Mutagenetix > Incidental Mutation

Incidental Mutation 'R1924:Krt26'

213298

Institutional Source

Beutler Lab

Gene Symbol

Krt26

Ensembl Gene

ENSMUSG00000075570

Gene Name

keratin 26

Synonyms

4732407F15Rik

MMRRC Submission

039942-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R1924 (G1)

Quality Score

217

Status

Validated

Chromosome

Chromosomal Location

99219376-99228792 bp(-) (GRCm39)

Type of Mutation

small deletion (1 aa in frame mutation)

DNA Base Change (assembly)

CTAGTA to CTA at 99224352 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000098051 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100482]

AlphaFold

Q3TRJ4

Predicted Effect

probably benign
Transcript: ENSMUST00000100482

SMART Domains

Protein: ENSMUSP00000098051
Gene: ENSMUSG00000075570

Domain	Start	End	E-Value	Type
low complexity region	40	65	N/A	INTRINSIC
Filament	79	394	1.1e-132	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148770

Coding Region Coverage

1x: 97.5%
3x: 96.9%
10x: 95.4%
20x: 92.9%

Validation Efficiency

94% (63/67)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. [provided by RefSeq, Jul 2009]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acacb	G	A	5: 114,368,781 (GRCm39)	M1666I	possibly damaging	Het
Adamts13	A	T	2: 26,874,153 (GRCm39)	Q434L	probably damaging	Het
Adgrg3	G	A	8: 95,762,562 (GRCm39)	R204H	probably benign	Het
Arhgef28	A	C	13: 98,073,324 (GRCm39)		probably benign	Het
AU041133	T	A	10: 81,987,101 (GRCm39)	C251*	probably null	Het
Axin2	T	A	11: 108,833,794 (GRCm39)	N580K	probably benign	Het
C4b	A	G	17: 34,948,631 (GRCm39)	C1560R	probably damaging	Het
Cacna1g	A	G	11: 94,334,880 (GRCm39)	I809T	possibly damaging	Het
Cacna1s	C	A	1: 136,016,755 (GRCm39)		probably null	Het
Cadps2	T	C	6: 23,688,857 (GRCm39)	S151G	probably damaging	Het
Capn1	T	C	19: 6,040,086 (GRCm39)		probably null	Het
Capn9	A	G	8: 125,302,965 (GRCm39)	S28G	probably benign	Het
Ccdc73	A	G	2: 104,822,637 (GRCm39)	D862G	probably damaging	Het
Cdk17	T	C	10: 93,061,979 (GRCm39)	L237P	probably damaging	Het
Cfap251	A	G	5: 123,440,802 (GRCm39)	I1120V	possibly damaging	Het
Chad	A	C	11: 94,456,384 (GRCm39)	N154T	possibly damaging	Het
Cog1	C	T	11: 113,547,038 (GRCm39)	T544I	probably benign	Het
Cracd	A	T	5: 77,006,470 (GRCm39)	T944S	unknown	Het
Ctnna2	T	C	6: 76,931,830 (GRCm39)	E590G	possibly damaging	Het
Dapk2	T	A	9: 66,072,642 (GRCm39)	M6K	probably benign	Het
Dchs1	T	C	7: 105,421,487 (GRCm39)	E311G	possibly damaging	Het
Ddr2	T	A	1: 169,809,641 (GRCm39)	T779S	probably benign	Het
Dhtkd1	A	G	2: 5,916,744 (GRCm39)	V644A	probably damaging	Het
Dock2	A	G	11: 34,414,934 (GRCm39)	V147A	possibly damaging	Het
Ear10	A	T	14: 44,160,357 (GRCm39)	*157K	probably null	Het
Gm10801	T	C	2: 98,494,197 (GRCm39)	I113T	probably damaging	Het
Gmps	T	G	3: 63,906,049 (GRCm39)	C449G	probably damaging	Het
Grin3a	A	G	4: 49,844,988 (GRCm39)	S32P	possibly damaging	Het
Igkv1-115	A	T	6: 68,138,592 (GRCm39)	D65V	probably damaging	Het
Klk1b4	A	G	7: 43,859,105 (GRCm39)	N41S	probably benign	Het
Lrrc8a	T	A	2: 30,145,262 (GRCm39)	D25E	probably damaging	Het
Muc5b	A	G	7: 141,421,960 (GRCm39)	R4426G	possibly damaging	Het
Muc6	G	A	7: 141,218,313 (GRCm39)	S2120F	possibly damaging	Het
Myo5a	G	T	9: 75,023,489 (GRCm39)	D17Y	probably damaging	Het
Nat1	C	G	8: 67,944,076 (GRCm39)	L154V	probably benign	Het
Nek3	T	A	8: 22,647,047 (GRCm39)	T163S	probably damaging	Het
Or2w25	G	T	11: 59,503,949 (GRCm39)	R53L	possibly damaging	Het
Or5p80	A	G	7: 108,229,562 (GRCm39)	D121G	probably damaging	Het
Or6c204	A	G	10: 129,023,044 (GRCm39)	I82T	possibly damaging	Het
Or8d2b	T	A	9: 38,789,147 (GRCm39)	I225N	probably damaging	Het
Or8g32	A	T	9: 39,305,163 (GRCm39)	E22D	possibly damaging	Het
Or9s13	T	C	1: 92,548,525 (GRCm39)	L299P	probably damaging	Het
Osr1	T	G	12: 9,629,268 (GRCm39)	L47R	probably damaging	Het
Pdlim2	C	T	14: 70,402,228 (GRCm39)	R296H	probably damaging	Het
Pik3ap1	T	A	19: 41,291,053 (GRCm39)	N493I	possibly damaging	Het
Polr3e	T	A	7: 120,539,820 (GRCm39)	N522K	probably damaging	Het
Rabgap1	T	A	2: 37,385,771 (GRCm39)		probably null	Het
Rp1l1	C	A	14: 64,268,992 (GRCm39)	A1526E	probably benign	Het
Scn3a	T	A	2: 65,291,878 (GRCm39)	I1623F	probably damaging	Het
Serpinb9e	A	G	13: 33,437,428 (GRCm39)	T104A	probably benign	Het
Sh3rf3	T	C	10: 58,939,989 (GRCm39)		probably benign	Het
Slc30a3	A	G	5: 31,245,748 (GRCm39)	Y213H	probably damaging	Het
Sptbn4	C	T	7: 27,106,563 (GRCm39)	R955H	probably damaging	Het
Tfb1m	A	T	17: 3,569,946 (GRCm39)	Y307N	probably damaging	Het
Tnrc6b	G	T	15: 80,768,407 (GRCm39)		probably null	Het
Tns2	C	T	15: 102,017,369 (GRCm39)	R281C	probably damaging	Het
Ulk1	A	G	5: 110,938,936 (GRCm39)	Y501H	probably damaging	Het
Zbtb17	A	G	4: 141,191,914 (GRCm39)	H315R	probably damaging	Het
Zeb2	A	G	2: 44,892,624 (GRCm39)	Y142H	probably damaging	Het
Zfr	T	C	15: 12,160,715 (GRCm39)	S763P	possibly damaging	Het

Other mutations in Krt26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00970:Krt26	APN	11	99,222,107 (GRCm39)	missense	probably benign	0.00
IGL02019:Krt26	APN	11	99,224,471 (GRCm39)	missense	probably benign	0.30
IGL02138:Krt26	APN	11	99,224,471 (GRCm39)	missense	probably benign	0.30
IGL02188:Krt26	APN	11	99,224,471 (GRCm39)	missense	probably benign	0.30
IGL02189:Krt26	APN	11	99,224,471 (GRCm39)	missense	probably benign	0.30
IGL02192:Krt26	APN	11	99,224,471 (GRCm39)	missense	probably benign	0.30
IGL02647:Krt26	APN	11	99,224,471 (GRCm39)	missense	probably benign	0.30
IGL02651:Krt26	APN	11	99,224,471 (GRCm39)	missense	probably benign	0.30
R0122:Krt26	UTSW	11	99,224,545 (GRCm39)	nonsense	probably null
R1842:Krt26	UTSW	11	99,224,352 (GRCm39)	small deletion	probably benign
R1843:Krt26	UTSW	11	99,224,352 (GRCm39)	small deletion	probably benign
R1923:Krt26	UTSW	11	99,224,352 (GRCm39)	small deletion	probably benign
R3872:Krt26	UTSW	11	99,225,570 (GRCm39)	missense	probably damaging	1.00
R3873:Krt26	UTSW	11	99,225,570 (GRCm39)	missense	probably damaging	1.00
R3874:Krt26	UTSW	11	99,225,570 (GRCm39)	missense	probably damaging	1.00
R3875:Krt26	UTSW	11	99,225,570 (GRCm39)	missense	probably damaging	1.00
R4014:Krt26	UTSW	11	99,226,128 (GRCm39)	missense	probably damaging	0.99
R4939:Krt26	UTSW	11	99,225,522 (GRCm39)	missense	probably benign	0.03
R5620:Krt26	UTSW	11	99,228,597 (GRCm39)	missense	possibly damaging	0.86
R6035:Krt26	UTSW	11	99,224,415 (GRCm39)	missense	probably benign	0.43
R6035:Krt26	UTSW	11	99,224,415 (GRCm39)	missense	probably benign	0.43
R6151:Krt26	UTSW	11	99,228,315 (GRCm39)	missense	probably benign	0.35
R6578:Krt26	UTSW	11	99,225,628 (GRCm39)	missense	probably damaging	1.00
R6626:Krt26	UTSW	11	99,220,528 (GRCm39)	missense	probably benign	0.28
R7413:Krt26	UTSW	11	99,225,887 (GRCm39)	missense	probably benign	0.25
R7557:Krt26	UTSW	11	99,225,567 (GRCm39)	missense	probably damaging	1.00
R7919:Krt26	UTSW	11	99,224,420 (GRCm39)	missense	probably damaging	1.00
R8051:Krt26	UTSW	11	99,228,672 (GRCm39)	missense	probably damaging	0.97
R8090:Krt26	UTSW	11	99,227,315 (GRCm39)	missense	probably benign	0.13
R8163:Krt26	UTSW	11	99,220,498 (GRCm39)	missense	probably benign	0.00
R8211:Krt26	UTSW	11	99,226,110 (GRCm39)	missense	probably damaging	0.98
R8480:Krt26	UTSW	11	99,228,426 (GRCm39)	missense	probably damaging	1.00
R9040:Krt26	UTSW	11	99,222,093 (GRCm39)	missense	probably benign	0.00
R9418:Krt26	UTSW	11	99,228,741 (GRCm39)	start gained	probably benign
Z1186:Krt26	UTSW	11	99,228,643 (GRCm39)	missense	probably damaging	0.99
Z1191:Krt26	UTSW	11	99,228,643 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CAAAAGAAGCCCCTGAGTTTTG -3'
(R):5'- ATTCATTGGCTGAGACCGAAG -3'

Sequencing Primer
(F):5'- ATTTCTGTTTTCATTTCATTGGATGC -3'
(R):5'- GGGAATTACTATGCTCAACTCCAG -3'

Posted On

2014-07-14