Mutagenetix > Incidental Mutation

Incidental Mutation 'R1918:Ltbp4'

212707

Institutional Source

Beutler Lab

Gene Symbol

Ltbp4

Ensembl Gene

ENSMUSG00000040488

Gene Name

latent transforming growth factor beta binding protein 4

Synonyms

2310046A13Rik

MMRRC Submission

039936-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1918 (G1)

Quality Score

131

Status

Validated

Chromosome

Chromosomal Location

27004561-27037117 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 27036994 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000113674 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000003857] [ENSMUST00000038618] [ENSMUST00000108369] [ENSMUST00000118583] [ENSMUST00000118961] [ENSMUST00000121175]

AlphaFold

Q8K4G1

Predicted Effect

probably benign
Transcript: ENSMUST00000003857

SMART Domains

Protein: ENSMUSP00000003857
Gene: ENSMUSG00000089832

Domain	Start	End	E-Value	Type
BTB	19	119	1.65e-16	SMART
low complexity region	183	194	N/A	INTRINSIC
Blast:WD40	196	271	1e-21	BLAST
WD40	277	313	1.9e2	SMART
WD40	419	457	3.45e-1	SMART
WD40	527	577	3.68e1	SMART
low complexity region	612	631	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000038618

SMART Domains

Protein: ENSMUSP00000037536
Gene: ENSMUSG00000040488

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	112	125	N/A	INTRINSIC
EGF	151	180	2.74e-3	SMART
low complexity region	244	265	N/A	INTRINSIC
EGF_CA	356	396	3.51e-10	SMART
Pfam:TB	416	457	4.8e-15	PFAM
low complexity region	490	501	N/A	INTRINSIC
low complexity region	507	568	N/A	INTRINSIC
low complexity region	579	590	N/A	INTRINSIC
EGF	591	629	6.06e-5	SMART
EGF_CA	630	671	8.3e-12	SMART
EGF_CA	672	713	7.34e-13	SMART
EGF_CA	714	751	8.43e-13	SMART
EGF_CA	753	794	1.66e-11	SMART
EGF_CA	795	836	3.61e-12	SMART
EGF_CA	837	876	5.61e-9	SMART
EGF_CA	877	919	1.73e-9	SMART
EGF_CA	920	961	7.12e-11	SMART
EGF_CA	962	1002	3.56e-11	SMART
EGF_CA	1003	1046	1.61e-9	SMART
EGF_CA	1047	1090	2.13e-9	SMART
EGF_CA	1091	1132	1.02e-11	SMART
EGF	1136	1175	1.69e1	SMART
low complexity region	1185	1223	N/A	INTRINSIC
Pfam:TB	1234	1276	1.7e-13	PFAM
EGF_CA	1295	1337	2.72e-7	SMART
EGF_CA	1338	1379	1.36e-7	SMART
Pfam:TB	1402	1443	4.3e-14	PFAM
low complexity region	1449	1461	N/A	INTRINSIC
low complexity region	1478	1500	N/A	INTRINSIC
EGF	1578	1615	6.06e-5	SMART
EGF_CA	1616	1660	9.54e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108369

SMART Domains

Protein: ENSMUSP00000104006
Gene: ENSMUSG00000040488

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
low complexity region	116	145	N/A	INTRINSIC
EGF	150	179	2.74e-3	SMART
low complexity region	243	264	N/A	INTRINSIC
EGF_CA	355	395	3.51e-10	SMART
Pfam:TB	414	456	2.5e-14	PFAM
low complexity region	489	500	N/A	INTRINSIC
low complexity region	506	567	N/A	INTRINSIC
low complexity region	578	589	N/A	INTRINSIC
EGF	590	628	6.06e-5	SMART
EGF_CA	629	670	8.3e-12	SMART
EGF_CA	671	712	7.34e-13	SMART
EGF_CA	713	750	8.43e-13	SMART
EGF_CA	752	793	1.66e-11	SMART
EGF_CA	794	835	3.61e-12	SMART
EGF_CA	836	875	5.61e-9	SMART
EGF_CA	876	918	1.73e-9	SMART
EGF_CA	919	960	7.12e-11	SMART
EGF_CA	961	1001	3.56e-11	SMART
EGF_CA	1002	1045	1.61e-9	SMART
EGF_CA	1046	1089	2.13e-9	SMART
EGF_CA	1090	1131	1.02e-11	SMART
EGF	1135	1174	1.69e1	SMART
low complexity region	1184	1222	N/A	INTRINSIC
Pfam:TB	1232	1275	2.4e-13	PFAM
EGF_CA	1294	1336	2.72e-7	SMART
EGF_CA	1337	1378	1.36e-7	SMART
Pfam:TB	1400	1442	7.6e-15	PFAM
low complexity region	1448	1460	N/A	INTRINSIC
low complexity region	1477	1499	N/A	INTRINSIC
EGF	1577	1614	6.06e-5	SMART
EGF_CA	1615	1659	9.54e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000118583

SMART Domains

Protein: ENSMUSP00000113523
Gene: ENSMUSG00000040488

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
low complexity region	69	80	N/A	INTRINSIC
EGF	85	114	2.74e-3	SMART
low complexity region	178	199	N/A	INTRINSIC
EGF_CA	290	330	3.51e-10	SMART
Pfam:TB	349	391	2.3e-14	PFAM
low complexity region	424	435	N/A	INTRINSIC
low complexity region	441	502	N/A	INTRINSIC
low complexity region	513	524	N/A	INTRINSIC
EGF	525	563	6.06e-5	SMART
EGF_CA	564	605	8.3e-12	SMART
EGF_CA	606	647	7.34e-13	SMART
EGF_CA	648	685	8.43e-13	SMART
EGF_CA	687	728	1.66e-11	SMART
EGF_CA	729	770	3.61e-12	SMART
EGF_CA	771	810	5.61e-9	SMART
EGF_CA	811	853	1.73e-9	SMART
EGF_CA	854	895	7.12e-11	SMART
EGF_CA	896	936	3.56e-11	SMART
EGF_CA	937	980	1.61e-9	SMART
EGF_CA	981	1024	2.13e-9	SMART
EGF_CA	1025	1066	1.02e-11	SMART
EGF	1070	1109	1.69e1	SMART
low complexity region	1119	1157	N/A	INTRINSIC
Pfam:TB	1167	1210	2.2e-13	PFAM
EGF_CA	1229	1271	2.72e-7	SMART
EGF_CA	1272	1313	1.36e-7	SMART
Pfam:TB	1335	1377	7.1e-15	PFAM
low complexity region	1383	1395	N/A	INTRINSIC
low complexity region	1412	1434	N/A	INTRINSIC
EGF	1512	1549	6.06e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000118961

SMART Domains

Protein: ENSMUSP00000113746
Gene: ENSMUSG00000040488

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
low complexity region	69	80	N/A	INTRINSIC
EGF	85	114	2.74e-3	SMART
low complexity region	178	199	N/A	INTRINSIC
EGF_CA	290	330	3.51e-10	SMART
Pfam:TB	349	391	1.6e-14	PFAM
low complexity region	424	435	N/A	INTRINSIC
low complexity region	441	502	N/A	INTRINSIC
low complexity region	513	524	N/A	INTRINSIC
EGF	525	563	6.06e-5	SMART
EGF_CA	564	605	8.3e-12	SMART
EGF_CA	606	647	7.34e-13	SMART
EGF_CA	648	685	8.43e-13	SMART
EGF_CA	687	728	1.66e-11	SMART
EGF_CA	729	770	3.61e-12	SMART
EGF_CA	771	810	5.61e-9	SMART
EGF_CA	811	853	1.73e-9	SMART
EGF_CA	854	895	7.12e-11	SMART
EGF_CA	896	936	3.56e-11	SMART
EGF_CA	937	980	1.61e-9	SMART
EGF_CA	981	1024	2.13e-9	SMART
EGF_CA	1025	1066	1.02e-11	SMART
EGF	1070	1109	1.69e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000121175

SMART Domains

Protein: ENSMUSP00000113674
Gene: ENSMUSG00000040488

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
low complexity region	69	80	N/A	INTRINSIC
EGF	85	114	2.74e-3	SMART
low complexity region	178	199	N/A	INTRINSIC
EGF_CA	290	330	3.51e-10	SMART
Pfam:TB	349	391	3.4e-14	PFAM
low complexity region	424	435	N/A	INTRINSIC
low complexity region	441	502	N/A	INTRINSIC
low complexity region	513	524	N/A	INTRINSIC
EGF	525	563	6.06e-5	SMART
EGF_CA	564	605	8.3e-12	SMART
EGF_CA	606	647	7.34e-13	SMART
EGF_CA	648	685	8.43e-13	SMART
EGF_CA	687	728	1.66e-11	SMART
EGF_CA	729	770	3.61e-12	SMART
EGF_CA	771	810	5.61e-9	SMART
EGF_CA	811	853	1.73e-9	SMART
EGF_CA	854	895	7.12e-11	SMART
EGF_CA	896	936	3.56e-11	SMART
EGF_CA	937	980	1.61e-9	SMART
EGF_CA	981	1024	2.13e-9	SMART
EGF_CA	1025	1066	1.02e-11	SMART
EGF	1070	1109	1.69e1	SMART
low complexity region	1119	1157	N/A	INTRINSIC
Pfam:TB	1167	1210	3.3e-13	PFAM
EGF_CA	1229	1271	2.72e-7	SMART
EGF_CA	1272	1313	1.36e-7	SMART
Pfam:TB	1335	1377	1e-14	PFAM
low complexity region	1383	1395	N/A	INTRINSIC
low complexity region	1412	1434	N/A	INTRINSIC
EGF	1512	1549	6.06e-5	SMART
EGF_CA	1550	1594	9.54e-12	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123190

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132684

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140638

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148933

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206413

Coding Region Coverage

1x: 97.5%
3x: 97.0%
10x: 95.7%
20x: 93.5%

Validation Efficiency

97% (113/116)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
PHENOTYPE: Homozygous disruption of this locus results in pulmonary emphysema, cardiomyopathy, and colon cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 116 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432E11Rik	T	G	7: 29,273,514 (GRCm39)		noncoding transcript	Het
A2m	T	C	6: 121,621,895 (GRCm39)	S314P	probably benign	Het
Abcc9	T	A	6: 142,643,408 (GRCm39)	I47F	probably damaging	Het
Abcd2	C	T	15: 91,075,684 (GRCm39)	R43H	probably benign	Het
Adgre5	A	G	8: 84,455,738 (GRCm39)	V190A	probably damaging	Het
Aen	C	T	7: 78,555,777 (GRCm39)	H242Y	possibly damaging	Het
Arfgef1	C	T	1: 10,270,103 (GRCm39)	A349T	probably benign	Het
Arhgap10	T	C	8: 77,985,708 (GRCm39)	I698V	probably benign	Het
Arpp21	C	T	9: 111,948,246 (GRCm39)		probably benign	Het
Atp10a	T	C	7: 58,477,683 (GRCm39)	I1294T	possibly damaging	Het
Atp13a2	T	C	4: 140,723,682 (GRCm39)	Y337H	possibly damaging	Het
Bsn	C	T	9: 107,984,772 (GRCm39)	G3094D	unknown	Het
Cadm2	G	A	16: 66,544,270 (GRCm39)		probably benign	Het
Cadps	T	C	14: 12,546,372 (GRCm38)	M495V	probably damaging	Het
Cass4	A	G	2: 172,269,259 (GRCm39)	H447R	possibly damaging	Het
Ccdc124	C	A	8: 71,321,588 (GRCm39)	R108L	probably benign	Het
Ccdc141	C	T	2: 76,845,047 (GRCm39)	R1340Q	probably benign	Het
Ccdc148	T	G	2: 58,872,911 (GRCm39)	R299S	probably damaging	Het
Cd300lg	A	G	11: 101,944,936 (GRCm39)	E382G	probably damaging	Het
Cd36	A	T	5: 18,002,034 (GRCm39)	C322*	probably null	Het
Celsr2	C	T	3: 108,305,966 (GRCm39)	G2046D	probably benign	Het
Clasrp	C	T	7: 19,319,188 (GRCm39)	W492*	probably null	Het
Cmtr1	T	C	17: 29,897,983 (GRCm39)	V154A	possibly damaging	Het
Ctnnb1	C	T	9: 120,780,100 (GRCm39)	P128S	possibly damaging	Het
Cyp11a1	A	G	9: 57,934,040 (GRCm39)	I496V	probably damaging	Het
Disp2	G	A	2: 118,622,408 (GRCm39)	V1047I	probably benign	Het
Dync2i1	A	C	12: 116,196,221 (GRCm39)	S509A	probably damaging	Het
Eps8l2	T	C	7: 140,941,637 (GRCm39)	V636A	probably damaging	Het
Fars2	T	C	13: 36,388,529 (GRCm39)	L6P	probably damaging	Het
Fem1al	A	G	11: 29,774,039 (GRCm39)	S473P	probably benign	Het
Fnip1	C	T	11: 54,371,510 (GRCm39)	T177I	probably damaging	Het
Fut8	G	T	12: 77,378,992 (GRCm39)	R31L	probably benign	Het
G6pd2	T	C	5: 61,967,664 (GRCm39)	F480L	probably benign	Het
Glipr1l2	T	A	10: 111,928,550 (GRCm39)	C148*	probably null	Het
Gm10142	G	A	10: 77,551,821 (GRCm39)	V61M	probably benign	Het
Gm5134	T	A	10: 75,812,180 (GRCm39)	M145K	possibly damaging	Het
Gnpda1	T	C	18: 38,466,243 (GRCm39)		probably null	Het
Gpc2	T	C	5: 138,276,641 (GRCm39)	T162A	probably benign	Het
Gtf2h4	G	A	17: 35,981,090 (GRCm39)	L246F	possibly damaging	Het
Hal	C	T	10: 93,332,469 (GRCm39)	P294S	probably damaging	Het
Hectd3	C	T	4: 116,857,540 (GRCm39)	A573V	possibly damaging	Het
Hephl1	T	A	9: 14,988,114 (GRCm39)	I665F	probably benign	Het
Herc1	T	C	9: 66,383,408 (GRCm39)		probably null	Het
Hif1an	A	G	19: 44,559,551 (GRCm39)		probably null	Het
Iho1	T	A	9: 108,290,184 (GRCm39)	H140L	probably benign	Het
Il12rb1	T	A	8: 71,266,324 (GRCm39)	M223K	probably benign	Het
Ilf3	C	T	9: 21,305,010 (GRCm39)	T201M	probably damaging	Het
Inpp5f	T	C	7: 128,265,693 (GRCm39)		probably benign	Het
Jcad	T	C	18: 4,674,292 (GRCm39)	Y685H	probably damaging	Het
Kcnj1	C	A	9: 32,308,034 (GRCm39)	Q153K	probably benign	Het
Kctd18	A	C	1: 57,998,379 (GRCm39)	H73Q	probably damaging	Het
Klhl36	T	A	8: 120,603,463 (GRCm39)	W573R	probably damaging	Het
Ldc1	A	T	4: 130,105,186 (GRCm39)	V328D	probably benign	Het
Lepr	A	G	4: 101,630,033 (GRCm39)	T583A	probably benign	Het
Mapt	A	T	11: 104,189,325 (GRCm39)	E114D	probably benign	Het
Mib1	T	A	18: 10,740,972 (GRCm39)		probably null	Het
Mthfd1	G	T	12: 76,361,750 (GRCm39)	A119S	probably damaging	Het
Mylk4	A	T	13: 32,908,836 (GRCm39)	D90E	probably benign	Het
Nceh1	T	G	3: 27,237,324 (GRCm39)	L33R	probably damaging	Het
Nfat5	T	C	8: 108,092,868 (GRCm39)	I91T	probably damaging	Het
Nxn	A	G	11: 76,152,498 (GRCm39)		probably benign	Het
Oasl1	G	A	5: 115,061,528 (GRCm39)	A20T	possibly damaging	Het
Or2m12	A	T	16: 19,105,052 (GRCm39)	M147K	probably benign	Het
Or4c127	T	C	2: 89,832,918 (GRCm39)	F56S	probably benign	Het
Or4d6	A	G	19: 12,086,871 (GRCm39)	V13A	probably benign	Het
Or5b97	A	G	19: 12,878,215 (GRCm39)	*310Q	probably null	Het
Or5t18	C	T	2: 86,637,171 (GRCm39)	M57I	probably damaging	Het
Or6c2	T	A	10: 129,362,918 (GRCm39)	V274D	probably damaging	Het
Pepd	T	C	7: 34,671,101 (GRCm39)	V215A	probably benign	Het
Pfkl	A	T	10: 77,837,260 (GRCm39)	N104K	probably damaging	Het
Phf24	T	C	4: 42,938,165 (GRCm39)		probably benign	Het
Pink1	T	C	4: 138,041,331 (GRCm39)	N530S	probably benign	Het
Pou3f2	T	C	4: 22,487,119 (GRCm39)	D338G	probably damaging	Het
Ppp1r13b	A	G	12: 111,801,244 (GRCm39)	V480A	probably damaging	Het
Ptgfrn	A	T	3: 100,963,623 (GRCm39)	I663N	probably benign	Het
Rad54b	A	C	4: 11,601,693 (GRCm39)	N416T	probably damaging	Het
Rasef	A	G	4: 73,662,351 (GRCm39)	S200P	possibly damaging	Het
Rbm33	T	A	5: 28,592,915 (GRCm39)	I605N	probably damaging	Het
Rps19bp1	T	C	15: 80,148,280 (GRCm39)	T31A	probably benign	Het
Ryr2	T	A	13: 11,571,584 (GRCm39)	T4885S	possibly damaging	Het
Serpinb6b	A	G	13: 33,162,223 (GRCm39)	I222V	probably benign	Het
Sik3	C	G	9: 46,132,387 (GRCm39)	H1276Q	probably benign	Het
Skor2	T	C	18: 76,947,051 (GRCm39)	S258P	unknown	Het
Slc22a29	C	T	19: 8,195,123 (GRCm39)		probably null	Het
Slc8a3	A	T	12: 81,361,618 (GRCm39)	F400L	probably damaging	Het
Slc9a8	T	C	2: 167,266,134 (GRCm39)	I37T	possibly damaging	Het
Smchd1	A	G	17: 71,714,232 (GRCm39)	I877T	possibly damaging	Het
Spag5	A	G	11: 78,195,002 (GRCm39)	N103S	probably benign	Het
Sptbn1	A	T	11: 30,092,414 (GRCm39)	F450L	probably damaging	Het
Strn4	T	A	7: 16,567,846 (GRCm39)	Y507N	probably damaging	Het
Stxbp5	C	A	10: 9,688,042 (GRCm39)	V420F	possibly damaging	Het
Syt17	G	T	7: 118,033,208 (GRCm39)	L267I	possibly damaging	Het
Tcstv4	T	C	13: 120,769,758 (GRCm39)	L26P	probably damaging	Het
Tdo2	T	A	3: 81,866,247 (GRCm39)	R339W	probably damaging	Het
Tex55	A	G	16: 38,648,450 (GRCm39)	Y220H	possibly damaging	Het
Timd5	A	G	11: 46,419,358 (GRCm39)	D58G	possibly damaging	Het
Ttn	A	G	2: 76,571,745 (GRCm39)	S26383P	probably damaging	Het
Ttn	G	T	2: 76,638,868 (GRCm39)	T13938K	probably damaging	Het
Tulp2	A	G	7: 45,167,365 (GRCm39)	N188D	possibly damaging	Het
Ube3c	C	T	5: 29,792,315 (GRCm39)	R37C	probably damaging	Het
Uggt2	G	T	14: 119,245,467 (GRCm39)		probably benign	Het
Umodl1	G	A	17: 31,203,017 (GRCm39)	V457M	probably damaging	Het
Usp17la	C	T	7: 104,509,953 (GRCm39)	T186I	probably benign	Het
Vmn1r226	T	C	17: 20,907,842 (GRCm39)	S25P	probably damaging	Het
Vmn1r235	T	A	17: 21,482,659 (GRCm39)	I328K	possibly damaging	Het
Vmn2r50	A	T	7: 9,781,610 (GRCm39)	S378R	probably benign	Het
Vwa2	C	T	19: 56,897,366 (GRCm39)	T557I	probably benign	Het
Vxn	T	C	1: 9,671,852 (GRCm39)	F15S	probably damaging	Het
Yes1	G	T	5: 32,842,079 (GRCm39)	Q534H	probably benign	Het
Zbtb25	A	T	12: 76,396,075 (GRCm39)	Y382*	probably null	Het
Zc3h3	G	A	15: 75,648,967 (GRCm39)	P722S	probably damaging	Het
Zfp36l2	T	C	17: 84,494,164 (GRCm39)	T158A	probably damaging	Het
Zfp536	T	C	7: 37,179,624 (GRCm39)	T994A	probably damaging	Het
Zfp592	C	T	7: 80,687,168 (GRCm39)	Q824*	probably null	Het
Zfp629	C	A	7: 127,211,172 (GRCm39)	K212N	probably damaging	Het
Zfp930	C	A	8: 69,681,357 (GRCm39)	Q350K	probably benign	Het

Other mutations in Ltbp4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00434:Ltbp4	APN	7	27,028,230 (GRCm39)	missense	probably damaging	0.96
IGL00585:Ltbp4	APN	7	27,026,158 (GRCm39)	missense	probably damaging	0.98
IGL01320:Ltbp4	APN	7	27,027,784 (GRCm39)	splice site	probably benign
IGL01860:Ltbp4	APN	7	27,019,071 (GRCm39)	missense	probably damaging	1.00
IGL02026:Ltbp4	APN	7	27,026,842 (GRCm39)	nonsense	probably null
IGL02226:Ltbp4	APN	7	27,006,359 (GRCm39)	missense	probably damaging	1.00
IGL02422:Ltbp4	APN	7	27,019,097 (GRCm39)	missense	probably damaging	1.00
IGL02611:Ltbp4	APN	7	27,010,080 (GRCm39)	missense	probably damaging	1.00
IGL02892:Ltbp4	APN	7	27,010,074 (GRCm39)	missense	probably damaging	1.00
IGL02926:Ltbp4	APN	7	27,028,297 (GRCm39)	splice site	probably null
IGL02950:Ltbp4	APN	7	27,006,143 (GRCm39)	missense	probably damaging	0.99
IGL03008:Ltbp4	APN	7	27,023,789 (GRCm39)	missense	probably damaging	0.99
IGL03271:Ltbp4	APN	7	27,029,240 (GRCm39)	missense	unknown
IGL02837:Ltbp4	UTSW	7	27,013,806 (GRCm39)	missense	probably damaging	1.00
R0792:Ltbp4	UTSW	7	27,024,485 (GRCm39)	missense	probably damaging	1.00
R0980:Ltbp4	UTSW	7	27,023,587 (GRCm39)	missense	probably damaging	1.00
R1017:Ltbp4	UTSW	7	27,005,501 (GRCm39)	missense	possibly damaging	0.95
R1185:Ltbp4	UTSW	7	27,009,960 (GRCm39)	missense	probably damaging	1.00
R1185:Ltbp4	UTSW	7	27,009,960 (GRCm39)	missense	probably damaging	1.00
R1185:Ltbp4	UTSW	7	27,009,960 (GRCm39)	missense	probably damaging	1.00
R1403:Ltbp4	UTSW	7	27,028,464 (GRCm39)	missense	unknown
R1403:Ltbp4	UTSW	7	27,028,464 (GRCm39)	missense	unknown
R1448:Ltbp4	UTSW	7	27,006,002 (GRCm39)	missense	possibly damaging	0.86
R1575:Ltbp4	UTSW	7	27,022,245 (GRCm39)	missense	probably damaging	1.00
R1932:Ltbp4	UTSW	7	27,007,191 (GRCm39)	critical splice donor site	probably null
R1959:Ltbp4	UTSW	7	27,028,443 (GRCm39)	missense	unknown
R1960:Ltbp4	UTSW	7	27,028,443 (GRCm39)	missense	unknown
R1976:Ltbp4	UTSW	7	27,026,195 (GRCm39)	missense	probably damaging	1.00
R2060:Ltbp4	UTSW	7	27,008,378 (GRCm39)	missense	probably damaging	1.00
R2333:Ltbp4	UTSW	7	27,027,203 (GRCm39)	missense	possibly damaging	0.82
R2431:Ltbp4	UTSW	7	27,019,101 (GRCm39)	missense	possibly damaging	0.91
R3125:Ltbp4	UTSW	7	27,027,203 (GRCm39)	missense	possibly damaging	0.82
R4093:Ltbp4	UTSW	7	27,024,641 (GRCm39)	missense	possibly damaging	0.93
R4095:Ltbp4	UTSW	7	27,024,641 (GRCm39)	missense	possibly damaging	0.93
R4592:Ltbp4	UTSW	7	27,024,608 (GRCm39)	missense	probably damaging	0.96
R4610:Ltbp4	UTSW	7	27,006,125 (GRCm39)	missense	probably damaging	1.00
R4650:Ltbp4	UTSW	7	27,013,734 (GRCm39)	missense	probably damaging	1.00
R4912:Ltbp4	UTSW	7	27,005,541 (GRCm39)	nonsense	probably null
R5002:Ltbp4	UTSW	7	27,027,110 (GRCm39)	frame shift	probably null
R5016:Ltbp4	UTSW	7	27,027,110 (GRCm39)	frame shift	probably null
R5216:Ltbp4	UTSW	7	27,026,736 (GRCm39)	small deletion	probably benign
R5218:Ltbp4	UTSW	7	27,026,736 (GRCm39)	small deletion	probably benign
R5219:Ltbp4	UTSW	7	27,026,746 (GRCm39)	missense	probably benign	0.01
R5219:Ltbp4	UTSW	7	27,026,736 (GRCm39)	small deletion	probably benign
R5539:Ltbp4	UTSW	7	27,027,149 (GRCm39)	missense	probably damaging	0.97
R5991:Ltbp4	UTSW	7	27,008,741 (GRCm39)	missense	probably damaging	1.00
R6082:Ltbp4	UTSW	7	27,035,105 (GRCm39)	unclassified	probably benign
R6125:Ltbp4	UTSW	7	27,027,180 (GRCm39)	missense	probably damaging	1.00
R6146:Ltbp4	UTSW	7	27,019,149 (GRCm39)	missense	probably damaging	0.99
R6156:Ltbp4	UTSW	7	27,029,587 (GRCm39)	missense	unknown
R6414:Ltbp4	UTSW	7	27,010,140 (GRCm39)	missense	probably damaging	1.00
R6563:Ltbp4	UTSW	7	27,008,488 (GRCm39)	missense	probably damaging	1.00
R6719:Ltbp4	UTSW	7	27,028,188 (GRCm39)	missense	probably damaging	0.99
R6940:Ltbp4	UTSW	7	27,008,369 (GRCm39)	missense	probably damaging	1.00
R7054:Ltbp4	UTSW	7	27,007,191 (GRCm39)	critical splice donor site	probably null
R7116:Ltbp4	UTSW	7	27,004,852 (GRCm39)	missense	probably damaging	0.99
R7326:Ltbp4	UTSW	7	27,029,180 (GRCm39)	missense	unknown
R7419:Ltbp4	UTSW	7	27,029,192 (GRCm39)	missense	unknown
R8068:Ltbp4	UTSW	7	27,023,593 (GRCm39)	missense	probably damaging	0.99
R8435:Ltbp4	UTSW	7	27,034,870 (GRCm39)	missense	unknown
R8543:Ltbp4	UTSW	7	27,024,666 (GRCm39)	missense	possibly damaging	0.84
R8897:Ltbp4	UTSW	7	27,026,119 (GRCm39)	missense	probably benign	0.09
R9103:Ltbp4	UTSW	7	27,028,186 (GRCm39)	missense	unknown
R9131:Ltbp4	UTSW	7	27,036,976 (GRCm39)	missense	unknown
R9206:Ltbp4	UTSW	7	27,022,350 (GRCm39)	missense	probably damaging	1.00
R9301:Ltbp4	UTSW	7	27,021,578 (GRCm39)	missense	probably damaging	0.98
R9302:Ltbp4	UTSW	7	27,008,481 (GRCm39)	missense	possibly damaging	0.80
X0025:Ltbp4	UTSW	7	27,025,227 (GRCm39)	missense	probably damaging	1.00
X0066:Ltbp4	UTSW	7	27,005,490 (GRCm39)	critical splice donor site	probably null
Z1088:Ltbp4	UTSW	7	27,007,217 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCTAAATCTGAAGGTCTTGCTCCTC -3'
(R):5'- TTACCGATTGGCCTCACTCG -3'

Sequencing Primer
(F):5'- AAGGTCTTGCTCCTCCGAGAC -3'
(R):5'- TCACTCGGAGCGCTGACAG -3'

Posted On

2014-07-14