Mutagenetix > Incidental Mutation

Incidental Mutation 'R1869:Aox1'

210472

Institutional Source

Beutler Lab

Gene Symbol

Aox1

Ensembl Gene

ENSMUSG00000063558

Gene Name

aldehyde oxidase 1

Synonyms

Aox-1, retinal oxidase, Aox-2, Aox2

MMRRC Submission

039891-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1869 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

58069090-58145572 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 58115262 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 749 (E749G)

Ref Sequence

ENSEMBL: ENSMUSP00000001027 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000001027]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000001027
AA Change: E749G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000001027
Gene: ENSMUSG00000063558
AA Change: E749G

Domain	Start	End	E-Value	Type
Pfam:Fer2	8	78	8.5e-11	PFAM
Pfam:Fer2_2	87	161	2.4e-32	PFAM
low complexity region	197	209	N/A	INTRINSIC
Pfam:FAD_binding_5	238	418	1.2e-46	PFAM
CO_deh_flav_C	425	529	8.06e-24	SMART
Ald_Xan_dh_C	593	696	6.99e-42	SMART
Pfam:Ald_Xan_dh_C2	707	1240	2.1e-176	PFAM

Meta Mutation Damage Score

0.9270

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.4%
20x: 92.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 127 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921536K21Rik	A	G	11: 3,840,067 (GRCm39)	L110P	probably damaging	Het
6030458C11Rik	T	C	15: 12,817,993 (GRCm39)	D168G	probably damaging	Het
Abca13	A	T	11: 9,242,134 (GRCm39)	E1332D	probably benign	Het
Abhd11	A	G	5: 135,040,471 (GRCm39)	Y168C	probably damaging	Het
Actr5	A	C	2: 158,480,643 (GRCm39)	T554P	probably damaging	Het
Adam34l	A	T	8: 44,078,132 (GRCm39)	Y697*	probably null	Het
Adamts16	A	G	13: 70,883,866 (GRCm39)	L1103P	probably damaging	Het
Adgrb3	A	T	1: 25,865,519 (GRCm39)	I108K	possibly damaging	Het
Agbl4	T	A	4: 111,423,826 (GRCm39)	M284K	possibly damaging	Het
Aoc3	T	A	11: 101,222,293 (GRCm39)	Y176*	probably null	Het
Ap4b1	T	A	3: 103,728,184 (GRCm39)	Y399*	probably null	Het
Arhgef5	A	T	6: 43,265,616 (GRCm39)	I1553F	probably damaging	Het
Bag6	T	C	17: 35,361,802 (GRCm39)	V541A	probably benign	Het
Bdp1	A	C	13: 100,178,709 (GRCm39)	V1879G	probably damaging	Het
Bod1l	G	A	5: 41,991,018 (GRCm39)	S179F	possibly damaging	Het
Bsnd	C	T	4: 106,343,833 (GRCm39)	V158I	probably benign	Het
Cachd1	C	A	4: 100,840,587 (GRCm39)	H880N	probably damaging	Het
Ccdc27	T	C	4: 154,111,220 (GRCm39)		probably null	Het
Cd74	C	T	18: 60,943,484 (GRCm39)	P190S	probably benign	Het
Cep68	A	T	11: 20,190,217 (GRCm39)	L265Q	probably damaging	Het
Cfap70	G	A	14: 20,458,678 (GRCm39)	Q772*	probably null	Het
CK137956	T	A	4: 127,864,327 (GRCm39)	S101C	possibly damaging	Het
Clca3a2	G	A	3: 144,512,164 (GRCm39)	T524M	probably benign	Het
Cxcr6	T	C	9: 123,639,022 (GRCm39)	S15P	probably benign	Het
Cyfip2	T	A	11: 46,114,995 (GRCm39)	Y904F	probably benign	Het
D130040H23Rik	T	A	8: 69,755,354 (GRCm39)	I253N	probably benign	Het
Ddx56	C	T	11: 6,213,993 (GRCm39)	V389M	possibly damaging	Het
Dmp1	A	T	5: 104,359,942 (GRCm39)	D206V	probably damaging	Het
Dnah17	A	T	11: 117,938,015 (GRCm39)	C3350*	probably null	Het
Dst	A	T	1: 34,291,913 (GRCm39)	S877C	probably damaging	Het
Ermp1	A	G	19: 29,623,415 (GRCm39)	S192P	possibly damaging	Het
F13b	G	A	1: 139,438,672 (GRCm39)	D359N	probably benign	Het
Fam171a1	A	T	2: 3,227,189 (GRCm39)	Q769L	possibly damaging	Het
Fap	T	C	2: 62,359,071 (GRCm39)	R411G	probably damaging	Het
Fbn1	A	G	2: 125,193,947 (GRCm39)	V1340A	probably benign	Het
Fbxw19	T	C	9: 109,311,100 (GRCm39)	I370V	probably benign	Het
Foxi1	A	T	11: 34,157,937 (GRCm39)	N29K	possibly damaging	Het
Frem2	T	G	3: 53,442,617 (GRCm39)	D2640A	probably benign	Het
Fzd4	T	C	7: 89,056,454 (GRCm39)	V167A	probably benign	Het
Galnt3	T	C	2: 65,928,123 (GRCm39)	I258V	possibly damaging	Het
Galr2	T	C	11: 116,174,069 (GRCm39)	V233A	possibly damaging	Het
Gldc	G	T	19: 30,116,732 (GRCm39)	Q407K	probably benign	Het
Gmcl1	T	C	6: 86,674,498 (GRCm39)	D460G	probably benign	Het
Gpr89	A	G	3: 96,782,975 (GRCm39)	I325T	probably benign	Het
Grap	T	A	11: 61,555,015 (GRCm39)	Y61N	possibly damaging	Het
Hbs1l	G	T	10: 21,234,305 (GRCm39)		probably null	Het
Hexb	T	A	13: 97,327,767 (GRCm39)	E134D	probably benign	Het
Hydin	T	A	8: 111,227,337 (GRCm39)	V1507D	possibly damaging	Het
Igkv8-16	C	A	6: 70,363,971 (GRCm39)	G17V	probably benign	Het
Kdm4a	T	A	4: 117,996,068 (GRCm39)	Q987L	probably null	Het
Krt76	A	G	15: 101,797,922 (GRCm39)		probably null	Het
Lap3	T	C	5: 45,660,729 (GRCm39)	S238P	probably benign	Het
Letm2	T	C	8: 26,071,729 (GRCm39)	D391G	probably damaging	Het
Lipn	A	G	19: 34,058,139 (GRCm39)	T287A	possibly damaging	Het
Macf1	T	C	4: 123,244,921 (GRCm39)	S466G	probably damaging	Het
Map3k5	C	A	10: 20,007,855 (GRCm39)	S1220*	probably null	Het
Map4	T	A	9: 109,897,996 (GRCm39)	S754R	possibly damaging	Het
Map4	T	C	9: 109,864,032 (GRCm39)	V419A	probably benign	Het
Mroh9	A	G	1: 162,854,082 (GRCm39)	S773P	probably damaging	Het
Mtus1	A	C	8: 41,529,267 (GRCm39)		probably null	Het
Muc1	C	T	3: 89,139,117 (GRCm39)	P533S	probably damaging	Het
Muc13	A	T	16: 33,624,970 (GRCm39)	I282F	probably damaging	Het
Mucl3	A	G	17: 35,949,305 (GRCm39)	L98P	possibly damaging	Het
Myh14	T	A	7: 44,261,067 (GRCm39)	Q1816L	possibly damaging	Het
Nalcn	A	C	14: 123,831,965 (GRCm39)	V103G	possibly damaging	Het
Nlrp9c	G	A	7: 26,084,245 (GRCm39)	Q445*	probably null	Het
Olfml2b	A	G	1: 170,496,812 (GRCm39)	D481G	probably damaging	Het
Or13g1	T	A	7: 85,955,875 (GRCm39)	I149F	possibly damaging	Het
Or2ag19	T	G	7: 106,444,301 (GRCm39)	I161S	probably benign	Het
Or5g23	A	G	2: 85,438,844 (GRCm39)	S137P	probably benign	Het
Or8b37	T	A	9: 37,959,498 (GRCm39)		probably null	Het
Or8k3b	T	A	2: 86,520,735 (GRCm39)	I195F	probably damaging	Het
Pcdhb2	A	T	18: 37,430,408 (GRCm39)		probably null	Het
Pcdhb22	A	C	18: 37,652,200 (GRCm39)	T223P	probably damaging	Het
Pcdhga1	T	A	18: 37,973,143 (GRCm39)	N907K	probably damaging	Het
Pcnt	T	C	10: 76,215,740 (GRCm39)	E2347G	probably null	Het
Phax	T	A	18: 56,706,176 (GRCm39)	V22D	probably benign	Het
Pik3ca	T	C	3: 32,504,499 (GRCm39)	F667S	probably damaging	Het
Pkd1	T	C	17: 24,813,905 (GRCm39)	F4123S	probably damaging	Het
Pkhd1	A	G	1: 20,685,491 (GRCm39)		probably null	Het
Plcb1	G	A	2: 135,152,934 (GRCm39)	R368K	probably benign	Het
Prrc2a	G	T	17: 35,372,284 (GRCm39)	R1739S	possibly damaging	Het
Psg23	A	T	7: 18,348,543 (GRCm39)	M88K	probably benign	Het
Pstk	T	A	7: 130,989,526 (GRCm39)	Y354N	probably damaging	Het
Rab39	A	G	9: 53,617,231 (GRCm39)	I62T	possibly damaging	Het
Ranbp2	A	G	10: 58,328,383 (GRCm39)	I2800V	probably damaging	Het
Rasgrp1	T	C	2: 117,120,828 (GRCm39)	Y431C	probably damaging	Het
Rest	T	A	5: 77,416,209 (GRCm39)	V141E	possibly damaging	Het
Rnf167	T	A	11: 70,540,965 (GRCm39)	I197N	possibly damaging	Het
Rtn1	A	G	12: 72,354,942 (GRCm39)	S335P	probably damaging	Het
Ryr2	G	T	13: 11,676,961 (GRCm39)	R3297S	probably damaging	Het
S1pr3	A	C	13: 51,573,952 (GRCm39)	K378Q	probably benign	Het
Scgb1b24	T	C	7: 33,443,469 (GRCm39)	Y43H	probably damaging	Het
Sh3rf3	T	A	10: 58,919,335 (GRCm39)	M484K	probably damaging	Het
Shank1	A	T	7: 43,991,539 (GRCm39)	R69*	probably null	Het
Siglecf	A	G	7: 43,004,967 (GRCm39)	N399S	probably benign	Het
Slc1a7	A	G	4: 107,865,561 (GRCm39)	T350A	probably damaging	Het
Slc25a54	T	A	3: 108,987,932 (GRCm39)	Y24*	probably null	Het
Slk	T	C	19: 47,613,891 (GRCm39)	F916L	probably damaging	Het
Snap91	T	A	9: 86,672,194 (GRCm39)		probably null	Het
Snrpb2	A	T	2: 142,907,106 (GRCm39)	R25S	possibly damaging	Het
Specc1l	T	C	10: 75,097,659 (GRCm39)	Y811H	probably damaging	Het
Sprr2h	A	G	3: 92,293,925 (GRCm39)		probably benign	Het
Sult2a5	A	T	7: 13,358,045 (GRCm39)	I26F	probably benign	Het
Syt13	C	T	2: 92,776,448 (GRCm39)	T245I	possibly damaging	Het
Tecrl	T	A	5: 83,502,706 (GRCm39)	T33S	probably benign	Het
Telo2	T	A	17: 25,333,968 (GRCm39)	D93V	probably benign	Het
Tet2	A	T	3: 133,187,202 (GRCm39)		probably null	Het
Tgm7	A	T	2: 120,931,570 (GRCm39)	C198S	probably damaging	Het
Ticrr	T	C	7: 79,328,883 (GRCm39)	F674S	probably damaging	Het
Tmem129	C	A	5: 33,811,843 (GRCm39)	C31F	probably damaging	Het
Tmem132a	T	A	19: 10,836,052 (GRCm39)	D826V	possibly damaging	Het
Tpd52	T	C	3: 9,018,862 (GRCm39)		probably null	Het
Trub2	A	G	2: 29,667,678 (GRCm39)	S321P	probably benign	Het
Ttc29	A	G	8: 79,009,014 (GRCm39)	T295A	probably benign	Het
Tubb1	G	A	2: 174,298,482 (GRCm39)	S89N	probably benign	Het
Tut4	T	A	4: 108,386,497 (GRCm39)	F1122L	probably damaging	Het
Ubap2	C	A	4: 41,233,617 (GRCm39)	G91V	probably damaging	Het
Ugt2b35	A	G	5: 87,149,147 (GRCm39)	N133D	probably damaging	Het
Usp34	A	G	11: 23,314,479 (GRCm39)	H807R	probably benign	Het
Vmn1r220	A	C	13: 23,368,457 (GRCm39)	C80G	probably damaging	Het
Vmn1r79	A	G	7: 11,910,574 (GRCm39)	E152G	probably benign	Het
Vmn2r28	T	C	7: 5,489,345 (GRCm39)	Y498C	probably benign	Het
Wif1	A	G	10: 120,920,824 (GRCm39)	I215M	probably benign	Het
Wnk1	T	C	6: 119,928,050 (GRCm39)	T1134A	probably damaging	Het
Zfp90	A	G	8: 107,145,755 (GRCm39)	H29R	probably benign	Het
Zfp972	A	G	2: 177,563,480 (GRCm39)		probably null	Het

Other mutations in Aox1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Aox1	APN	1	58,098,203 (GRCm39)	missense	probably damaging	1.00
IGL01014:Aox1	APN	1	58,361,960 (GRCm39)	missense	possibly damaging	0.73
IGL01077:Aox1	APN	1	58,096,569 (GRCm39)	splice site	probably benign
IGL01288:Aox1	APN	1	58,333,566 (GRCm39)	missense	probably damaging	0.99
IGL01335:Aox1	APN	1	58,121,312 (GRCm39)	nonsense	probably null
IGL01383:Aox1	APN	1	58,333,464 (GRCm39)	missense	probably benign	0.09
IGL01410:Aox1	APN	1	58,145,184 (GRCm39)	splice site	probably null
IGL01684:Aox1	APN	1	58,116,740 (GRCm39)	splice site	probably null
IGL01727:Aox1	APN	1	58,112,387 (GRCm39)	nonsense	probably null
IGL01734:Aox1	APN	1	58,393,469 (GRCm39)	missense	possibly damaging	0.95
IGL01793:Aox1	APN	1	58,375,783 (GRCm39)	missense	possibly damaging	0.79
IGL01805:Aox1	APN	1	58,120,672 (GRCm39)	missense	possibly damaging	0.94
IGL01834:Aox1	APN	1	58,348,183 (GRCm39)	missense	possibly damaging	0.90
IGL01924:Aox1	APN	1	58,326,902 (GRCm39)	missense	possibly damaging	0.90
IGL01996:Aox1	APN	1	58,121,225 (GRCm39)	missense	probably benign	0.11
IGL02060:Aox1	APN	1	58,137,114 (GRCm39)	missense	possibly damaging	0.95
IGL02206:Aox1	APN	1	58,104,499 (GRCm39)	missense	probably benign	0.00
IGL02591:Aox1	APN	1	58,398,158 (GRCm39)	nonsense	probably null
IGL02645:Aox1	APN	1	58,373,883 (GRCm39)	missense	probably damaging	1.00
IGL02710:Aox1	APN	1	58,373,928 (GRCm39)	critical splice donor site	probably null
IGL02801:Aox1	APN	1	58,393,336 (GRCm39)	missense	probably damaging	1.00
IGL02839:Aox1	APN	1	58,107,943 (GRCm39)	missense	probably benign	0.05
IGL02975:Aox1	APN	1	58,107,550 (GRCm39)	missense	probably damaging	1.00
IGL02988:Aox1	APN	1	58,376,509 (GRCm39)	missense	probably benign
IGL03062:Aox1	APN	1	58,117,624 (GRCm39)	missense	probably benign	0.01
IGL03104:Aox1	APN	1	58,321,918 (GRCm39)	missense	probably benign
IGL03121:Aox1	APN	1	58,398,113 (GRCm39)	missense	probably damaging	1.00
IGL03191:Aox1	APN	1	58,398,228 (GRCm39)	missense	probably null	0.98
IGL03236:Aox1	APN	1	58,349,156 (GRCm39)	nonsense	probably null
IGL03286:Aox1	APN	1	58,088,543 (GRCm39)	missense	probably benign	0.19
IGL03335:Aox1	APN	1	58,115,319 (GRCm39)	missense	probably damaging	0.98
IGL03395:Aox1	APN	1	58,107,884 (GRCm39)	splice site	probably benign
IGL03409:Aox1	APN	1	58,393,588 (GRCm39)	missense	possibly damaging	0.91
PIT4362001:Aox1	UTSW	1	58,321,839 (GRCm39)	missense	probably damaging	1.00
R0035:Aox1	UTSW	1	58,393,581 (GRCm39)	missense	probably benign	0.00
R0035:Aox1	UTSW	1	58,393,581 (GRCm39)	missense	probably benign	0.00
R0048:Aox1	UTSW	1	58,112,371 (GRCm39)	missense	probably damaging	0.98
R0144:Aox1	UTSW	1	58,109,233 (GRCm39)	missense	probably benign	0.00
R0207:Aox1	UTSW	1	58,144,173 (GRCm39)	missense	possibly damaging	0.82
R0267:Aox1	UTSW	1	58,378,605 (GRCm39)	splice site	probably benign
R0357:Aox1	UTSW	1	58,131,675 (GRCm39)	missense	probably damaging	1.00
R0383:Aox1	UTSW	1	58,100,400 (GRCm39)	missense	probably benign	0.00
R0388:Aox1	UTSW	1	58,393,565 (GRCm39)	missense	probably damaging	1.00
R0399:Aox1	UTSW	1	58,108,008 (GRCm39)	splice site	probably null
R0409:Aox1	UTSW	1	58,375,783 (GRCm39)	missense	possibly damaging	0.90
R0465:Aox1	UTSW	1	58,101,366 (GRCm39)	missense	probably damaging	1.00
R0480:Aox1	UTSW	1	58,082,810 (GRCm39)	splice site	probably benign
R0547:Aox1	UTSW	1	58,349,201 (GRCm39)	missense	probably damaging	0.96
R0630:Aox1	UTSW	1	58,376,480 (GRCm39)	splice site	probably benign
R0726:Aox1	UTSW	1	58,373,941 (GRCm39)	splice site	probably benign
R0734:Aox1	UTSW	1	58,344,500 (GRCm39)	missense	probably benign	0.22
R0831:Aox1	UTSW	1	58,378,842 (GRCm39)	missense	probably benign	0.28
R0961:Aox1	UTSW	1	58,349,230 (GRCm39)	missense	probably benign	0.00
R1005:Aox1	UTSW	1	58,104,511 (GRCm39)	missense	probably benign	0.00
R1404:Aox1	UTSW	1	58,385,371 (GRCm39)	splice site	probably benign
R1507:Aox1	UTSW	1	58,143,610 (GRCm39)	missense	probably benign	0.01
R1512:Aox1	UTSW	1	58,346,510 (GRCm39)	missense	probably benign	0.00
R1573:Aox1	UTSW	1	58,348,186 (GRCm39)	missense	probably benign	0.00
R1592:Aox1	UTSW	1	58,339,853 (GRCm39)	missense	probably benign	0.00
R1597:Aox1	UTSW	1	58,086,326 (GRCm39)	missense	probably damaging	1.00
R1693:Aox1	UTSW	1	58,124,701 (GRCm39)	missense	probably damaging	1.00
R1709:Aox1	UTSW	1	58,116,633 (GRCm39)	missense	probably benign
R1747:Aox1	UTSW	1	58,378,751 (GRCm39)	missense	probably benign	0.01
R1768:Aox1	UTSW	1	58,393,354 (GRCm39)	missense	probably benign	0.00
R1809:Aox1	UTSW	1	58,333,484 (GRCm39)	missense	probably benign
R1823:Aox1	UTSW	1	58,351,518 (GRCm39)	missense	probably benign	0.02
R1834:Aox1	UTSW	1	58,348,150 (GRCm39)	missense	probably benign	0.08
R1835:Aox1	UTSW	1	58,348,150 (GRCm39)	missense	probably benign	0.08
R1836:Aox1	UTSW	1	58,348,150 (GRCm39)	missense	probably benign	0.08
R1870:Aox1	UTSW	1	58,115,262 (GRCm39)	missense	probably damaging	1.00
R1898:Aox1	UTSW	1	58,117,601 (GRCm39)	missense	probably damaging	1.00
R1908:Aox1	UTSW	1	58,141,783 (GRCm39)	missense	probably damaging	1.00
R2002:Aox1	UTSW	1	58,086,300 (GRCm39)	missense	possibly damaging	0.69
R2062:Aox1	UTSW	1	58,098,351 (GRCm39)	splice site	probably null
R2065:Aox1	UTSW	1	58,098,351 (GRCm39)	splice site	probably null
R2219:Aox1	UTSW	1	58,388,289 (GRCm39)	splice site	probably null
R2220:Aox1	UTSW	1	58,388,289 (GRCm39)	splice site	probably null
R2265:Aox1	UTSW	1	58,120,679 (GRCm39)	missense	probably damaging	0.99
R2508:Aox1	UTSW	1	58,382,832 (GRCm39)	missense	probably benign	0.38
R2942:Aox1	UTSW	1	58,376,540 (GRCm39)	missense	probably benign	0.03
R2967:Aox1	UTSW	1	58,361,993 (GRCm39)	missense	probably damaging	0.96
R3082:Aox1	UTSW	1	58,322,759 (GRCm39)	splice site	probably benign
R3161:Aox1	UTSW	1	58,343,597 (GRCm39)	missense	possibly damaging	0.91
R3408:Aox1	UTSW	1	58,382,827 (GRCm39)	missense	probably benign	0.32
R3713:Aox1	UTSW	1	58,095,374 (GRCm39)	missense	probably benign	0.01
R3778:Aox1	UTSW	1	58,092,862 (GRCm39)	missense	possibly damaging	0.89
R3803:Aox1	UTSW	1	58,329,058 (GRCm39)	splice site	probably null
R3894:Aox1	UTSW	1	58,373,837 (GRCm39)	critical splice acceptor site	probably null
R4198:Aox1	UTSW	1	58,124,766 (GRCm39)	missense	probably benign
R4214:Aox1	UTSW	1	58,346,603 (GRCm39)	critical splice donor site	probably null
R4249:Aox1	UTSW	1	58,338,978 (GRCm39)	missense	probably benign	0.01
R4296:Aox1	UTSW	1	58,096,559 (GRCm39)	splice site	probably null
R4562:Aox1	UTSW	1	58,098,215 (GRCm39)	missense	probably damaging	0.99
R4666:Aox1	UTSW	1	58,343,756 (GRCm39)	nonsense	probably null
R4668:Aox1	UTSW	1	58,373,853 (GRCm39)	missense	possibly damaging	0.63
R4703:Aox1	UTSW	1	58,398,116 (GRCm39)	missense	possibly damaging	0.78
R4758:Aox1	UTSW	1	58,371,741 (GRCm39)	missense	probably benign	0.00
R4858:Aox1	UTSW	1	58,143,640 (GRCm39)	missense	probably benign
R4862:Aox1	UTSW	1	58,134,316 (GRCm39)	missense	probably damaging	0.98
R4890:Aox1	UTSW	1	58,373,862 (GRCm39)	missense	probably benign	0.11
R4900:Aox1	UTSW	1	58,344,544 (GRCm39)	missense	probably benign
R4924:Aox1	UTSW	1	58,344,503 (GRCm39)	missense	probably damaging	1.00
R4970:Aox1	UTSW	1	58,349,254 (GRCm39)	splice site	probably null
R5048:Aox1	UTSW	1	58,098,641 (GRCm39)	splice site	probably benign
R5112:Aox1	UTSW	1	58,349,254 (GRCm39)	splice site	probably null
R5127:Aox1	UTSW	1	58,069,185 (GRCm39)	missense	probably benign	0.00
R5139:Aox1	UTSW	1	58,100,456 (GRCm39)	missense	probably benign	0.03
R5157:Aox1	UTSW	1	58,109,222 (GRCm39)	missense	probably damaging	1.00
R5168:Aox1	UTSW	1	58,088,561 (GRCm39)	missense	probably damaging	1.00
R5186:Aox1	UTSW	1	58,107,529 (GRCm39)	missense	probably damaging	1.00
R5235:Aox1	UTSW	1	58,096,714 (GRCm39)	missense	possibly damaging	0.77
R5289:Aox1	UTSW	1	58,131,717 (GRCm39)	missense	probably damaging	0.99
R5466:Aox1	UTSW	1	58,080,619 (GRCm39)	missense	probably damaging	1.00
R5540:Aox1	UTSW	1	58,143,569 (GRCm39)	missense	probably benign	0.03
R5615:Aox1	UTSW	1	58,136,125 (GRCm39)	missense	probably benign
R5652:Aox1	UTSW	1	58,134,356 (GRCm39)	missense	probably damaging	1.00
R5920:Aox1	UTSW	1	58,088,631 (GRCm39)	missense	probably damaging	1.00
R5987:Aox1	UTSW	1	58,346,518 (GRCm39)	missense	probably benign	0.00
R6008:Aox1	UTSW	1	58,116,672 (GRCm39)	missense	probably damaging	1.00
R6073:Aox1	UTSW	1	58,143,668 (GRCm39)	critical splice donor site	probably null
R6215:Aox1	UTSW	1	58,124,620 (GRCm39)	missense	probably benign
R6239:Aox1	UTSW	1	58,344,550 (GRCm39)	critical splice donor site	probably null
R6273:Aox1	UTSW	1	58,378,831 (GRCm39)	missense	probably benign	0.00
R6291:Aox1	UTSW	1	58,369,965 (GRCm39)	missense	probably damaging	0.98
R6334:Aox1	UTSW	1	58,346,566 (GRCm39)	nonsense	probably null
R6403:Aox1	UTSW	1	58,107,594 (GRCm39)	missense	probably damaging	1.00
R6440:Aox1	UTSW	1	58,133,631 (GRCm39)	missense	probably damaging	1.00
R6601:Aox1	UTSW	1	58,102,665 (GRCm39)	missense	probably damaging	1.00
R6608:Aox1	UTSW	1	58,096,705 (GRCm39)	missense	probably benign	0.40
R6752:Aox1	UTSW	1	58,086,398 (GRCm39)	missense	probably benign	0.00
R6764:Aox1	UTSW	1	58,389,441 (GRCm39)	missense	probably damaging	0.97
R6766:Aox1	UTSW	1	58,388,227 (GRCm39)	missense	possibly damaging	0.95
R6789:Aox1	UTSW	1	58,343,644 (GRCm39)	missense	probably benign	0.01
R6804:Aox1	UTSW	1	58,343,757 (GRCm39)	missense	probably benign	0.04
R6989:Aox1	UTSW	1	58,124,611 (GRCm39)	missense	probably damaging	1.00
R7007:Aox1	UTSW	1	58,370,051 (GRCm39)	missense	probably damaging	1.00
R7015:Aox1	UTSW	1	58,321,917 (GRCm39)	missense	probably benign	0.00
R7042:Aox1	UTSW	1	58,141,759 (GRCm39)	missense	probably damaging	0.99
R7055:Aox1	UTSW	1	58,338,927 (GRCm39)	missense	probably benign	0.08
R7089:Aox1	UTSW	1	58,375,808 (GRCm39)	missense	probably benign	0.01
R7157:Aox1	UTSW	1	58,322,651 (GRCm39)	missense	probably benign	0.00
R7303:Aox1	UTSW	1	58,373,924 (GRCm39)	nonsense	probably null
R7426:Aox1	UTSW	1	58,329,142 (GRCm39)	nonsense	probably null
R7442:Aox1	UTSW	1	58,121,172 (GRCm39)	missense	probably damaging	1.00
R7506:Aox1	UTSW	1	58,088,562 (GRCm39)	missense	probably damaging	1.00
R7563:Aox1	UTSW	1	58,086,304 (GRCm39)	missense	probably benign	0.32
R7589:Aox1	UTSW	1	58,080,643 (GRCm39)	missense	probably damaging	1.00
R7735:Aox1	UTSW	1	58,107,451 (GRCm39)	missense	probably benign	0.01
R7762:Aox1	UTSW	1	58,388,263 (GRCm39)	missense	probably damaging	1.00
R7814:Aox1	UTSW	1	58,124,626 (GRCm39)	missense	probably benign
R7876:Aox1	UTSW	1	58,101,330 (GRCm39)	nonsense	probably null
R7899:Aox1	UTSW	1	58,320,396 (GRCm39)	splice site	probably null
R7905:Aox1	UTSW	1	58,143,557 (GRCm39)	missense	possibly damaging	0.72
R7908:Aox1	UTSW	1	58,145,227 (GRCm39)	missense	possibly damaging	0.68
R7942:Aox1	UTSW	1	58,376,590 (GRCm39)	missense	probably damaging	1.00
R7975:Aox1	UTSW	1	58,348,187 (GRCm39)	missense	probably benign	0.02
R8029:Aox1	UTSW	1	58,382,827 (GRCm39)	missense	probably benign	0.32
R8032:Aox1	UTSW	1	58,389,442 (GRCm39)	missense	probably benign	0.01
R8116:Aox1	UTSW	1	58,115,283 (GRCm39)	missense	probably damaging	1.00
R8147:Aox1	UTSW	1	58,339,821 (GRCm39)	missense	probably benign	0.02
R8165:Aox1	UTSW	1	58,348,088 (GRCm39)	missense	probably benign	0.08
R8179:Aox1	UTSW	1	58,137,117 (GRCm39)	missense	probably damaging	1.00
R8264:Aox1	UTSW	1	58,092,873 (GRCm39)	missense	possibly damaging	0.92
R8284:Aox1	UTSW	1	58,115,250 (GRCm39)	missense	probably damaging	1.00
R8326:Aox1	UTSW	1	58,335,046 (GRCm39)	missense	probably benign
R8415:Aox1	UTSW	1	58,080,638 (GRCm39)	missense	probably damaging	1.00
R8770:Aox1	UTSW	1	58,378,763 (GRCm39)	missense	probably benign	0.10
R8946:Aox1	UTSW	1	58,145,227 (GRCm39)	missense	possibly damaging	0.68
R8973:Aox1	UTSW	1	58,329,113 (GRCm39)	missense	probably benign	0.34
R8988:Aox1	UTSW	1	58,088,625 (GRCm39)	missense	possibly damaging	0.48
R9015:Aox1	UTSW	1	58,382,851 (GRCm39)	missense	probably damaging	1.00
R9097:Aox1	UTSW	1	58,326,887 (GRCm39)	missense	possibly damaging	0.82
R9101:Aox1	UTSW	1	58,371,796 (GRCm39)	missense	probably benign	0.03
R9108:Aox1	UTSW	1	58,321,851 (GRCm39)	missense	probably damaging	1.00
R9180:Aox1	UTSW	1	58,378,777 (GRCm39)	nonsense	probably null
R9258:Aox1	UTSW	1	58,351,515 (GRCm39)	missense	probably damaging	1.00
R9293:Aox1	UTSW	1	58,361,953 (GRCm39)	missense	possibly damaging	0.86
R9296:Aox1	UTSW	1	58,124,612 (GRCm39)	missense	probably damaging	1.00
R9382:Aox1	UTSW	1	58,104,501 (GRCm39)	missense	possibly damaging	0.48
R9461:Aox1	UTSW	1	58,116,736 (GRCm39)	critical splice donor site	probably null
R9519:Aox1	UTSW	1	58,373,926 (GRCm39)	missense	probably damaging	0.98
R9581:Aox1	UTSW	1	58,370,055 (GRCm39)	critical splice donor site	probably null
Z1088:Aox1	UTSW	1	58,120,701 (GRCm39)	missense	probably benign	0.01
Z1177:Aox1	UTSW	1	58,393,556 (GRCm39)	missense	possibly damaging	0.69

Predicted Primers

PCR Primer
(F):5'- GCTGAAAGCTAACACGGGTG -3'
(R):5'- TCTAAGTTAGGAAAGTCTAGGGTTGC -3'

Sequencing Primer
(F):5'- ACACGGGTGTTTGTCACTC -3'
(R):5'- GTCTAGGGTTGCTAATATACAATTGC -3'

Posted On

2014-06-30