Incidental Mutation 'R1923:Or8k32'
ID 213201
Institutional Source Beutler Lab
Gene Symbol Or8k32
Ensembl Gene ENSMUSG00000075179
Gene Name olfactory receptor family 8 subfamily K member 32
Synonyms GA_x6K02T2Q125-48024195-48023254, MOR189-1, Olfr1079
MMRRC Submission 039941-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R1923 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 86368310-86369257 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 86368857 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Serine at position 132 (Y132S)
Ref Sequence ENSEMBL: ENSMUSP00000151072 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099882] [ENSMUST00000111582] [ENSMUST00000216480]
AlphaFold Q8VF52
Predicted Effect probably damaging
Transcript: ENSMUST00000099882
AA Change: Y134S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097467
Gene: ENSMUSG00000075179
AA Change: Y134S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 37 175 1.2e-7 PFAM
Pfam:7tm_1 43 292 7.1e-32 PFAM
Pfam:7tm_4 141 285 1.3e-43 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111582
AA Change: Y132S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107208
Gene: ENSMUSG00000075179
AA Change: Y132S

DomainStartEndE-ValueType
Pfam:7tm_4 33 308 1.6e-48 PFAM
Pfam:7TM_GPCR_Srsx 37 175 1.2e-7 PFAM
Pfam:7tm_1 43 292 2.4e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216480
AA Change: Y132S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.2906 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.5%
  • 20x: 92.9%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik T C 10: 78,903,743 (GRCm39) E163G probably damaging Het
4921513D11Rik A G 17: 79,935,562 (GRCm39) probably benign Het
Acox3 T A 5: 35,749,459 (GRCm39) F195I possibly damaging Het
Acsl6 T C 11: 54,216,417 (GRCm39) Y135H probably damaging Het
Ankhd1 C A 18: 36,781,083 (GRCm39) A2045E probably benign Het
Ap5z1 A G 5: 142,458,096 (GRCm39) H423R probably benign Het
Arsk T A 13: 76,214,985 (GRCm39) probably benign Het
Bpi G A 2: 158,103,083 (GRCm39) G76D probably damaging Het
Carmil3 A G 14: 55,739,861 (GRCm39) T983A probably damaging Het
Ccdc192 A T 18: 57,666,959 (GRCm39) D12V probably damaging Het
Chmp2b A T 16: 65,342,213 (GRCm39) M125K possibly damaging Het
Clca3a2 T A 3: 144,511,491 (GRCm39) I26L probably damaging Het
Cubn T C 2: 13,315,337 (GRCm39) Y3032C probably damaging Het
Ehbp1 T A 11: 22,101,850 (GRCm39) D226V probably damaging Het
Enpp6 A T 8: 47,535,541 (GRCm39) D362V probably damaging Het
Fam53b A G 7: 132,317,521 (GRCm39) S374P probably damaging Het
Fmn1 T C 2: 113,260,066 (GRCm39) probably benign Het
Fndc7 C T 3: 108,784,003 (GRCm39) R202H probably benign Het
Frmd4b T G 6: 97,265,415 (GRCm39) D951A probably benign Het
Git2 A G 5: 114,877,162 (GRCm39) Y107H probably damaging Het
Gm11595 A T 11: 99,663,365 (GRCm39) V105E unknown Het
Krt26 CTAGTA CTA 11: 99,224,352 (GRCm39) probably benign Het
Lrriq4 C A 3: 30,713,242 (GRCm39) Q448K probably benign Het
Ly6g5c A G 17: 35,330,863 (GRCm39) I128M possibly damaging Het
Mroh9 T A 1: 162,903,860 (GRCm39) S51C probably damaging Het
Myh3 A G 11: 66,970,828 (GRCm39) S2G probably benign Het
Nat8f4 A G 6: 85,878,497 (GRCm39) Y9H probably damaging Het
Negr1 T C 3: 156,267,836 (GRCm39) V2A probably benign Het
Or2y1 C T 11: 49,386,131 (GRCm39) T257I probably damaging Het
Or7g19 C T 9: 18,856,781 (GRCm39) T279I probably benign Het
Otog G A 7: 45,895,707 (GRCm39) C107Y probably damaging Het
Pdgfra C A 5: 75,324,394 (GRCm39) T83K probably benign Het
Pdlim2 C T 14: 70,402,228 (GRCm39) R296H probably damaging Het
Retreg1 A G 15: 25,969,924 (GRCm39) D109G probably damaging Het
Rgs12 T A 5: 35,189,613 (GRCm39) W674R probably damaging Het
Rgs18 T C 1: 144,631,818 (GRCm39) D98G possibly damaging Het
Rnf146 A G 10: 29,223,715 (GRCm39) F57S probably damaging Het
Skic3 T A 13: 76,282,889 (GRCm39) V737D probably damaging Het
Slc22a20 C A 19: 6,021,464 (GRCm39) V513L probably benign Het
Stox2 G T 8: 47,646,661 (GRCm39) F266L probably damaging Het
Tbx21 C T 11: 96,990,863 (GRCm39) V272M probably damaging Het
Tmc7 A G 7: 118,144,850 (GRCm39) F570S probably benign Het
Tmem236 T C 2: 14,224,117 (GRCm39) I302T probably damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trpm3 T C 19: 22,862,776 (GRCm39) L506S probably damaging Het
Uggt1 T C 1: 36,218,694 (GRCm39) I78V probably damaging Het
Xpo4 A T 14: 57,828,328 (GRCm39) V844D probably damaging Het
Zfp507 C T 7: 35,493,150 (GRCm39) R631Q probably damaging Het
Other mutations in Or8k32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01109:Or8k32 APN 2 86,368,674 (GRCm39) missense probably benign 0.12
IGL02289:Or8k32 APN 2 86,368,792 (GRCm39) missense probably benign 0.07
IGL02794:Or8k32 APN 2 86,368,492 (GRCm39) missense possibly damaging 0.80
R1498:Or8k32 UTSW 2 86,368,902 (GRCm39) missense probably benign 0.00
R2195:Or8k32 UTSW 2 86,369,247 (GRCm39) missense probably benign 0.05
R2211:Or8k32 UTSW 2 86,368,857 (GRCm39) missense probably damaging 1.00
R2925:Or8k32 UTSW 2 86,368,891 (GRCm39) missense probably damaging 1.00
R4370:Or8k32 UTSW 2 86,368,764 (GRCm39) missense possibly damaging 0.78
R4430:Or8k32 UTSW 2 86,368,731 (GRCm39) missense probably damaging 0.98
R4678:Or8k32 UTSW 2 86,369,077 (GRCm39) missense possibly damaging 0.95
R4790:Or8k32 UTSW 2 86,369,224 (GRCm39) missense possibly damaging 0.63
R4996:Or8k32 UTSW 2 86,368,615 (GRCm39) missense probably benign 0.02
R5905:Or8k32 UTSW 2 86,369,113 (GRCm39) missense possibly damaging 0.91
R5984:Or8k32 UTSW 2 86,368,512 (GRCm39) missense probably damaging 1.00
R6028:Or8k32 UTSW 2 86,369,113 (GRCm39) missense possibly damaging 0.91
R6878:Or8k32 UTSW 2 86,369,109 (GRCm39) missense probably damaging 1.00
R7579:Or8k32 UTSW 2 86,368,872 (GRCm39) missense probably damaging 0.98
R7942:Or8k32 UTSW 2 86,368,566 (GRCm39) missense probably benign 0.42
R8079:Or8k32 UTSW 2 86,368,725 (GRCm39) missense possibly damaging 0.60
R8465:Or8k32 UTSW 2 86,368,731 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTTGTGCAGAGCAGAGATATCAAG -3'
(R):5'- TGGAATCAAGGCTGCAAACAC -3'

Sequencing Primer
(F):5'- TATCAAGGGAAGACCATCACAG -3'
(R):5'- GACACCTAGCTATCACAGATCTTGG -3'
Posted On 2014-07-14