Incidental Mutation 'R1918:A2m'
ID |
212702 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
A2m
|
Ensembl Gene |
ENSMUSG00000030111 |
Gene Name |
alpha-2-macroglobulin |
Synonyms |
A2mp |
MMRRC Submission |
039936-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R1918 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
6 |
Chromosomal Location |
121612920-121656197 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 121621895 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 314
(S314P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000032203
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032203]
|
AlphaFold |
Q6GQT1 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000032203
AA Change: S314P
PolyPhen 2
Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
|
SMART Domains |
Protein: ENSMUSP00000032203 Gene: ENSMUSG00000030111 AA Change: S314P
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
Pfam:A2M_N
|
134 |
227 |
2.1e-20 |
PFAM |
low complexity region
|
334 |
347 |
N/A |
INTRINSIC |
A2M_N_2
|
465 |
613 |
2.04e-31 |
SMART |
low complexity region
|
722 |
731 |
N/A |
INTRINSIC |
A2M
|
738 |
828 |
2.31e-39 |
SMART |
Pfam:Thiol-ester_cl
|
961 |
990 |
4.4e-18 |
PFAM |
Pfam:A2M_comp
|
1010 |
1266 |
1.4e-98 |
PFAM |
A2M_recep
|
1376 |
1463 |
2.69e-40 |
SMART |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.7%
- 20x: 93.5%
|
Validation Efficiency |
97% (113/116) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 116 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930432E11Rik |
T |
G |
7: 29,273,514 (GRCm39) |
|
noncoding transcript |
Het |
Abcc9 |
T |
A |
6: 142,643,408 (GRCm39) |
I47F |
probably damaging |
Het |
Abcd2 |
C |
T |
15: 91,075,684 (GRCm39) |
R43H |
probably benign |
Het |
Adgre5 |
A |
G |
8: 84,455,738 (GRCm39) |
V190A |
probably damaging |
Het |
Aen |
C |
T |
7: 78,555,777 (GRCm39) |
H242Y |
possibly damaging |
Het |
Arfgef1 |
C |
T |
1: 10,270,103 (GRCm39) |
A349T |
probably benign |
Het |
Arhgap10 |
T |
C |
8: 77,985,708 (GRCm39) |
I698V |
probably benign |
Het |
Arpp21 |
C |
T |
9: 111,948,246 (GRCm39) |
|
probably benign |
Het |
Atp10a |
T |
C |
7: 58,477,683 (GRCm39) |
I1294T |
possibly damaging |
Het |
Atp13a2 |
T |
C |
4: 140,723,682 (GRCm39) |
Y337H |
possibly damaging |
Het |
Bsn |
C |
T |
9: 107,984,772 (GRCm39) |
G3094D |
unknown |
Het |
Cadm2 |
G |
A |
16: 66,544,270 (GRCm39) |
|
probably benign |
Het |
Cadps |
T |
C |
14: 12,546,372 (GRCm38) |
M495V |
probably damaging |
Het |
Cass4 |
A |
G |
2: 172,269,259 (GRCm39) |
H447R |
possibly damaging |
Het |
Ccdc124 |
C |
A |
8: 71,321,588 (GRCm39) |
R108L |
probably benign |
Het |
Ccdc141 |
C |
T |
2: 76,845,047 (GRCm39) |
R1340Q |
probably benign |
Het |
Ccdc148 |
T |
G |
2: 58,872,911 (GRCm39) |
R299S |
probably damaging |
Het |
Cd300lg |
A |
G |
11: 101,944,936 (GRCm39) |
E382G |
probably damaging |
Het |
Cd36 |
A |
T |
5: 18,002,034 (GRCm39) |
C322* |
probably null |
Het |
Celsr2 |
C |
T |
3: 108,305,966 (GRCm39) |
G2046D |
probably benign |
Het |
Clasrp |
C |
T |
7: 19,319,188 (GRCm39) |
W492* |
probably null |
Het |
Cmtr1 |
T |
C |
17: 29,897,983 (GRCm39) |
V154A |
possibly damaging |
Het |
Ctnnb1 |
C |
T |
9: 120,780,100 (GRCm39) |
P128S |
possibly damaging |
Het |
Cyp11a1 |
A |
G |
9: 57,934,040 (GRCm39) |
I496V |
probably damaging |
Het |
Disp2 |
G |
A |
2: 118,622,408 (GRCm39) |
V1047I |
probably benign |
Het |
Dync2i1 |
A |
C |
12: 116,196,221 (GRCm39) |
S509A |
probably damaging |
Het |
Eps8l2 |
T |
C |
7: 140,941,637 (GRCm39) |
V636A |
probably damaging |
Het |
Fars2 |
T |
C |
13: 36,388,529 (GRCm39) |
L6P |
probably damaging |
Het |
Fem1al |
A |
G |
11: 29,774,039 (GRCm39) |
S473P |
probably benign |
Het |
Fnip1 |
C |
T |
11: 54,371,510 (GRCm39) |
T177I |
probably damaging |
Het |
Fut8 |
G |
T |
12: 77,378,992 (GRCm39) |
R31L |
probably benign |
Het |
G6pd2 |
T |
C |
5: 61,967,664 (GRCm39) |
F480L |
probably benign |
Het |
Glipr1l2 |
T |
A |
10: 111,928,550 (GRCm39) |
C148* |
probably null |
Het |
Gm10142 |
G |
A |
10: 77,551,821 (GRCm39) |
V61M |
probably benign |
Het |
Gm5134 |
T |
A |
10: 75,812,180 (GRCm39) |
M145K |
possibly damaging |
Het |
Gnpda1 |
T |
C |
18: 38,466,243 (GRCm39) |
|
probably null |
Het |
Gpc2 |
T |
C |
5: 138,276,641 (GRCm39) |
T162A |
probably benign |
Het |
Gtf2h4 |
G |
A |
17: 35,981,090 (GRCm39) |
L246F |
possibly damaging |
Het |
Hal |
C |
T |
10: 93,332,469 (GRCm39) |
P294S |
probably damaging |
Het |
Hectd3 |
C |
T |
4: 116,857,540 (GRCm39) |
A573V |
possibly damaging |
Het |
Hephl1 |
T |
A |
9: 14,988,114 (GRCm39) |
I665F |
probably benign |
Het |
Herc1 |
T |
C |
9: 66,383,408 (GRCm39) |
|
probably null |
Het |
Hif1an |
A |
G |
19: 44,559,551 (GRCm39) |
|
probably null |
Het |
Iho1 |
T |
A |
9: 108,290,184 (GRCm39) |
H140L |
probably benign |
Het |
Il12rb1 |
T |
A |
8: 71,266,324 (GRCm39) |
M223K |
probably benign |
Het |
Ilf3 |
C |
T |
9: 21,305,010 (GRCm39) |
T201M |
probably damaging |
Het |
Inpp5f |
T |
C |
7: 128,265,693 (GRCm39) |
|
probably benign |
Het |
Jcad |
T |
C |
18: 4,674,292 (GRCm39) |
Y685H |
probably damaging |
Het |
Kcnj1 |
C |
A |
9: 32,308,034 (GRCm39) |
Q153K |
probably benign |
Het |
Kctd18 |
A |
C |
1: 57,998,379 (GRCm39) |
H73Q |
probably damaging |
Het |
Klhl36 |
T |
A |
8: 120,603,463 (GRCm39) |
W573R |
probably damaging |
Het |
Ldc1 |
A |
T |
4: 130,105,186 (GRCm39) |
V328D |
probably benign |
Het |
Lepr |
A |
G |
4: 101,630,033 (GRCm39) |
T583A |
probably benign |
Het |
Ltbp4 |
G |
A |
7: 27,036,994 (GRCm39) |
|
probably benign |
Het |
Mapt |
A |
T |
11: 104,189,325 (GRCm39) |
E114D |
probably benign |
Het |
Mib1 |
T |
A |
18: 10,740,972 (GRCm39) |
|
probably null |
Het |
Mthfd1 |
G |
T |
12: 76,361,750 (GRCm39) |
A119S |
probably damaging |
Het |
Mylk4 |
A |
T |
13: 32,908,836 (GRCm39) |
D90E |
probably benign |
Het |
Nceh1 |
T |
G |
3: 27,237,324 (GRCm39) |
L33R |
probably damaging |
Het |
Nfat5 |
T |
C |
8: 108,092,868 (GRCm39) |
I91T |
probably damaging |
Het |
Nxn |
A |
G |
11: 76,152,498 (GRCm39) |
|
probably benign |
Het |
Oasl1 |
G |
A |
5: 115,061,528 (GRCm39) |
A20T |
possibly damaging |
Het |
Or2m12 |
A |
T |
16: 19,105,052 (GRCm39) |
M147K |
probably benign |
Het |
Or4c127 |
T |
C |
2: 89,832,918 (GRCm39) |
F56S |
probably benign |
Het |
Or4d6 |
A |
G |
19: 12,086,871 (GRCm39) |
V13A |
probably benign |
Het |
Or5b97 |
A |
G |
19: 12,878,215 (GRCm39) |
*310Q |
probably null |
Het |
Or5t18 |
C |
T |
2: 86,637,171 (GRCm39) |
M57I |
probably damaging |
Het |
Or6c2 |
T |
A |
10: 129,362,918 (GRCm39) |
V274D |
probably damaging |
Het |
Pepd |
T |
C |
7: 34,671,101 (GRCm39) |
V215A |
probably benign |
Het |
Pfkl |
A |
T |
10: 77,837,260 (GRCm39) |
N104K |
probably damaging |
Het |
Phf24 |
T |
C |
4: 42,938,165 (GRCm39) |
|
probably benign |
Het |
Pink1 |
T |
C |
4: 138,041,331 (GRCm39) |
N530S |
probably benign |
Het |
Pou3f2 |
T |
C |
4: 22,487,119 (GRCm39) |
D338G |
probably damaging |
Het |
Ppp1r13b |
A |
G |
12: 111,801,244 (GRCm39) |
V480A |
probably damaging |
Het |
Ptgfrn |
A |
T |
3: 100,963,623 (GRCm39) |
I663N |
probably benign |
Het |
Rad54b |
A |
C |
4: 11,601,693 (GRCm39) |
N416T |
probably damaging |
Het |
Rasef |
A |
G |
4: 73,662,351 (GRCm39) |
S200P |
possibly damaging |
Het |
Rbm33 |
T |
A |
5: 28,592,915 (GRCm39) |
I605N |
probably damaging |
Het |
Rps19bp1 |
T |
C |
15: 80,148,280 (GRCm39) |
T31A |
probably benign |
Het |
Ryr2 |
T |
A |
13: 11,571,584 (GRCm39) |
T4885S |
possibly damaging |
Het |
Serpinb6b |
A |
G |
13: 33,162,223 (GRCm39) |
I222V |
probably benign |
Het |
Sik3 |
C |
G |
9: 46,132,387 (GRCm39) |
H1276Q |
probably benign |
Het |
Skor2 |
T |
C |
18: 76,947,051 (GRCm39) |
S258P |
unknown |
Het |
Slc22a29 |
C |
T |
19: 8,195,123 (GRCm39) |
|
probably null |
Het |
Slc8a3 |
A |
T |
12: 81,361,618 (GRCm39) |
F400L |
probably damaging |
Het |
Slc9a8 |
T |
C |
2: 167,266,134 (GRCm39) |
I37T |
possibly damaging |
Het |
Smchd1 |
A |
G |
17: 71,714,232 (GRCm39) |
I877T |
possibly damaging |
Het |
Spag5 |
A |
G |
11: 78,195,002 (GRCm39) |
N103S |
probably benign |
Het |
Sptbn1 |
A |
T |
11: 30,092,414 (GRCm39) |
F450L |
probably damaging |
Het |
Strn4 |
T |
A |
7: 16,567,846 (GRCm39) |
Y507N |
probably damaging |
Het |
Stxbp5 |
C |
A |
10: 9,688,042 (GRCm39) |
V420F |
possibly damaging |
Het |
Syt17 |
G |
T |
7: 118,033,208 (GRCm39) |
L267I |
possibly damaging |
Het |
Tcstv4 |
T |
C |
13: 120,769,758 (GRCm39) |
L26P |
probably damaging |
Het |
Tdo2 |
T |
A |
3: 81,866,247 (GRCm39) |
R339W |
probably damaging |
Het |
Tex55 |
A |
G |
16: 38,648,450 (GRCm39) |
Y220H |
possibly damaging |
Het |
Timd5 |
A |
G |
11: 46,419,358 (GRCm39) |
D58G |
possibly damaging |
Het |
Ttn |
A |
G |
2: 76,571,745 (GRCm39) |
S26383P |
probably damaging |
Het |
Ttn |
G |
T |
2: 76,638,868 (GRCm39) |
T13938K |
probably damaging |
Het |
Tulp2 |
A |
G |
7: 45,167,365 (GRCm39) |
N188D |
possibly damaging |
Het |
Ube3c |
C |
T |
5: 29,792,315 (GRCm39) |
R37C |
probably damaging |
Het |
Uggt2 |
G |
T |
14: 119,245,467 (GRCm39) |
|
probably benign |
Het |
Umodl1 |
G |
A |
17: 31,203,017 (GRCm39) |
V457M |
probably damaging |
Het |
Usp17la |
C |
T |
7: 104,509,953 (GRCm39) |
T186I |
probably benign |
Het |
Vmn1r226 |
T |
C |
17: 20,907,842 (GRCm39) |
S25P |
probably damaging |
Het |
Vmn1r235 |
T |
A |
17: 21,482,659 (GRCm39) |
I328K |
possibly damaging |
Het |
Vmn2r50 |
A |
T |
7: 9,781,610 (GRCm39) |
S378R |
probably benign |
Het |
Vwa2 |
C |
T |
19: 56,897,366 (GRCm39) |
T557I |
probably benign |
Het |
Vxn |
T |
C |
1: 9,671,852 (GRCm39) |
F15S |
probably damaging |
Het |
Yes1 |
G |
T |
5: 32,842,079 (GRCm39) |
Q534H |
probably benign |
Het |
Zbtb25 |
A |
T |
12: 76,396,075 (GRCm39) |
Y382* |
probably null |
Het |
Zc3h3 |
G |
A |
15: 75,648,967 (GRCm39) |
P722S |
probably damaging |
Het |
Zfp36l2 |
T |
C |
17: 84,494,164 (GRCm39) |
T158A |
probably damaging |
Het |
Zfp536 |
T |
C |
7: 37,179,624 (GRCm39) |
T994A |
probably damaging |
Het |
Zfp592 |
C |
T |
7: 80,687,168 (GRCm39) |
Q824* |
probably null |
Het |
Zfp629 |
C |
A |
7: 127,211,172 (GRCm39) |
K212N |
probably damaging |
Het |
Zfp930 |
C |
A |
8: 69,681,357 (GRCm39) |
Q350K |
probably benign |
Het |
|
Other mutations in A2m |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00494:A2m
|
APN |
6 |
121,621,108 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL00798:A2m
|
APN |
6 |
121,647,969 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01154:A2m
|
APN |
6 |
121,650,501 (GRCm39) |
nonsense |
probably null |
|
IGL01313:A2m
|
APN |
6 |
121,621,969 (GRCm39) |
critical splice donor site |
probably null |
|
IGL01337:A2m
|
APN |
6 |
121,645,529 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01505:A2m
|
APN |
6 |
121,653,906 (GRCm39) |
missense |
possibly damaging |
0.83 |
IGL01508:A2m
|
APN |
6 |
121,636,326 (GRCm39) |
nonsense |
probably null |
|
IGL01672:A2m
|
APN |
6 |
121,618,316 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01951:A2m
|
APN |
6 |
121,644,149 (GRCm39) |
missense |
possibly damaging |
0.78 |
IGL02012:A2m
|
APN |
6 |
121,651,820 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02066:A2m
|
APN |
6 |
121,626,854 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02234:A2m
|
APN |
6 |
121,645,179 (GRCm39) |
missense |
possibly damaging |
0.67 |
IGL02397:A2m
|
APN |
6 |
121,623,834 (GRCm39) |
missense |
probably benign |
|
IGL02407:A2m
|
APN |
6 |
121,645,575 (GRCm39) |
nonsense |
probably null |
|
IGL02408:A2m
|
APN |
6 |
121,621,130 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02469:A2m
|
APN |
6 |
121,645,074 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02527:A2m
|
APN |
6 |
121,638,392 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02612:A2m
|
APN |
6 |
121,654,971 (GRCm39) |
missense |
probably benign |
|
IGL02746:A2m
|
APN |
6 |
121,646,462 (GRCm39) |
splice site |
probably benign |
|
IGL02952:A2m
|
APN |
6 |
121,654,984 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03056:A2m
|
APN |
6 |
121,647,862 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL03121:A2m
|
APN |
6 |
121,618,265 (GRCm39) |
missense |
probably benign |
0.02 |
IGL03303:A2m
|
APN |
6 |
121,644,122 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03369:A2m
|
APN |
6 |
121,653,862 (GRCm39) |
critical splice acceptor site |
probably null |
|
IGL03046:A2m
|
UTSW |
6 |
121,636,282 (GRCm39) |
missense |
probably benign |
0.04 |
R0040:A2m
|
UTSW |
6 |
121,622,165 (GRCm39) |
missense |
possibly damaging |
0.93 |
R0049:A2m
|
UTSW |
6 |
121,615,267 (GRCm39) |
missense |
possibly damaging |
0.77 |
R0049:A2m
|
UTSW |
6 |
121,615,267 (GRCm39) |
missense |
possibly damaging |
0.77 |
R0109:A2m
|
UTSW |
6 |
121,636,262 (GRCm39) |
missense |
probably benign |
0.00 |
R0147:A2m
|
UTSW |
6 |
121,639,405 (GRCm39) |
critical splice donor site |
probably null |
|
R0148:A2m
|
UTSW |
6 |
121,639,405 (GRCm39) |
critical splice donor site |
probably null |
|
R0345:A2m
|
UTSW |
6 |
121,615,231 (GRCm39) |
splice site |
probably benign |
|
R0445:A2m
|
UTSW |
6 |
121,634,914 (GRCm39) |
missense |
probably damaging |
1.00 |
R0766:A2m
|
UTSW |
6 |
121,653,849 (GRCm39) |
splice site |
probably benign |
|
R1186:A2m
|
UTSW |
6 |
121,638,493 (GRCm39) |
missense |
probably benign |
0.00 |
R1436:A2m
|
UTSW |
6 |
121,621,172 (GRCm39) |
missense |
probably benign |
0.09 |
R1452:A2m
|
UTSW |
6 |
121,655,015 (GRCm39) |
missense |
probably benign |
0.01 |
R1636:A2m
|
UTSW |
6 |
121,631,571 (GRCm39) |
missense |
probably benign |
0.04 |
R1637:A2m
|
UTSW |
6 |
121,631,571 (GRCm39) |
missense |
probably benign |
0.04 |
R1638:A2m
|
UTSW |
6 |
121,631,571 (GRCm39) |
missense |
probably benign |
0.04 |
R1698:A2m
|
UTSW |
6 |
121,622,117 (GRCm39) |
missense |
possibly damaging |
0.88 |
R1776:A2m
|
UTSW |
6 |
121,618,383 (GRCm39) |
missense |
probably damaging |
1.00 |
R1791:A2m
|
UTSW |
6 |
121,631,571 (GRCm39) |
missense |
probably benign |
0.04 |
R1921:A2m
|
UTSW |
6 |
121,631,571 (GRCm39) |
missense |
probably benign |
0.04 |
R1927:A2m
|
UTSW |
6 |
121,613,338 (GRCm39) |
missense |
probably damaging |
1.00 |
R1934:A2m
|
UTSW |
6 |
121,626,792 (GRCm39) |
missense |
probably damaging |
0.98 |
R1943:A2m
|
UTSW |
6 |
121,645,506 (GRCm39) |
missense |
possibly damaging |
0.90 |
R1996:A2m
|
UTSW |
6 |
121,646,556 (GRCm39) |
missense |
probably damaging |
1.00 |
R2039:A2m
|
UTSW |
6 |
121,636,908 (GRCm39) |
missense |
probably benign |
0.32 |
R2085:A2m
|
UTSW |
6 |
121,653,918 (GRCm39) |
missense |
probably damaging |
1.00 |
R2092:A2m
|
UTSW |
6 |
121,651,896 (GRCm39) |
nonsense |
probably null |
|
R2105:A2m
|
UTSW |
6 |
121,650,459 (GRCm39) |
missense |
probably benign |
0.04 |
R2107:A2m
|
UTSW |
6 |
121,631,571 (GRCm39) |
missense |
probably benign |
0.04 |
R2235:A2m
|
UTSW |
6 |
121,619,023 (GRCm39) |
missense |
probably benign |
0.21 |
R2292:A2m
|
UTSW |
6 |
121,650,518 (GRCm39) |
missense |
possibly damaging |
0.90 |
R2350:A2m
|
UTSW |
6 |
121,655,047 (GRCm39) |
splice site |
probably benign |
|
R3001:A2m
|
UTSW |
6 |
121,638,406 (GRCm39) |
missense |
possibly damaging |
0.88 |
R3002:A2m
|
UTSW |
6 |
121,638,406 (GRCm39) |
missense |
possibly damaging |
0.88 |
R3023:A2m
|
UTSW |
6 |
121,646,531 (GRCm39) |
missense |
probably benign |
0.08 |
R3429:A2m
|
UTSW |
6 |
121,613,249 (GRCm39) |
start codon destroyed |
probably null |
|
R3437:A2m
|
UTSW |
6 |
121,616,253 (GRCm39) |
missense |
probably null |
0.03 |
R3909:A2m
|
UTSW |
6 |
121,625,125 (GRCm39) |
missense |
probably damaging |
1.00 |
R4300:A2m
|
UTSW |
6 |
121,650,434 (GRCm39) |
missense |
probably benign |
0.00 |
R4332:A2m
|
UTSW |
6 |
121,634,406 (GRCm39) |
missense |
probably benign |
0.01 |
R4584:A2m
|
UTSW |
6 |
121,634,365 (GRCm39) |
missense |
probably benign |
0.07 |
R4697:A2m
|
UTSW |
6 |
121,615,243 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
R4710:A2m
|
UTSW |
6 |
121,618,262 (GRCm39) |
missense |
probably benign |
0.03 |
R4841:A2m
|
UTSW |
6 |
121,623,803 (GRCm39) |
missense |
probably benign |
0.06 |
R5206:A2m
|
UTSW |
6 |
121,651,766 (GRCm39) |
missense |
probably damaging |
1.00 |
R5219:A2m
|
UTSW |
6 |
121,653,909 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5230:A2m
|
UTSW |
6 |
121,651,820 (GRCm39) |
missense |
probably damaging |
1.00 |
R5330:A2m
|
UTSW |
6 |
121,615,375 (GRCm39) |
missense |
probably benign |
0.11 |
R5331:A2m
|
UTSW |
6 |
121,615,375 (GRCm39) |
missense |
probably benign |
0.11 |
R5377:A2m
|
UTSW |
6 |
121,622,212 (GRCm39) |
missense |
probably benign |
|
R5590:A2m
|
UTSW |
6 |
121,653,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R5835:A2m
|
UTSW |
6 |
121,616,295 (GRCm39) |
missense |
probably damaging |
1.00 |
R5910:A2m
|
UTSW |
6 |
121,645,076 (GRCm39) |
missense |
probably damaging |
1.00 |
R5915:A2m
|
UTSW |
6 |
121,644,122 (GRCm39) |
missense |
probably damaging |
1.00 |
R5949:A2m
|
UTSW |
6 |
121,655,032 (GRCm39) |
missense |
probably damaging |
1.00 |
R5994:A2m
|
UTSW |
6 |
121,647,862 (GRCm39) |
missense |
probably benign |
0.38 |
R5996:A2m
|
UTSW |
6 |
121,636,353 (GRCm39) |
missense |
probably damaging |
1.00 |
R6035:A2m
|
UTSW |
6 |
121,615,353 (GRCm39) |
missense |
probably damaging |
0.99 |
R6035:A2m
|
UTSW |
6 |
121,615,353 (GRCm39) |
missense |
probably damaging |
0.99 |
R6090:A2m
|
UTSW |
6 |
121,624,972 (GRCm39) |
missense |
probably benign |
0.45 |
R6241:A2m
|
UTSW |
6 |
121,623,788 (GRCm39) |
missense |
probably benign |
0.09 |
R6294:A2m
|
UTSW |
6 |
121,631,440 (GRCm39) |
missense |
probably benign |
|
R6492:A2m
|
UTSW |
6 |
121,631,464 (GRCm39) |
missense |
probably benign |
0.35 |
R6554:A2m
|
UTSW |
6 |
121,618,246 (GRCm39) |
missense |
probably damaging |
1.00 |
R6597:A2m
|
UTSW |
6 |
121,625,080 (GRCm39) |
missense |
probably damaging |
1.00 |
R6742:A2m
|
UTSW |
6 |
121,654,995 (GRCm39) |
missense |
probably benign |
0.01 |
R6795:A2m
|
UTSW |
6 |
121,625,281 (GRCm39) |
splice site |
probably null |
|
R6843:A2m
|
UTSW |
6 |
121,615,360 (GRCm39) |
missense |
probably benign |
0.01 |
R7013:A2m
|
UTSW |
6 |
121,618,345 (GRCm39) |
missense |
probably null |
0.00 |
R7137:A2m
|
UTSW |
6 |
121,654,944 (GRCm39) |
missense |
possibly damaging |
0.85 |
R7167:A2m
|
UTSW |
6 |
121,624,930 (GRCm39) |
missense |
probably benign |
|
R7294:A2m
|
UTSW |
6 |
121,650,541 (GRCm39) |
nonsense |
probably null |
|
R7452:A2m
|
UTSW |
6 |
121,618,291 (GRCm39) |
missense |
probably damaging |
1.00 |
R7507:A2m
|
UTSW |
6 |
121,652,177 (GRCm39) |
missense |
probably benign |
0.01 |
R7602:A2m
|
UTSW |
6 |
121,647,895 (GRCm39) |
missense |
possibly damaging |
0.79 |
R7602:A2m
|
UTSW |
6 |
121,618,966 (GRCm39) |
missense |
probably damaging |
1.00 |
R7709:A2m
|
UTSW |
6 |
121,637,063 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7766:A2m
|
UTSW |
6 |
121,615,300 (GRCm39) |
missense |
probably benign |
0.08 |
R7921:A2m
|
UTSW |
6 |
121,654,954 (GRCm39) |
missense |
probably benign |
0.00 |
R8007:A2m
|
UTSW |
6 |
121,647,845 (GRCm39) |
intron |
probably benign |
|
R8291:A2m
|
UTSW |
6 |
121,655,017 (GRCm39) |
missense |
probably damaging |
1.00 |
R8542:A2m
|
UTSW |
6 |
121,634,369 (GRCm39) |
missense |
probably benign |
0.03 |
R8856:A2m
|
UTSW |
6 |
121,618,349 (GRCm39) |
missense |
probably benign |
0.00 |
R9023:A2m
|
UTSW |
6 |
121,636,917 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9154:A2m
|
UTSW |
6 |
121,645,512 (GRCm39) |
missense |
probably damaging |
1.00 |
R9156:A2m
|
UTSW |
6 |
121,647,957 (GRCm39) |
missense |
probably damaging |
0.98 |
R9255:A2m
|
UTSW |
6 |
121,626,795 (GRCm39) |
missense |
probably damaging |
1.00 |
R9269:A2m
|
UTSW |
6 |
121,637,865 (GRCm39) |
missense |
probably benign |
0.38 |
R9325:A2m
|
UTSW |
6 |
121,646,578 (GRCm39) |
missense |
possibly damaging |
0.81 |
R9393:A2m
|
UTSW |
6 |
121,616,270 (GRCm39) |
missense |
possibly damaging |
0.91 |
R9563:A2m
|
UTSW |
6 |
121,645,009 (GRCm39) |
missense |
probably damaging |
0.99 |
X0057:A2m
|
UTSW |
6 |
121,645,135 (GRCm39) |
missense |
probably damaging |
1.00 |
X0060:A2m
|
UTSW |
6 |
121,653,039 (GRCm39) |
missense |
probably damaging |
1.00 |
X0063:A2m
|
UTSW |
6 |
121,623,835 (GRCm39) |
missense |
probably benign |
|
|
Predicted Primers |
PCR Primer
(F):5'- TAGTTAGTCCCTAGGCAGTGC -3'
(R):5'- GTTTCTTCCACACCTGAAACAG -3'
Sequencing Primer
(F):5'- AGTCCCTAGGCAGTGCATATTATG -3'
(R):5'- GCTGATGTCGGCGAATTTCTTATACC -3'
|
Posted On |
2014-07-14 |