Incidental Mutation 'R1911:Or7g12'
ID 210281
Institutional Source Beutler Lab
Gene Symbol Or7g12
Ensembl Gene ENSMUSG00000095525
Gene Name olfactory receptor family 7 subfamily G member 12
Synonyms GA_x6K02T2PVTD-12724921-12725859, MOR153-2, Olfr834, MOR153-4_p
MMRRC Submission 039929-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.312) question?
Stock # R1911 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 18899286-18900224 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 18900196 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 304 (L304P)
Ref Sequence ENSEMBL: ENSMUSP00000083680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086492]
AlphaFold Q7TRG8
Predicted Effect probably damaging
Transcript: ENSMUST00000086492
AA Change: L304P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000083680
Gene: ENSMUSG00000095525
AA Change: L304P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 7.2e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 305 7e-6 PFAM
Pfam:7tm_1 41 290 2.9e-20 PFAM
Meta Mutation Damage Score 0.7215 question?
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.8%
  • 10x: 95.4%
  • 20x: 93.2%
Validation Efficiency 99% (99/100)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 96 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik T A 6: 91,927,050 (GRCm39) probably benign Het
Abca7 T C 10: 79,842,468 (GRCm39) V1134A probably benign Het
Acaa2 A G 18: 74,925,483 (GRCm39) E82G probably benign Het
Acap1 T C 11: 69,772,548 (GRCm39) D521G probably damaging Het
Adam19 T C 11: 46,012,281 (GRCm39) V259A probably damaging Het
Adss1 T C 12: 112,599,443 (GRCm39) V140A probably benign Het
Aif1 G A 17: 35,391,127 (GRCm39) P44L probably benign Het
Aldh3b1 T G 19: 3,971,187 (GRCm39) D159A probably damaging Het
Ank1 T C 8: 23,589,666 (GRCm39) V589A probably damaging Het
Ano2 G A 6: 125,990,654 (GRCm39) D803N probably benign Het
Arid1b A G 17: 5,393,241 (GRCm39) E2257G probably damaging Het
Asb17 T C 3: 153,550,138 (GRCm39) Y57H probably benign Het
Asph T C 4: 9,453,335 (GRCm39) E646G probably damaging Het
Aspm T A 1: 139,405,832 (GRCm39) I1573K probably benign Het
Bcas1 C A 2: 170,229,863 (GRCm39) D236Y probably damaging Het
Bcas2 G T 3: 103,079,113 (GRCm39) G9* probably null Het
Btaf1 A G 19: 36,964,030 (GRCm39) Q867R probably benign Het
Calhm3 C T 19: 47,143,908 (GRCm39) V132I possibly damaging Het
Ccer1 A T 10: 97,530,539 (GRCm39) I401F possibly damaging Het
Cdcp3 T C 7: 130,839,818 (GRCm39) V580A probably damaging Het
Cecr2 T A 6: 120,739,526 (GRCm39) probably benign Het
Cep104 G A 4: 154,091,255 (GRCm39) R925Q possibly damaging Het
Cep164 T A 9: 45,682,104 (GRCm39) M1900L probably benign Het
Crybg1 A G 10: 43,873,673 (GRCm39) V1145A possibly damaging Het
Cyp2a4 T A 7: 26,008,399 (GRCm39) N180K possibly damaging Het
Dennd4a T C 9: 64,796,368 (GRCm39) L798P probably damaging Het
Dmxl1 T C 18: 50,011,230 (GRCm39) I1129T probably benign Het
Dnah2 T C 11: 69,406,578 (GRCm39) N555D possibly damaging Het
Dock1 T A 7: 134,601,029 (GRCm39) M988K probably damaging Het
Elp4 T A 2: 105,533,088 (GRCm39) H419L probably damaging Het
Endov T C 11: 119,393,177 (GRCm39) V109A possibly damaging Het
Epha8 T C 4: 136,663,625 (GRCm39) Y477C probably damaging Het
Erlin1 A G 19: 44,037,561 (GRCm39) M188T probably damaging Het
Fhip1a T A 3: 85,568,525 (GRCm39) D998V probably benign Het
Fhod3 A T 18: 25,245,643 (GRCm39) D1231V possibly damaging Het
Gimap3 T A 6: 48,742,646 (GRCm39) I95F possibly damaging Het
Gm10717 T G 9: 3,026,317 (GRCm39) F205C probably damaging Het
Grk1 C A 8: 13,457,923 (GRCm39) D274E probably damaging Het
Gsdmc2 G A 15: 63,699,621 (GRCm39) A269V probably benign Het
Krt33a T A 11: 99,903,175 (GRCm39) Q289L probably benign Het
Krt76 T A 15: 101,796,600 (GRCm39) K403* probably null Het
Lcn4 T C 2: 26,560,607 (GRCm39) probably benign Het
Mab21l1 T C 3: 55,691,048 (GRCm39) S212P possibly damaging Het
Mapk8ip3 A C 17: 25,123,025 (GRCm39) D610E probably benign Het
Mastl G T 2: 23,022,692 (GRCm39) S677* probably null Het
Mfap3 T C 11: 57,420,562 (GRCm39) F181S probably damaging Het
Mlkl T C 8: 112,038,732 (GRCm39) probably benign Het
Mov10 G A 3: 104,708,876 (GRCm39) probably benign Het
Muc5ac T C 7: 141,350,041 (GRCm39) F595L probably benign Het
Nbas T A 12: 13,616,145 (GRCm39) C2228S probably benign Het
Nit2 G A 16: 56,982,046 (GRCm39) probably benign Het
Nod1 C T 6: 54,921,425 (GRCm39) V298M probably damaging Het
Or3a4 C A 11: 73,945,210 (GRCm39) R125L probably damaging Het
Or4c111 A G 2: 88,843,565 (GRCm39) L281P probably damaging Het
Or52b1 T A 7: 104,978,590 (GRCm39) I270F probably benign Het
Or6c210 A T 10: 129,495,981 (GRCm39) D102V probably benign Het
Osbpl5 C A 7: 143,243,662 (GRCm39) R864L probably benign Het
Pcnt G A 10: 76,204,650 (GRCm39) T2585M possibly damaging Het
Pepd C T 7: 34,634,174 (GRCm39) probably benign Het
Pou6f2 T C 13: 18,326,548 (GRCm39) I341V probably damaging Het
Pramel32 T C 4: 88,548,309 (GRCm39) Q32R possibly damaging Het
Prune2 T A 19: 17,091,038 (GRCm39) F281I probably benign Het
Psg19 T G 7: 18,528,193 (GRCm39) Q183H probably damaging Het
Psme4 T G 11: 30,765,658 (GRCm39) S587A probably benign Het
Ptpro T C 6: 137,377,617 (GRCm39) probably benign Het
Pttg1ip2 C A 5: 5,502,019 (GRCm39) W144C probably benign Het
Rasgrp4 T C 7: 28,838,302 (GRCm39) V92A probably damaging Het
Rem1 G A 2: 152,476,455 (GRCm39) V238M probably damaging Het
Rexo5 C T 7: 119,398,867 (GRCm39) A68V probably damaging Het
Robo2 A T 16: 73,755,213 (GRCm39) N769K probably damaging Het
Sfrp5 C T 19: 42,187,237 (GRCm39) V278I probably benign Het
Sidt1 A G 16: 44,102,234 (GRCm39) S309P possibly damaging Het
Slc22a6 A C 19: 8,599,246 (GRCm39) Q292H probably benign Het
Slc4a3 G A 1: 75,530,367 (GRCm39) R690H probably damaging Het
Snx7 A T 3: 117,623,317 (GRCm39) probably null Het
Spag6 T A 2: 18,720,616 (GRCm39) Y129* probably null Het
Srcap T C 7: 127,133,994 (GRCm39) I905T probably damaging Het
St6gal1 T G 16: 23,140,383 (GRCm39) S185A probably damaging Het
Sult6b1 G A 17: 79,196,393 (GRCm39) H250Y possibly damaging Het
Tdrd6 T G 17: 43,937,979 (GRCm39) N1023T probably benign Het
Tecta C T 9: 42,249,232 (GRCm39) E1877K probably damaging Het
Tex10 C T 4: 48,456,800 (GRCm39) R637Q probably benign Het
Tex14 T A 11: 87,385,861 (GRCm39) D240E probably damaging Het
Tex47 T C 5: 7,355,022 (GRCm39) Y68H probably damaging Het
Thbs2 A G 17: 14,910,104 (GRCm39) V165A probably benign Het
Tmem126b T A 7: 90,118,367 (GRCm39) Y171F possibly damaging Het
Tpsg1 G T 17: 25,592,374 (GRCm39) M46I probably benign Het
Trmt2a A G 16: 18,069,070 (GRCm39) K304R probably benign Het
Ttc28 G T 5: 111,428,616 (GRCm39) R1845L possibly damaging Het
Umodl1 A T 17: 31,211,128 (GRCm39) T884S possibly damaging Het
Vmn2r77 A G 7: 86,461,001 (GRCm39) K776E probably damaging Het
Vmn2r88 T C 14: 51,655,671 (GRCm39) S627P probably damaging Het
Vrk1 T C 12: 106,024,236 (GRCm39) probably null Het
Zfp644 A G 5: 106,783,137 (GRCm39) M1079T possibly damaging Het
Znrf1 T C 8: 112,348,233 (GRCm39) *41Q probably null Het
Znrf1 T C 8: 112,348,244 (GRCm39) F183L possibly damaging Het
Other mutations in Or7g12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01804:Or7g12 APN 9 18,900,136 (GRCm39) missense probably benign 0.16
IGL02073:Or7g12 APN 9 18,899,621 (GRCm39) missense possibly damaging 0.89
IGL02119:Or7g12 APN 9 18,899,908 (GRCm39) missense probably benign 0.00
IGL02705:Or7g12 APN 9 18,899,696 (GRCm39) missense probably benign 0.03
R0462:Or7g12 UTSW 9 18,900,198 (GRCm39) missense probably benign
R0466:Or7g12 UTSW 9 18,899,551 (GRCm39) missense probably benign 0.00
R0709:Or7g12 UTSW 9 18,899,422 (GRCm39) missense probably damaging 0.98
R0711:Or7g12 UTSW 9 18,899,447 (GRCm39) missense probably benign 0.04
R1268:Or7g12 UTSW 9 18,899,652 (GRCm39) missense probably damaging 0.98
R1663:Or7g12 UTSW 9 18,900,006 (GRCm39) missense probably damaging 0.99
R1680:Or7g12 UTSW 9 18,899,812 (GRCm39) missense possibly damaging 0.81
R1686:Or7g12 UTSW 9 18,899,839 (GRCm39) missense probably damaging 1.00
R1903:Or7g12 UTSW 9 18,900,192 (GRCm39) nonsense probably null
R1907:Or7g12 UTSW 9 18,899,737 (GRCm39) missense possibly damaging 0.82
R2143:Or7g12 UTSW 9 18,900,099 (GRCm39) missense probably benign 0.06
R2431:Or7g12 UTSW 9 18,899,299 (GRCm39) missense probably damaging 1.00
R4014:Or7g12 UTSW 9 18,900,178 (GRCm39) missense probably benign 0.08
R4515:Or7g12 UTSW 9 18,899,278 (GRCm39) splice site probably null
R4575:Or7g12 UTSW 9 18,900,001 (GRCm39) nonsense probably null
R6974:Or7g12 UTSW 9 18,899,689 (GRCm39) missense probably damaging 0.99
R7394:Or7g12 UTSW 9 18,900,006 (GRCm39) missense probably damaging 0.99
R7455:Or7g12 UTSW 9 18,900,150 (GRCm39) missense possibly damaging 0.92
R7828:Or7g12 UTSW 9 18,900,216 (GRCm39) missense probably benign
R7962:Or7g12 UTSW 9 18,899,952 (GRCm39) missense probably damaging 0.97
R8360:Or7g12 UTSW 9 18,900,139 (GRCm39) missense probably benign 0.28
R8812:Or7g12 UTSW 9 18,899,812 (GRCm39) missense possibly damaging 0.81
R8905:Or7g12 UTSW 9 18,899,494 (GRCm39) missense possibly damaging 0.92
R8973:Or7g12 UTSW 9 18,899,974 (GRCm39) nonsense probably null
R8980:Or7g12 UTSW 9 18,899,423 (GRCm39) missense probably damaging 1.00
R9013:Or7g12 UTSW 9 18,899,874 (GRCm39) missense possibly damaging 0.94
R9058:Or7g12 UTSW 9 18,900,222 (GRCm39) makesense probably null
R9614:Or7g12 UTSW 9 18,899,526 (GRCm39) missense possibly damaging 0.75
R9779:Or7g12 UTSW 9 18,900,135 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TTCCATCAGCTGCAGGAAAATAC -3'
(R):5'- GGAACCTTAAACATTTGTGCACATGG -3'

Sequencing Primer
(F):5'- CAGCTGCAGGAAAATACAAAGTATTC -3'
(R):5'- ACATTTGTGCACATGGATAAGC -3'
Posted On 2014-06-30