Het
Ecsit A G 9: 21,987,815 (GRCm39) S75P possibly damaging Het
Enpp3 A G 10: 24,654,687 (GRCm39) C664R probably damaging Het
Evpl G T 11: 116,117,854 (GRCm39) D778E probably damaging Het
Eya3 T A 4: 132,448,663 (GRCm39) probably null Het
Fam217b A T 2: 178,062,374 (GRCm39) I113F probably benign Het
Galnt6 G A 15: 100,613,999 (GRCm39) P101S possibly damaging Het
Gm379 G A X: 107,707,870 (GRCm39) Q210* probably null Het
Grk4 A T 5: 34,833,531 (GRCm39) probably null Het
Gtf3c4 A G 2: 28,729,968 (GRCm39) V91A probably benign Het
Hcfc2 G T 10: 82,538,392 (GRCm39) G143V probably damaging Het
Heatr4 A C 12: 84,005,221 (GRCm39) H710Q probably damaging Het
Htr3a A T 9: 48,817,681 (GRCm39) D97E probably damaging Het
Htr4 T G 18: 62,561,193 (GRCm39) F151L probably benign Het
Il22ra1 A T 4: 135,478,219 (GRCm39) Q430L probably damaging Het
Invs T A 4: 48,402,824 (GRCm39) probably null Het
Ip6k1 G A 9: 107,918,195 (GRCm39) E77K possibly damaging Het
Irs1 T C 1: 82,267,182 (GRCm39) S345G probably damaging Het
Kdm4a A G 4: 118,017,596 (GRCm39) V490A probably benign Het
Kif28 A G 1: 179,530,088 (GRCm39) V691A possibly damaging Het
Klhl5 T A 5: 65,324,330 (GRCm39) L696Q probably benign Het
Krtap5-1 T C 7: 141,850,084 (GRCm39) probably benign Het
Lama2 A C 10: 27,064,395 (GRCm39) D1195E probably damaging Het
Lamb1 T G 12: 31,379,209 (GRCm39) L1722R probably damaging Het
Lrp11 T A 10: 7,499,544 (GRCm39) L245Q probably damaging Het
Ltbp2 T C 12: 84,876,879 (GRCm39) E422G probably benign Het
Man2b1 T A 8: 85,813,451 (GRCm39) D214E probably damaging Het
Mlxipl A T 5: 135,162,422 (GRCm39) D628V possibly damaging Het
Msantd5f6 T A 4: 73,321,675 (GRCm39) Y120F probably damaging Het
Myo18b G A 5: 112,840,624 (GRCm39) R2390C probably damaging Het
Mypn T A 10: 62,959,176 (GRCm39) R1048S probably benign Het
Napepld A G 5: 21,870,270 (GRCm39) S383P probably damaging Het
Napsa A G 7: 44,231,160 (GRCm39) T130A probably damaging Het
Nbr1 T C 11: 101,465,978 (GRCm39) I716T probably damaging Het
Nexn A T 3: 151,953,818 (GRCm39) M212K probably damaging Het
Nlrp9b T A 7: 19,757,182 (GRCm39) S140T probably benign Het
Nxpe2 T C 9: 48,230,906 (GRCm39) T488A probably benign Het
Or10g3 T G 14: 52,610,174 (GRCm39) Q112P possibly damaging Het
Or10v1 A T 19: 11,873,913 (GRCm39) Y176F probably benign Het
Or5ac25 A T 16: 59,182,526 (GRCm39) D18E probably benign Het
Or7g12 A T 9: 18,900,192 (GRCm39) K303* probably null Het
Or8k20 C T 2: 86,106,190 (GRCm39) V214I probably benign Het
Osbpl5 T C 7: 143,256,918 (GRCm39) D404G possibly damaging Het
Pan2 T G 10: 128,144,237 (GRCm39) L162R probably damaging Het
Parp1 G T 1: 180,416,235 (GRCm39) V545F probably damaging Het
Pcdh18 A G 3: 49,709,896 (GRCm39) V473A probably benign Het
Plb1 A T 5: 32,448,582 (GRCm39) N350I probably damaging Het
Polr1a A G 6: 71,944,898 (GRCm39) K1318R probably benign Het
Ppp1r18 C T 17: 36,184,738 (GRCm39) P130S probably damaging Het
Prss48 C T 3: 85,905,614 (GRCm39) W86* probably null Het
Rab3c A T 13: 110,220,744 (GRCm39) I137N probably damaging Het
Rab3gap2 G C 1: 184,954,099 (GRCm39) R57P probably benign Het
Rad54l2 A C 9: 106,570,916 (GRCm39) probably null Het
Ralgapb C A 2: 158,337,483 (GRCm39) N1147K probably benign Het
Rfx7 C T 9: 72,524,093 (GRCm39) R428C probably damaging Het
Robo1 A G 16: 72,757,092 (GRCm39) Q351R probably null Het
Samd4 T C 14: 47,311,585 (GRCm39) F81S probably damaging Het
Shprh T A 10: 11,059,541 (GRCm39) Y1097* probably null Het
Sik3 C G 9: 46,132,387 (GRCm39) H1276Q probably benign Het
Slc24a4 T A 12: 102,097,876 (GRCm39) D79E probably benign Het
Slc7a13 A T 4: 19,839,254 (GRCm39) I286F probably benign Het
Smarca1 G A X: 46,938,840 (GRCm39) Q723* probably null Het
Spata31d1b T C 13: 59,865,882 (GRCm39) L1010P probably damaging Het
Sult2a1 T C 7: 13,569,900 (GRCm39) S111G possibly damaging Het
Tecpr2 C T 12: 110,914,346 (GRCm39) T1219M probably damaging Het
Tesk1 T C 4: 43,446,998 (GRCm39) M462T probably benign Het
Thoc2l T A 5: 104,666,196 (GRCm39) S239R probably benign Het
Tmem171 C A 13: 98,822,924 (GRCm39) G292* probably null Het
Tmtc2 G T 10: 105,025,969 (GRCm39) T833N probably benign Het
Tnc G T 4: 63,918,299 (GRCm39) T1204K probably benign Het
Tnfaip3 T C 10: 18,883,937 (GRCm39) K148E probably benign Het
Tnrc18 G A 5: 142,800,895 (GRCm39) S21F probably damaging Het
Tns4 T C 11: 98,966,401 (GRCm39) T425A probably damaging Het
Tox T A 4: 6,688,948 (GRCm39) Y472F probably damaging Het
Trak2 A T 1: 58,958,014 (GRCm39) probably null Het
Trim33 T A 3: 103,244,760 (GRCm39) Y716N probably damaging Het
Trrap T G 5: 144,752,863 (GRCm39) I1813R probably damaging Het
Ttc29 A G 8: 78,978,361 (GRCm39) E137G probably benign Het
Ube2j2 A G 4: 156,033,483 (GRCm39) K19R probably benign Het
Ubxn2b T C 4: 6,208,889 (GRCm39) I206T possibly damaging Het
Usp40 A G 1: 87,909,778 (GRCm39) F559L probably benign Het
Utp4 T A 8: 107,638,982 (GRCm39) probably null Het
Vac14 A G 8: 111,409,166 (GRCm39) N524S probably benign Het
Vps13c T C 9: 67,801,334 (GRCm39) S605P probably damaging Het
Vwa5b2 G T 16: 20,423,582 (GRCm39) S1165I possibly damaging Het
Zdhhc19 C T 16: 32,317,231 (GRCm39) R28* probably null Het
Zfp106 T C 2: 120,357,329 (GRCm39) I1189V probably benign Het
Zfp189 C T 4: 49,529,511 (GRCm39) Q205* probably null Het
Other mutations in Kif26a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Kif26a APN 12 112,124,066 (GRCm39) missense probably damaging 0.97
IGL01734:Kif26a APN 12 112,143,262 (GRCm39) missense probably benign 0.23
IGL01916:Kif26a APN 12 112,143,328 (GRCm39) missense possibly damaging 0.49
IGL02080:Kif26a APN 12 112,124,000 (GRCm39) missense probably damaging 1.00
IGL02138:Kif26a APN 12 112,141,284 (GRCm39) missense probably damaging 1.00
IGL02145:Kif26a APN 12 112,143,409 (GRCm39) missense probably benign 0.00
IGL02285:Kif26a APN 12 112,123,941 (GRCm39) missense probably damaging 1.00
IGL02393:Kif26a APN 12 112,139,098 (GRCm39) missense probably damaging 1.00
IGL02445:Kif26a APN 12 112,140,177 (GRCm39) missense probably damaging 1.00
IGL02865:Kif26a APN 12 112,144,049 (GRCm39) nonsense probably null
IGL03057:Kif26a APN 12 112,142,208 (GRCm39) nonsense probably null
IGL03204:Kif26a APN 12 112,141,213 (GRCm39) missense probably damaging 1.00
R0013:Kif26a UTSW 12 112,144,314 (GRCm39) missense probably benign 0.03
R0034:Kif26a UTSW 12 112,135,397 (GRCm39) splice site probably benign
R0089:Kif26a UTSW 12 112,143,837 (GRCm39) missense probably damaging 0.98
R0111:Kif26a UTSW 12 112,129,771 (GRCm39) splice site probably benign
R0220:Kif26a UTSW 12 112,123,824 (GRCm39) missense probably damaging 0.98
R0346:Kif26a UTSW 12 112,145,782 (GRCm39) missense probably null 0.09
R0383:Kif26a UTSW 12 112,144,510 (GRCm39) missense possibly damaging 0.94
R0478:Kif26a UTSW 12 112,142,223 (GRCm39) missense probably damaging 1.00
R0494:Kif26a UTSW 12 112,145,905 (GRCm39) splice site probably null
R1163:Kif26a UTSW 12 112,146,379 (GRCm39) missense probably benign 0.08
R1450:Kif26a UTSW 12 112,140,286 (GRCm39) missense probably damaging 1.00
R1512:Kif26a UTSW 12 112,113,389 (GRCm39) missense possibly damaging 0.47
R1616:Kif26a UTSW 12 112,123,680 (GRCm39) critical splice acceptor site probably null
R1723:Kif26a UTSW 12 112,140,292 (GRCm39) missense possibly damaging 0.67
R1728:Kif26a UTSW 12 112,143,219 (GRCm39) missense possibly damaging 0.95
R1729:Kif26a UTSW 12 112,143,219 (GRCm39) missense possibly damaging 0.95
R2283:Kif26a UTSW 12 112,143,787 (GRCm39) missense possibly damaging 0.66
R3862:Kif26a UTSW 12 112,146,323 (GRCm39) missense probably benign 0.30
R3906:Kif26a UTSW 12 112,143,324 (GRCm39) missense probably benign
R4050:Kif26a UTSW 12 112,146,350 (GRCm39) missense probably benign 0.08
R4270:Kif26a UTSW 12 112,139,848 (GRCm39) missense probably damaging 1.00
R4271:Kif26a UTSW 12 112,139,848 (GRCm39) missense probably damaging 1.00
R4731:Kif26a UTSW 12 112,142,007 (GRCm39) missense probably benign
R4732:Kif26a UTSW 12 112,142,007 (GRCm39) missense probably benign
R4733:Kif26a UTSW 12 112,142,007 (GRCm39) missense probably benign
R4908:Kif26a UTSW 12 112,123,776 (GRCm39) missense probably damaging 1.00
R4946:Kif26a UTSW 12 112,144,228 (GRCm39) missense probably damaging 0.99
R5566:Kif26a UTSW 12 112,123,788 (GRCm39) missense probably damaging 1.00
R6280:Kif26a UTSW 12 112,141,303 (GRCm39) missense probably damaging 0.99
R6422:Kif26a UTSW 12 112,135,309 (GRCm39) missense possibly damaging 0.95
R6513:Kif26a UTSW 12 112,141,926 (GRCm39) missense probably damaging 0.97
R6860:Kif26a UTSW 12 112,113,263 (GRCm39) missense probably damaging 1.00
R6879:Kif26a UTSW 12 112,144,087 (GRCm39) missense probably benign
R7127:Kif26a UTSW 12 112,144,579 (GRCm39) missense probably damaging 1.00
R7366:Kif26a UTSW 12 112,129,976 (GRCm39) critical splice donor site probably null
R7595:Kif26a UTSW 12 112,145,759 (GRCm39) missense probably benign 0.30
R7630:Kif26a UTSW 12 112,142,131 (GRCm39) missense probably damaging 1.00
R7784:Kif26a UTSW 12 112,144,581 (GRCm39) missense possibly damaging 0.66
R7992:Kif26a UTSW 12 112,142,481 (GRCm39) missense probably benign
R8170:Kif26a UTSW 12 112,141,752 (GRCm39) splice site probably null
R9206:Kif26a UTSW 12 112,144,480 (GRCm39) missense possibly damaging 0.92
R9287:Kif26a UTSW 12 112,145,719 (GRCm39) nonsense probably null
R9293:Kif26a UTSW 12 112,112,835 (GRCm39) missense probably damaging 1.00
R9524:Kif26a UTSW 12 112,140,286 (GRCm39) missense probably damaging 1.00
R9559:Kif26a UTSW 12 112,142,004 (GRCm39) missense probably damaging 1.00
R9687:Kif26a UTSW 12 112,143,625 (GRCm39) missense probably damaging 0.99
R9793:Kif26a UTSW 12 112,142,887 (GRCm39) missense probably damaging 1.00
X0027:Kif26a UTSW 12 112,142,504 (GRCm39) missense probably benign 0.26
Z1176:Kif26a UTSW 12 112,144,052 (GRCm39) missense probably damaging 0.97
Z1177:Kif26a UTSW 12 112,144,045 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- ATATAGACCACACTCCCATGTTGC -3'
(R):5'- AACGTACTGCAGCGGAAGTG -3'

Sequencing Primer
(F):5'- ACACTCCCATGTTGCTGAGAG -3'
(R):5'- TACTGCAGCGGAAGTGGTCAG -3'
Posted On 2014-06-30