Incidental Mutation 'R0076:Crlf3'
ID |
212562 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Crlf3
|
Ensembl Gene |
ENSMUSG00000017561 |
Gene Name |
cytokine receptor-like factor 3 |
Synonyms |
Creme9, cytor4 |
MMRRC Submission |
038363-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R0076 (G1)
|
Quality Score |
33 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
79937319-79971817 bp(-) (GRCm39) |
Type of Mutation |
unclassified |
DNA Base Change (assembly) |
A to T
at 79947427 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000137124
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061283]
[ENSMUST00000103233]
[ENSMUST00000177825]
[ENSMUST00000178893]
[ENSMUST00000179855]
|
AlphaFold |
Q9Z2L7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000061283
|
SMART Domains |
Protein: ENSMUSP00000060028 Gene: ENSMUSG00000017561
Domain | Start | End | E-Value | Type |
coiled coil region
|
10 |
43 |
N/A |
INTRINSIC |
low complexity region
|
112 |
124 |
N/A |
INTRINSIC |
FN3
|
179 |
260 |
1.66e0 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000092858
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000103233
|
SMART Domains |
Protein: ENSMUSP00000099523 Gene: ENSMUSG00000017561
Domain | Start | End | E-Value | Type |
coiled coil region
|
10 |
43 |
N/A |
INTRINSIC |
low complexity region
|
112 |
124 |
N/A |
INTRINSIC |
FN3
|
179 |
260 |
1.66e0 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147164
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000177825
|
SMART Domains |
Protein: ENSMUSP00000136473 Gene: ENSMUSG00000017561
Domain | Start | End | E-Value | Type |
coiled coil region
|
10 |
43 |
N/A |
INTRINSIC |
low complexity region
|
112 |
124 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000178893
|
SMART Domains |
Protein: ENSMUSP00000137371 Gene: ENSMUSG00000017561
Domain | Start | End | E-Value | Type |
coiled coil region
|
10 |
39 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000179855
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.9%
- 10x: 97.7%
- 20x: 96.0%
|
Validation Efficiency |
100% (50/50) |
MGI Phenotype |
FUNCTION: This gene encodes a cytokine receptor-like factor that contains a fibronectin type 3 domain. The encoded protein may act as a negative regulator of the cell cycle. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level. [provided by MGI curators]
|
Allele List at MGI |
All alleles(39) : Targeted, other(2) Gene trapped(37) |
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acp3 |
A |
G |
9: 104,201,417 (GRCm39) |
|
probably benign |
Het |
Ankrd17 |
T |
A |
5: 90,392,265 (GRCm39) |
K1693* |
probably null |
Het |
Car10 |
G |
A |
11: 93,381,423 (GRCm39) |
E129K |
possibly damaging |
Het |
Ccnd1 |
A |
C |
7: 144,493,402 (GRCm39) |
V10G |
probably benign |
Het |
Cd19 |
T |
C |
7: 126,010,034 (GRCm39) |
D406G |
probably damaging |
Het |
Cfap91 |
G |
A |
16: 38,123,046 (GRCm39) |
Q661* |
probably null |
Het |
Col4a1 |
G |
A |
8: 11,268,713 (GRCm39) |
P1009L |
probably damaging |
Het |
Col9a1 |
G |
A |
1: 24,276,578 (GRCm39) |
|
probably null |
Het |
Dock3 |
A |
C |
9: 106,788,685 (GRCm39) |
|
probably benign |
Het |
Dus1l |
A |
T |
11: 120,683,634 (GRCm39) |
|
probably benign |
Het |
Dvl2 |
G |
A |
11: 69,898,926 (GRCm39) |
E438K |
probably damaging |
Het |
Eif3g |
A |
G |
9: 20,809,049 (GRCm39) |
F85S |
probably damaging |
Het |
Fam234b |
A |
G |
6: 135,204,224 (GRCm39) |
M456V |
probably benign |
Het |
Fbxo47 |
G |
A |
11: 97,748,481 (GRCm39) |
|
probably benign |
Het |
Galntl5 |
A |
G |
5: 25,391,070 (GRCm39) |
|
probably null |
Het |
Gm11437 |
T |
C |
11: 84,039,462 (GRCm39) |
T288A |
possibly damaging |
Het |
Gm5546 |
T |
A |
3: 104,260,448 (GRCm39) |
|
noncoding transcript |
Het |
Gmfb |
C |
A |
14: 47,054,912 (GRCm39) |
A11S |
probably benign |
Het |
Hnrnpa3 |
G |
T |
2: 75,492,040 (GRCm39) |
R52L |
probably damaging |
Het |
Ing3 |
T |
C |
6: 21,952,170 (GRCm39) |
M48T |
probably benign |
Het |
Kmt2a |
A |
G |
9: 44,741,356 (GRCm39) |
|
probably benign |
Het |
Megf8 |
G |
A |
7: 25,053,383 (GRCm39) |
|
probably null |
Het |
Pex3 |
A |
G |
10: 13,411,338 (GRCm39) |
V180A |
probably benign |
Het |
Pou6f1 |
G |
A |
15: 100,485,717 (GRCm39) |
Q106* |
probably null |
Het |
Ror2 |
T |
C |
13: 53,267,110 (GRCm39) |
M442V |
probably benign |
Het |
Rspo1 |
G |
A |
4: 124,885,190 (GRCm39) |
R22Q |
probably benign |
Het |
Sec1 |
A |
G |
7: 45,328,315 (GRCm39) |
V244A |
probably damaging |
Het |
Serac1 |
A |
G |
17: 6,115,212 (GRCm39) |
|
probably benign |
Het |
Sgcz |
A |
G |
8: 38,012,596 (GRCm39) |
|
probably benign |
Het |
Slc16a7 |
A |
T |
10: 125,063,939 (GRCm39) |
V466D |
probably benign |
Het |
Tbl1xr1 |
T |
A |
3: 22,243,949 (GRCm39) |
D74E |
probably benign |
Het |
Ube3b |
G |
T |
5: 114,546,278 (GRCm39) |
|
probably null |
Het |
Ugt2b37 |
A |
G |
5: 87,402,080 (GRCm39) |
S184P |
probably benign |
Het |
|
Other mutations in Crlf3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00690:Crlf3
|
APN |
11 |
79,950,163 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00835:Crlf3
|
APN |
11 |
79,938,501 (GRCm39) |
missense |
probably benign |
0.03 |
IGL01520:Crlf3
|
APN |
11 |
79,950,972 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01998:Crlf3
|
APN |
11 |
79,948,845 (GRCm39) |
unclassified |
probably benign |
|
IGL02622:Crlf3
|
APN |
11 |
79,950,150 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02748:Crlf3
|
APN |
11 |
79,950,145 (GRCm39) |
missense |
probably damaging |
0.98 |
R0064:Crlf3
|
UTSW |
11 |
79,948,728 (GRCm39) |
missense |
possibly damaging |
0.81 |
R0064:Crlf3
|
UTSW |
11 |
79,948,728 (GRCm39) |
missense |
possibly damaging |
0.81 |
R0583:Crlf3
|
UTSW |
11 |
79,950,107 (GRCm39) |
missense |
probably damaging |
0.99 |
R1753:Crlf3
|
UTSW |
11 |
79,948,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R2125:Crlf3
|
UTSW |
11 |
79,950,081 (GRCm39) |
missense |
probably benign |
0.21 |
R2571:Crlf3
|
UTSW |
11 |
79,938,339 (GRCm39) |
missense |
probably benign |
0.11 |
R5894:Crlf3
|
UTSW |
11 |
79,948,678 (GRCm39) |
missense |
probably damaging |
1.00 |
R6086:Crlf3
|
UTSW |
11 |
79,939,436 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7214:Crlf3
|
UTSW |
11 |
79,955,216 (GRCm39) |
missense |
possibly damaging |
0.92 |
R7238:Crlf3
|
UTSW |
11 |
79,947,351 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7511:Crlf3
|
UTSW |
11 |
79,954,812 (GRCm39) |
splice site |
probably null |
|
R8745:Crlf3
|
UTSW |
11 |
79,955,100 (GRCm39) |
missense |
probably damaging |
1.00 |
R8872:Crlf3
|
UTSW |
11 |
79,938,440 (GRCm39) |
missense |
|
|
R9297:Crlf3
|
UTSW |
11 |
79,950,031 (GRCm39) |
missense |
probably damaging |
1.00 |
X0064:Crlf3
|
UTSW |
11 |
79,955,013 (GRCm39) |
splice site |
probably null |
|
|
Predicted Primers |
|
Posted On |
2014-07-09 |