Incidental Mutation 'R1909:Lrp4'
| ID |
210117 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp4
|
| Ensembl Gene |
ENSMUSG00000027253 |
| Gene Name |
low density lipoprotein receptor-related protein 4 |
| Synonyms |
6430526J12Rik, Megf7, mdig |
| MMRRC Submission |
039928-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.774)
|
| Stock # |
R1909 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
91287856-91344124 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 91328753 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Aspartic acid
at position 1551
(V1551D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028689]
|
| AlphaFold |
Q8VI56 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000028689
AA Change: V1551D
PolyPhen 2
Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000028689
Gene: ENSMUSG00000027253
AA Change: V1551D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
LDLa
|
26 |
68 |
5.77e-10 |
SMART |
|
LDLa
|
70 |
107 |
4.05e-14 |
SMART |
|
LDLa
|
109 |
145 |
1.9e-10 |
SMART |
|
LDLa
|
147 |
184 |
1.51e-13 |
SMART |
|
LDLa
|
190 |
227 |
6.83e-12 |
SMART |
|
LDLa
|
230 |
267 |
2.45e-13 |
SMART |
|
LDLa
|
269 |
306 |
6.32e-16 |
SMART |
|
LDLa
|
311 |
351 |
3.24e-13 |
SMART |
|
EGF
|
357 |
394 |
1.4e0 |
SMART |
|
EGF_CA
|
395 |
434 |
1.05e-8 |
SMART |
|
LY
|
460 |
502 |
7.01e-10 |
SMART |
|
LY
|
503 |
545 |
4.41e-16 |
SMART |
|
LY
|
546 |
589 |
1.04e-12 |
SMART |
|
LY
|
590 |
632 |
5.07e-16 |
SMART |
|
LY
|
633 |
674 |
3.12e-7 |
SMART |
|
EGF
|
701 |
737 |
9.27e-1 |
SMART |
|
LY
|
765 |
807 |
7.29e-8 |
SMART |
|
LY
|
808 |
850 |
1.92e-16 |
SMART |
|
LY
|
851 |
894 |
3.05e-10 |
SMART |
|
LY
|
895 |
937 |
6.69e-16 |
SMART |
|
LY
|
938 |
979 |
8.71e-6 |
SMART |
|
EGF
|
1005 |
1044 |
1.64e-1 |
SMART |
|
LY
|
1073 |
1115 |
2.58e-8 |
SMART |
|
LY
|
1116 |
1158 |
1.57e-12 |
SMART |
|
LY
|
1159 |
1202 |
7.4e-9 |
SMART |
|
LY
|
1203 |
1245 |
9.39e-11 |
SMART |
|
LY
|
1246 |
1285 |
6.11e-1 |
SMART |
|
EGF
|
1312 |
1349 |
1.53e-1 |
SMART |
|
LY
|
1377 |
1419 |
4.42e-7 |
SMART |
|
LY
|
1420 |
1462 |
1.04e-12 |
SMART |
|
LY
|
1463 |
1506 |
2.11e-13 |
SMART |
|
LY
|
1507 |
1549 |
4.66e-15 |
SMART |
|
LY
|
1550 |
1590 |
2.02e-1 |
SMART |
|
EGF_like
|
1616 |
1649 |
5.79e1 |
SMART |
|
low complexity region
|
1674 |
1690 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1724 |
1746 |
N/A |
INTRINSIC |
|
low complexity region
|
1857 |
1870 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 93.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutations of this gene cause polysyndactyly. Additional phenotypes may include growth retardation, abnormal incisor development, kidney agenesis, and neonatal lethality associated with respiratory failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aarsd1 |
A |
C |
11: 101,301,057 (GRCm39) |
|
probably null |
Het |
| Abcc5 |
A |
G |
16: 20,195,259 (GRCm39) |
|
probably null |
Het |
| Abcc6 |
T |
C |
7: 45,669,558 (GRCm39) |
|
probably null |
Het |
| Adam15 |
C |
A |
3: 89,252,637 (GRCm39) |
M317I |
probably benign |
Het |
| Ago3 |
T |
C |
4: 126,240,530 (GRCm39) |
T111A |
probably damaging |
Het |
| Amz1 |
G |
T |
5: 140,738,216 (GRCm39) |
S492I |
probably benign |
Het |
| Arid1a |
T |
C |
4: 133,421,072 (GRCm39) |
N911S |
unknown |
Het |
| Ascl2 |
C |
A |
7: 142,521,900 (GRCm39) |
A115S |
probably damaging |
Het |
| Ash1l |
T |
C |
3: 88,891,835 (GRCm39) |
V1238A |
probably benign |
Het |
| Asxl2 |
G |
T |
12: 3,524,577 (GRCm39) |
V202F |
probably damaging |
Het |
| Atp10a |
A |
T |
7: 58,478,460 (GRCm39) |
Q1501L |
probably benign |
Het |
| Avpr1a |
A |
T |
10: 122,288,113 (GRCm39) |
I374L |
probably benign |
Het |
| Bmal2 |
A |
T |
6: 146,712,308 (GRCm39) |
E111V |
probably benign |
Het |
| Bmx |
T |
C |
X: 163,022,411 (GRCm39) |
H157R |
probably benign |
Het |
| Camk4 |
T |
A |
18: 33,291,869 (GRCm39) |
|
probably null |
Het |
| Ccdc103 |
G |
A |
11: 102,773,392 (GRCm39) |
D5N |
probably benign |
Het |
| Ccdc186 |
A |
T |
19: 56,781,793 (GRCm39) |
N70K |
probably damaging |
Het |
| Cebpz |
A |
T |
17: 79,242,336 (GRCm39) |
Y439* |
probably null |
Het |
| Cfap206 |
A |
C |
4: 34,722,714 (GRCm39) |
S122R |
probably benign |
Het |
| Cnst |
T |
C |
1: 179,450,356 (GRCm39) |
S607P |
probably damaging |
Het |
| Col8a2 |
C |
A |
4: 126,205,926 (GRCm39) |
D645E |
possibly damaging |
Het |
| Cpsf4l |
A |
T |
11: 113,594,204 (GRCm39) |
|
probably null |
Het |
| Crim1 |
C |
T |
17: 78,620,556 (GRCm39) |
T332I |
probably benign |
Het |
| Csmd1 |
A |
T |
8: 15,956,116 (GRCm39) |
Y3364N |
probably damaging |
Het |
| D5Ertd579e |
A |
T |
5: 36,771,402 (GRCm39) |
S998T |
probably benign |
Het |
| Dab2ip |
C |
G |
2: 35,608,827 (GRCm39) |
A587G |
probably damaging |
Het |
| Dach1 |
C |
T |
14: 98,138,829 (GRCm39) |
G486D |
probably damaging |
Het |
| Ddx24 |
T |
C |
12: 103,376,241 (GRCm39) |
I752V |
probably damaging |
Het |
| Dennd2b |
G |
A |
7: 109,124,533 (GRCm39) |
Q686* |
probably null |
Het |
| Dhx33 |
A |
G |
11: 70,879,933 (GRCm39) |
V359A |
probably benign |
Het |
| Dip2c |
A |
T |
13: 9,583,386 (GRCm39) |
T123S |
probably benign |
Het |
| Dync1h1 |
G |
A |
12: 110,629,063 (GRCm39) |
E4207K |
probably damaging |
Het |
| Eef1b2 |
G |
T |
1: 63,216,431 (GRCm39) |
D21Y |
probably damaging |
Het |
| Eif3b |
T |
C |
5: 140,418,692 (GRCm39) |
S462P |
probably damaging |
Het |
| Elmod2 |
G |
C |
8: 84,042,998 (GRCm39) |
R277G |
probably benign |
Het |
| Epg5 |
T |
A |
18: 78,002,247 (GRCm39) |
D555E |
probably benign |
Het |
| Ercc8 |
A |
T |
13: 108,312,100 (GRCm39) |
K172* |
probably null |
Het |
| Fat3 |
T |
C |
9: 15,909,411 (GRCm39) |
N2197S |
probably benign |
Het |
| Fbf1 |
A |
G |
11: 116,036,818 (GRCm39) |
V972A |
possibly damaging |
Het |
| Fcgbpl1 |
T |
C |
7: 27,843,773 (GRCm39) |
V887A |
possibly damaging |
Het |
| Fes |
T |
C |
7: 80,036,609 (GRCm39) |
R113G |
probably damaging |
Het |
| Fzd1 |
G |
T |
5: 4,807,481 (GRCm39) |
H34N |
probably benign |
Het |
| Galnt17 |
T |
A |
5: 131,140,676 (GRCm39) |
Y147F |
probably benign |
Het |
| Garre1 |
T |
A |
7: 33,957,461 (GRCm39) |
I59L |
probably benign |
Het |
| Gdf6 |
T |
C |
4: 9,859,971 (GRCm39) |
L351P |
probably damaging |
Het |
| Gm10277 |
TC |
T |
11: 77,676,828 (GRCm39) |
|
probably null |
Het |
| Gm2381 |
A |
T |
7: 42,469,352 (GRCm39) |
H257Q |
probably damaging |
Het |
| Hivep1 |
A |
T |
13: 42,309,122 (GRCm39) |
K454M |
probably benign |
Het |
| Hmmr |
T |
A |
11: 40,598,925 (GRCm39) |
E566D |
probably damaging |
Het |
| Hydin |
T |
G |
8: 111,314,404 (GRCm39) |
V4296G |
probably damaging |
Het |
| Il18r1 |
T |
A |
1: 40,514,074 (GRCm39) |
D93E |
probably damaging |
Het |
| Iqgap1 |
T |
C |
7: 80,393,576 (GRCm39) |
D667G |
probably benign |
Het |
| Lama3 |
T |
C |
18: 12,714,855 (GRCm39) |
I3278T |
probably benign |
Het |
| Mdn1 |
CGGAGGAGGAGGAGGAG |
CGGAGGAGGAGGAG |
4: 32,760,839 (GRCm39) |
|
probably benign |
Het |
| Mga |
T |
A |
2: 119,757,075 (GRCm39) |
H1018Q |
possibly damaging |
Het |
| Ncoa7 |
A |
T |
10: 30,565,796 (GRCm39) |
M666K |
probably damaging |
Het |
| Ndnf |
T |
G |
6: 65,680,297 (GRCm39) |
V192G |
possibly damaging |
Het |
| Nr4a1 |
T |
A |
15: 101,172,108 (GRCm39) |
I594N |
probably damaging |
Het |
| Or13a27 |
T |
C |
7: 139,925,378 (GRCm39) |
I175V |
probably benign |
Het |
| Or2ag16 |
T |
C |
7: 106,352,202 (GRCm39) |
N131S |
probably benign |
Het |
| Or4k44 |
T |
A |
2: 111,368,359 (GRCm39) |
I92F |
probably damaging |
Het |
| Or51q1 |
G |
A |
7: 103,628,997 (GRCm39) |
W199* |
probably null |
Het |
| Or52z13 |
A |
G |
7: 103,246,550 (GRCm39) |
N9S |
probably benign |
Het |
| Paxbp1 |
T |
C |
16: 90,841,193 (GRCm39) |
|
probably benign |
Het |
| Pcdhb8 |
A |
G |
18: 37,489,015 (GRCm39) |
E231G |
possibly damaging |
Het |
| Pcsk5 |
A |
T |
19: 17,410,825 (GRCm39) |
Y1856N |
probably benign |
Het |
| Pde3a |
T |
C |
6: 141,195,965 (GRCm39) |
V217A |
probably benign |
Het |
| Phf11 |
A |
T |
14: 59,496,062 (GRCm39) |
S17R |
probably benign |
Het |
| Pira13 |
A |
T |
7: 3,825,918 (GRCm39) |
I317N |
probably benign |
Het |
| Pirb |
A |
T |
7: 3,717,587 (GRCm39) |
D674E |
probably benign |
Het |
| Pnisr |
T |
A |
4: 21,869,517 (GRCm39) |
M335K |
possibly damaging |
Het |
| Pnpla7 |
T |
A |
2: 24,887,300 (GRCm39) |
M48K |
possibly damaging |
Het |
| Pomgnt2 |
A |
T |
9: 121,811,257 (GRCm39) |
I508N |
possibly damaging |
Het |
| Ppp2r5e |
C |
G |
12: 75,516,341 (GRCm39) |
A239P |
probably damaging |
Het |
| Prkca |
A |
T |
11: 107,830,438 (GRCm39) |
D217E |
possibly damaging |
Het |
| Rac3 |
A |
C |
11: 120,614,163 (GRCm39) |
I142L |
probably benign |
Het |
| Ralgapb |
G |
T |
2: 158,286,595 (GRCm39) |
A347S |
probably damaging |
Het |
| Rbm43 |
G |
C |
2: 51,815,446 (GRCm39) |
S258R |
possibly damaging |
Het |
| Rnf182 |
T |
A |
13: 43,821,899 (GRCm39) |
V150E |
probably benign |
Het |
| Rsph10b |
T |
C |
5: 143,922,309 (GRCm39) |
F409L |
probably benign |
Het |
| Ryr2 |
A |
T |
13: 11,715,235 (GRCm39) |
L2778M |
probably damaging |
Het |
| Scn1a |
T |
C |
2: 66,161,696 (GRCm39) |
N284S |
possibly damaging |
Het |
| Scyl2 |
A |
T |
10: 89,476,767 (GRCm39) |
M786K |
probably benign |
Het |
| Sema4g |
C |
A |
19: 44,986,061 (GRCm39) |
R301S |
probably damaging |
Het |
| Senp6 |
A |
T |
9: 80,021,056 (GRCm39) |
E245D |
possibly damaging |
Het |
| Setx |
T |
C |
2: 29,053,021 (GRCm39) |
V2095A |
possibly damaging |
Het |
| Slc13a2 |
A |
T |
11: 78,290,968 (GRCm39) |
M412K |
possibly damaging |
Het |
| Slc25a4 |
T |
C |
8: 46,662,437 (GRCm39) |
N74D |
probably damaging |
Het |
| Slc28a1 |
T |
A |
7: 80,791,783 (GRCm39) |
F316L |
probably damaging |
Het |
| Slfn8 |
G |
A |
11: 82,894,447 (GRCm39) |
Q731* |
probably null |
Het |
| Slitrk4 |
A |
G |
X: 63,316,229 (GRCm39) |
I146T |
probably damaging |
Het |
| Smg1 |
A |
G |
7: 117,753,422 (GRCm39) |
|
probably benign |
Het |
| Smg8 |
G |
T |
11: 86,971,439 (GRCm39) |
Y777* |
probably null |
Het |
| Smyd1 |
T |
A |
6: 71,216,563 (GRCm39) |
K61N |
probably benign |
Het |
| Sod2 |
T |
C |
17: 13,234,056 (GRCm39) |
*223R |
probably null |
Het |
| Sp6 |
G |
T |
11: 96,912,334 (GRCm39) |
A16S |
probably benign |
Het |
| Spata31d1a |
A |
C |
13: 59,850,509 (GRCm39) |
Y540D |
probably damaging |
Het |
| Spatc1l |
A |
G |
10: 76,399,751 (GRCm39) |
D91G |
probably damaging |
Het |
| Spg7 |
A |
G |
8: 123,807,480 (GRCm39) |
T419A |
probably benign |
Het |
| St8sia4 |
A |
G |
1: 95,555,298 (GRCm39) |
I244T |
probably damaging |
Het |
| Tbl2 |
C |
T |
5: 135,181,845 (GRCm39) |
R27W |
probably damaging |
Het |
| Tmed4 |
G |
A |
11: 6,224,694 (GRCm39) |
P47L |
probably damaging |
Het |
| Tmsb10b |
T |
C |
7: 24,561,731 (GRCm39) |
I10T |
possibly damaging |
Het |
| Tmtc1 |
T |
C |
6: 148,345,546 (GRCm39) |
D51G |
possibly damaging |
Het |
| Ttc28 |
T |
C |
5: 111,431,920 (GRCm39) |
|
probably null |
Het |
| Unc13d |
A |
G |
11: 115,961,121 (GRCm39) |
F412S |
probably damaging |
Het |
| Unc45b |
A |
C |
11: 82,816,913 (GRCm39) |
K451T |
probably damaging |
Het |
| Vmn2r16 |
A |
G |
5: 109,511,853 (GRCm39) |
M687V |
probably benign |
Het |
| Vmn2r68 |
T |
A |
7: 84,883,260 (GRCm39) |
H164L |
probably benign |
Het |
| Vps51 |
A |
G |
19: 6,119,499 (GRCm39) |
V625A |
probably benign |
Het |
| Wapl |
T |
A |
14: 34,413,869 (GRCm39) |
W244R |
probably damaging |
Het |
| Wdr75 |
C |
T |
1: 45,862,563 (GRCm39) |
T794I |
probably benign |
Het |
|
| Other mutations in Lrp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00225:Lrp4
|
APN |
2 |
91,325,371 (GRCm39) |
missense |
probably benign |
|
|
IGL00509:Lrp4
|
APN |
2 |
91,316,519 (GRCm39) |
splice site |
probably benign |
|
|
IGL01145:Lrp4
|
APN |
2 |
91,317,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01287:Lrp4
|
APN |
2 |
91,304,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01531:Lrp4
|
APN |
2 |
91,341,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01534:Lrp4
|
APN |
2 |
91,303,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01544:Lrp4
|
APN |
2 |
91,307,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01761:Lrp4
|
APN |
2 |
91,312,326 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01885:Lrp4
|
APN |
2 |
91,331,452 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01909:Lrp4
|
APN |
2 |
91,324,529 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02111:Lrp4
|
APN |
2 |
91,336,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Lrp4
|
APN |
2 |
91,305,065 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02403:Lrp4
|
APN |
2 |
91,338,927 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02431:Lrp4
|
APN |
2 |
91,306,982 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02452:Lrp4
|
APN |
2 |
91,304,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Lrp4
|
APN |
2 |
91,307,055 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02828:Lrp4
|
APN |
2 |
91,305,639 (GRCm39) |
missense |
probably benign |
|
|
IGL02832:Lrp4
|
APN |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02893:Lrp4
|
APN |
2 |
91,305,161 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
artiodactyl
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bubalus
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
riverhorse
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wallow
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
F5770:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0137:Lrp4
|
UTSW |
2 |
91,325,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Lrp4
|
UTSW |
2 |
91,321,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0368:Lrp4
|
UTSW |
2 |
91,308,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0531:Lrp4
|
UTSW |
2 |
91,305,523 (GRCm39) |
splice site |
probably benign |
|
|
R0827:Lrp4
|
UTSW |
2 |
91,325,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Lrp4
|
UTSW |
2 |
91,317,372 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Lrp4
|
UTSW |
2 |
91,307,864 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1587:Lrp4
|
UTSW |
2 |
91,306,650 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1693:Lrp4
|
UTSW |
2 |
91,322,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Lrp4
|
UTSW |
2 |
91,322,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1863:Lrp4
|
UTSW |
2 |
91,328,708 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1908:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1932:Lrp4
|
UTSW |
2 |
91,327,700 (GRCm39) |
nonsense |
probably null |
|
|
R1934:Lrp4
|
UTSW |
2 |
91,310,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2358:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2433:Lrp4
|
UTSW |
2 |
91,336,360 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2698:Lrp4
|
UTSW |
2 |
91,305,557 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2919:Lrp4
|
UTSW |
2 |
91,321,075 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3105:Lrp4
|
UTSW |
2 |
91,331,394 (GRCm39) |
missense |
probably benign |
|
|
R3709:Lrp4
|
UTSW |
2 |
91,320,811 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3711:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Lrp4
|
UTSW |
2 |
91,328,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Lrp4
|
UTSW |
2 |
91,307,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3894:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3895:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4397:Lrp4
|
UTSW |
2 |
91,342,015 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4741:Lrp4
|
UTSW |
2 |
91,341,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Lrp4
|
UTSW |
2 |
91,316,231 (GRCm39) |
missense |
probably benign |
|
|
R5050:Lrp4
|
UTSW |
2 |
91,322,767 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5096:Lrp4
|
UTSW |
2 |
91,316,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5110:Lrp4
|
UTSW |
2 |
91,327,417 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5141:Lrp4
|
UTSW |
2 |
91,309,023 (GRCm39) |
splice site |
probably benign |
|
|
R5439:Lrp4
|
UTSW |
2 |
91,327,418 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5725:Lrp4
|
UTSW |
2 |
91,325,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5795:Lrp4
|
UTSW |
2 |
91,304,816 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5820:Lrp4
|
UTSW |
2 |
91,322,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5883:Lrp4
|
UTSW |
2 |
91,318,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5919:Lrp4
|
UTSW |
2 |
91,303,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Lrp4
|
UTSW |
2 |
91,342,029 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6080:Lrp4
|
UTSW |
2 |
91,332,345 (GRCm39) |
missense |
probably benign |
|
|
R6189:Lrp4
|
UTSW |
2 |
91,305,579 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6192:Lrp4
|
UTSW |
2 |
91,338,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6319:Lrp4
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Lrp4
|
UTSW |
2 |
91,324,174 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6479:Lrp4
|
UTSW |
2 |
91,317,429 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6500:Lrp4
|
UTSW |
2 |
91,322,765 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6643:Lrp4
|
UTSW |
2 |
91,332,340 (GRCm39) |
missense |
probably benign |
|
|
R6657:Lrp4
|
UTSW |
2 |
91,322,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6696:Lrp4
|
UTSW |
2 |
91,327,690 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6714:Lrp4
|
UTSW |
2 |
91,306,710 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6734:Lrp4
|
UTSW |
2 |
91,316,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6770:Lrp4
|
UTSW |
2 |
91,327,648 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6774:Lrp4
|
UTSW |
2 |
91,341,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6957:Lrp4
|
UTSW |
2 |
91,317,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6978:Lrp4
|
UTSW |
2 |
91,322,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7065:Lrp4
|
UTSW |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7142:Lrp4
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7219:Lrp4
|
UTSW |
2 |
91,322,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7237:Lrp4
|
UTSW |
2 |
91,303,528 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7387:Lrp4
|
UTSW |
2 |
91,306,959 (GRCm39) |
missense |
probably benign |
|
|
R7585:Lrp4
|
UTSW |
2 |
91,322,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Lrp4
|
UTSW |
2 |
91,325,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7872:Lrp4
|
UTSW |
2 |
91,321,061 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7968:Lrp4
|
UTSW |
2 |
91,324,424 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8222:Lrp4
|
UTSW |
2 |
91,305,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Lrp4
|
UTSW |
2 |
91,322,713 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8342:Lrp4
|
UTSW |
2 |
91,318,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8435:Lrp4
|
UTSW |
2 |
91,307,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8720:Lrp4
|
UTSW |
2 |
91,324,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8774:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8774-TAIL:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8792:Lrp4
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8913:Lrp4
|
UTSW |
2 |
91,331,785 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9017:Lrp4
|
UTSW |
2 |
91,324,397 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9062:Lrp4
|
UTSW |
2 |
91,303,925 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9118:Lrp4
|
UTSW |
2 |
91,308,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9640:Lrp4
|
UTSW |
2 |
91,316,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9649:Lrp4
|
UTSW |
2 |
91,338,914 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9708:Lrp4
|
UTSW |
2 |
91,342,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9748:Lrp4
|
UTSW |
2 |
91,316,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Lrp4
|
UTSW |
2 |
91,316,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7580:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7581:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7582:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7583:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Lrp4
|
UTSW |
2 |
91,331,407 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTTCCCTGCTTATGAGTTACATTC -3'
(R):5'- GCCAGGCCTTCAAATGACAG -3'
Sequencing Primer
(F):5'- TGACCTCTCGTCAGGAGTG -3'
(R):5'- GGCCTTCAAATGACAGAACACGG -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation