Incidental Mutation 'R1869:Nalcn'
| ID |
210589 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nalcn
|
| Ensembl Gene |
ENSMUSG00000000197 |
| Gene Name |
sodium leak channel, non-selective |
| Synonyms |
Vgcnl1, A530023G15Rik |
| MMRRC Submission |
039891-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1869 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
123514046-123864556 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 123831965 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 103
(V103G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000000201
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000201]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000000201
AA Change: V103G
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000000201
Gene: ENSMUSG00000000197
AA Change: V103G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Ion_trans
|
35 |
333 |
2.8e-37 |
PFAM |
|
low complexity region
|
338 |
348 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
383 |
609 |
5.7e-34 |
PFAM |
|
coiled coil region
|
796 |
830 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
885 |
1166 |
2.4e-42 |
PFAM |
|
Pfam:Ion_trans
|
1209 |
1458 |
6.9e-30 |
PFAM |
|
low complexity region
|
1548 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1634 |
1649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226617
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000227818
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228766
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228789
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228860
|
| Meta Mutation Damage Score |
0.6445 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 92.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal breathing at birth and die within 24 hours. Mice homozygous for a gain of function ENU mutation exhibit reduced the total amount and episode duration of REMS. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 127 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921536K21Rik |
A |
G |
11: 3,840,067 (GRCm39) |
L110P |
probably damaging |
Het |
| 6030458C11Rik |
T |
C |
15: 12,817,993 (GRCm39) |
D168G |
probably damaging |
Het |
| Abca13 |
A |
T |
11: 9,242,134 (GRCm39) |
E1332D |
probably benign |
Het |
| Abhd11 |
A |
G |
5: 135,040,471 (GRCm39) |
Y168C |
probably damaging |
Het |
| Actr5 |
A |
C |
2: 158,480,643 (GRCm39) |
T554P |
probably damaging |
Het |
| Adam34l |
A |
T |
8: 44,078,132 (GRCm39) |
Y697* |
probably null |
Het |
| Adamts16 |
A |
G |
13: 70,883,866 (GRCm39) |
L1103P |
probably damaging |
Het |
| Adgrb3 |
A |
T |
1: 25,865,519 (GRCm39) |
I108K |
possibly damaging |
Het |
| Agbl4 |
T |
A |
4: 111,423,826 (GRCm39) |
M284K |
possibly damaging |
Het |
| Aoc3 |
T |
A |
11: 101,222,293 (GRCm39) |
Y176* |
probably null |
Het |
| Aox1 |
A |
G |
1: 58,115,262 (GRCm39) |
E749G |
probably damaging |
Het |
| Ap4b1 |
T |
A |
3: 103,728,184 (GRCm39) |
Y399* |
probably null |
Het |
| Arhgef5 |
A |
T |
6: 43,265,616 (GRCm39) |
I1553F |
probably damaging |
Het |
| Bag6 |
T |
C |
17: 35,361,802 (GRCm39) |
V541A |
probably benign |
Het |
| Bdp1 |
A |
C |
13: 100,178,709 (GRCm39) |
V1879G |
probably damaging |
Het |
| Bod1l |
G |
A |
5: 41,991,018 (GRCm39) |
S179F |
possibly damaging |
Het |
| Bsnd |
C |
T |
4: 106,343,833 (GRCm39) |
V158I |
probably benign |
Het |
| Cachd1 |
C |
A |
4: 100,840,587 (GRCm39) |
H880N |
probably damaging |
Het |
| Ccdc27 |
T |
C |
4: 154,111,220 (GRCm39) |
|
probably null |
Het |
| Cd74 |
C |
T |
18: 60,943,484 (GRCm39) |
P190S |
probably benign |
Het |
| Cep68 |
A |
T |
11: 20,190,217 (GRCm39) |
L265Q |
probably damaging |
Het |
| Cfap70 |
G |
A |
14: 20,458,678 (GRCm39) |
Q772* |
probably null |
Het |
| CK137956 |
T |
A |
4: 127,864,327 (GRCm39) |
S101C |
possibly damaging |
Het |
| Clca3a2 |
G |
A |
3: 144,512,164 (GRCm39) |
T524M |
probably benign |
Het |
| Cxcr6 |
T |
C |
9: 123,639,022 (GRCm39) |
S15P |
probably benign |
Het |
| Cyfip2 |
T |
A |
11: 46,114,995 (GRCm39) |
Y904F |
probably benign |
Het |
| D130040H23Rik |
T |
A |
8: 69,755,354 (GRCm39) |
I253N |
probably benign |
Het |
| Ddx56 |
C |
T |
11: 6,213,993 (GRCm39) |
V389M |
possibly damaging |
Het |
| Dmp1 |
A |
T |
5: 104,359,942 (GRCm39) |
D206V |
probably damaging |
Het |
| Dnah17 |
A |
T |
11: 117,938,015 (GRCm39) |
C3350* |
probably null |
Het |
| Dst |
A |
T |
1: 34,291,913 (GRCm39) |
S877C |
probably damaging |
Het |
| Ermp1 |
A |
G |
19: 29,623,415 (GRCm39) |
S192P |
possibly damaging |
Het |
| F13b |
G |
A |
1: 139,438,672 (GRCm39) |
D359N |
probably benign |
Het |
| Fam171a1 |
A |
T |
2: 3,227,189 (GRCm39) |
Q769L |
possibly damaging |
Het |
| Fap |
T |
C |
2: 62,359,071 (GRCm39) |
R411G |
probably damaging |
Het |
| Fbn1 |
A |
G |
2: 125,193,947 (GRCm39) |
V1340A |
probably benign |
Het |
| Fbxw19 |
T |
C |
9: 109,311,100 (GRCm39) |
I370V |
probably benign |
Het |
| Foxi1 |
A |
T |
11: 34,157,937 (GRCm39) |
N29K |
possibly damaging |
Het |
| Frem2 |
T |
G |
3: 53,442,617 (GRCm39) |
D2640A |
probably benign |
Het |
| Fzd4 |
T |
C |
7: 89,056,454 (GRCm39) |
V167A |
probably benign |
Het |
| Galnt3 |
T |
C |
2: 65,928,123 (GRCm39) |
I258V |
possibly damaging |
Het |
| Galr2 |
T |
C |
11: 116,174,069 (GRCm39) |
V233A |
possibly damaging |
Het |
| Gldc |
G |
T |
19: 30,116,732 (GRCm39) |
Q407K |
probably benign |
Het |
| Gmcl1 |
T |
C |
6: 86,674,498 (GRCm39) |
D460G |
probably benign |
Het |
| Gpr89 |
A |
G |
3: 96,782,975 (GRCm39) |
I325T |
probably benign |
Het |
| Grap |
T |
A |
11: 61,555,015 (GRCm39) |
Y61N |
possibly damaging |
Het |
| Hbs1l |
G |
T |
10: 21,234,305 (GRCm39) |
|
probably null |
Het |
| Hexb |
T |
A |
13: 97,327,767 (GRCm39) |
E134D |
probably benign |
Het |
| Hydin |
T |
A |
8: 111,227,337 (GRCm39) |
V1507D |
possibly damaging |
Het |
| Igkv8-16 |
C |
A |
6: 70,363,971 (GRCm39) |
G17V |
probably benign |
Het |
| Kdm4a |
T |
A |
4: 117,996,068 (GRCm39) |
Q987L |
probably null |
Het |
| Krt76 |
A |
G |
15: 101,797,922 (GRCm39) |
|
probably null |
Het |
| Lap3 |
T |
C |
5: 45,660,729 (GRCm39) |
S238P |
probably benign |
Het |
| Letm2 |
T |
C |
8: 26,071,729 (GRCm39) |
D391G |
probably damaging |
Het |
| Lipn |
A |
G |
19: 34,058,139 (GRCm39) |
T287A |
possibly damaging |
Het |
| Macf1 |
T |
C |
4: 123,244,921 (GRCm39) |
S466G |
probably damaging |
Het |
| Map3k5 |
C |
A |
10: 20,007,855 (GRCm39) |
S1220* |
probably null |
Het |
| Map4 |
T |
A |
9: 109,897,996 (GRCm39) |
S754R |
possibly damaging |
Het |
| Map4 |
T |
C |
9: 109,864,032 (GRCm39) |
V419A |
probably benign |
Het |
| Mroh9 |
A |
G |
1: 162,854,082 (GRCm39) |
S773P |
probably damaging |
Het |
| Mtus1 |
A |
C |
8: 41,529,267 (GRCm39) |
|
probably null |
Het |
| Muc1 |
C |
T |
3: 89,139,117 (GRCm39) |
P533S |
probably damaging |
Het |
| Muc13 |
A |
T |
16: 33,624,970 (GRCm39) |
I282F |
probably damaging |
Het |
| Mucl3 |
A |
G |
17: 35,949,305 (GRCm39) |
L98P |
possibly damaging |
Het |
| Myh14 |
T |
A |
7: 44,261,067 (GRCm39) |
Q1816L |
possibly damaging |
Het |
| Nlrp9c |
G |
A |
7: 26,084,245 (GRCm39) |
Q445* |
probably null |
Het |
| Olfml2b |
A |
G |
1: 170,496,812 (GRCm39) |
D481G |
probably damaging |
Het |
| Or13g1 |
T |
A |
7: 85,955,875 (GRCm39) |
I149F |
possibly damaging |
Het |
| Or2ag19 |
T |
G |
7: 106,444,301 (GRCm39) |
I161S |
probably benign |
Het |
| Or5g23 |
A |
G |
2: 85,438,844 (GRCm39) |
S137P |
probably benign |
Het |
| Or8b37 |
T |
A |
9: 37,959,498 (GRCm39) |
|
probably null |
Het |
| Or8k3b |
T |
A |
2: 86,520,735 (GRCm39) |
I195F |
probably damaging |
Het |
| Pcdhb2 |
A |
T |
18: 37,430,408 (GRCm39) |
|
probably null |
Het |
| Pcdhb22 |
A |
C |
18: 37,652,200 (GRCm39) |
T223P |
probably damaging |
Het |
| Pcdhga1 |
T |
A |
18: 37,973,143 (GRCm39) |
N907K |
probably damaging |
Het |
| Pcnt |
T |
C |
10: 76,215,740 (GRCm39) |
E2347G |
probably null |
Het |
| Phax |
T |
A |
18: 56,706,176 (GRCm39) |
V22D |
probably benign |
Het |
| Pik3ca |
T |
C |
3: 32,504,499 (GRCm39) |
F667S |
probably damaging |
Het |
| Pkd1 |
T |
C |
17: 24,813,905 (GRCm39) |
F4123S |
probably damaging |
Het |
| Pkhd1 |
A |
G |
1: 20,685,491 (GRCm39) |
|
probably null |
Het |
| Plcb1 |
G |
A |
2: 135,152,934 (GRCm39) |
R368K |
probably benign |
Het |
| Prrc2a |
G |
T |
17: 35,372,284 (GRCm39) |
R1739S |
possibly damaging |
Het |
| Psg23 |
A |
T |
7: 18,348,543 (GRCm39) |
M88K |
probably benign |
Het |
| Pstk |
T |
A |
7: 130,989,526 (GRCm39) |
Y354N |
probably damaging |
Het |
| Rab39 |
A |
G |
9: 53,617,231 (GRCm39) |
I62T |
possibly damaging |
Het |
| Ranbp2 |
A |
G |
10: 58,328,383 (GRCm39) |
I2800V |
probably damaging |
Het |
| Rasgrp1 |
T |
C |
2: 117,120,828 (GRCm39) |
Y431C |
probably damaging |
Het |
| Rest |
T |
A |
5: 77,416,209 (GRCm39) |
V141E |
possibly damaging |
Het |
| Rnf167 |
T |
A |
11: 70,540,965 (GRCm39) |
I197N |
possibly damaging |
Het |
| Rtn1 |
A |
G |
12: 72,354,942 (GRCm39) |
S335P |
probably damaging |
Het |
| Ryr2 |
G |
T |
13: 11,676,961 (GRCm39) |
R3297S |
probably damaging |
Het |
| S1pr3 |
A |
C |
13: 51,573,952 (GRCm39) |
K378Q |
probably benign |
Het |
| Scgb1b24 |
T |
C |
7: 33,443,469 (GRCm39) |
Y43H |
probably damaging |
Het |
| Sh3rf3 |
T |
A |
10: 58,919,335 (GRCm39) |
M484K |
probably damaging |
Het |
| Shank1 |
A |
T |
7: 43,991,539 (GRCm39) |
R69* |
probably null |
Het |
| Siglecf |
A |
G |
7: 43,004,967 (GRCm39) |
N399S |
probably benign |
Het |
| Slc1a7 |
A |
G |
4: 107,865,561 (GRCm39) |
T350A |
probably damaging |
Het |
| Slc25a54 |
T |
A |
3: 108,987,932 (GRCm39) |
Y24* |
probably null |
Het |
| Slk |
T |
C |
19: 47,613,891 (GRCm39) |
F916L |
probably damaging |
Het |
| Snap91 |
T |
A |
9: 86,672,194 (GRCm39) |
|
probably null |
Het |
| Snrpb2 |
A |
T |
2: 142,907,106 (GRCm39) |
R25S |
possibly damaging |
Het |
| Specc1l |
T |
C |
10: 75,097,659 (GRCm39) |
Y811H |
probably damaging |
Het |
| Sprr2h |
A |
G |
3: 92,293,925 (GRCm39) |
|
probably benign |
Het |
| Sult2a5 |
A |
T |
7: 13,358,045 (GRCm39) |
I26F |
probably benign |
Het |
| Syt13 |
C |
T |
2: 92,776,448 (GRCm39) |
T245I |
possibly damaging |
Het |
| Tecrl |
T |
A |
5: 83,502,706 (GRCm39) |
T33S |
probably benign |
Het |
| Telo2 |
T |
A |
17: 25,333,968 (GRCm39) |
D93V |
probably benign |
Het |
| Tet2 |
A |
T |
3: 133,187,202 (GRCm39) |
|
probably null |
Het |
| Tgm7 |
A |
T |
2: 120,931,570 (GRCm39) |
C198S |
probably damaging |
Het |
| Ticrr |
T |
C |
7: 79,328,883 (GRCm39) |
F674S |
probably damaging |
Het |
| Tmem129 |
C |
A |
5: 33,811,843 (GRCm39) |
C31F |
probably damaging |
Het |
| Tmem132a |
T |
A |
19: 10,836,052 (GRCm39) |
D826V |
possibly damaging |
Het |
| Tpd52 |
T |
C |
3: 9,018,862 (GRCm39) |
|
probably null |
Het |
| Trub2 |
A |
G |
2: 29,667,678 (GRCm39) |
S321P |
probably benign |
Het |
| Ttc29 |
A |
G |
8: 79,009,014 (GRCm39) |
T295A |
probably benign |
Het |
| Tubb1 |
G |
A |
2: 174,298,482 (GRCm39) |
S89N |
probably benign |
Het |
| Tut4 |
T |
A |
4: 108,386,497 (GRCm39) |
F1122L |
probably damaging |
Het |
| Ubap2 |
C |
A |
4: 41,233,617 (GRCm39) |
G91V |
probably damaging |
Het |
| Ugt2b35 |
A |
G |
5: 87,149,147 (GRCm39) |
N133D |
probably damaging |
Het |
| Usp34 |
A |
G |
11: 23,314,479 (GRCm39) |
H807R |
probably benign |
Het |
| Vmn1r220 |
A |
C |
13: 23,368,457 (GRCm39) |
C80G |
probably damaging |
Het |
| Vmn1r79 |
A |
G |
7: 11,910,574 (GRCm39) |
E152G |
probably benign |
Het |
| Vmn2r28 |
T |
C |
7: 5,489,345 (GRCm39) |
Y498C |
probably benign |
Het |
| Wif1 |
A |
G |
10: 120,920,824 (GRCm39) |
I215M |
probably benign |
Het |
| Wnk1 |
T |
C |
6: 119,928,050 (GRCm39) |
T1134A |
probably damaging |
Het |
| Zfp90 |
A |
G |
8: 107,145,755 (GRCm39) |
H29R |
probably benign |
Het |
| Zfp972 |
A |
G |
2: 177,563,480 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Nalcn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00952:Nalcn
|
APN |
14 |
123,586,201 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00964:Nalcn
|
APN |
14 |
123,532,796 (GRCm39) |
splice site |
probably benign |
|
|
IGL01310:Nalcn
|
APN |
14 |
123,554,661 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01578:Nalcn
|
APN |
14 |
123,809,503 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01925:Nalcn
|
APN |
14 |
123,529,260 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02072:Nalcn
|
APN |
14 |
123,560,770 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02096:Nalcn
|
APN |
14 |
123,831,915 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02212:Nalcn
|
APN |
14 |
123,752,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02306:Nalcn
|
APN |
14 |
123,560,750 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02471:Nalcn
|
APN |
14 |
123,560,726 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02478:Nalcn
|
APN |
14 |
123,558,717 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02551:Nalcn
|
APN |
14 |
123,560,750 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02630:Nalcn
|
APN |
14 |
123,555,291 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02632:Nalcn
|
APN |
14 |
123,555,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02661:Nalcn
|
APN |
14 |
123,830,321 (GRCm39) |
splice site |
probably benign |
|
|
IGL02830:Nalcn
|
APN |
14 |
123,530,881 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02939:Nalcn
|
APN |
14 |
123,536,284 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL03035:Nalcn
|
APN |
14 |
123,515,630 (GRCm39) |
nonsense |
probably null |
|
|
IGL03226:Nalcn
|
APN |
14 |
123,518,527 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03242:Nalcn
|
APN |
14 |
123,558,899 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Narnia
|
UTSW |
14 |
123,528,459 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0019:Nalcn
|
UTSW |
14 |
123,744,901 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0144:Nalcn
|
UTSW |
14 |
123,647,251 (GRCm39) |
splice site |
probably benign |
|
|
R0144:Nalcn
|
UTSW |
14 |
123,608,948 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0359:Nalcn
|
UTSW |
14 |
123,536,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0383:Nalcn
|
UTSW |
14 |
123,744,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0400:Nalcn
|
UTSW |
14 |
123,528,372 (GRCm39) |
splice site |
probably benign |
|
|
R0467:Nalcn
|
UTSW |
14 |
123,528,459 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0506:Nalcn
|
UTSW |
14 |
123,834,026 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0583:Nalcn
|
UTSW |
14 |
123,531,755 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0620:Nalcn
|
UTSW |
14 |
123,536,553 (GRCm39) |
splice site |
probably benign |
|
|
R0624:Nalcn
|
UTSW |
14 |
123,607,444 (GRCm39) |
missense |
probably benign |
|
|
R0883:Nalcn
|
UTSW |
14 |
123,702,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Nalcn
|
UTSW |
14 |
123,551,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Nalcn
|
UTSW |
14 |
123,702,068 (GRCm39) |
splice site |
probably benign |
|
|
R1689:Nalcn
|
UTSW |
14 |
123,522,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1726:Nalcn
|
UTSW |
14 |
123,545,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Nalcn
|
UTSW |
14 |
123,515,678 (GRCm39) |
missense |
probably benign |
|
|
R1854:Nalcn
|
UTSW |
14 |
123,697,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1871:Nalcn
|
UTSW |
14 |
123,831,965 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1873:Nalcn
|
UTSW |
14 |
123,521,013 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1899:Nalcn
|
UTSW |
14 |
123,553,538 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1915:Nalcn
|
UTSW |
14 |
123,540,181 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2016:Nalcn
|
UTSW |
14 |
123,831,993 (GRCm39) |
splice site |
probably null |
|
|
R2034:Nalcn
|
UTSW |
14 |
123,521,015 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2087:Nalcn
|
UTSW |
14 |
123,518,557 (GRCm39) |
missense |
probably benign |
|
|
R2149:Nalcn
|
UTSW |
14 |
123,607,429 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2157:Nalcn
|
UTSW |
14 |
123,647,164 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2166:Nalcn
|
UTSW |
14 |
123,607,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2932:Nalcn
|
UTSW |
14 |
123,830,430 (GRCm39) |
missense |
probably benign |
0.06 |
|
R3408:Nalcn
|
UTSW |
14 |
123,834,029 (GRCm39) |
missense |
probably null |
0.98 |
|
R3778:Nalcn
|
UTSW |
14 |
123,702,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3807:Nalcn
|
UTSW |
14 |
123,515,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Nalcn
|
UTSW |
14 |
123,530,834 (GRCm39) |
splice site |
probably benign |
|
|
R3937:Nalcn
|
UTSW |
14 |
123,607,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4001:Nalcn
|
UTSW |
14 |
123,834,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4015:Nalcn
|
UTSW |
14 |
123,723,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4033:Nalcn
|
UTSW |
14 |
123,837,401 (GRCm39) |
splice site |
probably benign |
|
|
R4231:Nalcn
|
UTSW |
14 |
123,837,325 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4464:Nalcn
|
UTSW |
14 |
123,560,762 (GRCm39) |
missense |
probably benign |
|
|
R4512:Nalcn
|
UTSW |
14 |
123,532,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Nalcn
|
UTSW |
14 |
123,558,889 (GRCm39) |
synonymous |
silent |
|
|
R4557:Nalcn
|
UTSW |
14 |
123,558,647 (GRCm39) |
intron |
probably benign |
|
|
R4869:Nalcn
|
UTSW |
14 |
123,837,296 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5083:Nalcn
|
UTSW |
14 |
123,560,706 (GRCm39) |
splice site |
probably null |
|
|
R5109:Nalcn
|
UTSW |
14 |
123,515,650 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5131:Nalcn
|
UTSW |
14 |
123,753,182 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5158:Nalcn
|
UTSW |
14 |
123,753,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5259:Nalcn
|
UTSW |
14 |
123,753,063 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5422:Nalcn
|
UTSW |
14 |
123,752,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5514:Nalcn
|
UTSW |
14 |
123,521,123 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5523:Nalcn
|
UTSW |
14 |
123,647,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5551:Nalcn
|
UTSW |
14 |
123,515,698 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R5667:Nalcn
|
UTSW |
14 |
123,532,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5671:Nalcn
|
UTSW |
14 |
123,532,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5750:Nalcn
|
UTSW |
14 |
123,809,450 (GRCm39) |
missense |
probably benign |
|
|
R5765:Nalcn
|
UTSW |
14 |
123,702,138 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6324:Nalcn
|
UTSW |
14 |
123,647,161 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6523:Nalcn
|
UTSW |
14 |
123,555,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6558:Nalcn
|
UTSW |
14 |
123,723,919 (GRCm39) |
missense |
probably benign |
|
|
R6631:Nalcn
|
UTSW |
14 |
123,697,663 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6667:Nalcn
|
UTSW |
14 |
123,558,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6670:Nalcn
|
UTSW |
14 |
123,702,084 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6724:Nalcn
|
UTSW |
14 |
123,535,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6731:Nalcn
|
UTSW |
14 |
123,837,346 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6957:Nalcn
|
UTSW |
14 |
123,744,966 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6970:Nalcn
|
UTSW |
14 |
123,551,506 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7010:Nalcn
|
UTSW |
14 |
123,530,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7018:Nalcn
|
UTSW |
14 |
123,647,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7040:Nalcn
|
UTSW |
14 |
123,525,267 (GRCm39) |
missense |
probably benign |
|
|
R7089:Nalcn
|
UTSW |
14 |
123,515,761 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7128:Nalcn
|
UTSW |
14 |
123,831,914 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7149:Nalcn
|
UTSW |
14 |
123,837,277 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7361:Nalcn
|
UTSW |
14 |
123,529,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7378:Nalcn
|
UTSW |
14 |
123,540,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7408:Nalcn
|
UTSW |
14 |
123,529,272 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7470:Nalcn
|
UTSW |
14 |
123,809,456 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7483:Nalcn
|
UTSW |
14 |
123,551,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7521:Nalcn
|
UTSW |
14 |
123,530,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7558:Nalcn
|
UTSW |
14 |
123,723,797 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7585:Nalcn
|
UTSW |
14 |
123,753,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7591:Nalcn
|
UTSW |
14 |
123,561,297 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7761:Nalcn
|
UTSW |
14 |
123,531,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7761:Nalcn
|
UTSW |
14 |
123,531,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7811:Nalcn
|
UTSW |
14 |
123,536,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7983:Nalcn
|
UTSW |
14 |
123,830,409 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8089:Nalcn
|
UTSW |
14 |
123,537,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8110:Nalcn
|
UTSW |
14 |
123,702,113 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8190:Nalcn
|
UTSW |
14 |
123,837,351 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8273:Nalcn
|
UTSW |
14 |
123,554,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8407:Nalcn
|
UTSW |
14 |
123,554,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8497:Nalcn
|
UTSW |
14 |
123,752,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Nalcn
|
UTSW |
14 |
123,608,935 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8549:Nalcn
|
UTSW |
14 |
123,607,448 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8731:Nalcn
|
UTSW |
14 |
123,837,266 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8862:Nalcn
|
UTSW |
14 |
123,647,199 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8919:Nalcn
|
UTSW |
14 |
123,561,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9072:Nalcn
|
UTSW |
14 |
123,532,863 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9073:Nalcn
|
UTSW |
14 |
123,532,863 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9182:Nalcn
|
UTSW |
14 |
123,834,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Nalcn
|
UTSW |
14 |
123,545,792 (GRCm39) |
nonsense |
probably null |
|
|
R9241:Nalcn
|
UTSW |
14 |
123,809,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Nalcn
|
UTSW |
14 |
123,518,567 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9274:Nalcn
|
UTSW |
14 |
123,753,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9277:Nalcn
|
UTSW |
14 |
123,518,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9376:Nalcn
|
UTSW |
14 |
123,515,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
X0060:Nalcn
|
UTSW |
14 |
123,522,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nalcn
|
UTSW |
14 |
123,831,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nalcn
|
UTSW |
14 |
123,531,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCACATTTGAAATGCATTCC -3'
(R):5'- AGCGCTCATTAGCCTCTGTTAC -3'
Sequencing Primer
(F):5'- CCACATTTGAAATGCATTCCTTAATG -3'
(R):5'- GGCTTTGACTATTTCCATCATAT -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation