Incidental Mutation 'R1888:Rapgef6'
ID |
211910 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Rapgef6
|
Ensembl Gene |
ENSMUSG00000037533 |
Gene Name |
Rap guanine nucleotide exchange factor (GEF) 6 |
Synonyms |
PDZ-GEF2, C030018K18Rik, Pdzgef2, RA-GEF-2 |
MMRRC Submission |
039909-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R1888 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
11 |
Chromosomal Location |
54413673-54590111 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 54551654 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Proline
at position 836
(T836P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000099804
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094536]
[ENSMUST00000101206]
[ENSMUST00000102743]
[ENSMUST00000108894]
[ENSMUST00000207429]
|
AlphaFold |
Q5NCJ1 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000094536
AA Change: T551P
PolyPhen 2
Score 0.693 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000092114 Gene: ENSMUSG00000037533 AA Change: T551P
Domain | Start | End | E-Value | Type |
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
RA
|
464 |
550 |
1.47e-20 |
SMART |
RasGEF
|
571 |
853 |
3.88e-84 |
SMART |
low complexity region
|
944 |
957 |
N/A |
INTRINSIC |
low complexity region
|
972 |
989 |
N/A |
INTRINSIC |
low complexity region
|
1016 |
1061 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000101206
AA Change: T836P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000098766 Gene: ENSMUSG00000037533 AA Change: T836P
Domain | Start | End | E-Value | Type |
internal_repeat_1
|
10 |
82 |
1.45e-5 |
PROSPERO |
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
RA
|
749 |
835 |
1.47e-20 |
SMART |
RasGEF
|
856 |
1095 |
5.35e-87 |
SMART |
low complexity region
|
1237 |
1250 |
N/A |
INTRINSIC |
low complexity region
|
1270 |
1293 |
N/A |
INTRINSIC |
low complexity region
|
1345 |
1364 |
N/A |
INTRINSIC |
low complexity region
|
1368 |
1380 |
N/A |
INTRINSIC |
low complexity region
|
1444 |
1452 |
N/A |
INTRINSIC |
low complexity region
|
1555 |
1568 |
N/A |
INTRINSIC |
low complexity region
|
1591 |
1604 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000102743
AA Change: T836P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000099804 Gene: ENSMUSG00000037533 AA Change: T836P
Domain | Start | End | E-Value | Type |
internal_repeat_1
|
10 |
82 |
1.42e-5 |
PROSPERO |
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
RA
|
749 |
835 |
1.47e-20 |
SMART |
RasGEF
|
856 |
1138 |
3.88e-84 |
SMART |
low complexity region
|
1229 |
1242 |
N/A |
INTRINSIC |
low complexity region
|
1262 |
1285 |
N/A |
INTRINSIC |
low complexity region
|
1337 |
1356 |
N/A |
INTRINSIC |
low complexity region
|
1360 |
1372 |
N/A |
INTRINSIC |
low complexity region
|
1436 |
1444 |
N/A |
INTRINSIC |
low complexity region
|
1547 |
1560 |
N/A |
INTRINSIC |
low complexity region
|
1583 |
1596 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000108894
AA Change: T551P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000104522 Gene: ENSMUSG00000037533 AA Change: T551P
Domain | Start | End | E-Value | Type |
cNMP
|
1 |
113 |
6.64e-7 |
SMART |
RasGEFN
|
127 |
240 |
4.35e-33 |
SMART |
PDZ
|
255 |
327 |
8.86e-16 |
SMART |
low complexity region
|
409 |
420 |
N/A |
INTRINSIC |
RA
|
464 |
550 |
1.47e-20 |
SMART |
RasGEF
|
571 |
810 |
5.35e-87 |
SMART |
low complexity region
|
952 |
965 |
N/A |
INTRINSIC |
low complexity region
|
980 |
997 |
N/A |
INTRINSIC |
low complexity region
|
1024 |
1069 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175600
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000207429
AA Change: T841P
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
Meta Mutation Damage Score |
0.1046 |
Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.4%
- 20x: 92.9%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production. [provided by MGI curators]
|
Allele List at MGI |
All alleles(16) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(13) |
Other mutations in this stock |
Total: 87 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930447C04Rik |
A |
G |
12: 72,960,030 (GRCm39) |
M80T |
unknown |
Het |
4930578I06Rik |
A |
G |
14: 64,223,632 (GRCm39) |
L48P |
probably damaging |
Het |
Abcc9 |
A |
G |
6: 142,625,040 (GRCm39) |
S452P |
probably benign |
Het |
Adgrb2 |
T |
C |
4: 129,907,419 (GRCm39) |
F977S |
probably damaging |
Het |
Adgrf5 |
T |
G |
17: 43,737,896 (GRCm39) |
|
probably null |
Het |
Adgrl4 |
A |
G |
3: 151,144,914 (GRCm39) |
N21S |
probably benign |
Het |
Adss2 |
A |
T |
1: 177,612,517 (GRCm39) |
Y77* |
probably null |
Het |
Ahnak |
A |
T |
19: 8,984,452 (GRCm39) |
D1912V |
probably damaging |
Het |
Ahnak2 |
A |
G |
12: 112,740,325 (GRCm39) |
M1249T |
possibly damaging |
Het |
Akap6 |
A |
T |
12: 53,188,958 (GRCm39) |
D2124V |
possibly damaging |
Het |
Bbs12 |
C |
A |
3: 37,374,712 (GRCm39) |
L387I |
probably damaging |
Het |
Ciita |
T |
C |
16: 10,328,948 (GRCm39) |
Y411H |
probably damaging |
Het |
Ckb |
TCCACCACCA |
TCCACCA |
12: 111,636,079 (GRCm39) |
|
probably benign |
Het |
Clec9a |
G |
A |
6: 129,387,249 (GRCm39) |
V35I |
probably benign |
Het |
Cntn5 |
T |
A |
9: 9,984,082 (GRCm39) |
Q382L |
possibly damaging |
Het |
Cracdl |
T |
C |
1: 37,663,364 (GRCm39) |
K845E |
possibly damaging |
Het |
Dock2 |
A |
T |
11: 34,598,169 (GRCm39) |
I334N |
probably damaging |
Het |
Dock9 |
G |
T |
14: 121,862,617 (GRCm39) |
T833K |
probably benign |
Het |
Drd2 |
G |
A |
9: 49,313,442 (GRCm39) |
V204I |
probably benign |
Het |
Fam120a |
A |
T |
13: 49,039,342 (GRCm39) |
I938N |
possibly damaging |
Het |
Fndc1 |
T |
C |
17: 7,990,621 (GRCm39) |
E1025G |
unknown |
Het |
Fsip2 |
G |
A |
2: 82,774,504 (GRCm39) |
D64N |
probably benign |
Het |
Gm14496 |
T |
A |
2: 181,641,989 (GRCm39) |
C553* |
probably null |
Het |
Gm6020 |
C |
T |
19: 61,172,391 (GRCm39) |
H22Y |
possibly damaging |
Het |
Hexa |
A |
G |
9: 59,464,586 (GRCm39) |
T159A |
probably benign |
Het |
Hmcn1 |
C |
G |
1: 150,695,251 (GRCm39) |
A218P |
possibly damaging |
Het |
Hpgds |
A |
G |
6: 65,115,217 (GRCm39) |
F22S |
probably damaging |
Het |
Il5ra |
T |
A |
6: 106,708,874 (GRCm39) |
N289Y |
probably damaging |
Het |
Irf2 |
A |
T |
8: 47,260,388 (GRCm39) |
R107* |
probably null |
Het |
Kcnk6 |
T |
C |
7: 28,925,075 (GRCm39) |
I180M |
probably benign |
Het |
Krtap5-3 |
G |
A |
7: 141,755,979 (GRCm39) |
|
probably benign |
Het |
Lrig1 |
C |
T |
6: 94,631,859 (GRCm39) |
A114T |
probably benign |
Het |
Lrrc37a |
A |
G |
11: 103,389,587 (GRCm39) |
V1946A |
probably benign |
Het |
Lrrc8b |
T |
C |
5: 105,629,217 (GRCm39) |
V521A |
probably benign |
Het |
Macf1 |
T |
G |
4: 123,348,835 (GRCm39) |
I2154L |
possibly damaging |
Het |
Macf1 |
C |
A |
4: 123,368,505 (GRCm39) |
E2085D |
probably benign |
Het |
Maml1 |
C |
T |
11: 50,157,468 (GRCm39) |
A236T |
probably benign |
Het |
Mdc1 |
C |
A |
17: 36,165,117 (GRCm39) |
T1481K |
probably benign |
Het |
Mecp2 |
C |
T |
X: 73,080,781 (GRCm39) |
A79T |
probably damaging |
Het |
Mfap3l |
T |
C |
8: 61,124,424 (GRCm39) |
V222A |
possibly damaging |
Het |
Mis18bp1 |
A |
G |
12: 65,196,102 (GRCm39) |
I554T |
probably benign |
Het |
Mpped2 |
T |
C |
2: 106,529,790 (GRCm39) |
I13T |
probably benign |
Het |
Mthfd1l |
C |
A |
10: 4,056,528 (GRCm39) |
T948K |
probably damaging |
Het |
Mtus1 |
C |
T |
8: 41,537,362 (GRCm39) |
S118N |
probably damaging |
Het |
Mtx3 |
A |
G |
13: 92,984,191 (GRCm39) |
E156G |
probably benign |
Het |
Mybbp1a |
C |
T |
11: 72,336,863 (GRCm39) |
T565I |
probably benign |
Het |
Myh2 |
G |
A |
11: 67,071,676 (GRCm39) |
V498M |
probably damaging |
Het |
Myo15b |
G |
A |
11: 115,777,899 (GRCm39) |
G1049S |
probably damaging |
Het |
Myo1b |
T |
A |
1: 51,799,562 (GRCm39) |
|
probably null |
Het |
Ndufa2 |
T |
A |
18: 36,877,573 (GRCm39) |
|
probably benign |
Het |
Nipal2 |
T |
C |
15: 34,625,167 (GRCm39) |
I129M |
possibly damaging |
Het |
Nt5dc3 |
A |
G |
10: 86,669,926 (GRCm39) |
N507S |
possibly damaging |
Het |
Or4b12 |
A |
G |
2: 90,095,913 (GRCm39) |
L287P |
probably damaging |
Het |
Or8b12b |
T |
A |
9: 37,684,163 (GRCm39) |
D69E |
possibly damaging |
Het |
Pcdhb17 |
G |
A |
18: 37,620,438 (GRCm39) |
|
probably null |
Het |
Pcyt2 |
A |
G |
11: 120,508,677 (GRCm39) |
M1T |
probably null |
Het |
Pla2g2d |
T |
C |
4: 138,503,126 (GRCm39) |
M1T |
probably null |
Het |
Plekhg6 |
T |
C |
6: 125,340,306 (GRCm39) |
T685A |
probably damaging |
Het |
Pramel19 |
T |
A |
4: 101,798,335 (GRCm39) |
V102E |
probably damaging |
Het |
Pwwp4a |
G |
T |
X: 72,171,261 (GRCm39) |
G218C |
probably damaging |
Het |
Pxk |
T |
C |
14: 8,151,540 (GRCm38) |
S452P |
probably damaging |
Het |
Rab42 |
A |
T |
4: 132,030,529 (GRCm39) |
D40E |
probably benign |
Het |
Serpina3a |
A |
G |
12: 104,082,362 (GRCm39) |
D45G |
probably benign |
Het |
Sntb1 |
T |
A |
15: 55,612,745 (GRCm39) |
R278* |
probably null |
Het |
Spice1 |
T |
G |
16: 44,185,989 (GRCm39) |
S111A |
probably damaging |
Het |
Stk40 |
T |
A |
4: 126,019,538 (GRCm39) |
L90Q |
probably damaging |
Het |
Syk |
A |
G |
13: 52,794,826 (GRCm39) |
Y520C |
probably damaging |
Het |
Syngr2 |
G |
A |
11: 117,704,224 (GRCm39) |
V170M |
possibly damaging |
Het |
Tcf12 |
A |
T |
9: 71,765,816 (GRCm39) |
D541E |
possibly damaging |
Het |
Tedc2 |
T |
A |
17: 24,435,291 (GRCm39) |
E366V |
probably damaging |
Het |
Tedc2 |
C |
A |
17: 24,435,292 (GRCm39) |
E366* |
probably null |
Het |
Tlr4 |
T |
C |
4: 66,759,409 (GRCm39) |
V734A |
probably damaging |
Het |
Tmem132a |
T |
C |
19: 10,840,863 (GRCm39) |
E389G |
probably damaging |
Het |
Tmem150b |
A |
G |
7: 4,712,044 (GRCm39) |
I112T |
probably benign |
Het |
Tril |
A |
G |
6: 53,796,577 (GRCm39) |
L215P |
probably damaging |
Het |
Trim24 |
G |
T |
6: 37,934,013 (GRCm39) |
R652L |
probably damaging |
Het |
Ttn |
G |
A |
2: 76,623,151 (GRCm39) |
P15429S |
probably damaging |
Het |
Ttn |
T |
A |
2: 76,706,302 (GRCm39) |
|
probably benign |
Het |
Tubgcp2 |
A |
G |
7: 139,579,183 (GRCm39) |
V701A |
probably damaging |
Het |
Tubgcp2 |
A |
G |
7: 139,586,069 (GRCm39) |
F407L |
probably damaging |
Het |
Vmn1r30 |
A |
C |
6: 58,412,475 (GRCm39) |
L119R |
possibly damaging |
Het |
Washc5 |
A |
C |
15: 59,231,174 (GRCm39) |
L363R |
probably damaging |
Het |
Zan |
T |
C |
5: 137,387,590 (GRCm39) |
T4874A |
unknown |
Het |
Zfp420 |
A |
T |
7: 29,573,933 (GRCm39) |
H51L |
probably damaging |
Het |
Zfp512b |
C |
A |
2: 181,230,235 (GRCm39) |
R497L |
probably damaging |
Het |
Zmat4 |
A |
G |
8: 24,505,177 (GRCm39) |
N139S |
probably damaging |
Het |
Zng1 |
A |
T |
19: 24,932,769 (GRCm39) |
V88D |
probably damaging |
Het |
|
Other mutations in Rapgef6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00436:Rapgef6
|
APN |
11 |
54,570,091 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00507:Rapgef6
|
APN |
11 |
54,554,935 (GRCm39) |
nonsense |
probably null |
|
IGL00809:Rapgef6
|
APN |
11 |
54,540,126 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00843:Rapgef6
|
APN |
11 |
54,582,099 (GRCm39) |
missense |
probably benign |
0.03 |
IGL00899:Rapgef6
|
APN |
11 |
54,510,844 (GRCm39) |
nonsense |
probably null |
|
IGL01372:Rapgef6
|
APN |
11 |
54,559,437 (GRCm39) |
splice site |
probably benign |
|
IGL01604:Rapgef6
|
APN |
11 |
54,585,389 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01935:Rapgef6
|
APN |
11 |
54,501,668 (GRCm39) |
missense |
possibly damaging |
0.78 |
IGL01991:Rapgef6
|
APN |
11 |
54,443,695 (GRCm39) |
missense |
probably benign |
0.37 |
IGL02243:Rapgef6
|
APN |
11 |
54,567,226 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02407:Rapgef6
|
APN |
11 |
54,567,181 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL02676:Rapgef6
|
APN |
11 |
54,540,172 (GRCm39) |
unclassified |
probably benign |
|
IGL02934:Rapgef6
|
APN |
11 |
54,516,690 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03076:Rapgef6
|
APN |
11 |
54,516,793 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03110:Rapgef6
|
APN |
11 |
54,586,915 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL03256:Rapgef6
|
APN |
11 |
54,548,255 (GRCm39) |
missense |
probably damaging |
1.00 |
shocker
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
D4216:Rapgef6
|
UTSW |
11 |
54,559,572 (GRCm39) |
splice site |
probably benign |
|
PIT4305001:Rapgef6
|
UTSW |
11 |
54,570,203 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4366001:Rapgef6
|
UTSW |
11 |
54,582,446 (GRCm39) |
missense |
probably damaging |
0.98 |
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
R0125:Rapgef6
|
UTSW |
11 |
54,516,701 (GRCm39) |
nonsense |
probably null |
|
R0189:Rapgef6
|
UTSW |
11 |
54,582,075 (GRCm39) |
missense |
probably benign |
|
R0201:Rapgef6
|
UTSW |
11 |
54,510,767 (GRCm39) |
missense |
probably damaging |
1.00 |
R0505:Rapgef6
|
UTSW |
11 |
54,516,789 (GRCm39) |
missense |
probably benign |
0.00 |
R0524:Rapgef6
|
UTSW |
11 |
54,581,110 (GRCm39) |
missense |
probably benign |
0.32 |
R0853:Rapgef6
|
UTSW |
11 |
54,559,503 (GRCm39) |
missense |
probably damaging |
1.00 |
R1203:Rapgef6
|
UTSW |
11 |
54,582,525 (GRCm39) |
missense |
probably benign |
0.09 |
R1440:Rapgef6
|
UTSW |
11 |
54,517,534 (GRCm39) |
missense |
probably damaging |
1.00 |
R1453:Rapgef6
|
UTSW |
11 |
54,530,553 (GRCm39) |
splice site |
probably null |
|
R1530:Rapgef6
|
UTSW |
11 |
54,552,009 (GRCm39) |
missense |
probably damaging |
1.00 |
R1593:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1620:Rapgef6
|
UTSW |
11 |
54,517,420 (GRCm39) |
missense |
possibly damaging |
0.88 |
R1628:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1629:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1630:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1634:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1640:Rapgef6
|
UTSW |
11 |
54,548,231 (GRCm39) |
missense |
probably damaging |
1.00 |
R1686:Rapgef6
|
UTSW |
11 |
54,582,458 (GRCm39) |
missense |
possibly damaging |
0.81 |
R1722:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1743:Rapgef6
|
UTSW |
11 |
54,567,110 (GRCm39) |
missense |
probably damaging |
1.00 |
R1816:Rapgef6
|
UTSW |
11 |
54,585,314 (GRCm39) |
missense |
probably benign |
|
R1851:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
R1852:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
R1868:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
R1942:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1943:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
R2031:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.30 |
R2087:Rapgef6
|
UTSW |
11 |
54,522,075 (GRCm39) |
missense |
probably damaging |
1.00 |
R2106:Rapgef6
|
UTSW |
11 |
54,559,512 (GRCm39) |
missense |
probably benign |
0.17 |
R2362:Rapgef6
|
UTSW |
11 |
54,585,098 (GRCm39) |
missense |
probably damaging |
1.00 |
R2484:Rapgef6
|
UTSW |
11 |
54,533,582 (GRCm39) |
missense |
possibly damaging |
0.48 |
R2566:Rapgef6
|
UTSW |
11 |
54,578,537 (GRCm39) |
missense |
possibly damaging |
0.66 |
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R3744:Rapgef6
|
UTSW |
11 |
54,516,760 (GRCm39) |
missense |
probably benign |
0.40 |
R3848:Rapgef6
|
UTSW |
11 |
54,582,134 (GRCm39) |
missense |
probably damaging |
0.97 |
R4823:Rapgef6
|
UTSW |
11 |
54,585,326 (GRCm39) |
missense |
probably benign |
0.08 |
R4859:Rapgef6
|
UTSW |
11 |
54,526,989 (GRCm39) |
missense |
probably benign |
|
R4906:Rapgef6
|
UTSW |
11 |
54,443,662 (GRCm39) |
missense |
probably damaging |
1.00 |
R4911:Rapgef6
|
UTSW |
11 |
54,513,143 (GRCm39) |
missense |
probably damaging |
0.97 |
R4937:Rapgef6
|
UTSW |
11 |
54,548,143 (GRCm39) |
missense |
probably damaging |
1.00 |
R5033:Rapgef6
|
UTSW |
11 |
54,582,207 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5249:Rapgef6
|
UTSW |
11 |
54,413,943 (GRCm39) |
missense |
probably benign |
0.19 |
R5304:Rapgef6
|
UTSW |
11 |
54,548,200 (GRCm39) |
missense |
probably benign |
0.01 |
R5656:Rapgef6
|
UTSW |
11 |
54,526,962 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5701:Rapgef6
|
UTSW |
11 |
54,567,220 (GRCm39) |
missense |
possibly damaging |
0.76 |
R5758:Rapgef6
|
UTSW |
11 |
54,559,470 (GRCm39) |
missense |
probably damaging |
1.00 |
R5973:Rapgef6
|
UTSW |
11 |
54,530,609 (GRCm39) |
missense |
probably damaging |
1.00 |
R6177:Rapgef6
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
R6268:Rapgef6
|
UTSW |
11 |
54,540,073 (GRCm39) |
missense |
probably damaging |
1.00 |
R6287:Rapgef6
|
UTSW |
11 |
54,517,164 (GRCm39) |
splice site |
probably null |
|
R6293:Rapgef6
|
UTSW |
11 |
54,525,607 (GRCm39) |
missense |
probably damaging |
1.00 |
R6471:Rapgef6
|
UTSW |
11 |
54,582,563 (GRCm39) |
missense |
probably damaging |
0.99 |
R6863:Rapgef6
|
UTSW |
11 |
54,437,206 (GRCm39) |
missense |
probably benign |
0.00 |
R6950:Rapgef6
|
UTSW |
11 |
54,567,206 (GRCm39) |
missense |
probably benign |
0.09 |
R7144:Rapgef6
|
UTSW |
11 |
54,548,191 (GRCm39) |
missense |
possibly damaging |
0.78 |
R7171:Rapgef6
|
UTSW |
11 |
54,567,189 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7199:Rapgef6
|
UTSW |
11 |
54,437,252 (GRCm39) |
missense |
probably benign |
0.00 |
R7291:Rapgef6
|
UTSW |
11 |
54,582,065 (GRCm39) |
missense |
probably benign |
0.05 |
R7436:Rapgef6
|
UTSW |
11 |
54,501,747 (GRCm39) |
critical splice donor site |
probably null |
|
R7498:Rapgef6
|
UTSW |
11 |
54,510,830 (GRCm39) |
missense |
probably damaging |
1.00 |
R7506:Rapgef6
|
UTSW |
11 |
54,526,997 (GRCm39) |
missense |
probably benign |
0.00 |
R7527:Rapgef6
|
UTSW |
11 |
54,525,787 (GRCm39) |
missense |
unknown |
|
R7646:Rapgef6
|
UTSW |
11 |
54,516,780 (GRCm39) |
missense |
probably benign |
0.00 |
R7655:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
R7656:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
R7687:Rapgef6
|
UTSW |
11 |
54,551,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7768:Rapgef6
|
UTSW |
11 |
54,517,414 (GRCm39) |
missense |
probably damaging |
1.00 |
R7788:Rapgef6
|
UTSW |
11 |
54,585,225 (GRCm39) |
missense |
probably damaging |
1.00 |
R7890:Rapgef6
|
UTSW |
11 |
54,517,549 (GRCm39) |
missense |
probably damaging |
1.00 |
R8113:Rapgef6
|
UTSW |
11 |
54,516,784 (GRCm39) |
missense |
probably benign |
0.03 |
R8337:Rapgef6
|
UTSW |
11 |
54,522,127 (GRCm39) |
nonsense |
probably null |
|
R8393:Rapgef6
|
UTSW |
11 |
54,578,487 (GRCm39) |
missense |
probably benign |
|
R8465:Rapgef6
|
UTSW |
11 |
54,582,308 (GRCm39) |
missense |
probably benign |
0.00 |
R8492:Rapgef6
|
UTSW |
11 |
54,581,063 (GRCm39) |
missense |
probably damaging |
0.99 |
R8791:Rapgef6
|
UTSW |
11 |
54,459,295 (GRCm39) |
missense |
probably benign |
0.15 |
R8866:Rapgef6
|
UTSW |
11 |
54,443,700 (GRCm39) |
critical splice donor site |
probably null |
|
R8917:Rapgef6
|
UTSW |
11 |
54,582,392 (GRCm39) |
nonsense |
probably null |
|
R8921:Rapgef6
|
UTSW |
11 |
54,570,065 (GRCm39) |
missense |
probably benign |
0.09 |
R9031:Rapgef6
|
UTSW |
11 |
54,578,667 (GRCm39) |
missense |
probably benign |
0.00 |
R9093:Rapgef6
|
UTSW |
11 |
54,487,912 (GRCm39) |
nonsense |
probably null |
|
R9354:Rapgef6
|
UTSW |
11 |
54,510,749 (GRCm39) |
missense |
possibly damaging |
0.66 |
R9514:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.14 |
R9516:Rapgef6
|
UTSW |
11 |
54,582,169 (GRCm39) |
missense |
probably damaging |
1.00 |
R9739:Rapgef6
|
UTSW |
11 |
54,513,189 (GRCm39) |
missense |
probably benign |
0.03 |
R9789:Rapgef6
|
UTSW |
11 |
54,540,097 (GRCm39) |
missense |
probably benign |
0.03 |
|
Predicted Primers |
PCR Primer
(F):5'- TGATGGTTCACACATGCAAGTAG -3'
(R):5'- AGGCAACCCAGAATGTCTCTTG -3'
Sequencing Primer
(F):5'- GCAAGTAGTTTCTTAAAATGACTGAC -3'
(R):5'- GCAACCCAGAATGTCTCTTGGTTTAC -3'
|
Posted On |
2014-06-30 |