Incidental Mutation 'R0076:Crlf3'
ID 212562
Institutional Source Beutler Lab
Gene Symbol Crlf3
Ensembl Gene ENSMUSG00000017561
Gene Name cytokine receptor-like factor 3
Synonyms Creme9, cytor4
MMRRC Submission 038363-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0076 (G1)
Quality Score 33
Status Validated
Chromosome 11
Chromosomal Location 79937319-79971817 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 79947427 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137124 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061283] [ENSMUST00000103233] [ENSMUST00000177825] [ENSMUST00000178893] [ENSMUST00000179855]
AlphaFold Q9Z2L7
Predicted Effect probably benign
Transcript: ENSMUST00000061283
SMART Domains Protein: ENSMUSP00000060028
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
FN3 179 260 1.66e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000092858
Predicted Effect probably benign
Transcript: ENSMUST00000103233
SMART Domains Protein: ENSMUSP00000099523
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
FN3 179 260 1.66e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147164
Predicted Effect probably benign
Transcript: ENSMUST00000177825
SMART Domains Protein: ENSMUSP00000136473
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178893
SMART Domains Protein: ENSMUSP00000137371
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 39 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179855
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 96.0%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: This gene encodes a cytokine receptor-like factor that contains a fibronectin type 3 domain. The encoded protein may act as a negative regulator of the cell cycle. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level. [provided by MGI curators]
Allele List at MGI

All alleles(39) : Targeted, other(2) Gene trapped(37)

Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp3 A G 9: 104,201,417 (GRCm39) probably benign Het
Ankrd17 T A 5: 90,392,265 (GRCm39) K1693* probably null Het
Car10 G A 11: 93,381,423 (GRCm39) E129K possibly damaging Het
Ccnd1 A C 7: 144,493,402 (GRCm39) V10G probably benign Het
Cd19 T C 7: 126,010,034 (GRCm39) D406G probably damaging Het
Cfap91 G A 16: 38,123,046 (GRCm39) Q661* probably null Het
Col4a1 G A 8: 11,268,713 (GRCm39) P1009L probably damaging Het
Col9a1 G A 1: 24,276,578 (GRCm39) probably null Het
Dock3 A C 9: 106,788,685 (GRCm39) probably benign Het
Dus1l A T 11: 120,683,634 (GRCm39) probably benign Het
Dvl2 G A 11: 69,898,926 (GRCm39) E438K probably damaging Het
Eif3g A G 9: 20,809,049 (GRCm39) F85S probably damaging Het
Fam234b A G 6: 135,204,224 (GRCm39) M456V probably benign Het
Fbxo47 G A 11: 97,748,481 (GRCm39) probably benign Het
Galntl5 A G 5: 25,391,070 (GRCm39) probably null Het
Gm11437 T C 11: 84,039,462 (GRCm39) T288A possibly damaging Het
Gm5546 T A 3: 104,260,448 (GRCm39) noncoding transcript Het
Gmfb C A 14: 47,054,912 (GRCm39) A11S probably benign Het
Hnrnpa3 G T 2: 75,492,040 (GRCm39) R52L probably damaging Het
Ing3 T C 6: 21,952,170 (GRCm39) M48T probably benign Het
Kmt2a A G 9: 44,741,356 (GRCm39) probably benign Het
Megf8 G A 7: 25,053,383 (GRCm39) probably null Het
Pex3 A G 10: 13,411,338 (GRCm39) V180A probably benign Het
Pou6f1 G A 15: 100,485,717 (GRCm39) Q106* probably null Het
Ror2 T C 13: 53,267,110 (GRCm39) M442V probably benign Het
Rspo1 G A 4: 124,885,190 (GRCm39) R22Q probably benign Het
Sec1 A G 7: 45,328,315 (GRCm39) V244A probably damaging Het
Serac1 A G 17: 6,115,212 (GRCm39) probably benign Het
Sgcz A G 8: 38,012,596 (GRCm39) probably benign Het
Slc16a7 A T 10: 125,063,939 (GRCm39) V466D probably benign Het
Tbl1xr1 T A 3: 22,243,949 (GRCm39) D74E probably benign Het
Ube3b G T 5: 114,546,278 (GRCm39) probably null Het
Ugt2b37 A G 5: 87,402,080 (GRCm39) S184P probably benign Het
Other mutations in Crlf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00690:Crlf3 APN 11 79,950,163 (GRCm39) missense probably damaging 1.00
IGL00835:Crlf3 APN 11 79,938,501 (GRCm39) missense probably benign 0.03
IGL01520:Crlf3 APN 11 79,950,972 (GRCm39) missense probably benign 0.01
IGL01998:Crlf3 APN 11 79,948,845 (GRCm39) unclassified probably benign
IGL02622:Crlf3 APN 11 79,950,150 (GRCm39) missense probably damaging 1.00
IGL02748:Crlf3 APN 11 79,950,145 (GRCm39) missense probably damaging 0.98
R0064:Crlf3 UTSW 11 79,948,728 (GRCm39) missense possibly damaging 0.81
R0064:Crlf3 UTSW 11 79,948,728 (GRCm39) missense possibly damaging 0.81
R0583:Crlf3 UTSW 11 79,950,107 (GRCm39) missense probably damaging 0.99
R1753:Crlf3 UTSW 11 79,948,698 (GRCm39) missense probably damaging 1.00
R2125:Crlf3 UTSW 11 79,950,081 (GRCm39) missense probably benign 0.21
R2571:Crlf3 UTSW 11 79,938,339 (GRCm39) missense probably benign 0.11
R5894:Crlf3 UTSW 11 79,948,678 (GRCm39) missense probably damaging 1.00
R6086:Crlf3 UTSW 11 79,939,436 (GRCm39) missense possibly damaging 0.81
R7214:Crlf3 UTSW 11 79,955,216 (GRCm39) missense possibly damaging 0.92
R7238:Crlf3 UTSW 11 79,947,351 (GRCm39) missense possibly damaging 0.94
R7511:Crlf3 UTSW 11 79,954,812 (GRCm39) splice site probably null
R8745:Crlf3 UTSW 11 79,955,100 (GRCm39) missense probably damaging 1.00
R8872:Crlf3 UTSW 11 79,938,440 (GRCm39) missense
R9297:Crlf3 UTSW 11 79,950,031 (GRCm39) missense probably damaging 1.00
X0064:Crlf3 UTSW 11 79,955,013 (GRCm39) splice site probably null
Predicted Primers
Posted On 2014-07-09