Mutagenetix > Incidental Mutation

Incidental Mutation 'R1872:Col11a2'

210891

Institutional Source

Beutler Lab

Gene Symbol

Col11a2

Ensembl Gene

ENSMUSG00000024330

Gene Name

collagen, type XI, alpha 2

Synonyms

MMRRC Submission

039894-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.936) question?

Stock #

R1872 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

34258411-34285659 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to A at 34281529 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000115026 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087497] [ENSMUST00000114252] [ENSMUST00000114255] [ENSMUST00000143354]

AlphaFold

Q64739

Predicted Effect

unknown
Transcript: ENSMUST00000087497
AA Change: P1285Q

SMART Domains

Protein: ENSMUSP00000084772
Gene: ENSMUSG00000024330
AA Change: P1285Q

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
TSPN	31	214	4.25e-72	SMART
LamG	82	213	1.08e-9	SMART
Pfam:Collagen	306	364	2.2e-9	PFAM
Pfam:Collagen	399	460	1e-10	PFAM
Pfam:Collagen	437	520	1.2e-7	PFAM
Pfam:Collagen	479	553	5.7e-9	PFAM
Pfam:Collagen	506	579	1.6e-8	PFAM
internal_repeat_4	584	614	3.98e-5	PROSPERO
internal_repeat_2	584	669	5.49e-20	PROSPERO
internal_repeat_1	587	740	2.58e-22	PROSPERO
Pfam:Collagen	743	814	1.5e-8	PFAM
Pfam:Collagen	767	839	4.8e-7	PFAM
low complexity region	854	872	N/A	INTRINSIC
Pfam:Collagen	881	946	4.5e-8	PFAM
Pfam:Collagen	905	976	2e-7	PFAM
Pfam:Collagen	933	1002	2.7e-8	PFAM
low complexity region	1013	1047	N/A	INTRINSIC
low complexity region	1064	1112	N/A	INTRINSIC
low complexity region	1121	1199	N/A	INTRINSIC
low complexity region	1216	1232	N/A	INTRINSIC
low complexity region	1289	1320	N/A	INTRINSIC
Pfam:Collagen	1358	1417	1.7e-8	PFAM
COLFI	1454	1649	4.42e-117	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000114252
AA Change: P1290Q

SMART Domains

Protein: ENSMUSP00000109890
Gene: ENSMUSG00000024330
AA Change: P1290Q

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
TSPN	31	214	4.25e-72	SMART
LamG	82	213	1.08e-9	SMART
Pfam:Collagen	311	369	2.3e-9	PFAM
Pfam:Collagen	404	465	1.1e-10	PFAM
Pfam:Collagen	442	525	1.3e-7	PFAM
Pfam:Collagen	484	558	6.4e-9	PFAM
Pfam:Collagen	511	584	1.7e-8	PFAM
internal_repeat_4	589	619	3.69e-5	PROSPERO
internal_repeat_2	589	674	4.46e-20	PROSPERO
internal_repeat_1	592	745	2.05e-22	PROSPERO
internal_repeat_3	636	752	7.84e-10	PROSPERO
Pfam:Collagen	772	844	5.5e-7	PFAM
Pfam:Collagen	800	869	1.9e-8	PFAM
Pfam:Collagen	886	951	5e-8	PFAM
Pfam:Collagen	910	981	2.2e-7	PFAM
Pfam:Collagen	934	1007	6.9e-7	PFAM
low complexity region	1018	1052	N/A	INTRINSIC
low complexity region	1069	1117	N/A	INTRINSIC
low complexity region	1126	1204	N/A	INTRINSIC
low complexity region	1221	1237	N/A	INTRINSIC
low complexity region	1294	1325	N/A	INTRINSIC
Pfam:Collagen	1363	1422	1.9e-8	PFAM
COLFI	1459	1654	4.42e-117	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000114255
AA Change: P1324Q

SMART Domains

Protein: ENSMUSP00000109893
Gene: ENSMUSG00000024330
AA Change: P1324Q

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
TSPN	31	214	4.25e-72	SMART
LamG	82	213	1.08e-9	SMART
low complexity region	257	268	N/A	INTRINSIC
low complexity region	295	307	N/A	INTRINSIC
Pfam:Collagen	345	403	2.1e-9	PFAM
Pfam:Collagen	438	499	1.1e-10	PFAM
Pfam:Collagen	521	593	2.2e-8	PFAM
Pfam:Collagen	545	613	9.1e-10	PFAM
internal_repeat_4	623	653	2.83e-5	PROSPERO
internal_repeat_2	623	708	2.11e-20	PROSPERO
internal_repeat_1	626	779	9e-23	PROSPERO
internal_repeat_3	670	786	5.16e-10	PROSPERO
low complexity region	788	819	N/A	INTRINSIC
low complexity region	830	857	N/A	INTRINSIC
low complexity region	866	887	N/A	INTRINSIC
low complexity region	893	911	N/A	INTRINSIC
low complexity region	919	935	N/A	INTRINSIC
Pfam:Collagen	973	1041	2.9e-8	PFAM
low complexity region	1052	1086	N/A	INTRINSIC
low complexity region	1103	1151	N/A	INTRINSIC
low complexity region	1160	1238	N/A	INTRINSIC
low complexity region	1255	1271	N/A	INTRINSIC
low complexity region	1328	1359	N/A	INTRINSIC
Pfam:Collagen	1394	1456	1.5e-8	PFAM
COLFI	1493	1688	4.42e-117	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000143354

SMART Domains

Protein: ENSMUSP00000115026
Gene: ENSMUSG00000024330

Domain	Start	End	E-Value	Type
Pfam:Collagen	3	56	4.7e-9	PFAM
Pfam:Collagen	91	152	1.7e-9	PFAM
internal_repeat_1	158	301	3.7e-11	PROSPERO
internal_repeat_2	276	321	1.18e-9	PROSPERO
internal_repeat_4	291	306	1.06e-5	PROSPERO
internal_repeat_3	303	353	1.87e-6	PROSPERO
internal_repeat_2	315	360	1.18e-9	PROSPERO
internal_repeat_1	323	439	3.7e-11	PROSPERO
low complexity region	441	472	N/A	INTRINSIC
low complexity region	483	510	N/A	INTRINSIC
low complexity region	519	540	N/A	INTRINSIC
low complexity region	546	564	N/A	INTRINSIC
low complexity region	572	588	N/A	INTRINSIC
Pfam:Collagen	603	673	6.6e-6	PFAM
Pfam:Collagen	627	694	5.4e-7	PFAM
Pfam:Collagen	660	734	3.2e-7	PFAM
Pfam:Collagen	711	770	1.1e-8	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144927

Meta Mutation Damage Score

0.1790

Coding Region Coverage

1x: 97.3%
3x: 96.8%
10x: 95.4%
20x: 93.0%

Validation Efficiency

97% (113/117)

MGI Phenotype

FUNCTION: This gene encodes the alpha-2 subunit of type XI collagen, one of the low abundance fibrillar collagens found in cartilage. The encoded protein, in association with other collagen subunits, forms a heterotrimeric type XI procollagen that may undergo proteolytic processing similar to the alpha-1 subunit. Mice lacking the encoded protein exhibit a mild phenotype similar to nonocular Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED) as well as a nonsyndromic form of deafness called DFNA13. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
PHENOTYPE: Homozygous mutant animals exhibit reduced body size, short snout, a slightly bulged forehead, deafness, and disorganization of chondrocytes in the growth plate of long bones. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 108 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700003H04Rik	C	T	3: 124,350,493 (GRCm39)	C133Y	unknown	Het
Abce1	A	G	8: 80,416,880 (GRCm39)	M377T	possibly damaging	Het
Adam25	A	T	8: 41,208,263 (GRCm39)	R510*	probably null	Het
Adamts12	G	T	15: 11,217,966 (GRCm39)	E308*	probably null	Het
Adgrg3	C	A	8: 95,760,070 (GRCm39)	N96K	possibly damaging	Het
Afdn	T	C	17: 14,101,578 (GRCm39)	V1022A	probably damaging	Het
Akap9	T	C	5: 4,051,406 (GRCm39)	V1391A	probably damaging	Het
Akip1	A	G	7: 109,310,982 (GRCm39)	Y174C	probably damaging	Het
Aoc1l1	A	G	6: 48,952,554 (GRCm39)	I160V	probably benign	Het
Ap3b2	T	C	7: 81,113,898 (GRCm39)	T830A	unknown	Het
Aph1a	A	G	3: 95,802,876 (GRCm39)	T159A	probably damaging	Het
Ccdc146	T	C	5: 21,506,288 (GRCm39)	T718A	probably benign	Het
Cdk5r2	T	C	1: 74,894,981 (GRCm39)	L242P	probably damaging	Het
Cep97	T	A	16: 55,748,229 (GRCm39)	N67I	probably damaging	Het
Cgas	T	C	9: 78,340,484 (GRCm39)	D416G	probably benign	Het
Chic2	A	T	5: 75,172,140 (GRCm39)	W121R	possibly damaging	Het
Clock	A	G	5: 76,396,309 (GRCm39)	S147P	possibly damaging	Het
Cntnap5a	T	G	1: 116,016,940 (GRCm39)	S178A	probably benign	Het
Col6a3	T	A	1: 90,757,936 (GRCm39)	H6L	probably damaging	Het
Cpne5	T	C	17: 29,423,667 (GRCm39)	N154D	probably benign	Het
Ctsz	T	G	2: 174,269,769 (GRCm39)	K273Q	probably benign	Het
Cybrd1	G	A	2: 70,960,104 (GRCm39)	V101M	probably benign	Het
Cyp2c23	T	A	19: 43,993,990 (GRCm39)	K459*	probably null	Het
Cyp4a31	A	T	4: 115,431,933 (GRCm39)	H419L	probably damaging	Het
D930020B18Rik	G	A	10: 121,477,879 (GRCm39)	V35M	probably damaging	Het
Depp1	G	A	6: 116,628,683 (GRCm39)	V9M	possibly damaging	Het
Dnah9	C	T	11: 65,928,316 (GRCm39)	V2118M	probably benign	Het
Dtna	T	C	18: 23,730,617 (GRCm39)		probably null	Het
Ednra	C	T	8: 78,447,025 (GRCm39)	V18I	possibly damaging	Het
Elac1	T	C	18: 73,875,717 (GRCm39)	R105G	probably benign	Het
Exoc2	A	G	13: 31,006,644 (GRCm39)	S844P	probably benign	Het
Fam185a	A	T	5: 21,685,328 (GRCm39)		probably null	Het
Fam204a	A	G	19: 60,187,881 (GRCm39)	M233T	possibly damaging	Het
Fat1	C	A	8: 45,406,341 (GRCm39)	H1031N	probably benign	Het
Fat1	T	A	8: 45,491,386 (GRCm39)	Y3816N	probably damaging	Het
Fbxo38	C	T	18: 62,650,094 (GRCm39)	R621Q	probably benign	Het
Fhod3	C	A	18: 25,263,667 (GRCm39)	R1524S	probably damaging	Het
Fnip1	A	T	11: 54,378,561 (GRCm39)	R192W	probably damaging	Het
Frem3	T	A	8: 81,339,205 (GRCm39)	H499Q	probably damaging	Het
Gab2	C	T	7: 96,948,250 (GRCm39)	T280I	probably damaging	Het
Gdpgp1	A	G	7: 79,888,172 (GRCm39)	R68G	probably benign	Het
Gm10382	C	T	5: 125,466,624 (GRCm39)		probably benign	Het
Gmps	A	G	3: 63,908,938 (GRCm39)	H480R	probably benign	Het
Hecw1	G	A	13: 14,455,034 (GRCm39)	R674*	probably null	Het
Herc2	T	A	7: 55,807,257 (GRCm39)	F2478L	probably benign	Het
Homer2	C	T	7: 81,286,150 (GRCm39)	V21M	probably damaging	Het
Ifna9	A	G	4: 88,510,492 (GRCm39)	M44T	probably damaging	Het
Igfl3	A	G	7: 17,913,821 (GRCm39)	D57G	possibly damaging	Het
Jcad	T	C	18: 4,673,048 (GRCm39)	M270T	probably benign	Het
Kdm5b	T	C	1: 134,552,732 (GRCm39)	L1236P	probably damaging	Het
Kif14	T	A	1: 136,414,096 (GRCm39)	L724Q	probably damaging	Het
Lhb	T	C	7: 45,070,757 (GRCm39)	V45A	probably damaging	Het
Lhpp	A	G	7: 132,235,816 (GRCm39)	N134D	probably benign	Het
Mas1	T	C	17: 13,061,078 (GRCm39)	Y115C	probably damaging	Het
Mgam	A	T	6: 40,638,234 (GRCm39)	K395*	probably null	Het
Mms22l	A	G	4: 24,598,807 (GRCm39)	N1134S	probably damaging	Het
Mrc1	A	G	2: 14,330,192 (GRCm39)		probably null	Het
Mrgprg	G	A	7: 143,318,281 (GRCm39)	S277L	probably damaging	Het
Mrpl49	G	T	19: 6,107,010 (GRCm39)	P60T	possibly damaging	Het
Mrps10	G	A	17: 47,683,377 (GRCm39)	G104D	possibly damaging	Het
Msantd3	A	G	4: 48,552,771 (GRCm39)	Y120C	probably damaging	Het
Mtcl2	A	G	2: 156,882,181 (GRCm39)	C624R	possibly damaging	Het
N4bp2	C	T	5: 65,951,861 (GRCm39)		probably benign	Het
Nbea	A	G	3: 55,550,310 (GRCm39)	V2706A	probably benign	Het
Nfic	T	A	10: 81,256,518 (GRCm39)	M71L	possibly damaging	Het
Ntn4	C	T	10: 93,543,215 (GRCm39)	R314W	probably damaging	Het
Or12e1	A	G	2: 87,022,222 (GRCm39)	T64A	possibly damaging	Het
Or14j4	G	T	17: 37,920,803 (GRCm39)	P280T	probably damaging	Het
Or4a15	A	G	2: 89,192,933 (GRCm39)	L280P	probably damaging	Het
Or4c105	T	A	2: 88,648,280 (GRCm39)	V255E	probably benign	Het
Pak5	T	C	2: 135,927,508 (GRCm39)	I655V	possibly damaging	Het
Pip5k1c	A	G	10: 81,142,153 (GRCm39)	N121S	probably damaging	Het
Plce1	A	T	19: 38,748,521 (GRCm39)	I1737F	probably damaging	Het
Prrt1	T	C	17: 34,849,925 (GRCm39)	L113P	probably damaging	Het
Ptprq	T	A	10: 107,479,860 (GRCm39)	T1137S	probably benign	Het
Recql5	T	C	11: 115,814,135 (GRCm39)	I223V	probably benign	Het
Reg3g	A	T	6: 78,444,836 (GRCm39)	Y47*	probably null	Het
Rgs12	T	G	5: 35,123,165 (GRCm39)	M316R	probably damaging	Het
Ric1	T	C	19: 29,580,068 (GRCm39)	S1290P	probably benign	Het
Rpl36al	A	G	12: 69,229,697 (GRCm39)	C72R	probably damaging	Het
Rplp0	T	A	5: 115,701,374 (GRCm39)	F275L	possibly damaging	Het
Rpp30	G	A	19: 36,064,793 (GRCm39)	V89I	probably benign	Het
Ryr3	A	G	2: 112,539,482 (GRCm39)	F3253L	possibly damaging	Het
Serpina3n	A	T	12: 104,375,203 (GRCm39)	N92Y	probably benign	Het
Setd7	G	T	3: 51,450,252 (GRCm39)	T58N	probably benign	Het
Sh3tc2	T	A	18: 62,144,954 (GRCm39)	L1136Q	probably damaging	Het
Slc35b4	G	A	6: 34,135,440 (GRCm39)	Q291*	probably null	Het
Sort1	A	G	3: 108,248,011 (GRCm39)	N452S	probably benign	Het
Sympk	A	G	7: 18,763,070 (GRCm39)	I46V	probably benign	Het
Syngr2	T	C	11: 117,703,364 (GRCm39)	V60A	probably damaging	Het
Syt17	A	T	7: 118,007,341 (GRCm39)	F318I	probably benign	Het
Tdpoz8	T	A	3: 92,981,729 (GRCm39)	L249H	probably damaging	Het
Tgfb1	T	A	7: 25,391,891 (GRCm39)	L149M	probably damaging	Het
Ticam1	A	T	17: 56,578,897 (GRCm39)	M66K	probably benign	Het
Tmem131	G	T	1: 36,847,008 (GRCm39)	D1363E	probably benign	Het
Tns4	A	C	11: 98,970,926 (GRCm39)	D261E	probably damaging	Het
Trim30a	T	C	7: 104,078,417 (GRCm39)	N220D	probably benign	Het
Trmt10a	T	C	3: 137,862,481 (GRCm39)	L257P	probably damaging	Het
Troap	G	T	15: 98,973,233 (GRCm39)		probably benign	Het
Ttc6	T	C	12: 57,751,338 (GRCm39)		probably null	Het
Ttn	A	T	2: 76,641,587 (GRCm39)	L5176Q	possibly damaging	Het
Vav1	A	C	17: 57,631,750 (GRCm39)	K775T	probably damaging	Het
Vmn1r236	A	G	17: 21,507,673 (GRCm39)	K264E	possibly damaging	Het
Vmn1r84	A	G	7: 12,096,555 (GRCm39)	V46A	probably benign	Het
Wdr59	A	T	8: 112,185,649 (GRCm39)	W835R	probably damaging	Het
Zfp513	T	G	5: 31,357,767 (GRCm39)	K202T	probably damaging	Het
Zfp7	T	G	15: 76,775,977 (GRCm39)	I673S	probably benign	Het
Zmynd11	A	G	13: 9,748,737 (GRCm39)	I108T	possibly damaging	Het

Other mutations in Col11a2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01723:Col11a2	APN	17	34,280,254 (GRCm39)	unclassified	probably benign
IGL01839:Col11a2	APN	17	34,283,056 (GRCm39)	unclassified	probably benign
IGL02429:Col11a2	APN	17	34,261,266 (GRCm39)	missense	probably damaging	1.00
IGL02491:Col11a2	APN	17	34,283,181 (GRCm39)	unclassified	probably benign
BB010:Col11a2	UTSW	17	34,275,029 (GRCm39)	nonsense	probably null
BB020:Col11a2	UTSW	17	34,275,029 (GRCm39)	nonsense	probably null
PIT4531001:Col11a2	UTSW	17	34,265,412 (GRCm39)	critical splice acceptor site	probably null
R0001:Col11a2	UTSW	17	34,280,586 (GRCm39)	missense	probably benign	0.00
R0005:Col11a2	UTSW	17	34,281,853 (GRCm39)	unclassified	probably benign
R0099:Col11a2	UTSW	17	34,268,648 (GRCm39)	missense	probably damaging	0.99
R0106:Col11a2	UTSW	17	34,276,249 (GRCm39)	missense	probably damaging	0.99
R0243:Col11a2	UTSW	17	34,281,520 (GRCm39)	unclassified	probably benign
R0254:Col11a2	UTSW	17	34,283,777 (GRCm39)	unclassified	probably benign
R0352:Col11a2	UTSW	17	34,261,501 (GRCm39)	missense	probably benign	0.43
R0362:Col11a2	UTSW	17	34,281,420 (GRCm39)	splice site	probably null
R0491:Col11a2	UTSW	17	34,261,186 (GRCm39)	missense	probably null	0.00
R0531:Col11a2	UTSW	17	34,277,351 (GRCm39)	splice site	probably benign
R0538:Col11a2	UTSW	17	34,270,302 (GRCm39)	splice site	probably benign
R0646:Col11a2	UTSW	17	34,278,322 (GRCm39)	critical splice donor site	probably null
R0676:Col11a2	UTSW	17	34,276,249 (GRCm39)	missense	probably damaging	0.99
R0919:Col11a2	UTSW	17	34,278,124 (GRCm39)	missense	possibly damaging	0.93
R1522:Col11a2	UTSW	17	34,274,228 (GRCm39)	missense	probably damaging	1.00
R1767:Col11a2	UTSW	17	34,282,869 (GRCm39)	unclassified	probably benign
R1941:Col11a2	UTSW	17	34,263,925 (GRCm39)	missense	probably benign	0.01
R1945:Col11a2	UTSW	17	34,278,142 (GRCm39)	missense	probably damaging	1.00
R2101:Col11a2	UTSW	17	34,271,143 (GRCm39)	missense	probably damaging	1.00
R2161:Col11a2	UTSW	17	34,283,771 (GRCm39)	unclassified	probably benign
R2258:Col11a2	UTSW	17	34,258,651 (GRCm39)	missense	probably benign
R2259:Col11a2	UTSW	17	34,258,651 (GRCm39)	missense	probably benign
R2260:Col11a2	UTSW	17	34,258,651 (GRCm39)	missense	probably benign
R2761:Col11a2	UTSW	17	34,270,000 (GRCm39)	missense	probably damaging	1.00
R3114:Col11a2	UTSW	17	34,265,442 (GRCm39)	missense	possibly damaging	0.69
R3824:Col11a2	UTSW	17	34,273,154 (GRCm39)	missense	probably damaging	1.00
R3938:Col11a2	UTSW	17	34,258,599 (GRCm39)	unclassified	probably benign
R4039:Col11a2	UTSW	17	34,264,748 (GRCm39)	missense	probably benign	0.00
R4675:Col11a2	UTSW	17	34,283,267 (GRCm39)	critical splice donor site	probably null
R4810:Col11a2	UTSW	17	34,276,086 (GRCm39)	missense	probably damaging	0.99
R4824:Col11a2	UTSW	17	34,269,937 (GRCm39)	missense	probably damaging	1.00
R4944:Col11a2	UTSW	17	34,261,164 (GRCm39)	missense	possibly damaging	0.47
R5112:Col11a2	UTSW	17	34,283,062 (GRCm39)	unclassified	probably benign
R5355:Col11a2	UTSW	17	34,270,775 (GRCm39)	missense	probably benign	0.07
R5384:Col11a2	UTSW	17	34,278,148 (GRCm39)	critical splice donor site	probably null
R5534:Col11a2	UTSW	17	34,269,998 (GRCm39)	missense	probably damaging	0.99
R5860:Col11a2	UTSW	17	34,283,159 (GRCm39)	unclassified	probably benign
R6252:Col11a2	UTSW	17	34,261,186 (GRCm39)	missense	probably null	0.00
R6327:Col11a2	UTSW	17	34,262,291 (GRCm39)	missense	probably benign	0.32
R6828:Col11a2	UTSW	17	34,272,607 (GRCm39)	splice site	probably null
R6860:Col11a2	UTSW	17	34,272,572 (GRCm39)	missense	probably damaging	1.00
R6873:Col11a2	UTSW	17	34,283,993 (GRCm39)	missense	unknown
R6992:Col11a2	UTSW	17	34,266,118 (GRCm39)	missense	probably benign	0.01
R7292:Col11a2	UTSW	17	34,270,482 (GRCm39)	missense	unknown
R7543:Col11a2	UTSW	17	34,269,430 (GRCm39)	missense	unknown
R7933:Col11a2	UTSW	17	34,275,029 (GRCm39)	nonsense	probably null
R8157:Col11a2	UTSW	17	34,280,230 (GRCm39)	missense	unknown
R8161:Col11a2	UTSW	17	34,270,264 (GRCm39)	missense	unknown
R8209:Col11a2	UTSW	17	34,266,253 (GRCm39)	critical splice donor site	probably null
R8493:Col11a2	UTSW	17	34,278,936 (GRCm39)	missense	possibly damaging	0.82
R8705:Col11a2	UTSW	17	34,268,769 (GRCm39)	missense	unknown
R8901:Col11a2	UTSW	17	34,262,254 (GRCm39)	missense	probably damaging	1.00
R8946:Col11a2	UTSW	17	34,270,757 (GRCm39)	missense	probably benign	0.40
R9010:Col11a2	UTSW	17	34,283,760 (GRCm39)	missense	unknown
R9108:Col11a2	UTSW	17	34,276,634 (GRCm39)	missense	probably benign	0.21
R9138:Col11a2	UTSW	17	34,279,847 (GRCm39)	missense
R9147:Col11a2	UTSW	17	34,273,119 (GRCm39)	splice site	probably benign
R9148:Col11a2	UTSW	17	34,273,119 (GRCm39)	splice site	probably benign
R9338:Col11a2	UTSW	17	34,266,204 (GRCm39)	missense	unknown
R9485:Col11a2	UTSW	17	34,258,669 (GRCm39)	missense	unknown
X0017:Col11a2	UTSW	17	34,278,959 (GRCm39)	critical splice donor site	probably null
X0064:Col11a2	UTSW	17	34,261,221 (GRCm39)	missense	possibly damaging	0.88
Z1176:Col11a2	UTSW	17	34,275,376 (GRCm39)	missense	unknown
Z1177:Col11a2	UTSW	17	34,270,640 (GRCm39)	missense	probably benign	0.40

Predicted Primers

PCR Primer
(F):5'- TGTGTTCAGATGTTCCCCATAC -3'
(R):5'- AGTGAGTCGCTTACCACAGG -3'

Sequencing Primer
(F):5'- TCTGTGCTGAGCCCCTG -3'
(R):5'- AGTCGCTTACCACAGGACCTG -3'

Posted On

2014-06-30