Incidental Mutation 'R1926:Trip12'
| ID |
213398 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
039944-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1926 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 84727012 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1153
(V1153A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139563
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000185909]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000189670]
[ENSMUST00000189841]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027421
AA Change: V1186A
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: V1186A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185909
|
| SMART Domains |
Protein: ENSMUSP00000139986
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186465
AA Change: V1186A
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: V1186A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186648
AA Change: V1153A
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: V1153A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189670
|
| SMART Domains |
Protein: ENSMUSP00000140789
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
138 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
167 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
168 |
222 |
5e-8 |
BLAST |
|
Blast:HECTc
|
378 |
434 |
1e-24 |
BLAST |
|
HECTc
|
441 |
830 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189841
|
| SMART Domains |
Protein: ENSMUSP00000140879
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
1 |
24 |
N/A |
INTRINSIC |
|
low complexity region
|
51 |
63 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190125
|
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.7%
- 10x: 95.0%
- 20x: 91.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm3 |
C |
T |
7: 119,376,359 (GRCm39) |
T362M |
probably damaging |
Het |
| Ang6 |
A |
G |
14: 44,239,695 (GRCm39) |
V11A |
possibly damaging |
Het |
| Ankrd17 |
A |
G |
5: 90,392,028 (GRCm39) |
Y1880H |
probably damaging |
Het |
| Bmi1 |
A |
G |
2: 18,687,084 (GRCm39) |
I55V |
probably benign |
Het |
| Bnipl |
G |
A |
3: 95,150,354 (GRCm39) |
T297M |
probably damaging |
Het |
| Bpifa2 |
T |
C |
2: 153,855,669 (GRCm39) |
V198A |
probably benign |
Het |
| Brms1l |
G |
T |
12: 55,909,946 (GRCm39) |
V239F |
possibly damaging |
Het |
| Ccdc158 |
A |
G |
5: 92,798,647 (GRCm39) |
V351A |
probably benign |
Het |
| Ces1c |
A |
G |
8: 93,854,232 (GRCm39) |
F101S |
possibly damaging |
Het |
| Cpb2 |
T |
C |
14: 75,479,837 (GRCm39) |
Y15H |
probably benign |
Het |
| Dglucy |
A |
T |
12: 100,833,414 (GRCm39) |
N535I |
possibly damaging |
Het |
| Dop1a |
C |
A |
9: 86,405,072 (GRCm39) |
H1763Q |
probably damaging |
Het |
| Dpy19l1 |
C |
T |
9: 24,385,120 (GRCm39) |
M236I |
probably benign |
Het |
| Efna2 |
T |
C |
10: 80,022,710 (GRCm39) |
Y85H |
probably damaging |
Het |
| Eipr1 |
A |
T |
12: 28,914,836 (GRCm39) |
|
probably null |
Het |
| Eln |
A |
T |
5: 134,735,421 (GRCm39) |
Y787* |
probably null |
Het |
| Erbb2 |
G |
C |
11: 98,315,990 (GRCm39) |
E364D |
probably benign |
Het |
| F5 |
A |
G |
1: 164,007,077 (GRCm39) |
T294A |
probably damaging |
Het |
| Fam47e |
A |
G |
5: 92,733,244 (GRCm39) |
T194A |
possibly damaging |
Het |
| Galk1 |
T |
C |
11: 115,901,073 (GRCm39) |
D202G |
probably damaging |
Het |
| Glb1l2 |
T |
C |
9: 26,682,362 (GRCm39) |
D163G |
probably damaging |
Het |
| Gmip |
A |
G |
8: 70,268,170 (GRCm39) |
E408G |
probably benign |
Het |
| Gp1ba |
A |
T |
11: 70,531,715 (GRCm39) |
|
probably benign |
Het |
| Grm3 |
A |
T |
5: 9,554,881 (GRCm39) |
C804S |
probably damaging |
Het |
| Gzmd |
A |
G |
14: 56,367,737 (GRCm39) |
C179R |
probably damaging |
Het |
| Hadhb |
T |
A |
5: 30,385,935 (GRCm39) |
L415Q |
possibly damaging |
Het |
| Ift80 |
T |
C |
3: 68,823,498 (GRCm39) |
Y588C |
probably damaging |
Het |
| Jazf1 |
T |
C |
6: 53,045,516 (GRCm39) |
T13A |
probably benign |
Het |
| Kat8 |
T |
A |
7: 127,514,467 (GRCm39) |
Y67* |
probably null |
Het |
| Kcnab1 |
G |
A |
3: 65,283,933 (GRCm39) |
E384K |
possibly damaging |
Het |
| Lhx3 |
A |
T |
2: 26,092,200 (GRCm39) |
Y230* |
probably null |
Het |
| Lmx1b |
T |
A |
2: 33,454,674 (GRCm39) |
M365L |
probably damaging |
Het |
| Ly6k |
G |
T |
15: 74,669,051 (GRCm39) |
P76Q |
probably benign |
Het |
| Lypd10 |
G |
A |
7: 24,413,541 (GRCm39) |
G186R |
probably damaging |
Het |
| Map1b |
A |
T |
13: 99,567,200 (GRCm39) |
H1840Q |
unknown |
Het |
| Map3k2 |
A |
G |
18: 32,336,163 (GRCm39) |
I117V |
probably damaging |
Het |
| Med13 |
C |
A |
11: 86,179,899 (GRCm39) |
A1350S |
possibly damaging |
Het |
| Midn |
T |
C |
10: 79,987,495 (GRCm39) |
S109P |
probably damaging |
Het |
| Msh6 |
A |
G |
17: 88,293,653 (GRCm39) |
T803A |
probably benign |
Het |
| Nckap1 |
T |
C |
2: 80,337,182 (GRCm39) |
Y1018C |
probably damaging |
Het |
| Ndufc1 |
A |
T |
3: 51,314,816 (GRCm39) |
N63K |
probably benign |
Het |
| Neb |
A |
T |
2: 52,169,647 (GRCm39) |
S1811R |
probably damaging |
Het |
| Notch1 |
T |
C |
2: 26,371,669 (GRCm39) |
D260G |
probably damaging |
Het |
| Ntn4 |
C |
T |
10: 93,543,215 (GRCm39) |
R314W |
probably damaging |
Het |
| Oas1g |
T |
C |
5: 121,017,205 (GRCm39) |
K283R |
probably benign |
Het |
| Obscn |
T |
C |
11: 58,954,300 (GRCm39) |
T4037A |
|
Het |
| Or6b1 |
T |
G |
6: 42,815,247 (GRCm39) |
L144R |
probably damaging |
Het |
| Or6b3 |
A |
G |
1: 92,439,330 (GRCm39) |
L140P |
probably damaging |
Het |
| Otop2 |
A |
T |
11: 115,217,781 (GRCm39) |
T206S |
probably benign |
Het |
| Pamr1 |
A |
G |
2: 102,471,342 (GRCm39) |
|
probably null |
Het |
| Pkp1 |
G |
A |
1: 135,805,411 (GRCm39) |
T675I |
probably benign |
Het |
| Plxna2 |
G |
A |
1: 194,444,758 (GRCm39) |
V717I |
probably benign |
Het |
| Ptgs2 |
T |
C |
1: 149,975,979 (GRCm39) |
L2P |
possibly damaging |
Het |
| Rarg |
A |
G |
15: 102,147,980 (GRCm39) |
F277S |
probably damaging |
Het |
| Rassf5 |
A |
T |
1: 131,140,076 (GRCm39) |
I161N |
probably damaging |
Het |
| Resf1 |
C |
T |
6: 149,230,902 (GRCm39) |
T1316I |
probably benign |
Het |
| Rxfp4 |
A |
G |
3: 88,559,659 (GRCm39) |
V264A |
probably benign |
Het |
| Secisbp2l |
T |
A |
2: 125,582,597 (GRCm39) |
Q953L |
probably damaging |
Het |
| Serpinb9c |
T |
C |
13: 33,334,218 (GRCm39) |
I275V |
probably benign |
Het |
| Slc2a12 |
T |
C |
10: 22,541,141 (GRCm39) |
V332A |
probably damaging |
Het |
| Slc7a1 |
T |
C |
5: 148,285,113 (GRCm39) |
S127G |
probably damaging |
Het |
| Slc7a4 |
A |
T |
16: 17,393,568 (GRCm39) |
V77E |
probably damaging |
Het |
| Sp8 |
G |
A |
12: 118,812,964 (GRCm39) |
S273N |
possibly damaging |
Het |
| Spag6l |
G |
T |
16: 16,580,921 (GRCm39) |
N475K |
probably benign |
Het |
| St18 |
A |
G |
1: 6,872,913 (GRCm39) |
H216R |
probably benign |
Het |
| Tcirg1 |
C |
T |
19: 3,952,843 (GRCm39) |
|
probably benign |
Het |
| Tmeff1 |
A |
G |
4: 48,658,788 (GRCm39) |
Y87C |
probably damaging |
Het |
| Tmem94 |
T |
C |
11: 115,683,726 (GRCm39) |
V713A |
possibly damaging |
Het |
| Tnrc6b |
G |
T |
15: 80,765,363 (GRCm39) |
R955L |
probably damaging |
Het |
| Tshz3 |
T |
C |
7: 36,468,800 (GRCm39) |
L263S |
probably damaging |
Het |
| Tubb6 |
G |
A |
18: 67,534,391 (GRCm39) |
|
probably null |
Het |
| Ube3a |
T |
C |
7: 58,926,127 (GRCm39) |
W302R |
probably damaging |
Het |
| Vcpkmt |
A |
T |
12: 69,629,519 (GRCm39) |
V81E |
probably damaging |
Het |
| Vmn1r175 |
T |
A |
7: 23,508,466 (GRCm39) |
I54F |
possibly damaging |
Het |
| Vwa8 |
T |
A |
14: 79,258,075 (GRCm39) |
N741K |
probably benign |
Het |
| Yeats2 |
A |
G |
16: 20,033,176 (GRCm39) |
T1034A |
probably benign |
Het |
| Zc3h6 |
G |
A |
2: 128,839,715 (GRCm39) |
R176Q |
probably damaging |
Het |
| Zfp207 |
T |
A |
11: 80,286,253 (GRCm39) |
Y424* |
probably null |
Het |
| Zfp729a |
A |
G |
13: 67,767,676 (GRCm39) |
V851A |
probably benign |
Het |
| Zkscan1 |
G |
T |
5: 138,099,625 (GRCm39) |
A450S |
probably benign |
Het |
| Zkscan3 |
A |
G |
13: 21,580,616 (GRCm39) |
V24A |
possibly damaging |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7144:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGACTCTTAGTACCCATGAGC -3'
(R):5'- TGCTTAACATAGTGACCCTTCCAG -3'
Sequencing Primer
(F):5'- CATGAGCACTATCAACTTACTGGAG -3'
(R):5'- GATCTAAGCCCAGTAGTGCTCTAG -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation