Mutagenetix > Incidental Mutation

Incidental Mutation 'R1911:Dmxl1'

210323

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

MMRRC Submission

039929-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.956) question?

Stock #

R1911 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

49965737-50098540 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 50011230 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 1129 (I1129T)

Ref Sequence

ENSEMBL: ENSMUSP00000137871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000041772
AA Change: I1129T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: I1129T

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000180611
AA Change: I1129T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: I1129T

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Meta Mutation Damage Score

0.0749

Coding Region Coverage

1x: 97.3%
3x: 96.8%
10x: 95.4%
20x: 93.2%

Validation Efficiency

99% (99/100)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 96 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	T	A	6: 91,927,050 (GRCm39)		probably benign	Het
Abca7	T	C	10: 79,842,468 (GRCm39)	V1134A	probably benign	Het
Acaa2	A	G	18: 74,925,483 (GRCm39)	E82G	probably benign	Het
Acap1	T	C	11: 69,772,548 (GRCm39)	D521G	probably damaging	Het
Adam19	T	C	11: 46,012,281 (GRCm39)	V259A	probably damaging	Het
Adss1	T	C	12: 112,599,443 (GRCm39)	V140A	probably benign	Het
Aif1	G	A	17: 35,391,127 (GRCm39)	P44L	probably benign	Het
Aldh3b1	T	G	19: 3,971,187 (GRCm39)	D159A	probably damaging	Het
Ank1	T	C	8: 23,589,666 (GRCm39)	V589A	probably damaging	Het
Ano2	G	A	6: 125,990,654 (GRCm39)	D803N	probably benign	Het
Arid1b	A	G	17: 5,393,241 (GRCm39)	E2257G	probably damaging	Het
Asb17	T	C	3: 153,550,138 (GRCm39)	Y57H	probably benign	Het
Asph	T	C	4: 9,453,335 (GRCm39)	E646G	probably damaging	Het
Aspm	T	A	1: 139,405,832 (GRCm39)	I1573K	probably benign	Het
Bcas1	C	A	2: 170,229,863 (GRCm39)	D236Y	probably damaging	Het
Bcas2	G	T	3: 103,079,113 (GRCm39)	G9*	probably null	Het
Btaf1	A	G	19: 36,964,030 (GRCm39)	Q867R	probably benign	Het
Calhm3	C	T	19: 47,143,908 (GRCm39)	V132I	possibly damaging	Het
Ccer1	A	T	10: 97,530,539 (GRCm39)	I401F	possibly damaging	Het
Cdcp3	T	C	7: 130,839,818 (GRCm39)	V580A	probably damaging	Het
Cecr2	T	A	6: 120,739,526 (GRCm39)		probably benign	Het
Cep104	G	A	4: 154,091,255 (GRCm39)	R925Q	possibly damaging	Het
Cep164	T	A	9: 45,682,104 (GRCm39)	M1900L	probably benign	Het
Crybg1	A	G	10: 43,873,673 (GRCm39)	V1145A	possibly damaging	Het
Cyp2a4	T	A	7: 26,008,399 (GRCm39)	N180K	possibly damaging	Het
Dennd4a	T	C	9: 64,796,368 (GRCm39)	L798P	probably damaging	Het
Dnah2	T	C	11: 69,406,578 (GRCm39)	N555D	possibly damaging	Het
Dock1	T	A	7: 134,601,029 (GRCm39)	M988K	probably damaging	Het
Elp4	T	A	2: 105,533,088 (GRCm39)	H419L	probably damaging	Het
Endov	T	C	11: 119,393,177 (GRCm39)	V109A	possibly damaging	Het
Epha8	T	C	4: 136,663,625 (GRCm39)	Y477C	probably damaging	Het
Erlin1	A	G	19: 44,037,561 (GRCm39)	M188T	probably damaging	Het
Fhip1a	T	A	3: 85,568,525 (GRCm39)	D998V	probably benign	Het
Fhod3	A	T	18: 25,245,643 (GRCm39)	D1231V	possibly damaging	Het
Gimap3	T	A	6: 48,742,646 (GRCm39)	I95F	possibly damaging	Het
Gm10717	T	G	9: 3,026,317 (GRCm39)	F205C	probably damaging	Het
Grk1	C	A	8: 13,457,923 (GRCm39)	D274E	probably damaging	Het
Gsdmc2	G	A	15: 63,699,621 (GRCm39)	A269V	probably benign	Het
Krt33a	T	A	11: 99,903,175 (GRCm39)	Q289L	probably benign	Het
Krt76	T	A	15: 101,796,600 (GRCm39)	K403*	probably null	Het
Lcn4	T	C	2: 26,560,607 (GRCm39)		probably benign	Het
Mab21l1	T	C	3: 55,691,048 (GRCm39)	S212P	possibly damaging	Het
Mapk8ip3	A	C	17: 25,123,025 (GRCm39)	D610E	probably benign	Het
Mastl	G	T	2: 23,022,692 (GRCm39)	S677*	probably null	Het
Mfap3	T	C	11: 57,420,562 (GRCm39)	F181S	probably damaging	Het
Mlkl	T	C	8: 112,038,732 (GRCm39)		probably benign	Het
Mov10	G	A	3: 104,708,876 (GRCm39)		probably benign	Het
Muc5ac	T	C	7: 141,350,041 (GRCm39)	F595L	probably benign	Het
Nbas	T	A	12: 13,616,145 (GRCm39)	C2228S	probably benign	Het
Nit2	G	A	16: 56,982,046 (GRCm39)		probably benign	Het
Nod1	C	T	6: 54,921,425 (GRCm39)	V298M	probably damaging	Het
Or3a4	C	A	11: 73,945,210 (GRCm39)	R125L	probably damaging	Het
Or4c111	A	G	2: 88,843,565 (GRCm39)	L281P	probably damaging	Het
Or52b1	T	A	7: 104,978,590 (GRCm39)	I270F	probably benign	Het
Or6c210	A	T	10: 129,495,981 (GRCm39)	D102V	probably benign	Het
Or7g12	T	C	9: 18,900,196 (GRCm39)	L304P	probably damaging	Het
Osbpl5	C	A	7: 143,243,662 (GRCm39)	R864L	probably benign	Het
Pcnt	G	A	10: 76,204,650 (GRCm39)	T2585M	possibly damaging	Het
Pepd	C	T	7: 34,634,174 (GRCm39)		probably benign	Het
Pou6f2	T	C	13: 18,326,548 (GRCm39)	I341V	probably damaging	Het
Pramel32	T	C	4: 88,548,309 (GRCm39)	Q32R	possibly damaging	Het
Prune2	T	A	19: 17,091,038 (GRCm39)	F281I	probably benign	Het
Psg19	T	G	7: 18,528,193 (GRCm39)	Q183H	probably damaging	Het
Psme4	T	G	11: 30,765,658 (GRCm39)	S587A	probably benign	Het
Ptpro	T	C	6: 137,377,617 (GRCm39)		probably benign	Het
Pttg1ip2	C	A	5: 5,502,019 (GRCm39)	W144C	probably benign	Het
Rasgrp4	T	C	7: 28,838,302 (GRCm39)	V92A	probably damaging	Het
Rem1	G	A	2: 152,476,455 (GRCm39)	V238M	probably damaging	Het
Rexo5	C	T	7: 119,398,867 (GRCm39)	A68V	probably damaging	Het
Robo2	A	T	16: 73,755,213 (GRCm39)	N769K	probably damaging	Het
Sfrp5	C	T	19: 42,187,237 (GRCm39)	V278I	probably benign	Het
Sidt1	A	G	16: 44,102,234 (GRCm39)	S309P	possibly damaging	Het
Slc22a6	A	C	19: 8,599,246 (GRCm39)	Q292H	probably benign	Het
Slc4a3	G	A	1: 75,530,367 (GRCm39)	R690H	probably damaging	Het
Snx7	A	T	3: 117,623,317 (GRCm39)		probably null	Het
Spag6	T	A	2: 18,720,616 (GRCm39)	Y129*	probably null	Het
Srcap	T	C	7: 127,133,994 (GRCm39)	I905T	probably damaging	Het
St6gal1	T	G	16: 23,140,383 (GRCm39)	S185A	probably damaging	Het
Sult6b1	G	A	17: 79,196,393 (GRCm39)	H250Y	possibly damaging	Het
Tdrd6	T	G	17: 43,937,979 (GRCm39)	N1023T	probably benign	Het
Tecta	C	T	9: 42,249,232 (GRCm39)	E1877K	probably damaging	Het
Tex10	C	T	4: 48,456,800 (GRCm39)	R637Q	probably benign	Het
Tex14	T	A	11: 87,385,861 (GRCm39)	D240E	probably damaging	Het
Tex47	T	C	5: 7,355,022 (GRCm39)	Y68H	probably damaging	Het
Thbs2	A	G	17: 14,910,104 (GRCm39)	V165A	probably benign	Het
Tmem126b	T	A	7: 90,118,367 (GRCm39)	Y171F	possibly damaging	Het
Tpsg1	G	T	17: 25,592,374 (GRCm39)	M46I	probably benign	Het
Trmt2a	A	G	16: 18,069,070 (GRCm39)	K304R	probably benign	Het
Ttc28	G	T	5: 111,428,616 (GRCm39)	R1845L	possibly damaging	Het
Umodl1	A	T	17: 31,211,128 (GRCm39)	T884S	possibly damaging	Het
Vmn2r77	A	G	7: 86,461,001 (GRCm39)	K776E	probably damaging	Het
Vmn2r88	T	C	14: 51,655,671 (GRCm39)	S627P	probably damaging	Het
Vrk1	T	C	12: 106,024,236 (GRCm39)		probably null	Het
Zfp644	A	G	5: 106,783,137 (GRCm39)	M1079T	possibly damaging	Het
Znrf1	T	C	8: 112,348,233 (GRCm39)	*41Q	probably null	Het
Znrf1	T	C	8: 112,348,244 (GRCm39)	F183L	possibly damaging	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49,984,534 (GRCm39)	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	50,072,620 (GRCm39)	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	50,050,735 (GRCm39)	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	50,045,792 (GRCm39)	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	50,045,818 (GRCm39)	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49,990,401 (GRCm39)	missense	probably benign
IGL01475:Dmxl1	APN	18	50,004,781 (GRCm39)	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	50,054,005 (GRCm39)	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	50,095,272 (GRCm39)	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49,996,092 (GRCm39)	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49,997,935 (GRCm39)	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	50,011,449 (GRCm39)	nonsense	probably null
IGL01933:Dmxl1	APN	18	50,010,852 (GRCm39)	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	50,023,721 (GRCm39)	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	50,027,245 (GRCm39)	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	50,094,230 (GRCm39)	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	50,010,741 (GRCm39)	splice site	probably benign
IGL02261:Dmxl1	APN	18	49,973,566 (GRCm39)	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49,997,962 (GRCm39)	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	50,011,247 (GRCm39)	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	50,053,960 (GRCm39)	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49,997,885 (GRCm39)	missense	probably benign
capture	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
carnivora	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
digestion	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
drowning	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
hibiscus	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
impound	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
pitcher	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	50,065,030 (GRCm39)	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	50,021,964 (GRCm39)	splice site	probably benign
R0027:Dmxl1	UTSW	18	50,090,362 (GRCm39)	splice site	probably benign
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	50,088,870 (GRCm39)	splice site	probably benign
R0349:Dmxl1	UTSW	18	50,012,349 (GRCm39)	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	50,012,429 (GRCm39)	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	50,024,534 (GRCm39)	nonsense	probably null
R0539:Dmxl1	UTSW	18	49,990,497 (GRCm39)	splice site	probably benign
R0542:Dmxl1	UTSW	18	50,026,761 (GRCm39)	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	50,068,374 (GRCm39)	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49,984,490 (GRCm39)	splice site	probably benign
R0744:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	50,026,469 (GRCm39)	missense	probably damaging	1.00
R1218:Dmxl1	UTSW	18	50,026,678 (GRCm39)	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	50,026,292 (GRCm39)	missense	probably benign
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	50,021,920 (GRCm39)	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49,990,316 (GRCm39)	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49,985,434 (GRCm39)	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49,992,353 (GRCm39)	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	50,023,834 (GRCm39)	nonsense	probably null
R1646:Dmxl1	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	50,067,704 (GRCm39)	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	50,036,055 (GRCm39)	missense	probably benign
R1732:Dmxl1	UTSW	18	50,026,511 (GRCm39)	nonsense	probably null
R1886:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R1887:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	50,088,981 (GRCm39)	splice site	probably null
R2020:Dmxl1	UTSW	18	50,022,625 (GRCm39)	nonsense	probably null
R2116:Dmxl1	UTSW	18	50,011,884 (GRCm39)	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	50,050,698 (GRCm39)	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	50,027,161 (GRCm39)	missense	probably benign	0.12
R2216:Dmxl1	UTSW	18	50,026,990 (GRCm39)	missense	probably benign	0.00
R2255:Dmxl1	UTSW	18	49,979,706 (GRCm39)	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	50,053,043 (GRCm39)	splice site	probably null
R2343:Dmxl1	UTSW	18	50,023,745 (GRCm39)	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	50,013,858 (GRCm39)	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49,997,029 (GRCm39)	missense	probably benign
R4033:Dmxl1	UTSW	18	49,984,498 (GRCm39)	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	50,094,264 (GRCm39)	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	50,011,084 (GRCm39)	nonsense	probably null
R4406:Dmxl1	UTSW	18	50,022,620 (GRCm39)	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49,981,828 (GRCm39)	missense	probably benign
R4454:Dmxl1	UTSW	18	50,026,399 (GRCm39)	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	50,094,283 (GRCm39)	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	50,095,248 (GRCm39)	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	50,011,698 (GRCm39)	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	50,011,088 (GRCm39)	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49,996,059 (GRCm39)	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49,984,543 (GRCm39)	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	50,090,348 (GRCm39)	intron	probably benign
R4885:Dmxl1	UTSW	18	50,011,862 (GRCm39)	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	50,028,194 (GRCm39)	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	50,003,990 (GRCm39)	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	50,026,651 (GRCm39)	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	50,084,302 (GRCm39)	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49,996,186 (GRCm39)	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	50,000,966 (GRCm39)	splice site	probably null
R5484:Dmxl1	UTSW	18	50,022,531 (GRCm39)	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49,997,545 (GRCm39)	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	50,024,693 (GRCm39)	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	50,027,324 (GRCm39)	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	50,065,008 (GRCm39)	nonsense	probably null
R5706:Dmxl1	UTSW	18	50,090,462 (GRCm39)	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R5876:Dmxl1	UTSW	18	50,004,051 (GRCm39)	missense	possibly damaging	0.70
R6054:Dmxl1	UTSW	18	49,990,453 (GRCm39)	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	50,045,833 (GRCm39)	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	50,026,402 (GRCm39)	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49,996,082 (GRCm39)	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	50,035,434 (GRCm39)	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	50,004,799 (GRCm39)	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R6319:Dmxl1	UTSW	18	49,985,367 (GRCm39)	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49,997,645 (GRCm39)	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49,992,246 (GRCm39)	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	50,011,313 (GRCm39)	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	50,013,847 (GRCm39)	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	50,027,041 (GRCm39)	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49,985,355 (GRCm39)	nonsense	probably null
R6857:Dmxl1	UTSW	18	49,997,902 (GRCm39)	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	50,068,372 (GRCm39)	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49,976,851 (GRCm39)	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	50,053,969 (GRCm39)	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49,996,124 (GRCm39)	missense	possibly damaging	0.51
R6897:Dmxl1	UTSW	18	49,984,562 (GRCm39)	missense	probably null	0.99
R6917:Dmxl1	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	50,088,920 (GRCm39)	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49,997,681 (GRCm39)	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	50,011,679 (GRCm39)	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	50,027,024 (GRCm39)	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	50,035,861 (GRCm39)	missense	probably benign
R7629:Dmxl1	UTSW	18	49,992,337 (GRCm39)	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	50,026,619 (GRCm39)	missense	probably benign
R7688:Dmxl1	UTSW	18	50,088,938 (GRCm39)	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49,979,685 (GRCm39)	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	50,026,528 (GRCm39)	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	50,011,382 (GRCm39)	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	50,054,044 (GRCm39)	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49,973,557 (GRCm39)	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	50,094,214 (GRCm39)	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	50,026,474 (GRCm39)	missense	possibly damaging	0.65
R8073:Dmxl1	UTSW	18	50,011,500 (GRCm39)	missense	probably damaging	1.00
R8089:Dmxl1	UTSW	18	50,021,897 (GRCm39)	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49,976,878 (GRCm39)	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	50,031,781 (GRCm39)	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	50,011,409 (GRCm39)	missense	probably benign
R8402:Dmxl1	UTSW	18	50,011,393 (GRCm39)	nonsense	probably null
R8402:Dmxl1	UTSW	18	50,011,394 (GRCm39)	missense	probably benign	0.09
R8423:Dmxl1	UTSW	18	49,998,183 (GRCm39)	missense	probably damaging	1.00
R8678:Dmxl1	UTSW	18	50,004,759 (GRCm39)	nonsense	probably null
R8702:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	50,088,937 (GRCm39)	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	50,090,406 (GRCm39)	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	50,026,741 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,997,575 (GRCm39)	missense	possibly damaging	0.96
R8978:Dmxl1	UTSW	18	50,055,679 (GRCm39)	missense	probably benign	0.37
R8987:Dmxl1	UTSW	18	50,026,919 (GRCm39)	missense
R9011:Dmxl1	UTSW	18	49,997,240 (GRCm39)	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	50,011,992 (GRCm39)	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
R9254:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49,976,919 (GRCm39)	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	50,091,477 (GRCm39)	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	50,010,788 (GRCm39)	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	50,026,777 (GRCm39)	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	50,011,271 (GRCm39)	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49,998,228 (GRCm39)	missense	probably damaging	1.00
R9642:Dmxl1	UTSW	18	50,013,825 (GRCm39)	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	50,026,461 (GRCm39)	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49,997,435 (GRCm39)	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	50,052,966 (GRCm39)	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	50,054,032 (GRCm39)	missense	probably benign
Z1188:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- ATACAAGTCGCTTAGCAGTAGC -3'
(R):5'- TGTCCCAGAGAGGAAATGCC -3'

Sequencing Primer
(F):5'- GCCCACTGGTAATAGTAGATCTCAG -3'
(R):5'- GGAAATGCCTGGTTTTCCTTTCCAG -3'

Posted On

2014-06-30