Incidental Mutation 'R1894:Or7e177'
ID 211811
Institutional Source Beutler Lab
Gene Symbol Or7e177
Ensembl Gene ENSMUSG00000049028
Gene Name olfactory receptor family 7 subfamily E member 177
Synonyms Olfr873, GA_x6K02T2PVTD-14040245-14041204, MOR145-2
MMRRC Submission 039914-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R1894 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 20211507-20212466 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20211633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 47 (S47P)
Ref Sequence ENSEMBL: ENSMUSP00000075135 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053919] [ENSMUST00000075717] [ENSMUST00000215540]
AlphaFold E9PX82
Predicted Effect probably benign
Transcript: ENSMUST00000053919
AA Change: S43P

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000054778
Gene: ENSMUSG00000049028
AA Change: S43P

DomainStartEndE-ValueType
Pfam:7tm_4 41 317 1.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 45 315 1.6e-8 PFAM
Pfam:7tm_1 51 300 3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000075717
AA Change: S47P

PolyPhen 2 Score 0.232 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000075135
Gene: ENSMUSG00000049028
AA Change: S47P

DomainStartEndE-ValueType
Pfam:7tm_4 45 321 6.2e-43 PFAM
Pfam:7TM_GPCR_Srsx 49 309 3e-8 PFAM
Pfam:7tm_1 55 304 1.5e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212393
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213057
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213445
Predicted Effect probably benign
Transcript: ENSMUST00000215540
AA Change: S46P

PolyPhen 2 Score 0.068 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217193
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216567
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.8%
  • 10x: 95.4%
  • 20x: 93.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb2 T C 4: 129,907,419 (GRCm39) F977S probably damaging Het
Ago4 A G 4: 126,406,393 (GRCm39) Y306H probably benign Het
Cblc T C 7: 19,526,502 (GRCm39) T196A probably damaging Het
Cfap52 T A 11: 67,844,445 (GRCm39) probably null Het
Cops3 T C 11: 59,710,844 (GRCm39) N375S probably benign Het
Crb1 T C 1: 139,170,931 (GRCm39) T759A probably benign Het
Dnah3 T C 7: 119,685,557 (GRCm39) K153E probably benign Het
Elovl1 C T 4: 118,287,945 (GRCm39) S27F probably damaging Het
Erc2 A G 14: 27,863,185 (GRCm39) E804G probably damaging Het
Fam110b G T 4: 5,798,840 (GRCm39) C86F probably damaging Het
Fbn1 T A 2: 125,236,541 (GRCm39) R380W probably damaging Het
Gatad2a C T 8: 70,369,301 (GRCm39) R221Q probably damaging Het
Gcn1 C T 5: 115,727,174 (GRCm39) P677L probably damaging Het
Gm6020 C T 19: 61,172,391 (GRCm39) H22Y possibly damaging Het
Gm9817 T C 13: 45,232,605 (GRCm39) V136A unknown Het
Gmip T A 8: 70,273,622 (GRCm39) L971H probably damaging Het
Gnptab G A 10: 88,254,989 (GRCm39) E192K possibly damaging Het
Grm7 G A 6: 111,335,568 (GRCm39) V660I probably benign Het
Helz2 G A 2: 180,876,082 (GRCm39) P1471S probably damaging Het
Herc1 G A 9: 66,386,743 (GRCm39) G3786S probably damaging Het
Isg20 T C 7: 78,569,647 (GRCm39) V206A probably benign Het
Jund T A 8: 71,152,470 (GRCm39) I255N probably damaging Het
Kcnt2 A T 1: 140,353,079 (GRCm39) I263F probably damaging Het
Kif2c A T 4: 117,019,420 (GRCm39) L561Q probably benign Het
Klhl3 T C 13: 58,157,189 (GRCm39) D546G probably damaging Het
Klk1b4 A T 7: 43,859,054 (GRCm39) Q24L probably benign Het
Ltbp2 A T 12: 84,834,735 (GRCm39) C225S probably damaging Het
Mcub T C 3: 129,728,312 (GRCm39) H55R probably benign Het
Mecp2 C T X: 73,080,781 (GRCm39) A79T probably damaging Het
Med18 G A 4: 132,187,242 (GRCm39) R86* probably null Het
Mfsd2b T C 12: 4,919,155 (GRCm39) E63G probably damaging Het
Mtus1 C T 8: 41,537,362 (GRCm39) S118N probably damaging Het
Mybbp1a C T 11: 72,336,863 (GRCm39) T565I probably benign Het
Myo15b G A 11: 115,777,899 (GRCm39) G1049S probably damaging Het
Nfrkb T A 9: 31,326,064 (GRCm39) V1169E probably benign Het
Nr2f2 T A 7: 70,004,419 (GRCm39) M411L probably benign Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Nup214 A T 2: 31,886,392 (GRCm39) T585S possibly damaging Het
Or5m13 C T 2: 85,748,599 (GRCm39) T110I probably benign Het
Or6c214 A T 10: 129,590,943 (GRCm39) C125* probably null Het
Or8b12b T A 9: 37,684,163 (GRCm39) D69E possibly damaging Het
Pih1d1 T A 7: 44,807,165 (GRCm39) I166N probably damaging Het
Prl2c5 T C 13: 13,366,263 (GRCm39) F181L probably benign Het
Prx C T 7: 27,218,535 (GRCm39) T1012I possibly damaging Het
Rassf8 T A 6: 145,754,199 (GRCm39) V5E probably damaging Het
Rassf9 C A 10: 102,380,755 (GRCm39) R44S possibly damaging Het
Relch A T 1: 105,592,301 (GRCm39) I157F probably benign Het
Sde2 G A 1: 180,687,573 (GRCm39) S153N probably benign Het
Sec16b T A 1: 157,380,545 (GRCm39) M372K possibly damaging Het
Sgcd A T 11: 47,085,937 (GRCm39) I71N probably damaging Het
Slco5a1 C T 1: 12,942,483 (GRCm39) C721Y probably damaging Het
Slx4ip A T 2: 136,910,038 (GRCm39) K344N probably benign Het
Sorcs3 A T 19: 48,782,713 (GRCm39) Q1076L probably benign Het
Spata21 A T 4: 140,838,692 (GRCm39) N581I possibly damaging Het
Spata31d1d G T 13: 59,875,936 (GRCm39) P533H probably benign Het
Spice1 T G 16: 44,185,989 (GRCm39) S111A probably damaging Het
Tex14 T G 11: 87,365,274 (GRCm39) F61V probably damaging Het
Timp3 C T 10: 86,181,716 (GRCm39) R196* probably null Het
Tll2 A G 19: 41,077,110 (GRCm39) probably null Het
Tppp A G 13: 74,169,326 (GRCm39) D22G possibly damaging Het
Trim24 G T 6: 37,934,013 (GRCm39) R652L probably damaging Het
Uaca T C 9: 60,777,718 (GRCm39) S702P possibly damaging Het
Uggt2 T C 14: 119,287,130 (GRCm39) E146G probably damaging Het
Vmn1r233 T C 17: 21,213,994 (GRCm39) S319G probably benign Het
Wdr47 A T 3: 108,530,692 (GRCm39) Q395L possibly damaging Het
Wrnip1 A G 13: 32,989,319 (GRCm39) probably null Het
Zfp420 A T 7: 29,573,933 (GRCm39) H51L probably damaging Het
Other mutations in Or7e177
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02122:Or7e177 APN 9 20,211,880 (GRCm39) missense probably damaging 1.00
IGL02268:Or7e177 APN 9 20,211,588 (GRCm39) missense probably damaging 1.00
IGL02416:Or7e177 APN 9 20,211,541 (GRCm39) missense probably benign 0.01
IGL03124:Or7e177 APN 9 20,212,459 (GRCm39) missense probably benign 0.00
R0147:Or7e177 UTSW 9 20,212,387 (GRCm39) missense probably damaging 1.00
R0148:Or7e177 UTSW 9 20,212,387 (GRCm39) missense probably damaging 1.00
R0266:Or7e177 UTSW 9 20,212,454 (GRCm39) missense probably benign 0.01
R0831:Or7e177 UTSW 9 20,211,861 (GRCm39) missense probably benign 0.20
R1456:Or7e177 UTSW 9 20,212,134 (GRCm39) missense probably benign 0.35
R1928:Or7e177 UTSW 9 20,212,354 (GRCm39) missense probably benign 0.12
R2135:Or7e177 UTSW 9 20,211,593 (GRCm39) missense probably benign 0.00
R2379:Or7e177 UTSW 9 20,211,963 (GRCm39) missense possibly damaging 0.87
R2911:Or7e177 UTSW 9 20,211,775 (GRCm39) missense possibly damaging 0.60
R3788:Or7e177 UTSW 9 20,211,666 (GRCm39) missense probably benign 0.13
R4657:Or7e177 UTSW 9 20,211,919 (GRCm39) missense probably damaging 1.00
R5754:Or7e177 UTSW 9 20,212,390 (GRCm39) missense probably damaging 1.00
R6291:Or7e177 UTSW 9 20,211,899 (GRCm39) missense probably damaging 1.00
R6410:Or7e177 UTSW 9 20,211,748 (GRCm39) missense probably damaging 1.00
R7014:Or7e177 UTSW 9 20,211,959 (GRCm39) nonsense probably null
R7521:Or7e177 UTSW 9 20,212,036 (GRCm39) missense probably benign 0.00
R8201:Or7e177 UTSW 9 20,212,317 (GRCm39) missense probably damaging 1.00
R8355:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8455:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8523:Or7e177 UTSW 9 20,212,093 (GRCm39) missense probably benign 0.10
R8874:Or7e177 UTSW 9 20,212,069 (GRCm39) missense possibly damaging 0.95
R9283:Or7e177 UTSW 9 20,212,419 (GRCm39) missense possibly damaging 0.61
R9397:Or7e177 UTSW 9 20,211,748 (GRCm39) missense possibly damaging 0.50
R9595:Or7e177 UTSW 9 20,211,661 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAAAATACAGTGTCGAGTGATAG -3'
(R):5'- GGCCATCACAGTCAGAAGCAAG -3'

Sequencing Primer
(F):5'- CAGTGTCGAGTGATAGTAAACTTCTG -3'
(R):5'- TCTGTGTAAGGCATCCCACATAG -3'
Posted On 2014-06-30