|Institutional Source||Beutler Lab|
|Gene Name||neuron navigator 1|
|Synonyms||steerin-1, C230080M11Rik, unc53H1, 9930003A20Rik, POMFIL3|
|Is this an essential gene?||Probably essential (E-score: 0.833)|
|Stock #||R1925 (G1)|
|Chromosomal Location||135434580-135607295 bp(-) (GRCm38)|
|Type of Mutation||utr 5 prime|
|DNA Base Change (assembly)||T to A at 135607229 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000140322 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000190298]|
|Predicted Effect||noncoding transcript
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.256|
|Coding Region Coverage||
|Validation Efficiency||99% (79/80)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Nav1||
(F):5'- TCCCTGGTTCTTGTCAAGGC -3'
(R):5'- ACCCCAGTCAAGCTGTTATGG -3'
(F):5'- TTCTTGTCAAGGCCCCAGAG -3'
(R):5'- CCCAGTCAAGCTGTTATGGAGAAAC -3'