Incidental Mutation 'R1891:Tedc2'
ID 211546
Institutional Source Beutler Lab
Gene Symbol Tedc2
Ensembl Gene ENSMUSG00000024118
Gene Name tubulin epsilon and delta complex 2
Synonyms 1600002H07Rik
MMRRC Submission 039911-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.819) question?
Stock # R1891 (G1)
Quality Score 139
Status Not validated
Chromosome 17
Chromosomal Location 24434028-24439825 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 24435291 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 366 (E366V)
Ref Sequence ENSEMBL: ENSMUSP00000024930 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024930]
AlphaFold Q6GQV0
Predicted Effect probably damaging
Transcript: ENSMUST00000024930
AA Change: E366V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000024930
Gene: ENSMUSG00000024118
AA Change: E366V

DomainStartEndE-ValueType
low complexity region 32 49 N/A INTRINSIC
low complexity region 78 84 N/A INTRINSIC
low complexity region 111 131 N/A INTRINSIC
Pfam:DUF4693 150 434 8.6e-145 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124557
SMART Domains Protein: ENSMUSP00000119405
Gene: ENSMUSG00000024118

DomainStartEndE-ValueType
low complexity region 16 32 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137648
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137883
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138818
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148704
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149916
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171563
Meta Mutation Damage Score 0.4034 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.4%
  • 20x: 92.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 95 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T C 10: 79,840,874 (GRCm39) I921T possibly damaging Het
Abca8a T C 11: 109,982,433 (GRCm39) K3R probably benign Het
Adgrl3 A T 5: 81,659,891 (GRCm39) D152V probably damaging Het
Akap6 A T 12: 53,188,958 (GRCm39) D2124V possibly damaging Het
Akt1 A G 12: 112,626,009 (GRCm39) F88L probably damaging Het
Ankrd24 T C 10: 81,479,342 (GRCm39) probably benign Het
Arid4b T A 13: 14,310,821 (GRCm39) N141K possibly damaging Het
Cacna1c C A 6: 118,753,480 (GRCm39) D219Y probably damaging Het
Ccdc113 A G 8: 96,267,544 (GRCm39) K170E probably damaging Het
Ceacam9 A G 7: 16,457,880 (GRCm39) E136G probably damaging Het
Cfap43 A G 19: 47,802,380 (GRCm39) L333P probably damaging Het
Chl1 A G 6: 103,691,544 (GRCm39) D1062G possibly damaging Het
Cimip4 T A 15: 78,262,952 (GRCm39) D234V probably damaging Het
Ckb TCCACCACCA TCCACCA 12: 111,636,079 (GRCm39) probably benign Het
Clpp T A 17: 57,298,307 (GRCm39) V91E probably damaging Het
Cndp1 A T 18: 84,637,758 (GRCm39) H325Q probably null Het
Cngb3 A G 4: 19,366,446 (GRCm39) N169S probably benign Het
Cog6 A C 3: 52,890,601 (GRCm39) I613R probably benign Het
Creb3l1 A G 2: 91,817,385 (GRCm39) L376P probably damaging Het
Cry2 A T 2: 92,243,985 (GRCm39) V396D possibly damaging Het
Cxxc5 A G 18: 35,992,318 (GRCm39) M240V possibly damaging Het
Defa28 G A 8: 22,073,801 (GRCm39) C68Y probably damaging Het
Ecd A G 14: 20,388,227 (GRCm39) I187T probably damaging Het
Erg28 A G 12: 85,862,962 (GRCm39) S117P probably benign Het
Ergic2 A T 6: 148,084,577 (GRCm39) C319S probably damaging Het
Ess2 C T 16: 17,725,644 (GRCm39) W183* probably null Het
Evc2 A C 5: 37,549,423 (GRCm39) D773A probably damaging Het
Fam151b T A 13: 92,586,678 (GRCm39) T252S probably benign Het
Fbxo28 A T 1: 182,145,389 (GRCm39) M233K probably benign Het
Fbxw26 T G 9: 109,551,232 (GRCm39) D355A probably benign Het
Gm4884 G C 7: 40,692,539 (GRCm39) E169D possibly damaging Het
Hk2 C T 6: 82,726,264 (GRCm39) R94Q probably benign Het
Hps4 G A 5: 112,517,422 (GRCm39) probably null Het
Hspg2 T A 4: 137,292,801 (GRCm39) D4126E probably damaging Het
Kif13a T C 13: 47,082,695 (GRCm39) E48G possibly damaging Het
Krt31 T A 11: 99,938,634 (GRCm39) N320Y probably damaging Het
Lca5 T C 9: 83,277,661 (GRCm39) Y561C probably damaging Het
Lrrk1 G A 7: 65,929,048 (GRCm39) L1195F probably damaging Het
Ly6g6d A C 17: 35,293,269 (GRCm39) Y25* probably null Het
Map3k13 T G 16: 21,729,836 (GRCm39) M489R probably damaging Het
Mcm6 C T 1: 128,263,547 (GRCm39) R658H probably damaging Het
Mecp2 C T X: 73,080,781 (GRCm39) A79T probably damaging Het
Mitf A G 6: 97,918,237 (GRCm39) T94A probably benign Het
Mpo T A 11: 87,692,106 (GRCm39) L513* probably null Het
Mst1r T A 9: 107,790,661 (GRCm39) N722K probably damaging Het
Mthfd1l T A 10: 3,982,284 (GRCm39) L497* probably null Het
Mtus1 C T 8: 41,537,362 (GRCm39) S118N probably damaging Het
Mybbp1a C T 11: 72,336,863 (GRCm39) T565I probably benign Het
Naip2 C T 13: 100,291,395 (GRCm39) R1181K probably benign Het
Nbas T C 12: 13,440,973 (GRCm39) M1101T possibly damaging Het
Odad3 G T 9: 21,906,677 (GRCm39) probably null Het
Or2y1b T C 11: 49,208,684 (GRCm39) F104L probably benign Het
Or4f60 A T 2: 111,902,739 (GRCm39) L63Q probably damaging Het
Or52l1 A T 7: 104,829,754 (GRCm39) Y270* probably null Het
Or5ae1 T A 7: 84,565,461 (GRCm39) V158D possibly damaging Het
Or6c33 T C 10: 129,853,439 (GRCm39) S70P probably damaging Het
Or7a40 T A 16: 16,491,441 (GRCm39) I135F probably damaging Het
Or7g20 T C 9: 18,947,274 (GRCm39) L285S probably damaging Het
Or8b12b T A 9: 37,684,163 (GRCm39) D69E possibly damaging Het
Oxct2b A G 4: 123,010,938 (GRCm39) D286G probably benign Het
Pax5 A T 4: 44,691,859 (GRCm39) V129E probably damaging Het
Pax7 G A 4: 139,511,937 (GRCm39) R215C probably damaging Het
Pcdh7 A T 5: 57,878,217 (GRCm39) I591F probably damaging Het
Pcdhb22 T C 18: 37,652,357 (GRCm39) V275A probably damaging Het
Pkp3 C T 7: 140,663,969 (GRCm39) probably null Het
Plekhb1 A G 7: 100,304,599 (GRCm39) L35P probably damaging Het
Pole T A 5: 110,480,408 (GRCm39) F1993Y probably damaging Het
Pramel28 A T 4: 143,693,235 (GRCm39) V81E probably damaging Het
Prdx1 T C 4: 116,556,451 (GRCm39) *200R probably null Het
Prkdc C A 16: 15,543,300 (GRCm39) T1777N probably benign Het
Prss59 A T 6: 40,902,967 (GRCm39) M135K possibly damaging Het
Ptpn14 G A 1: 189,530,850 (GRCm39) V106M probably damaging Het
Ptpn23 T C 9: 110,222,868 (GRCm39) E63G possibly damaging Het
Qser1 A C 2: 104,620,444 (GRCm39) S123A probably benign Het
Rbm11 A G 16: 75,397,675 (GRCm39) N202D possibly damaging Het
Robo3 T A 9: 37,339,351 (GRCm39) Y212F probably damaging Het
Sde2 G A 1: 180,687,573 (GRCm39) S153N probably benign Het
Serpinb1c T A 13: 33,068,235 (GRCm39) D179V probably benign Het
Skint6 T C 4: 112,703,893 (GRCm39) D994G possibly damaging Het
Sorbs1 A G 19: 40,381,904 (GRCm39) S46P probably damaging Het
St8sia4 T C 1: 95,519,433 (GRCm39) T352A possibly damaging Het
Stab1 C A 14: 30,863,287 (GRCm39) R2133L probably benign Het
Stk11ip T C 1: 75,509,060 (GRCm39) C730R probably benign Het
Tle4 A T 19: 14,522,150 (GRCm39) probably null Het
Tmem200a T A 10: 25,869,970 (GRCm39) N100Y probably damaging Het
Tnnt2 A T 1: 135,768,597 (GRCm39) probably null Het
Ttn T A 2: 76,706,302 (GRCm39) probably benign Het
Ubac1 A G 2: 25,904,974 (GRCm39) V88A probably benign Het
Urgcp T C 11: 5,666,910 (GRCm39) E476G probably benign Het
Vmn1r201 G A 13: 22,659,425 (GRCm39) R213H probably benign Het
Vmn2r84 C T 10: 130,221,938 (GRCm39) V761M possibly damaging Het
Vwde A T 6: 13,187,454 (GRCm39) Y678N probably damaging Het
Wnk2 C A 13: 49,206,200 (GRCm39) E1865* probably null Het
Zc3h3 A C 15: 75,628,780 (GRCm39) M838R possibly damaging Het
Zfp959 T A 17: 56,204,604 (GRCm39) C211S probably damaging Het
Other mutations in Tedc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01963:Tedc2 APN 17 24,436,926 (GRCm39) missense probably benign 0.01
IGL02111:Tedc2 APN 17 24,437,140 (GRCm39) splice site probably benign
IGL02347:Tedc2 APN 17 24,439,584 (GRCm39) missense probably damaging 1.00
IGL03400:Tedc2 APN 17 24,438,777 (GRCm39) missense probably benign
R0766:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R0766:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1066:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1066:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1067:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1067:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1085:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1085:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1086:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1086:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1136:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1136:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1137:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1137:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1203:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1203:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1345:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1345:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1385:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1385:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1396:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1396:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1888:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1888:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1888:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1888:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1891:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1943:Tedc2 UTSW 17 24,436,923 (GRCm39) missense possibly damaging 0.90
R1984:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1984:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1985:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1985:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1986:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1986:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R2026:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R2026:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R2054:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R2054:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R2086:Tedc2 UTSW 17 24,436,874 (GRCm39) missense probably damaging 1.00
R2317:Tedc2 UTSW 17 24,435,358 (GRCm39) missense probably benign 0.00
R3705:Tedc2 UTSW 17 24,435,361 (GRCm39) missense probably benign 0.30
R4085:Tedc2 UTSW 17 24,438,813 (GRCm39) missense probably benign 0.01
R4664:Tedc2 UTSW 17 24,439,114 (GRCm39) splice site probably benign
R4676:Tedc2 UTSW 17 24,438,985 (GRCm39) missense probably benign
R4686:Tedc2 UTSW 17 24,436,862 (GRCm39) critical splice donor site probably null
R4762:Tedc2 UTSW 17 24,435,354 (GRCm39) missense probably benign 0.05
R4837:Tedc2 UTSW 17 24,439,567 (GRCm39) missense probably damaging 1.00
R4863:Tedc2 UTSW 17 24,436,910 (GRCm39) missense probably damaging 1.00
R5936:Tedc2 UTSW 17 24,435,315 (GRCm39) missense probably damaging 1.00
R9159:Tedc2 UTSW 17 24,436,705 (GRCm39) missense probably damaging 1.00
R9643:Tedc2 UTSW 17 24,435,328 (GRCm39) missense probably benign
RF031:Tedc2 UTSW 17 24,435,213 (GRCm39) critical splice donor site probably benign
Z1177:Tedc2 UTSW 17 24,439,545 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- AGGATGTCCCAGCTCACATG -3'
(R):5'- TGGCCTATAAGAAGAGAGACCTTG -3'

Sequencing Primer
(F):5'- CAGCTCACATGGAGGCCAAG -3'
(R):5'- AGACCTTGGTGATGGCTGTCAC -3'
Posted On 2014-06-30