Incidental Mutation 'R0125:Cdc42bpa'
| ID |
21257 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cdc42bpa
|
| Ensembl Gene |
ENSMUSG00000026490 |
| Gene Name |
CDC42 binding protein kinase alpha |
| Synonyms |
DMPK-like, A930014J19Rik |
| MMRRC Submission |
038410-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.834)
|
| Stock # |
R0125 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
1 |
| Chromosomal Location |
179788037-179993168 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 179788763 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Methionine
at position 30
(T30M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148469
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076687]
[ENSMUST00000097450]
[ENSMUST00000097453]
[ENSMUST00000111117]
[ENSMUST00000134959]
[ENSMUST00000212756]
|
| AlphaFold |
Q3UU96 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000076687
AA Change: T30M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000075980
Gene: ENSMUSG00000026490
AA Change: T30M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
588 |
N/A |
INTRINSIC |
|
coiled coil region
|
632 |
735 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
800 |
860 |
2.7e-29 |
PFAM |
|
C1
|
919 |
968 |
4.09e-7 |
SMART |
|
PH
|
989 |
1109 |
6.02e-8 |
SMART |
|
CNH
|
1134 |
1411 |
3.37e-17 |
SMART |
|
low complexity region
|
1456 |
1468 |
N/A |
INTRINSIC |
|
PBD
|
1477 |
1512 |
2.05e-10 |
SMART |
|
low complexity region
|
1531 |
1546 |
N/A |
INTRINSIC |
|
low complexity region
|
1567 |
1580 |
N/A |
INTRINSIC |
|
low complexity region
|
1606 |
1620 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097450
AA Change: T30M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000095059
Gene: ENSMUSG00000026490
AA Change: T30M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.2e-29 |
PFAM |
|
C1
|
1000 |
1049 |
4.09e-7 |
SMART |
|
PH
|
1070 |
1190 |
6.02e-8 |
SMART |
|
CNH
|
1215 |
1492 |
3.37e-17 |
SMART |
|
low complexity region
|
1537 |
1549 |
N/A |
INTRINSIC |
|
PBD
|
1558 |
1593 |
2.05e-10 |
SMART |
|
low complexity region
|
1612 |
1627 |
N/A |
INTRINSIC |
|
low complexity region
|
1648 |
1661 |
N/A |
INTRINSIC |
|
low complexity region
|
1687 |
1701 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097453
AA Change: T30M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000095062
Gene: ENSMUSG00000026490
AA Change: T30M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
coiled coil region
|
435 |
669 |
N/A |
INTRINSIC |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.5e-29 |
PFAM |
|
C1
|
972 |
1021 |
4.09e-7 |
SMART |
|
PH
|
1042 |
1162 |
6.02e-8 |
SMART |
|
CNH
|
1187 |
1464 |
3.37e-17 |
SMART |
|
low complexity region
|
1509 |
1521 |
N/A |
INTRINSIC |
|
PBD
|
1530 |
1565 |
2.05e-10 |
SMART |
|
low complexity region
|
1584 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1620 |
1633 |
N/A |
INTRINSIC |
|
low complexity region
|
1659 |
1673 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111117
AA Change: T30M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000106746
Gene: ENSMUSG00000026490
AA Change: T30M
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
77 |
343 |
1.06e-86 |
SMART |
|
S_TK_X
|
344 |
406 |
1.18e-15 |
SMART |
|
low complexity region
|
484 |
499 |
N/A |
INTRINSIC |
|
Pfam:KELK
|
529 |
608 |
1.1e-32 |
PFAM |
|
coiled coil region
|
713 |
816 |
N/A |
INTRINSIC |
|
Pfam:DMPK_coil
|
881 |
941 |
2.6e-29 |
PFAM |
|
C1
|
1013 |
1062 |
4.09e-7 |
SMART |
|
PH
|
1083 |
1203 |
6.02e-8 |
SMART |
|
CNH
|
1228 |
1505 |
3.37e-17 |
SMART |
|
low complexity region
|
1550 |
1562 |
N/A |
INTRINSIC |
|
PBD
|
1571 |
1606 |
2.05e-10 |
SMART |
|
low complexity region
|
1625 |
1640 |
N/A |
INTRINSIC |
|
low complexity region
|
1661 |
1674 |
N/A |
INTRINSIC |
|
low complexity region
|
1700 |
1714 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000134959
AA Change: T30M
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000142018
Gene: ENSMUSG00000026490
AA Change: T30M
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4AW2|A
|
2 |
90 |
1e-58 |
PDB |
|
SCOP:d1koba_
|
50 |
90 |
7e-5 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000212756
AA Change: T30M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.9%
- 10x: 94.7%
- 20x: 87.1%
|
| Validation Efficiency |
98% (96/98) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930012K11Rik |
T |
C |
14: 70,394,096 (GRCm39) |
|
probably benign |
Het |
| Adam23 |
T |
C |
1: 63,573,515 (GRCm39) |
L261P |
probably benign |
Het |
| Adgra3 |
G |
A |
5: 50,159,194 (GRCm39) |
|
probably benign |
Het |
| Agtr1b |
A |
G |
3: 20,369,704 (GRCm39) |
F301L |
probably benign |
Het |
| Ahnak2 |
G |
A |
12: 112,748,776 (GRCm39) |
T357I |
probably benign |
Het |
| Aldh1a7 |
T |
C |
19: 20,704,430 (GRCm39) |
|
probably benign |
Het |
| Apoh |
A |
T |
11: 108,302,899 (GRCm39) |
N288I |
probably damaging |
Het |
| Arfgap3 |
A |
G |
15: 83,227,340 (GRCm39) |
V24A |
probably benign |
Het |
| Atp6v0a1 |
A |
G |
11: 100,929,677 (GRCm39) |
|
probably null |
Het |
| Axl |
A |
T |
7: 25,486,368 (GRCm39) |
M112K |
probably benign |
Het |
| Bnc2 |
A |
C |
4: 84,211,169 (GRCm39) |
I425S |
probably damaging |
Het |
| Ccn4 |
T |
C |
15: 66,789,194 (GRCm39) |
S227P |
possibly damaging |
Het |
| Cebpz |
C |
A |
17: 79,227,317 (GRCm39) |
R1051M |
possibly damaging |
Het |
| Ces1d |
A |
C |
8: 93,901,810 (GRCm39) |
|
probably benign |
Het |
| Chd1l |
T |
C |
3: 97,494,465 (GRCm39) |
N405S |
probably benign |
Het |
| Chodl |
G |
T |
16: 78,738,311 (GRCm39) |
G93V |
probably damaging |
Het |
| Cpeb2 |
C |
T |
5: 43,395,743 (GRCm39) |
|
probably benign |
Het |
| Crebbp |
A |
G |
16: 3,935,105 (GRCm39) |
|
probably benign |
Het |
| Crybb3 |
T |
C |
5: 113,227,675 (GRCm39) |
T49A |
possibly damaging |
Het |
| Ctps1 |
A |
G |
4: 120,418,722 (GRCm39) |
|
probably benign |
Het |
| Cyp26b1 |
A |
G |
6: 84,551,497 (GRCm39) |
Y240H |
probably damaging |
Het |
| Cyp2d11 |
A |
C |
15: 82,273,422 (GRCm39) |
V483G |
probably benign |
Het |
| Dennd2b |
T |
C |
7: 109,155,545 (GRCm39) |
K402E |
probably benign |
Het |
| Dnah14 |
A |
T |
1: 181,579,628 (GRCm39) |
N3054Y |
probably damaging |
Het |
| Dspp |
A |
C |
5: 104,325,905 (GRCm39) |
D756A |
unknown |
Het |
| Dst |
T |
C |
1: 34,309,984 (GRCm39) |
S1553P |
probably damaging |
Het |
| Elp4 |
A |
G |
2: 105,622,559 (GRCm39) |
|
probably null |
Het |
| Eml6 |
G |
T |
11: 29,832,088 (GRCm39) |
T194K |
probably benign |
Het |
| Evi5 |
A |
G |
5: 107,943,638 (GRCm39) |
I569T |
probably benign |
Het |
| Fancm |
C |
T |
12: 65,168,730 (GRCm39) |
P1698S |
possibly damaging |
Het |
| Fhdc1 |
T |
C |
3: 84,352,852 (GRCm39) |
D791G |
probably benign |
Het |
| Frem1 |
A |
G |
4: 82,930,188 (GRCm39) |
Y253H |
probably damaging |
Het |
| Gpn3 |
A |
G |
5: 122,519,481 (GRCm39) |
Y196C |
probably benign |
Het |
| Hcls1 |
A |
G |
16: 36,782,525 (GRCm39) |
D398G |
probably benign |
Het |
| Hydin |
T |
C |
8: 111,189,163 (GRCm39) |
V1189A |
probably benign |
Het |
| Itgb3 |
G |
A |
11: 104,534,789 (GRCm39) |
D549N |
probably damaging |
Het |
| Itpr2 |
A |
G |
6: 146,141,951 (GRCm39) |
F1697S |
probably benign |
Het |
| Klk1b11 |
A |
G |
7: 43,648,475 (GRCm39) |
T161A |
probably benign |
Het |
| Kntc1 |
G |
A |
5: 123,903,120 (GRCm39) |
|
probably benign |
Het |
| Map3k19 |
A |
T |
1: 127,750,837 (GRCm39) |
F838Y |
probably benign |
Het |
| Map6 |
T |
A |
7: 98,985,187 (GRCm39) |
|
probably null |
Het |
| Mcrs1 |
A |
G |
15: 99,142,608 (GRCm39) |
|
probably benign |
Het |
| Mdn1 |
A |
T |
4: 32,729,956 (GRCm39) |
Y2766F |
probably damaging |
Het |
| Med23 |
C |
T |
10: 24,776,686 (GRCm39) |
H739Y |
probably damaging |
Het |
| Mmp17 |
T |
A |
5: 129,671,646 (GRCm39) |
D65E |
possibly damaging |
Het |
| Mmp9 |
T |
A |
2: 164,793,177 (GRCm39) |
L442Q |
probably damaging |
Het |
| Myo19 |
T |
C |
11: 84,779,001 (GRCm39) |
|
probably benign |
Het |
| Nedd1 |
A |
C |
10: 92,527,791 (GRCm39) |
S468A |
possibly damaging |
Het |
| Niban2 |
T |
A |
2: 32,813,833 (GRCm39) |
V682D |
probably benign |
Het |
| Nlrp4d |
A |
C |
7: 10,116,316 (GRCm39) |
V152G |
probably damaging |
Het |
| Nxf1 |
T |
A |
19: 8,740,170 (GRCm39) |
D112E |
probably benign |
Het |
| Oas1h |
A |
T |
5: 121,000,626 (GRCm39) |
K79* |
probably null |
Het |
| Omg |
T |
A |
11: 79,393,679 (GRCm39) |
I60F |
possibly damaging |
Het |
| Or5p69 |
A |
G |
7: 107,967,576 (GRCm39) |
Y293C |
probably damaging |
Het |
| Or8b101 |
A |
G |
9: 38,020,815 (GRCm39) |
T278A |
probably benign |
Het |
| Or8b1b |
T |
A |
9: 38,375,757 (GRCm39) |
L140* |
probably null |
Het |
| Pck1 |
G |
A |
2: 172,997,874 (GRCm39) |
W314* |
probably null |
Het |
| Pla2g15 |
T |
C |
8: 106,889,756 (GRCm39) |
Y343H |
probably benign |
Het |
| Plcb3 |
T |
C |
19: 6,936,276 (GRCm39) |
E749G |
probably damaging |
Het |
| Plgrkt |
A |
G |
19: 29,328,442 (GRCm39) |
|
probably null |
Het |
| Pprc1 |
A |
G |
19: 46,057,951 (GRCm39) |
|
probably benign |
Het |
| Prkdc |
A |
T |
16: 15,516,871 (GRCm39) |
I1082F |
probably damaging |
Het |
| Rapgef6 |
T |
A |
11: 54,516,701 (GRCm39) |
Y172* |
probably null |
Het |
| Ros1 |
G |
T |
10: 52,001,885 (GRCm39) |
A1079D |
probably benign |
Het |
| Sap30 |
T |
C |
8: 57,938,545 (GRCm39) |
E147G |
probably null |
Het |
| Sell |
T |
C |
1: 163,899,674 (GRCm39) |
|
probably benign |
Het |
| Senp1 |
A |
T |
15: 97,946,112 (GRCm39) |
D544E |
probably damaging |
Het |
| Shpk |
G |
A |
11: 73,105,048 (GRCm39) |
|
probably benign |
Het |
| Slc35b1 |
A |
T |
11: 95,277,353 (GRCm39) |
T74S |
probably benign |
Het |
| Slc6a3 |
T |
A |
13: 73,718,098 (GRCm39) |
|
probably benign |
Het |
| Slf1 |
T |
C |
13: 77,191,864 (GRCm39) |
N990S |
probably benign |
Het |
| Smgc |
A |
G |
15: 91,738,746 (GRCm39) |
|
probably benign |
Het |
| Snx19 |
T |
A |
9: 30,351,515 (GRCm39) |
V861D |
probably damaging |
Het |
| Sprr2e |
C |
T |
3: 92,260,285 (GRCm39) |
P39S |
unknown |
Het |
| Sstr2 |
T |
A |
11: 113,515,303 (GRCm39) |
M74K |
probably damaging |
Het |
| Svep1 |
T |
C |
4: 58,099,937 (GRCm39) |
|
probably benign |
Het |
| Tas2r143 |
A |
G |
6: 42,377,889 (GRCm39) |
I240V |
probably benign |
Het |
| Tbrg1 |
T |
C |
9: 37,563,937 (GRCm39) |
I233V |
probably benign |
Het |
| Tecpr1 |
G |
T |
5: 144,134,717 (GRCm39) |
D1055E |
probably damaging |
Het |
| Thap2 |
A |
T |
10: 115,212,277 (GRCm39) |
|
probably null |
Het |
| Tinagl1 |
A |
G |
4: 130,060,101 (GRCm39) |
Y388H |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,585,896 (GRCm39) |
Y21945F |
probably damaging |
Het |
| Ugt2b1 |
A |
T |
5: 87,073,961 (GRCm39) |
W133R |
probably benign |
Het |
| Usp24 |
C |
T |
4: 106,254,496 (GRCm39) |
P1491L |
possibly damaging |
Het |
| Utp15 |
A |
G |
13: 98,387,390 (GRCm39) |
S395P |
possibly damaging |
Het |
| Vav1 |
T |
A |
17: 57,606,847 (GRCm39) |
L254Q |
probably damaging |
Het |
| Vmn2r104 |
T |
C |
17: 20,250,069 (GRCm39) |
Y734C |
probably damaging |
Het |
| Vps8 |
T |
A |
16: 21,288,904 (GRCm39) |
V421E |
probably benign |
Het |
| Xkr7 |
G |
T |
2: 152,874,346 (GRCm39) |
A138S |
probably benign |
Het |
|
| Other mutations in Cdc42bpa |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00498:Cdc42bpa
|
APN |
1 |
179,933,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00807:Cdc42bpa
|
APN |
1 |
179,969,018 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL00972:Cdc42bpa
|
APN |
1 |
179,902,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01084:Cdc42bpa
|
APN |
1 |
179,969,839 (GRCm39) |
splice site |
probably benign |
|
|
IGL01149:Cdc42bpa
|
APN |
1 |
179,902,137 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01377:Cdc42bpa
|
APN |
1 |
179,892,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01541:Cdc42bpa
|
APN |
1 |
179,978,723 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL01657:Cdc42bpa
|
APN |
1 |
179,939,431 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01720:Cdc42bpa
|
APN |
1 |
179,938,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02227:Cdc42bpa
|
APN |
1 |
179,921,989 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02234:Cdc42bpa
|
APN |
1 |
179,978,756 (GRCm39) |
nonsense |
probably null |
|
|
IGL02253:Cdc42bpa
|
APN |
1 |
179,859,161 (GRCm39) |
splice site |
probably benign |
|
|
IGL02587:Cdc42bpa
|
APN |
1 |
179,921,510 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02671:Cdc42bpa
|
APN |
1 |
179,889,387 (GRCm39) |
missense |
probably benign |
|
|
IGL02746:Cdc42bpa
|
APN |
1 |
179,939,312 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02756:Cdc42bpa
|
APN |
1 |
179,936,824 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02994:Cdc42bpa
|
APN |
1 |
179,827,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03073:Cdc42bpa
|
APN |
1 |
179,921,941 (GRCm39) |
splice site |
probably benign |
|
|
IGL03295:Cdc42bpa
|
APN |
1 |
179,977,769 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0022:Cdc42bpa
|
UTSW |
1 |
179,788,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Cdc42bpa
|
UTSW |
1 |
179,859,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0268:Cdc42bpa
|
UTSW |
1 |
179,983,347 (GRCm39) |
intron |
probably benign |
|
|
R0472:Cdc42bpa
|
UTSW |
1 |
179,867,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0492:Cdc42bpa
|
UTSW |
1 |
179,928,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0609:Cdc42bpa
|
UTSW |
1 |
179,867,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Cdc42bpa
|
UTSW |
1 |
179,972,400 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0738:Cdc42bpa
|
UTSW |
1 |
179,827,027 (GRCm39) |
splice site |
probably benign |
|
|
R1547:Cdc42bpa
|
UTSW |
1 |
179,902,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1553:Cdc42bpa
|
UTSW |
1 |
179,921,540 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1601:Cdc42bpa
|
UTSW |
1 |
179,892,566 (GRCm39) |
nonsense |
probably null |
|
|
R1709:Cdc42bpa
|
UTSW |
1 |
179,894,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2101:Cdc42bpa
|
UTSW |
1 |
179,974,533 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2279:Cdc42bpa
|
UTSW |
1 |
179,864,484 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2357:Cdc42bpa
|
UTSW |
1 |
179,894,792 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2373:Cdc42bpa
|
UTSW |
1 |
179,939,349 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2570:Cdc42bpa
|
UTSW |
1 |
179,977,742 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3709:Cdc42bpa
|
UTSW |
1 |
179,892,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Cdc42bpa
|
UTSW |
1 |
179,892,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3816:Cdc42bpa
|
UTSW |
1 |
179,972,451 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3854:Cdc42bpa
|
UTSW |
1 |
179,983,543 (GRCm39) |
intron |
probably benign |
|
|
R3855:Cdc42bpa
|
UTSW |
1 |
179,983,543 (GRCm39) |
intron |
probably benign |
|
|
R3917:Cdc42bpa
|
UTSW |
1 |
179,933,719 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4604:Cdc42bpa
|
UTSW |
1 |
179,936,759 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4622:Cdc42bpa
|
UTSW |
1 |
179,902,223 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4664:Cdc42bpa
|
UTSW |
1 |
179,972,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4665:Cdc42bpa
|
UTSW |
1 |
179,972,130 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4887:Cdc42bpa
|
UTSW |
1 |
179,972,200 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4989:Cdc42bpa
|
UTSW |
1 |
179,965,366 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5033:Cdc42bpa
|
UTSW |
1 |
179,892,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5050:Cdc42bpa
|
UTSW |
1 |
179,900,018 (GRCm39) |
nonsense |
probably null |
|
|
R5077:Cdc42bpa
|
UTSW |
1 |
179,922,098 (GRCm39) |
intron |
probably benign |
|
|
R5196:Cdc42bpa
|
UTSW |
1 |
179,899,978 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5276:Cdc42bpa
|
UTSW |
1 |
179,965,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5313:Cdc42bpa
|
UTSW |
1 |
179,911,998 (GRCm39) |
missense |
probably benign |
|
|
R5364:Cdc42bpa
|
UTSW |
1 |
179,894,747 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5372:Cdc42bpa
|
UTSW |
1 |
179,892,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5405:Cdc42bpa
|
UTSW |
1 |
179,966,085 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5405:Cdc42bpa
|
UTSW |
1 |
179,894,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5646:Cdc42bpa
|
UTSW |
1 |
179,933,659 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5713:Cdc42bpa
|
UTSW |
1 |
179,911,975 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6012:Cdc42bpa
|
UTSW |
1 |
179,892,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6029:Cdc42bpa
|
UTSW |
1 |
179,939,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Cdc42bpa
|
UTSW |
1 |
179,921,561 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6609:Cdc42bpa
|
UTSW |
1 |
179,928,839 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7122:Cdc42bpa
|
UTSW |
1 |
179,892,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7289:Cdc42bpa
|
UTSW |
1 |
179,889,362 (GRCm39) |
nonsense |
probably null |
|
|
R7670:Cdc42bpa
|
UTSW |
1 |
179,892,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7912:Cdc42bpa
|
UTSW |
1 |
179,921,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8139:Cdc42bpa
|
UTSW |
1 |
179,896,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8362:Cdc42bpa
|
UTSW |
1 |
179,989,690 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8378:Cdc42bpa
|
UTSW |
1 |
179,989,709 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8794:Cdc42bpa
|
UTSW |
1 |
179,894,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8835:Cdc42bpa
|
UTSW |
1 |
179,896,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cdc42bpa
|
UTSW |
1 |
179,958,373 (GRCm39) |
intron |
probably benign |
|
|
R9012:Cdc42bpa
|
UTSW |
1 |
179,859,077 (GRCm39) |
missense |
|
|
|
R9110:Cdc42bpa
|
UTSW |
1 |
179,945,258 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9178:Cdc42bpa
|
UTSW |
1 |
179,958,401 (GRCm39) |
missense |
|
|
|
R9184:Cdc42bpa
|
UTSW |
1 |
179,972,301 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9204:Cdc42bpa
|
UTSW |
1 |
179,939,460 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9227:Cdc42bpa
|
UTSW |
1 |
179,933,638 (GRCm39) |
missense |
probably benign |
|
|
R9230:Cdc42bpa
|
UTSW |
1 |
179,933,638 (GRCm39) |
missense |
probably benign |
|
|
R9299:Cdc42bpa
|
UTSW |
1 |
179,972,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9366:Cdc42bpa
|
UTSW |
1 |
179,921,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9381:Cdc42bpa
|
UTSW |
1 |
179,969,048 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9461:Cdc42bpa
|
UTSW |
1 |
179,969,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9559:Cdc42bpa
|
UTSW |
1 |
179,939,459 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0026:Cdc42bpa
|
UTSW |
1 |
179,788,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Cdc42bpa
|
UTSW |
1 |
179,892,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCAGCACCGGCATTGCATGAC -3'
(R):5'- CAACAACTAAGTGGCACCGCTTTG -3'
Sequencing Primer
(F):5'- CAGTAGACATCGTAAGGGCA -3'
(R):5'- TTGCCCTGGCAAACAGTTAAG -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation