Incidental Mutation 'R1918:Celsr2'
| ID |
212683 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Celsr2
|
| Ensembl Gene |
ENSMUSG00000068740 |
| Gene Name |
cadherin, EGF LAG seven-pass G-type receptor 2 |
| Synonyms |
EGFL2, Adgrc2, flamingo, mfmi1 |
| MMRRC Submission |
039936-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1918 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
108298167-108323383 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 108305966 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 2046
(G2046D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088046
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090558]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090558
AA Change: G2046D
PolyPhen 2
Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000088046
Gene: ENSMUSG00000068740
AA Change: G2046D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
|
low complexity region
|
35 |
53 |
N/A |
INTRINSIC |
|
CA
|
203 |
287 |
1.36e-26 |
SMART |
|
CA
|
311 |
397 |
1.33e-29 |
SMART |
|
CA
|
421 |
503 |
2.59e-27 |
SMART |
|
CA
|
527 |
608 |
3.33e-30 |
SMART |
|
CA
|
632 |
710 |
5.18e-18 |
SMART |
|
CA
|
734 |
813 |
1.08e-29 |
SMART |
|
CA
|
837 |
919 |
8.08e-29 |
SMART |
|
low complexity region
|
920 |
932 |
N/A |
INTRINSIC |
|
CA
|
943 |
1021 |
4.3e-24 |
SMART |
|
CA
|
1049 |
1125 |
1.87e-1 |
SMART |
|
low complexity region
|
1188 |
1198 |
N/A |
INTRINSIC |
|
EGF
|
1231 |
1286 |
1.81e-3 |
SMART |
|
EGF_CA
|
1288 |
1324 |
2.24e-8 |
SMART |
|
EGF
|
1331 |
1366 |
6.65e-2 |
SMART |
|
LamG
|
1387 |
1554 |
8.4e-30 |
SMART |
|
EGF
|
1577 |
1610 |
8e-5 |
SMART |
|
LamG
|
1636 |
1770 |
1.56e-24 |
SMART |
|
EGF
|
1796 |
1829 |
2.35e-2 |
SMART |
|
EGF
|
1831 |
1867 |
3.88e-3 |
SMART |
|
TNFR
|
1908 |
1943 |
1.35e-1 |
SMART |
|
EGF_Lam
|
1924 |
1969 |
9.54e-12 |
SMART |
|
HormR
|
1972 |
2034 |
1.57e-20 |
SMART |
|
Pfam:GAIN
|
2046 |
2289 |
3e-62 |
PFAM |
|
GPS
|
2315 |
2368 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
2373 |
2605 |
1.1e-48 |
PFAM |
|
low complexity region
|
2715 |
2733 |
N/A |
INTRINSIC |
|
low complexity region
|
2857 |
2873 |
N/A |
INTRINSIC |
|
low complexity region
|
2874 |
2881 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126349
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130941
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000147251
AA Change: G34D
|
| SMART Domains |
Protein: ENSMUSP00000122329
Gene: ENSMUSG00000068740
AA Change: G34D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GAIN
|
35 |
278 |
5.1e-63 |
PFAM |
|
GPS
|
304 |
357 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
362 |
594 |
2e-49 |
PFAM |
|
low complexity region
|
704 |
722 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
870 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147565
|
| SMART Domains |
Protein: ENSMUSP00000122516
Gene: ENSMUSG00000068740
| Domain | Start | End | E-Value | Type |
|---|
|
EGF
|
13 |
46 |
8e-5 |
SMART |
|
LamG
|
72 |
206 |
1.56e-24 |
SMART |
|
| Meta Mutation Damage Score |
0.1052 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.7%
- 20x: 93.5%
|
| Validation Efficiency |
97% (113/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted, knock-out(1) Targeted, other(3)
|
| Other mutations in this stock |
Total: 116 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432E11Rik |
T |
G |
7: 29,273,514 (GRCm39) |
|
noncoding transcript |
Het |
| A2m |
T |
C |
6: 121,621,895 (GRCm39) |
S314P |
probably benign |
Het |
| Abcc9 |
T |
A |
6: 142,643,408 (GRCm39) |
I47F |
probably damaging |
Het |
| Abcd2 |
C |
T |
15: 91,075,684 (GRCm39) |
R43H |
probably benign |
Het |
| Adgre5 |
A |
G |
8: 84,455,738 (GRCm39) |
V190A |
probably damaging |
Het |
| Aen |
C |
T |
7: 78,555,777 (GRCm39) |
H242Y |
possibly damaging |
Het |
| Arfgef1 |
C |
T |
1: 10,270,103 (GRCm39) |
A349T |
probably benign |
Het |
| Arhgap10 |
T |
C |
8: 77,985,708 (GRCm39) |
I698V |
probably benign |
Het |
| Arpp21 |
C |
T |
9: 111,948,246 (GRCm39) |
|
probably benign |
Het |
| Atp10a |
T |
C |
7: 58,477,683 (GRCm39) |
I1294T |
possibly damaging |
Het |
| Atp13a2 |
T |
C |
4: 140,723,682 (GRCm39) |
Y337H |
possibly damaging |
Het |
| Bsn |
C |
T |
9: 107,984,772 (GRCm39) |
G3094D |
unknown |
Het |
| Cadm2 |
G |
A |
16: 66,544,270 (GRCm39) |
|
probably benign |
Het |
| Cadps |
T |
C |
14: 12,546,372 (GRCm38) |
M495V |
probably damaging |
Het |
| Cass4 |
A |
G |
2: 172,269,259 (GRCm39) |
H447R |
possibly damaging |
Het |
| Ccdc124 |
C |
A |
8: 71,321,588 (GRCm39) |
R108L |
probably benign |
Het |
| Ccdc141 |
C |
T |
2: 76,845,047 (GRCm39) |
R1340Q |
probably benign |
Het |
| Ccdc148 |
T |
G |
2: 58,872,911 (GRCm39) |
R299S |
probably damaging |
Het |
| Cd300lg |
A |
G |
11: 101,944,936 (GRCm39) |
E382G |
probably damaging |
Het |
| Cd36 |
A |
T |
5: 18,002,034 (GRCm39) |
C322* |
probably null |
Het |
| Clasrp |
C |
T |
7: 19,319,188 (GRCm39) |
W492* |
probably null |
Het |
| Cmtr1 |
T |
C |
17: 29,897,983 (GRCm39) |
V154A |
possibly damaging |
Het |
| Ctnnb1 |
C |
T |
9: 120,780,100 (GRCm39) |
P128S |
possibly damaging |
Het |
| Cyp11a1 |
A |
G |
9: 57,934,040 (GRCm39) |
I496V |
probably damaging |
Het |
| Disp2 |
G |
A |
2: 118,622,408 (GRCm39) |
V1047I |
probably benign |
Het |
| Dync2i1 |
A |
C |
12: 116,196,221 (GRCm39) |
S509A |
probably damaging |
Het |
| Eps8l2 |
T |
C |
7: 140,941,637 (GRCm39) |
V636A |
probably damaging |
Het |
| Fars2 |
T |
C |
13: 36,388,529 (GRCm39) |
L6P |
probably damaging |
Het |
| Fem1al |
A |
G |
11: 29,774,039 (GRCm39) |
S473P |
probably benign |
Het |
| Fnip1 |
C |
T |
11: 54,371,510 (GRCm39) |
T177I |
probably damaging |
Het |
| Fut8 |
G |
T |
12: 77,378,992 (GRCm39) |
R31L |
probably benign |
Het |
| G6pd2 |
T |
C |
5: 61,967,664 (GRCm39) |
F480L |
probably benign |
Het |
| Glipr1l2 |
T |
A |
10: 111,928,550 (GRCm39) |
C148* |
probably null |
Het |
| Gm10142 |
G |
A |
10: 77,551,821 (GRCm39) |
V61M |
probably benign |
Het |
| Gm5134 |
T |
A |
10: 75,812,180 (GRCm39) |
M145K |
possibly damaging |
Het |
| Gnpda1 |
T |
C |
18: 38,466,243 (GRCm39) |
|
probably null |
Het |
| Gpc2 |
T |
C |
5: 138,276,641 (GRCm39) |
T162A |
probably benign |
Het |
| Gtf2h4 |
G |
A |
17: 35,981,090 (GRCm39) |
L246F |
possibly damaging |
Het |
| Hal |
C |
T |
10: 93,332,469 (GRCm39) |
P294S |
probably damaging |
Het |
| Hectd3 |
C |
T |
4: 116,857,540 (GRCm39) |
A573V |
possibly damaging |
Het |
| Hephl1 |
T |
A |
9: 14,988,114 (GRCm39) |
I665F |
probably benign |
Het |
| Herc1 |
T |
C |
9: 66,383,408 (GRCm39) |
|
probably null |
Het |
| Hif1an |
A |
G |
19: 44,559,551 (GRCm39) |
|
probably null |
Het |
| Iho1 |
T |
A |
9: 108,290,184 (GRCm39) |
H140L |
probably benign |
Het |
| Il12rb1 |
T |
A |
8: 71,266,324 (GRCm39) |
M223K |
probably benign |
Het |
| Ilf3 |
C |
T |
9: 21,305,010 (GRCm39) |
T201M |
probably damaging |
Het |
| Inpp5f |
T |
C |
7: 128,265,693 (GRCm39) |
|
probably benign |
Het |
| Jcad |
T |
C |
18: 4,674,292 (GRCm39) |
Y685H |
probably damaging |
Het |
| Kcnj1 |
C |
A |
9: 32,308,034 (GRCm39) |
Q153K |
probably benign |
Het |
| Kctd18 |
A |
C |
1: 57,998,379 (GRCm39) |
H73Q |
probably damaging |
Het |
| Klhl36 |
T |
A |
8: 120,603,463 (GRCm39) |
W573R |
probably damaging |
Het |
| Ldc1 |
A |
T |
4: 130,105,186 (GRCm39) |
V328D |
probably benign |
Het |
| Lepr |
A |
G |
4: 101,630,033 (GRCm39) |
T583A |
probably benign |
Het |
| Ltbp4 |
G |
A |
7: 27,036,994 (GRCm39) |
|
probably benign |
Het |
| Mapt |
A |
T |
11: 104,189,325 (GRCm39) |
E114D |
probably benign |
Het |
| Mib1 |
T |
A |
18: 10,740,972 (GRCm39) |
|
probably null |
Het |
| Mthfd1 |
G |
T |
12: 76,361,750 (GRCm39) |
A119S |
probably damaging |
Het |
| Mylk4 |
A |
T |
13: 32,908,836 (GRCm39) |
D90E |
probably benign |
Het |
| Nceh1 |
T |
G |
3: 27,237,324 (GRCm39) |
L33R |
probably damaging |
Het |
| Nfat5 |
T |
C |
8: 108,092,868 (GRCm39) |
I91T |
probably damaging |
Het |
| Nxn |
A |
G |
11: 76,152,498 (GRCm39) |
|
probably benign |
Het |
| Oasl1 |
G |
A |
5: 115,061,528 (GRCm39) |
A20T |
possibly damaging |
Het |
| Or2m12 |
A |
T |
16: 19,105,052 (GRCm39) |
M147K |
probably benign |
Het |
| Or4c127 |
T |
C |
2: 89,832,918 (GRCm39) |
F56S |
probably benign |
Het |
| Or4d6 |
A |
G |
19: 12,086,871 (GRCm39) |
V13A |
probably benign |
Het |
| Or5b97 |
A |
G |
19: 12,878,215 (GRCm39) |
*310Q |
probably null |
Het |
| Or5t18 |
C |
T |
2: 86,637,171 (GRCm39) |
M57I |
probably damaging |
Het |
| Or6c2 |
T |
A |
10: 129,362,918 (GRCm39) |
V274D |
probably damaging |
Het |
| Pepd |
T |
C |
7: 34,671,101 (GRCm39) |
V215A |
probably benign |
Het |
| Pfkl |
A |
T |
10: 77,837,260 (GRCm39) |
N104K |
probably damaging |
Het |
| Phf24 |
T |
C |
4: 42,938,165 (GRCm39) |
|
probably benign |
Het |
| Pink1 |
T |
C |
4: 138,041,331 (GRCm39) |
N530S |
probably benign |
Het |
| Pou3f2 |
T |
C |
4: 22,487,119 (GRCm39) |
D338G |
probably damaging |
Het |
| Ppp1r13b |
A |
G |
12: 111,801,244 (GRCm39) |
V480A |
probably damaging |
Het |
| Ptgfrn |
A |
T |
3: 100,963,623 (GRCm39) |
I663N |
probably benign |
Het |
| Rad54b |
A |
C |
4: 11,601,693 (GRCm39) |
N416T |
probably damaging |
Het |
| Rasef |
A |
G |
4: 73,662,351 (GRCm39) |
S200P |
possibly damaging |
Het |
| Rbm33 |
T |
A |
5: 28,592,915 (GRCm39) |
I605N |
probably damaging |
Het |
| Rps19bp1 |
T |
C |
15: 80,148,280 (GRCm39) |
T31A |
probably benign |
Het |
| Ryr2 |
T |
A |
13: 11,571,584 (GRCm39) |
T4885S |
possibly damaging |
Het |
| Serpinb6b |
A |
G |
13: 33,162,223 (GRCm39) |
I222V |
probably benign |
Het |
| Sik3 |
C |
G |
9: 46,132,387 (GRCm39) |
H1276Q |
probably benign |
Het |
| Skor2 |
T |
C |
18: 76,947,051 (GRCm39) |
S258P |
unknown |
Het |
| Slc22a29 |
C |
T |
19: 8,195,123 (GRCm39) |
|
probably null |
Het |
| Slc8a3 |
A |
T |
12: 81,361,618 (GRCm39) |
F400L |
probably damaging |
Het |
| Slc9a8 |
T |
C |
2: 167,266,134 (GRCm39) |
I37T |
possibly damaging |
Het |
| Smchd1 |
A |
G |
17: 71,714,232 (GRCm39) |
I877T |
possibly damaging |
Het |
| Spag5 |
A |
G |
11: 78,195,002 (GRCm39) |
N103S |
probably benign |
Het |
| Sptbn1 |
A |
T |
11: 30,092,414 (GRCm39) |
F450L |
probably damaging |
Het |
| Strn4 |
T |
A |
7: 16,567,846 (GRCm39) |
Y507N |
probably damaging |
Het |
| Stxbp5 |
C |
A |
10: 9,688,042 (GRCm39) |
V420F |
possibly damaging |
Het |
| Syt17 |
G |
T |
7: 118,033,208 (GRCm39) |
L267I |
possibly damaging |
Het |
| Tcstv4 |
T |
C |
13: 120,769,758 (GRCm39) |
L26P |
probably damaging |
Het |
| Tdo2 |
T |
A |
3: 81,866,247 (GRCm39) |
R339W |
probably damaging |
Het |
| Tex55 |
A |
G |
16: 38,648,450 (GRCm39) |
Y220H |
possibly damaging |
Het |
| Timd5 |
A |
G |
11: 46,419,358 (GRCm39) |
D58G |
possibly damaging |
Het |
| Ttn |
A |
G |
2: 76,571,745 (GRCm39) |
S26383P |
probably damaging |
Het |
| Ttn |
G |
T |
2: 76,638,868 (GRCm39) |
T13938K |
probably damaging |
Het |
| Tulp2 |
A |
G |
7: 45,167,365 (GRCm39) |
N188D |
possibly damaging |
Het |
| Ube3c |
C |
T |
5: 29,792,315 (GRCm39) |
R37C |
probably damaging |
Het |
| Uggt2 |
G |
T |
14: 119,245,467 (GRCm39) |
|
probably benign |
Het |
| Umodl1 |
G |
A |
17: 31,203,017 (GRCm39) |
V457M |
probably damaging |
Het |
| Usp17la |
C |
T |
7: 104,509,953 (GRCm39) |
T186I |
probably benign |
Het |
| Vmn1r226 |
T |
C |
17: 20,907,842 (GRCm39) |
S25P |
probably damaging |
Het |
| Vmn1r235 |
T |
A |
17: 21,482,659 (GRCm39) |
I328K |
possibly damaging |
Het |
| Vmn2r50 |
A |
T |
7: 9,781,610 (GRCm39) |
S378R |
probably benign |
Het |
| Vwa2 |
C |
T |
19: 56,897,366 (GRCm39) |
T557I |
probably benign |
Het |
| Vxn |
T |
C |
1: 9,671,852 (GRCm39) |
F15S |
probably damaging |
Het |
| Yes1 |
G |
T |
5: 32,842,079 (GRCm39) |
Q534H |
probably benign |
Het |
| Zbtb25 |
A |
T |
12: 76,396,075 (GRCm39) |
Y382* |
probably null |
Het |
| Zc3h3 |
G |
A |
15: 75,648,967 (GRCm39) |
P722S |
probably damaging |
Het |
| Zfp36l2 |
T |
C |
17: 84,494,164 (GRCm39) |
T158A |
probably damaging |
Het |
| Zfp536 |
T |
C |
7: 37,179,624 (GRCm39) |
T994A |
probably damaging |
Het |
| Zfp592 |
C |
T |
7: 80,687,168 (GRCm39) |
Q824* |
probably null |
Het |
| Zfp629 |
C |
A |
7: 127,211,172 (GRCm39) |
K212N |
probably damaging |
Het |
| Zfp930 |
C |
A |
8: 69,681,357 (GRCm39) |
Q350K |
probably benign |
Het |
|
| Other mutations in Celsr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00898:Celsr2
|
APN |
3 |
108,321,195 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01020:Celsr2
|
APN |
3 |
108,310,586 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01420:Celsr2
|
APN |
3 |
108,301,079 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01448:Celsr2
|
APN |
3 |
108,300,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01559:Celsr2
|
APN |
3 |
108,314,183 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01674:Celsr2
|
APN |
3 |
108,322,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01863:Celsr2
|
APN |
3 |
108,301,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02309:Celsr2
|
APN |
3 |
108,303,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02325:Celsr2
|
APN |
3 |
108,320,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02409:Celsr2
|
APN |
3 |
108,321,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02514:Celsr2
|
APN |
3 |
108,304,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02812:Celsr2
|
APN |
3 |
108,321,429 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02894:Celsr2
|
APN |
3 |
108,302,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03281:Celsr2
|
APN |
3 |
108,320,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
barrow
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
goldeneye
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
1mM(1):Celsr2
|
UTSW |
3 |
108,308,154 (GRCm39) |
missense |
probably benign |
0.01 |
|
ANU74:Celsr2
|
UTSW |
3 |
108,319,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02799:Celsr2
|
UTSW |
3 |
108,321,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Celsr2
|
UTSW |
3 |
108,320,718 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0031:Celsr2
|
UTSW |
3 |
108,320,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0090:Celsr2
|
UTSW |
3 |
108,300,643 (GRCm39) |
splice site |
probably benign |
|
|
R0140:Celsr2
|
UTSW |
3 |
108,305,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Celsr2
|
UTSW |
3 |
108,308,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Celsr2
|
UTSW |
3 |
108,311,211 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0662:Celsr2
|
UTSW |
3 |
108,305,836 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0690:Celsr2
|
UTSW |
3 |
108,322,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Celsr2
|
UTSW |
3 |
108,319,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Celsr2
|
UTSW |
3 |
108,320,028 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0730:Celsr2
|
UTSW |
3 |
108,305,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0815:Celsr2
|
UTSW |
3 |
108,308,617 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0848:Celsr2
|
UTSW |
3 |
108,321,654 (GRCm39) |
missense |
probably benign |
|
|
R0989:Celsr2
|
UTSW |
3 |
108,310,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1474:Celsr2
|
UTSW |
3 |
108,301,055 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1608:Celsr2
|
UTSW |
3 |
108,309,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1653:Celsr2
|
UTSW |
3 |
108,320,836 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1659:Celsr2
|
UTSW |
3 |
108,321,411 (GRCm39) |
missense |
probably benign |
|
|
R1689:Celsr2
|
UTSW |
3 |
108,314,620 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1848:Celsr2
|
UTSW |
3 |
108,308,626 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1859:Celsr2
|
UTSW |
3 |
108,303,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1974:Celsr2
|
UTSW |
3 |
108,321,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2042:Celsr2
|
UTSW |
3 |
108,309,811 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2167:Celsr2
|
UTSW |
3 |
108,320,509 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2333:Celsr2
|
UTSW |
3 |
108,305,921 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2434:Celsr2
|
UTSW |
3 |
108,311,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Celsr2
|
UTSW |
3 |
108,320,907 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3420:Celsr2
|
UTSW |
3 |
108,321,732 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3712:Celsr2
|
UTSW |
3 |
108,308,155 (GRCm39) |
missense |
probably benign |
|
|
R3723:Celsr2
|
UTSW |
3 |
108,304,731 (GRCm39) |
splice site |
probably benign |
|
|
R3809:Celsr2
|
UTSW |
3 |
108,310,555 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4018:Celsr2
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4126:Celsr2
|
UTSW |
3 |
108,309,413 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4177:Celsr2
|
UTSW |
3 |
108,321,294 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4232:Celsr2
|
UTSW |
3 |
108,321,088 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4293:Celsr2
|
UTSW |
3 |
108,300,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4458:Celsr2
|
UTSW |
3 |
108,302,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4621:Celsr2
|
UTSW |
3 |
108,302,532 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4645:Celsr2
|
UTSW |
3 |
108,303,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Celsr2
|
UTSW |
3 |
108,304,547 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4732:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4901:Celsr2
|
UTSW |
3 |
108,314,303 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4932:Celsr2
|
UTSW |
3 |
108,310,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4989:Celsr2
|
UTSW |
3 |
108,319,945 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5052:Celsr2
|
UTSW |
3 |
108,319,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5093:Celsr2
|
UTSW |
3 |
108,320,689 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5114:Celsr2
|
UTSW |
3 |
108,301,312 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5120:Celsr2
|
UTSW |
3 |
108,300,436 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5135:Celsr2
|
UTSW |
3 |
108,305,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5247:Celsr2
|
UTSW |
3 |
108,304,946 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5381:Celsr2
|
UTSW |
3 |
108,310,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5412:Celsr2
|
UTSW |
3 |
108,307,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5445:Celsr2
|
UTSW |
3 |
108,299,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5528:Celsr2
|
UTSW |
3 |
108,320,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5598:Celsr2
|
UTSW |
3 |
108,310,119 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5652:Celsr2
|
UTSW |
3 |
108,304,051 (GRCm39) |
missense |
probably null |
0.49 |
|
R5697:Celsr2
|
UTSW |
3 |
108,311,237 (GRCm39) |
nonsense |
probably null |
|
|
R5718:Celsr2
|
UTSW |
3 |
108,300,674 (GRCm39) |
missense |
probably benign |
|
|
R5869:Celsr2
|
UTSW |
3 |
108,321,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Celsr2
|
UTSW |
3 |
108,321,259 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6021:Celsr2
|
UTSW |
3 |
108,308,561 (GRCm39) |
missense |
probably benign |
|
|
R6054:Celsr2
|
UTSW |
3 |
108,314,279 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6244:Celsr2
|
UTSW |
3 |
108,300,444 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6313:Celsr2
|
UTSW |
3 |
108,308,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6322:Celsr2
|
UTSW |
3 |
108,319,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6555:Celsr2
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6682:Celsr2
|
UTSW |
3 |
108,307,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7062:Celsr2
|
UTSW |
3 |
108,309,826 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7110:Celsr2
|
UTSW |
3 |
108,305,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Celsr2
|
UTSW |
3 |
108,322,675 (GRCm39) |
missense |
unknown |
|
|
R7326:Celsr2
|
UTSW |
3 |
108,302,311 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7425:Celsr2
|
UTSW |
3 |
108,309,773 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Celsr2
|
UTSW |
3 |
108,320,406 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7461:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7502:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7613:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7644:Celsr2
|
UTSW |
3 |
108,320,806 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Celsr2
|
UTSW |
3 |
108,305,904 (GRCm39) |
missense |
probably benign |
|
|
R7687:Celsr2
|
UTSW |
3 |
108,305,085 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7695:Celsr2
|
UTSW |
3 |
108,310,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8002:Celsr2
|
UTSW |
3 |
108,311,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Celsr2
|
UTSW |
3 |
108,319,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Celsr2
|
UTSW |
3 |
108,303,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Celsr2
|
UTSW |
3 |
108,320,847 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8381:Celsr2
|
UTSW |
3 |
108,302,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8427:Celsr2
|
UTSW |
3 |
108,299,949 (GRCm39) |
makesense |
probably null |
|
|
R8435:Celsr2
|
UTSW |
3 |
108,321,715 (GRCm39) |
missense |
probably benign |
|
|
R8438:Celsr2
|
UTSW |
3 |
108,301,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8460:Celsr2
|
UTSW |
3 |
108,304,093 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8462:Celsr2
|
UTSW |
3 |
108,320,167 (GRCm39) |
nonsense |
probably null |
|
|
R8479:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8480:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8512:Celsr2
|
UTSW |
3 |
108,321,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8694:Celsr2
|
UTSW |
3 |
108,314,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Celsr2
|
UTSW |
3 |
108,304,389 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8843:Celsr2
|
UTSW |
3 |
108,303,443 (GRCm39) |
splice site |
probably benign |
|
|
R8888:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8895:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8917:Celsr2
|
UTSW |
3 |
108,303,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9119:Celsr2
|
UTSW |
3 |
108,309,288 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9169:Celsr2
|
UTSW |
3 |
108,309,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9209:Celsr2
|
UTSW |
3 |
108,321,349 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9342:Celsr2
|
UTSW |
3 |
108,320,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Celsr2
|
UTSW |
3 |
108,322,084 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9493:Celsr2
|
UTSW |
3 |
108,301,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9564:Celsr2
|
UTSW |
3 |
108,321,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9598:Celsr2
|
UTSW |
3 |
108,322,578 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9629:Celsr2
|
UTSW |
3 |
108,308,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9691:Celsr2
|
UTSW |
3 |
108,301,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Celsr2
|
UTSW |
3 |
108,303,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0050:Celsr2
|
UTSW |
3 |
108,308,588 (GRCm39) |
missense |
probably benign |
0.09 |
|
Z1088:Celsr2
|
UTSW |
3 |
108,321,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,319,657 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,300,447 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,320,887 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,319,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1191:Celsr2
|
UTSW |
3 |
108,321,865 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACATCCTGTGTGGCGGATAG -3'
(R):5'- GGGCTTCGTAAGTTGATCCCTC -3'
Sequencing Primer
(F):5'- GCGGATAGCCCAAAGCC -3'
(R):5'- CACACCCTTGTCTTTGGAAGTAGAG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation